I-TASSER results

I-TASSER results for job id Rv1702c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (454 residues)
MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCEKIRRRLPAAEHPFINK
LADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPRRTLTGQPLPPLLTATAAA
QRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCL
NPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADD
TPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTEL
QSRAGHALTGGGTLLPMSDVIRLASHANHYLRIFDHGRELALYHTKRLASPGQRIVLYAK
DRGCSFPNCDVPGYLTEVHHVTDFAQCQETDINELTQGCGPHHQLATTGGWITRKRKDGT
TEWLPPAHLDHGQPRTNSYFHPEKLLHDSDEDDP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCEKIRRRLPAAEHPFINKLADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPRRTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCLNPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADDTPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTELQSRAGHALTGGGTLLPMSDVIRLASHANHYLRIFDHGRELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVTDFAQCQETDINELTQGCGPHHQLATTGGWITRKRKDGTTEWLPPAHLDHGQPRTNSYFHPEKLLHDSDEDDP
Prediction	CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEHCCHHHHHCCCCCCHCCCCCCCCHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	9887679999999999999999997986559989999999999999999999999999999986544556786478999988666789999999988875554455555567769999999988999999999999998688888999999999999998656999999999999999988888988578877558699855899879999997799999999999999876568899876666677765566678887544445568999886557888887767655788874677765678875558888889999999987585799977899876676667889999999999858888999999986445455576667899999888555656665566778858885899856887899999999999988887555788899999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCEKIRRRLPAAEHPFINKLADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPRRTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCLNPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADDTPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTELQSRAGHALTGGGTLLPMSDVIRLASHANHYLRIFDHGRELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVTDFAQCQETDINELTQGCGPHHQLATTGGWITRKRKDGTTEWLPPAHLDHGQPRTNSYFHPEKLLHDSDEDDP
Prediction	8644435302400430330043017031540324101300330240111020110200110141134442314012020120101242022113204422422222043035102100300311220240010013002202210214114301320052047131630250042004203452545466423421101034210000100010103010001200230022011223231211322344332442411211220100100021002224123323122211022313313442212101200100031013101202102001443221312333320341101001001200011203200220101002214541200040011003200201222101011246341201113313233212121010430146666768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCEEEEHCCCCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEEHCCHHHHHCCCCCCHCCCCCCCCHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEHCCCCCEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MYSSSREEAVAAFDNLDTALNRVLKVSPDDLTIPECLAMLQRCEKIRRRLPAAEHPFINKLADQTDQTELGGKLPFALAERLHISRGEASRRIHEAADLGPRRTLTGQPLPPLLTATAAAQRAGHLGPAHVQVIRCFLHQLPHHVDLPTREKAEAELATLGGRFRPDQLHKLATKLADCLNPDGNYNDTDRARRRSIILGNQGPDGMSAISGYLTPEARATVDAVLAKLAAPGMANPADDTPCLAGTPSQAAIEADTRSAGQRHHDGLLAALRALLCSGELGQHNGLPAAIIVSTSLTELQSRAGHALTGGGTLLPMSDVIRLASHANHYLRIFDHGRELALYHTKRLASPGQRIVLYAKDRGCSFPNCDVPGYLTEVHHVTDFAQCQETDINELTQGCGPHHQLATTGGWITRKRKDGTTEWLPPAHLDHGQPRTNSYFHPEKLLHDSDEDDP

5gaoE

0.14

0.10

0.73

1.17

PPAS

-----------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---------------AAAAAAAA-------------AAAAA-------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA-------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAA-AAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--------------------------------------------

4cg4A

0.07

0.05

0.79

1.14

Env-PPAS

VALEHKKKIQKQLEHLKKLRKSGEEQRSYG--EEKAVSFLKQTEALKQRVQRKLEQVYYFLEQQEHF------FVASLEDVGQMVGQIRKAYDTRVSQDIALLDALIGELEAKECQSEWELLQ---DIGDILHRAKTVPVPEKWTTPQEIKQKIQLLHQKSEFVEKSTKYFSETLRSEMEMFNVPELIGAQAHAVNVILDAETAYPNLIFS---------------------------DDLKSVRLGNKWERLPDGPQRFDSC------------IIVLGSPSFLSGRRYWEVEVG-----------------------------DKTAWILGACKTSISRKGNMTLSPENGYWVVIMMKENEYQA--SSVPPTRLLIKEPPKYRVGSISNVTARSHIYTFASCSFSGPGTRDGGKNTAPLTICPVGG-----QGPDALEVLFQ----------

1ciyA

0.12

0.99

1.05

Env-PPAS

EFVPGAGFVLGLVDIIPSQWDAFLVQIEQRIEEFARNQAISRLEGLSNLYQIYAESFREWEAD-----PTNPALREEMRIQFNDMNSALTTAIPLLAVQNYQVPLYVQAANLHLSVLRDVSVFGQFDAATINSRYNDLTRLIGNYTDYAVRWYNTGLERVWGPDSRDWVRYNQFRRELTLTNFDGSFRGMAQRIEQNIRQPHLMDILNSITIYTDVHRGFNYWSGHQITASPVGFSGPEFAFPLFGNAGNAAPPVLVSLTGLGIFRTLSSPLYRRIILGSGPNNQELFVLDGTEFSFASLTTNLPSTIYRQRGTVDSLDVPPRAGFSHRLSHVTMLSQAAGAVYTLRAPTFSWQHRSAEFSQITQIPLTKSTNLGSGTSVVKPGFTGGRTSPGQISTLVNITAPLSTNLQFHTSIDGRPINQGNFSATMSSGSNLQSGSFRTVGFTTPFNFSNG

3crlB

0.13

0.11

0.81

1.00

Env-PPAS

-----------SLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINL---LPDRVLSTP--SVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVT--IRNRHNDVVPTMAQGVTYGDDPVSNQNIQYFLDRFYL--SRISIRMLINQHTLIFDGSTNPAH-------------PKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNATQPIH--MVYVPSHLYHMLFELFKNAMRASHESSLTLPPIKIMVALGEEDLS----IKMSDRGGGVPLRKIERLFSYM--YSTAPLAGFGYGL--------PISRLYAKYFQGDLQMEGTDAKALSTDSVERLPVYN----------KSAWRHYQTIQEAG-----------DWCVPSTEPKNTSTY------------------

4k6jA

0.13

0.12

0.95

0.72

MUSTER

VVEFGEN--QEFTDDIEYLLSGLKSTQPLNTRCLSVISLATKCAMPSFRMHLRAHGMVAMVFKTLDDSQHHQNLSLCTAALMYILSRDRRASLDLMIRLLELEQLNMNKIKEKIRRLCETVHNKHLDLENITTGHLAMETLLSLTSKRAGDWFKEELRLLGG---LDHIVDKVKECVDHLSRDEDEEKLVASLWGAERVTVHNPENQSYLIAYKDSQLIVSSAKALQHCEELIQQYNRAEDSICLADSKPLPHQNVTNHVGKAVEDCMRAIIGVLLGSTKTGEQDGL--IGTALNCVLQVPKYLPQEQRFDIRVLGLGLLINLVEYSARNRHCLVNME----TSCQVHAVQALVQLFLERERAAQLAE-DNKALQHAGKHMEDCIVASYT-ALLLGCLCQESPINVTT---VREYLPEGDFSIMTEMTCAVGTTGQKSISRVIEYLEHC-----

4cgkA

0.12

0.09

0.74

0.66

dPPAS

NLTAQQQEAQKQVDQIQEQVSAIQAESNLQAENDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVTSYINTIVNSSITEAISRVAAMSEIVSANNKMLEQQKADKKAISEKQVANNDAINTVIANQQKLADDAQALTTKQAELKAAELSLAAEKATAEGEKASLLEQKAAAEAEARAAAVAEAAY---------KEKRASQQQSVLASANTNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGEAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIACWNDG-----GYGHVAVVTAVESTTRIQVSESNYAGNRTIGNHRGWFNPTTTSEGFVAD--------------------------------------------------------------------------------------------------------

4cgkA

0.12

0.09

0.71

0.62

wdPPAS

LTAQ-QQEAQKQVDQIQEQVSAIQA-EQSNLQNDRLQAESKKLEGEITELSKNIVSRNQSLEKQARSAQTNGAVTSYINTIVNSSITEAISRVAAMSEIVSAN-------NKMLEQQKADKKA----SEKQVANNDAINTV-----IANQQKLADDAQALTTK--QAELKAAELSLAAEK-----ATAEGEKAS---------------------LEQKAAAEAEARAAAVAEAAYKEKRASQQQSVLASAN--------TNLTAQVQAVSESAAAPVRAKVRPTYSTNASSYPIGECTWGVKTLAPWAGDYWGNGAQWATSAAAAGFRTGSTPQVGAIACWNDGGY--------------------G-----------HVA---AGNRT------------HR-----GWFNPTTTSGFVTYIYAD---------------------------

5dlqB

0.09

0.94

0.82

wMUSTER

ISSGNPTVQTLACSILTALLSEFSNCKRVFQEFMLTVGVLQEFSRLSAQMSSVFQRYLALANQVLSWNFLPPTLFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKDDMVYMEAYDK-----------LLESWLTLKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEEEISELQEDDR-DQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHQQDNKMLDYEDIHWLILVTGYLLADDTQGETPLIPPESSEVDINTTLQILGSPGE----KASSIPGYSRTDSVIR--------LSAVLRVSEVESRAIRADLTHLLSPQ--DIVWFAKTYLLVDEKLYDQISLPSTAFGADTEGSQ

4ogcA3

0.11

0.03

0.27

0.87

wPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGFTSRDKANRRRYNDNQEAKKIQRDYGK-----EGYISRGDIVRLDALELQGCCLY--CGTGYHTCQLDHIVPQAGPGSNNRGNLVAVCERCNRSKSN---------------TPFVWAQKCGIPHVGVKEAIGRVRGWRKQTP

4ke2A

0.12

0.05

0.43

0.90

dPPAS2

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIA-------AAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAK--------AAATAV---------------------SAAAAAAAAAIAFAAAP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.46

Estimated TM-score = 0.33±0.11

Estimated RMSD = 15.8±3.2Å

Download Model 2

C-score=-2.34

Download Model 3

C-score=-2.53

Download Model 4

C-score=-4.89

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4cg4A	0.738	2.11	0.067	0.788
2	3errA	0.355	6.66	0.065	0.555
3	2wl1A	0.352	2.40	0.080	0.383
4	1vw1A	0.348	7.03	0.049	0.559
5	3qneA	0.345	6.73	0.058	0.533
6	2zr3A	0.344	6.87	0.085	0.535
7	4pj3A	0.341	7.08	0.036	0.559
8	4b8eA	0.341	3.16	0.056	0.388
9	1wleB	0.339	6.95	0.056	0.526
10	2uvcG	0.336	6.86	0.044	0.520

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.16	7	2entA	ZN	Rep, Mult	364,369,379,380
2	0.07	3	5bu8A	CA	Rep, Mult	38,41
3	0.05	2	1x4vA	ZN	Rep, Mult	364,369,399,402
4	0.02	1	5dooA	CA	Rep, Mult	95,98
5	0.02	1	3gl6A	ZN	Rep, Mult	364,369
6	0.02	1	3aodA	MIY	Rep, Mult	378,382,385,395
7	0.02	1	1t9wA	NFN	Rep, Mult	331,333,357
8	0.02	1	3csvA	ZN	Rep, Mult	377,379
9	0.02	1	4fppA	MG	Rep, Mult	163,167
10	0.02	1	4zm5B	MG	Rep, Mult	47,50
11	0.02	1	4lmxD	PEB	Rep, Mult	6,9
12	0.02	1	3hd7A	GGG	Rep, Mult	86,87
13	0.02	1	4q7rA	ZN	Rep, Mult	183,402

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2dq3A	0.321	6.72	0.047	0.498	6.1.1.11	339
2	0.060	1w36B	0.306	7.60	0.030	0.535	3.1.11.5	218,299
3	0.060	3kf5A	0.322	5.38	0.052	0.434	3.2.1.26	NA
4	0.060	1ej6A	0.301	7.15	0.038	0.496	2.7.7.50	NA
5	0.060	1k3iA	0.240	7.13	0.029	0.379	1.1.3.9	NA
6	0.060	3la4A	0.306	7.28	0.038	0.511	3.5.1.5	217,419
7	0.060	1gthA	0.314	7.20	0.054	0.518	1.3.1.2	NA
8	0.060	1serB	0.332	6.65	0.067	0.507	6.1.1.11	377
9	0.060	2np0A	0.301	7.41	0.046	0.498	3.4.24.69	NA
10	0.060	2zr3B	0.345	7.07	0.088	0.546	6.1.1.11	356
11	0.060	2uv8G	0.308	7.46	0.048	0.524	2.3.1.86	NA
12	0.060	3errA	0.355	6.66	0.065	0.555	6.1.1.11	383
13	0.060	1ofdA	0.278	6.95	0.022	0.441	1.4.7.1	NA
14	0.060	2p0mA	0.293	7.17	0.046	0.485	1.13.11.33	NA
15	0.060	2p0mB	0.243	7.87	0.016	0.434	1.13.11.33	297,322
16	0.060	2iw5A	0.293	6.78	0.028	0.454	1.-.-.-	298
17	0.060	3iydD	0.298	7.70	0.061	0.518	2.7.7.6	289,292,346
18	0.060	3g61A	0.329	6.47	0.039	0.485	3.6.3.44	210
19	0.060	2vy0A	0.296	4.82	0.032	0.386	3.2.1.39	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.13	0.738	2.11	0.07	0.79	4cg4A	GO:0001726 GO:0002376 GO:0003779 GO:0005622 GO:0005634 GO:0005737 GO:0005776 GO:0005829 GO:0005856 GO:0005874 GO:0005875 GO:0006954 GO:0008270 GO:0010508 GO:0030027 GO:0031410 GO:0032691 GO:0032695 GO:0034341 GO:0042995 GO:0045087 GO:0046872 GO:0050728 GO:0071641 GO:1900016 GO:1900226 GO:2001056
1	0.06	0.355	6.66	0.07	0.56	3errA	GO:0000166 GO:0003341 GO:0003774 GO:0003777 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005813 GO:0005856 GO:0005868 GO:0005874 GO:0006412 GO:0006418 GO:0006434 GO:0006810 GO:0007018 GO:0016020 GO:0016260 GO:0016874 GO:0016887 GO:0030175 GO:0030286 GO:0033962 GO:0034063 GO:0044822 GO:0051293 GO:0051959 GO:0070062 GO:0097056
2	0.06	0.345	6.73	0.06	0.53	3qneA	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006434 GO:0016874 GO:0097056
3	0.06	0.344	6.87	0.09	0.54	2zr3A	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006434 GO:0016260 GO:0016874 GO:0097056
4	0.06	0.339	6.65	0.06	0.51	4l87A	GO:0000166 GO:0003723 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006434 GO:0008033 GO:0016259 GO:0016874 GO:0070062 GO:0097056 GO:0098619
5	0.06	0.333	2.96	0.05	0.37	3kb5A	GO:0001778 GO:0001786 GO:0003012 GO:0005622 GO:0005886 GO:0006810 GO:0006887 GO:0006936 GO:0007517 GO:0008270 GO:0010832 GO:0016020 GO:0016567 GO:0030659 GO:0031410 GO:0031624 GO:0042383 GO:0043161 GO:0043569 GO:0046627 GO:0046872 GO:0051260 GO:0061630
6	0.06	0.332	6.65	0.07	0.51	1serB	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006434 GO:0016260 GO:0016874 GO:0097056
7	0.06	0.317	6.79	0.04	0.49	2dq3A	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006434 GO:0016260 GO:0016874 GO:0097056
8	0.06	0.319	7.09	0.06	0.52	3lssA	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005739 GO:0005829 GO:0006418 GO:0006434 GO:0016874
9	0.06	0.336	2.92	0.06	0.38	2fbeC	GO:0008270 GO:0046872
10	0.06	0.331	6.79	0.05	0.51	3lssB	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005739 GO:0005829 GO:0006418 GO:0006434 GO:0016874
11	0.06	0.328	6.78	0.04	0.50	3vbbB	GO:0000166 GO:0003723 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005829 GO:0006412 GO:0006418 GO:0006434 GO:0008033 GO:0016259 GO:0016874 GO:0070062 GO:0097056 GO:0098619
12	0.06	0.341	3.16	0.06	0.39	4b8eA	GO:0002376 GO:0004842 GO:0005654 GO:0005737 GO:0006513 GO:0008270 GO:0016567 GO:0016740 GO:0016874 GO:0016881 GO:0036503 GO:0042787 GO:0043123 GO:0043627 GO:0044822 GO:0045087 GO:0046596 GO:0046597 GO:0046872 GO:0051091 GO:0051092 GO:0051607 GO:1902186 GO:1902187 GO:1904264
13	0.06	0.340	2.40	0.08	0.37	2vokA	GO:0000209 GO:0000932 GO:0003677 GO:0003723 GO:0004842 GO:0005622 GO:0005634 GO:0005737 GO:0005776 GO:0006513 GO:0007049 GO:0008270 GO:0010508 GO:0016567 GO:0016874 GO:0019005 GO:0030529 GO:0031410 GO:0031648 GO:0032088 GO:0032897 GO:0034341 GO:0042802 GO:0045087 GO:0045787 GO:0046872 GO:0051091 GO:0051865 GO:0070206 GO:0090086 GO:1902187
14	0.06	0.329	3.22	0.04	0.38	4wvmA	GO:0005576 GO:0019835 GO:0044179
15	0.06	0.339	6.95	0.06	0.53	1wleB	GO:0000166 GO:0004812 GO:0004828 GO:0005524 GO:0005737 GO:0005739 GO:0005759 GO:0006412 GO:0006418 GO:0006434 GO:0016874 GO:0097056
16	0.06	0.327	2.54	0.09	0.36	2iwgB	GO:0000209 GO:0000932 GO:0003677 GO:0003723 GO:0004842 GO:0005622 GO:0005634 GO:0005737 GO:0005776 GO:0005829 GO:0006513 GO:0007049 GO:0008270 GO:0010508 GO:0016567 GO:0016874 GO:0019005 GO:0030529 GO:0031410 GO:0031648 GO:0032088 GO:0032479 GO:0032897 GO:0034341 GO:0042802 GO:0045087 GO:0045787 GO:0046598 GO:0046872 GO:0051091 GO:0051865 GO:0060333 GO:0070206 GO:0090086 GO:1902187
17	0.06	0.332	2.89	0.07	0.37	4v1pA	GO:0002250 GO:0002376 GO:0005886 GO:0016020 GO:0016021 GO:0050663 GO:0050798 GO:0050852 GO:0072643
18	0.06	0.328	3.17	0.08	0.37	2lm3A	GO:0000932 GO:0002218 GO:0002221 GO:0002376 GO:0004842 GO:0005622 GO:0005634 GO:0005737 GO:0006914 GO:0008270 GO:0008329 GO:0016567 GO:0016874 GO:0019901 GO:0030674 GO:0031664 GO:0032880 GO:0032897 GO:0042802 GO:0042803 GO:0043123 GO:0043410 GO:0045071 GO:0045087 GO:0046597 GO:0046872 GO:0051091 GO:0051092 GO:0051607 GO:0070206 GO:0070534 GO:1902187 GO:1990462

Consensus prediction of GO terms

Molecular Function	GO:0032559	GO:0004812	GO:0035639	GO:0032550
GO-Score	0.47	0.47	0.47	0.47
Biological Processes	GO:0043043	GO:0043039	GO:0044267	GO:0032774	GO:0010467	GO:0034645
GO-Score	0.47	0.47	0.47	0.47	0.47	0.47
Cellular Component	GO:0015630	GO:0044444	GO:0099513
GO-Score	0.36	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.