I-TASSER results

I-TASSER results for job id Rv1718

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (272 residues)
MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAHIHLRDENERPTADPN
IARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRMATLNPCSMSFGAGEFRNP
PQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLLAEPLQFSIVLGVRGGMAATA
DNLLTMVRRLPPGAIWQVIAIGKANMELTAMGLALGGNARVGLEDTLYLRKGELAPSNLA
LVSRTIRLAEALDLPIASVEEAEAALQLPGTS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAHIHLRDENERPTADPNIARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRMATLNPCSMSFGAGEFRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLLAEPLQFSIVLGVRGGMAATADNLLTMVRRLPPGAIWQVIAIGKANMELTAMGLALGGNARVGLEDTLYLRKGELAPSNLALVSRTIRLAEALDLPIASVEEAEAALQLPGTS
Prediction	CCEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHCCCHHHHHHHHHHHHCCCEEEHCCCCEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
Conf.Score	96899995679988866699999999999999999999899799998569999988899999999999999899599868888889999999888875886787567766788877779999999999999998997699986999999999999989999985899996688888999999999999869999478986587589999999999898589556764568986579999999999999999899999999999998899999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAHIHLRDENERPTADPNIARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRMATLNPCSMSFGAGEFRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLLAEPLQFSIVLGVRGGMAATADNLLTMVRRLPPGAIWQVIAIGKANMELTAMGLALGGNARVGLEDTLYLRKGELAPSNLALVSRTIRLAEALDLPIASVEEAEAALQLPGTS
Prediction	52000000000244246513312220530052024016010000000012663530331520340052037404000000002034232420130261313000010111334532131226102300410473503000000112003002301643105421100000003212212051023006203760300000114301200220041312010000310114744415201400420050066173521206301521715568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEHCCCHHHHHHHHHHHHCCCEEEHCCCCEHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
MSIVITVAPTGPIATKADNPALPTSPEEIATAVEQAYHAGAAVAHIHLRDENERPTADPNIARRAMDLIGERCPILIQLSTGVGLTVPFEQREQLVELRPRMATLNPCSMSFGAGEFRNPPQAVRRLAARMRELDIKPELEIYDTGHLEACLRLWAEDLLAEPLQFSIVLGVRGGMAATADNLLTMVRRLPPGAIWQVIAIGKANMELTAMGLALGGNARVGLEDTLYLRKGELAPSNLALVSRTIRLAEALDLPIASVEEAEAALQLPGTS

2y7dA

0.37

0.36

0.96

2.86

MUSTER

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTG-------DKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIITQPLHIQFVLGVPGGMSGKPKNLMYMMEHLKPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

4.42

dPPAS

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTGDKRL-------APLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLIPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

4.54

wdPPAS

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTG-------DKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLIPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

3.42

wMUSTER

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTG-------DKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIITQPLHIQFVLGVPGGMSGKPKNLMYMMEHLKPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

4.51

wPPAS

HPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTG-------DKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLIPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

8.45

dPPAS2

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTGDKRL-------APLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLKPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

4.10

PPAS

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTG-------DKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLKPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

2y7dA

0.37

0.36

0.96

5.41

Env-PPAS

EPLILTAAITGAETTRADQPNLPITPEEQAKEAKACFEAGARVIHLHIREDDGRPSQRLDRFQEAISAIREVVPIIIQISTG-------DKRLAPLALKPEMATLNAGTLNFGDDIFINHPADIIRLAEAFKQYNVVPEVEVYESGMVDAVARLIKKGIIQNPLHIQFVLGVPGGMSGKPKNLMYMMEHLKPTATWAVAGIGRWHIPTSLIAMVTGGHIRCGFEDNIFYHKGVIAESNAQLVARLARIAKEIGRPLATPEQAREILALN---

3fa5A

0.34

0.33

0.97

2.69

MUSTER

KPCIICVAITGSLPTKENNPAVPITLAEQVESTHEAFEAGASIAHCHVRDDEGRPTSDPDRFAALKEGLERHCPGIVQLSTGGRSGAGQARGA--LPLCPD-ASLSVGSNNFPTRVYENP-PDLVDWLAAELKYDIKPEIEAFDLSHILQAKRAGDGR-LAGTPYVQFV-GVRNA-PADRDVFDYYIHTVGEDAPWCAAGIGPSQIVLNEWAISSGGHARTGLEDNVRLDRDRLAPSNAALVGRAVELCEKYERPVATWRQARQILGLRV--

3fa5A

0.33

0.32

0.97

4.13

dPPAS

KPCIICVAITGSLPTKENNPAVPITLAEQVESTHEAFEAGASIAHCHVRDDEGRPTSDPDRFAALKEGLERHCPGIVQLSTGGRSGA--GQARGALPLCPD-ASLSVGSNNFPTRVYENP-PDLVDWLAAELKYDIKPEIEAFDLSHILQAKRAGDGR-LAGTPYVQFVGVRNAPADRDDYYIHTVRRLFGEDAPWCAAGIGPSQIVLNEWAISSGGHARTGLEDNVRLDRDRLAPSNAALVGRAVELCEKYERPVATWRQARQILGLRV--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 1 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.78

Estimated TM-score = 0.97±0.05

Estimated RMSD = 2.5±1.9Å

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2y7dA	0.952	0.70	0.366	0.963
2	3e49A	0.928	1.59	0.330	0.982
3	3fa5A	0.926	1.35	0.361	0.967
4	3lotD	0.922	1.51	0.333	0.971
5	3e02A	0.910	1.64	0.363	0.963
6	3no5A	0.907	1.57	0.340	0.952
7	3c6cA	0.902	1.64	0.331	0.956
8	5ikyA	0.901	2.29	0.239	1.000
9	4nnaA	0.878	2.34	0.241	0.978
10	3t7vA	0.705	3.97	0.116	0.908

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.53	29	3fa5B	MG	Rep, Mult	45,47,224
2	0.29	14	2y7gA	AAE	Rep, Mult	45,47,80,82,104,106,141,143,169,220,224
3	0.15	8	2y7fA	KMH	Rep, Mult	13,45,47,80,82,104,106,112,117,143,224
4	0.06	4	3lotB	UNL	Rep, Mult	12,47,82,224
5	0.06	9	1xbzA	LX1	Rep, Mult	8,10,45,80,82,169,199,201,220,222,223
6	0.05	4	3e49B	IMD	Rep, Mult	171,172,176,177,178
7	0.02	2	3e49D	IMD	Rep, Mult	187,191,196,215,216
8	0.02	2	3lotA	UNL	Rep, Mult	143,220,224,225
9	0.01	2	1piiA	PO4	Rep, Mult	9,200,201,221,222,223
10	0.01	1	3iizA	UUU	Rep, Mult	209,221,229,241,244,245,248
11	0.01	1	2y7fD	MG	Rep, Mult	60,64
12	0.01	1	3chvA	ZN	Rep, Mult	70
13	0.01	1	3e49D	IMD	Rep, Mult	203,228,230,231
14	0.01	1	3iivB	MG	Rep, Mult	45,104,220

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.170	1tqxA	0.602	3.57	0.138	0.750	5.1.3.1	NA
2	0.170	1xi3A	0.597	2.99	0.115	0.706	2.5.1.3	NA
3	0.155	2v81A	0.591	3.35	0.139	0.724	4.1.2.21	NA
4	0.153	1vlwB	0.591	3.01	0.125	0.706	4.1.3.16	NA
5	0.145	1y0eA	0.589	3.30	0.123	0.702	5.1.3.9	221
6	0.140	1m5wF	0.645	4.02	0.177	0.816	2.6.99.2	47,222
7	0.118	2yw3E	0.569	3.13	0.144	0.691	4.1.2.14	NA
8	0.117	1nsjA	0.581	3.51	0.091	0.721	5.3.1.24	NA
9	0.096	2h6rB	0.581	3.31	0.116	0.721	5.3.1.1	141
10	0.096	1xbzB	0.612	3.56	0.114	0.768	4.1.1.85	NA
11	0.095	1v5xA	0.571	3.56	0.122	0.706	5.3.1.24	NA
12	0.093	1xi3B	0.599	2.98	0.115	0.706	2.5.1.3	205
13	0.089	3f4wA	0.605	3.53	0.102	0.757	4.1.2.-	48
14	0.084	2yswA	0.603	3.36	0.113	0.739	4.2.1.10	45
15	0.083	2yswC	0.602	3.37	0.123	0.735	4.2.1.10	84,199,202
16	0.081	3inpA	0.600	3.65	0.115	0.754	5.1.3.1	NA
17	0.077	1h1yA	0.599	3.63	0.124	0.750	5.1.3.1	NA
18	0.077	1h1yB	0.598	3.56	0.114	0.746	5.1.3.1	NA
19	0.072	2fliC	0.601	3.41	0.137	0.735	5.1.3.1	NA
20	0.060	1cb7B	0.686	3.40	0.085	0.842	5.4.99.1	139
21	0.060	1b1yA	0.676	3.97	0.056	0.864	3.2.1.2	NA
22	0.060	1fa2A	0.673	4.06	0.064	0.871	3.2.1.2	NA
23	0.060	3gnrA	0.674	4.16	0.065	0.901	3.2.1.21	NA
24	0.060	1myrA	0.674	4.14	0.065	0.897	3.2.1.147	5
25	0.060	1gonA	0.688	4.19	0.100	0.912	3.2.1.21	NA
26	0.060	2e9lA	0.681	4.07	0.069	0.901	3.2.1.21	NA
27	0.060	2whjA	0.679	4.07	0.087	0.879	3.2.1.78	139
28	0.060	2uv8G	0.672	3.90	0.100	0.879	2.3.1.86	NA
29	0.060	1wkyA	0.680	4.14	0.095	0.879	3.2.1.78	139
30	0.060	2e3zA	0.682	4.20	0.077	0.912	3.2.1.21	NA
31	0.060	1dwaM	0.673	4.11	0.069	0.893	3.2.1.147	NA
32	0.060	2z1sA	0.682	4.25	0.065	0.912	3.2.1.21	NA
33	0.060	1nvmA	0.678	3.47	0.063	0.824	4.1.3.38	NA
34	0.060	1wdpA	0.678	4.00	0.060	0.875	3.2.1.2	NA
35	0.060	1e1eB	0.675	4.13	0.094	0.897	3.2.1.21	NA
36	0.060	2jf6B	0.670	4.23	0.069	0.901	3.2.1.105	NA
37	0.060	1np2A	0.682	4.19	0.097	0.901	3.2.1.21	NA
38	0.060	1tr1D	0.681	4.15	0.083	0.904	3.2.1.21	101,197

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.62	0.966	1.08	0.36	0.99	2y7dD	GO:0003824 GO:0016740 GO:0019475 GO:0046872
1	0.60	0.956	1.32	0.35	1.00	3chvA	GO:0003824 GO:0016740 GO:0019475
2	0.59	0.954	1.44	0.34	1.00	3lotD	GO:0003824 GO:0016740 GO:0019475 GO:0046872
3	0.59	0.952	1.33	0.36	0.99	3fa5A	GO:0003824 GO:0016740 GO:0019475 GO:0046872
4	0.57	0.934	1.63	0.32	0.99	3c6cA	GO:0003824 GO:0016740 GO:0019475
5	0.56	0.950	1.52	0.34	1.00	3e49A	GO:0003824 GO:0016740 GO:0019475 GO:0046872
6	0.55	0.948	1.54	0.36	1.00	3e02A	GO:0003824 GO:0016740 GO:0019475 GO:0046872
7	0.53	0.933	1.60	0.34	0.98	3no5E	GO:0003824 GO:0016740 GO:0019475 GO:0046872
8	0.42	0.895	2.29	0.24	0.99	4nnaA	GO:0003824 GO:0016740 GO:0019475 GO:0046872
9	0.34	0.901	2.29	0.24	1.00	5ikyA	GO:0003824 GO:0016740 GO:0019475
10	0.10	0.612	4.44	0.08	0.84	3ij6A	GO:0016787 GO:0046872
11	0.08	0.614	4.21	0.05	0.79	2qq6B	GO:0003824 GO:0008152 GO:0009063 GO:0046872
12	0.07	0.582	3.81	0.11	0.75	1wv2A	GO:0003824 GO:0005737 GO:0009228 GO:0009229 GO:0016740 GO:0016783
13	0.07	0.597	4.24	0.06	0.81	1h7rA	GO:0003824 GO:0004655 GO:0005829 GO:0006779 GO:0006782 GO:0006783 GO:0008270 GO:0016829 GO:0032791 GO:0033014 GO:0046872
14	0.07	0.595	4.19	0.10	0.77	3e96B	GO:0003824 GO:0008152 GO:0016829
15	0.07	0.510	5.07	0.08	0.75	4u0pB	GO:0003824 GO:0005737 GO:0009107 GO:0009249 GO:0016740 GO:0016783 GO:0016992 GO:0046872 GO:0051536 GO:0051539
16	0.07	0.579	4.36	0.07	0.78	3es7A	GO:0003824 GO:0008152 GO:0016829 GO:0046872
17	0.07	0.591	3.60	0.08	0.74	2zadA	GO:0003824 GO:0008152 GO:0016853 GO:0016855 GO:0016998 GO:0046872 GO:0071555
18	0.06	0.375	5.62	0.06	0.60	1ji0A	GO:0000166 GO:0005524 GO:0015658 GO:0015803 GO:0016887
19	0.06	0.327	5.66	0.07	0.52	3ab1B	GO:0004324 GO:0016491 GO:0050660 GO:0050661 GO:0055114
20	0.06	0.307	6.10	0.05	0.51	1rwrA	GO:0009986

Consensus prediction of GO terms

Molecular Function	GO:0016740	GO:0046872
GO-Score	0.99	0.94
Biological Processes	GO:0019475
GO-Score	0.99
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.