I-TASSER results

I-TASSER results for job id Rv1698

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (314 residues)
MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALRE
KLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLT
QEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQA
QRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGS
GTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGH
YGTGHGAMSVTVSQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHCCEEEEEEEEHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCCEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCEEEEHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
Conf.Score	98668999999999999999999855567756788999999999999999999999999999999999999999998784589789999979999899999999999979989999999646559756889999999755567888887667756789999999998688888888998999999999998598898578888877589999689998766666557999999998767887998756777888746887647567658886578997556799999999998758888876688887678999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ
Prediction	73432000000001230122111000001354125415543550454355045435514542542450145104400444056230000003424462153025105616041203030354124474354035204441433545145744443330031003002234554554345741440041047341041345452411100000002435654644322014004303643220000033434555220010214543553001002163330200000001311663431111326506434378
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHCCCCCHHHHHHHHHHHHHHCCEEEEEEEEHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEHCCCCCCCCCEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCCCCCCEEEEHCCHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MISLRQHAVSLAAVFLALAMGVVLGSGFFSDTLLSSLRSEKRDLYTQIDRLTDQRDALREKLSAADNFDIQVGSRIVHDALVGKSVVIFRTPDAHDDDIAAVSKIVGQAGGAVTATVSLTQEFVEANSAEKLRSVVNSSILPAGSQLSTKLVDQGSQAGDLLGIALLSNADPAAPTVEQAQRDTVLAALRETGFITYQPRDRIGTANATVVVTGGALSTDAGNQGVSVARFAAALAPRGSGTLLAGRDGSANRPAAVAVTRADADMAAEISTVDDIDAEPGRITVILALHDLINGGHVGHYGTGHGAMSVTVSQ

4yxzA

0.11

0.10

0.85

0.60

MUSTER

--------ISVEELLKLAKAAYYSGTT------VEEAYKLALKLGISVEELLKLAEAAYYSGTT----VEEAYKLALKLGIS-------------VEELLKLAKAAYYSGTTVEEAYKLALKLISVEELLKLAKAAYYSGTTVAYKLALKLGISVEELLKLAEAAYYSGTTVEEAYKLALKLGISVEELLKLAKAAYYSGTTVEEAYKLAL--------KLGISVEELLKLAKAAYYSGTTVEEAYKLALKLGISVEELLKLAEAAYYSGTTVEKLGISVEELLKLAKAAYYSGTTVEEAYKL---ALKL----

5gaoE

0.15

0.13

0.88

0.57

dPPAS

--------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2o7sA1

0.15

0.10

0.62

0.56

wdPPAS

--------------------------------------------------------------------------------VKNPSLICAPVMADSIDKMVIETSKAHELGAD---LVEIRDWLKDFNPLEDLKTIIKKSPLP------------------TL--TYRPKWEGGQYEGDENERRDVLRLAMELGYIDVELQDGKKPGKFKVIVS----NYQNTPSVEDLDGLVARIQQTGADIVKIATTAVDIAD-VARMFHITSKAQVPTIGL-----ERGLMSRILCSK-----GGY--FGTLDSSKVSAPGQ

5dlqB

0.13

0.12

0.92

0.62

wMUSTER

RENLSAQMSSVFQRYLALANQVLSPPTLLDSRVMELFFTVHRKIRED-SDMAQDSLQCLAQLASLEGSQVDYLAHFIEGLLN-----TINGIEIEDSEAVGISSIISNL-ITVFPRNVLTA--IPSELFSSFVNCLTHLTSAALEEVLDKDDMVYMEAYDKLLESWLTLVRKGF---FTQHAVQVFNSYIQCHLAAPDGTRNLTANG----VASREEEEISELQEDDRDQFSDQLASVGM----LGRIAAEHCMPLLTVTRLHGQLQRHQQDNKMLDDLYEDIHWLILVTGYLLADDT------QGETPLIPPE

3kc2A

0.12

0.10

0.81

0.60

wPPAS

----KK------AFAFDI--GVLFGKKPIAG-----ASDALKLLNRNGFSERARTEFISSKLDSPLQIIQTPYKSLVN---KYSRILAV----------PSVRGVAEGYG------------FQDVVHQTDIVRY--RDIAPFSGLSDEQSRDIPDLTTKKFDAVLVF----NDPHDWAADIQIISDAINSENGLNTLRNEKSGKPSIPIYFSNQDLANPYKLN-LLVRRLYLELNGEPLQDYTLGKPTKL---HVLIDWEKRLSGTKPSTSVDNPASNYG-WNSCLVK--------TGVYNEGDDLKECKPTL

5gaoE

0.15

0.13

0.87

0.72

dPPAS2

-----------------------------------------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

5gaoE

0.15

0.14

0.97

0.94

PPAS

--------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

2e8gA

0.14

0.11

0.76

0.68

Env-PPAS

MWDTSKYRLLVAEKSVELFIRTIEGAKFRGQWDKKRSIQLAKEMIPDIQALRYSYIDPEELVDPQMKDLKEKAKGIIE-ALGGEDWHHKFLSQASREDREKVEEQVARIK----------------FFLNTILNLDRRLKL-------GKINDPVIAVDIVVGEVMSVGKHPSADR------------LL---VTNVNIGER-----AVTVVTNDLTVKEG-----NRVAVALLPPRNFFGIVSEGMFLGAGEGVL-------KNVKGEIGGLPK-GIPLEALNETRNAVEAFLK-------------------

4wjgE

0.12

0.09

0.79

0.60

MUSTER

LKTKDEVEKACHLAQQLKEVSITLG------VIYRTTERHSVQVEAHKTAIDKHADAVSRAVEALTRVDVAL------QRLKEL-------GKANDTKAVKIIENITSA----------------RENLALFNNETQAVLT-------------ARDHVHKHRAAALQGWSDAKEKG-DAAAEDVWVLLNAAK----KGNGSADVKAAA-----CSRYSSSSTSETELQKAIDAAANVG--------GLSAHKSKYGDVLNKFKLSNASVGAVDTSGRGGKHMEKVNNVAKLLKDAEVSLAAAAAEIEEVKNAH

5cwiA

0.10

0.07

0.74

0.53

dPPAS

--------------------------------DIEKLCKKAESEAREARSKAEELRQRHPDSQAARDAQKLASQAEEAVKLAC---ELAQEHPNADIAKLCIKAASEAA------------------EAASKAAELAQRHPDSQAARDAIKLASQAAEAVKLACELAQEHPNADIAKLCIKAASEAAEAASKAAELAQRHPDSQAARDAI---------KLASQAAEAVKLACELAQEHPNADIAKKCIKAASEAAEEASKAAEEAQRHPDSQKARDEIKEASQKAEEVKERCER-------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-5.00

Estimated TM-score = 0.21±0.05

Estimated RMSD = 19.2±2.0Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-4.63

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.76

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3kc2A	0.483	6.13	0.075	0.774
2	5ebbA	0.469	5.33	0.054	0.707
3	5fi9A	0.467	5.89	0.054	0.742
4	4eplA	0.466	6.00	0.054	0.745
5	2yeqA	0.462	6.00	0.066	0.742
6	4ui9A	0.460	6.40	0.051	0.771
7	1jqoA	0.459	6.57	0.049	0.806
8	4b2gA	0.457	6.18	0.062	0.748
9	1l2aA	0.450	6.59	0.046	0.783
10	3aibA3	0.447	6.27	0.091	0.748

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	8	1vf5B	TDS	Rep, Mult	15,18
2	0.08	4	1ea0A	F3S	Rep, Mult	295,296,297,298,299,300,301,307,312
3	0.06	3	3r0dA	ZN	Rep, Mult	274,275
4	0.06	3	1j7lA	MG	Rep, Mult	252,274
5	0.04	2	4xk8i	CLA	Rep, Mult	17,20
6	0.02	1	3cisB	MG	Rep, Mult	248,312
7	0.02	1	2y00A	2CV	Rep, Mult	19,22,33,40
8	0.02	1	1ofdA	F3S	Rep, Mult	1,11,13,14,15,283,285,286
9	0.02	1	3k30A	SF4	Rep, Mult	260,263,264,279,280,281,282,283,284
10	0.02	1	4lmxD	PEB	Rep, Mult	5,8
11	0.02	1	1g6uA	TFA	Rep, Mult	10,11,12

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1jqoA	0.459	6.57	0.049	0.806	4.1.1.31	NA
2	0.060	2x4dA	0.424	5.48	0.099	0.631	3.6.1.1	NA
3	0.060	2dqmA	0.428	6.48	0.053	0.733	3.4.11.2	NA
4	0.060	2gq3A	0.426	5.93	0.049	0.675	2.3.3.9	NA
5	0.060	2dgaA	0.422	6.10	0.068	0.691	3.2.1.21	91
6	0.060	1ho5A	0.430	6.09	0.079	0.710	3.1.3.5,3.6.1.45	NA
7	0.060	1g87B	0.431	6.34	0.072	0.701	3.2.1.4	NA
8	0.060	1k87A	0.427	6.46	0.059	0.726	1.5.99.8	35,95
9	0.060	2vdcF	0.379	6.06	0.033	0.608	1.4.1.13	NA
10	0.060	1ry2A	0.432	5.40	0.049	0.659	6.2.1.1	25,70
11	0.060	1h54B	0.427	6.33	0.058	0.720	2.4.1.8	NA
12	0.060	1uwkA	0.427	6.21	0.061	0.701	4.2.1.49	NA
13	0.060	1djnA	0.423	6.32	0.058	0.707	1.5.8.2,1.5.99.7	NA
14	0.060	2vn4A	0.423	6.95	0.075	0.767	3.2.1.3	NA
15	0.060	2z1aA	0.442	5.86	0.089	0.710	3.1.3.5	55
16	0.060	2qnoA	0.439	6.63	0.056	0.764	3.2.1.4	NA
17	0.060	1fmiA	0.426	6.54	0.052	0.729	3.2.1.113	NA
18	0.060	1tiwA	0.405	6.39	0.057	0.675	1.5.1.12,1.5.99.8	95
19	0.060	1ayxA	0.417	6.13	0.041	0.678	3.2.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.484	6.11	0.08	0.78	3rf6B	GO:0046474
1	0.07	0.477	6.16	0.10	0.77	3kc2B	GO:0046474
2	0.07	0.474	5.62	0.05	0.73	5fc1A	GO:0004767 GO:0005576 GO:0005615 GO:0006685 GO:0008081 GO:0008270 GO:0009143 GO:0016787 GO:0046872 GO:0070062
3	0.07	0.453	5.93	0.04	0.73	4epmA	GO:0006952 GO:0009626 GO:0010112 GO:0016874 GO:0034052 GO:0044419
4	0.07	0.471	5.43	0.04	0.72	5ebeA	GO:0004767 GO:0005576 GO:0005615 GO:0006685 GO:0008081 GO:0008270 GO:0009143 GO:0016787 GO:0046872 GO:0070062
5	0.07	0.466	6.00	0.05	0.75	4eplA	GO:0002376 GO:0005737 GO:0006952 GO:0009611 GO:0009694 GO:0009864 GO:0010046 GO:0010224 GO:0016874 GO:0019899 GO:0045087 GO:0071365 GO:0080123 GO:2000030
6	0.07	0.432	5.73	0.09	0.65	4bkmA	GO:0000121 GO:0000287 GO:0004647 GO:0004721 GO:0004725 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005975 GO:0006114 GO:0006470 GO:0006650 GO:0007088 GO:0008152 GO:0008967 GO:0015629 GO:0016020 GO:0016311 GO:0016787 GO:0016791 GO:0030027 GO:0030496 GO:0030836 GO:0031072 GO:0031247 GO:0031258 GO:0032154 GO:0032361 GO:0032465 GO:0032587 GO:0033883 GO:0035335 GO:0042803 GO:0042995 GO:0043136 GO:0045721 GO:0046872 GO:0070062 GO:0070938 GO:0071318 GO:0098519
7	0.06	0.399	5.77	0.12	0.63	4bx2A	GO:0000287 GO:0004647 GO:0004721 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0006470 GO:0007088 GO:0008152 GO:0015629 GO:0016020 GO:0016787 GO:0016791 GO:0030027 GO:0030496 GO:0030836 GO:0031072 GO:0031247 GO:0031258 GO:0032154 GO:0032361 GO:0032465 GO:0032587 GO:0033883 GO:0042803 GO:0042995 GO:0046872 GO:0070062 GO:0070938 GO:0071318
8	0.06	0.435	6.01	0.03	0.70	4ewvB	GO:0006952 GO:0009626 GO:0010112 GO:0016874 GO:0034052 GO:0044419
9	0.06	0.412	6.36	0.06	0.68	1a0cA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
10	0.06	0.394	5.85	0.09	0.62	2hx1A	GO:0046872
11	0.06	0.403	5.72	0.08	0.62	1zjjB	GO:0046872
12	0.06	0.408	5.82	0.11	0.64	1vjrA	GO:0016311 GO:0016791 GO:0046872
13	0.06	0.387	5.62	0.07	0.60	3hltA	GO:0016311 GO:0016791 GO:0019899 GO:0046872 GO:0070062
14	0.06	0.402	5.47	0.07	0.59	1yv9A	GO:0016787
15	0.06	0.398	5.47	0.06	0.59	3pdwA	GO:0016311 GO:0016787 GO:0016791 GO:0046872
16	0.06	0.403	5.26	0.05	0.58	3eprA	GO:0016787
17	0.06	0.401	5.19	0.06	0.57	1ys9A
18	0.06	0.382	6.36	0.03	0.65	2nxfA	GO:0008663 GO:0016787 GO:0030145 GO:0046872 GO:0047631 GO:0047734

Consensus prediction of GO terms

Molecular Function	GO:0008270	GO:0004767	GO:0016874
GO-Score	0.13	0.13	0.07
Biological Processes	GO:0046474	GO:0006685	GO:0009143	GO:0034052	GO:0010112	GO:0044419
GO-Score	0.13	0.13	0.13	0.07	0.07	0.07
Cellular Component	GO:0070062	GO:0005615
GO-Score	0.13	0.13

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.