I-TASSER results

I-TASSER results for job id Rv1697

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (393 residues)
MRMSALLSRNTSRPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLDLDRITADALVEAEIA
AVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPEIFKKVKDGAKVRLYEGGVYAGDRRL
IRGTERTDHDIADLMREAKSGLVAHLEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRR
HVVIVADEPSGPDDLKSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEV
LKCGAQVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALLVTAGH
AANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHISGGAIALLALTMLIAI
IVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRMSALLSRNTSRPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLDLDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPEIFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAHLEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDLKSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGAQVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALLVTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHISGGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS
Prediction	CCCCCCCCCCCCCCCEEEEEEHCCCHHHHHHHCCCCCEEEEHCCCCCHHHHHHHHHHCCCEEEHCCCCCCCCCCCHHHHHHHHHCCEEEHCCCHHHHHHCCCCEEEEEHCCEEEHCCEEEEEEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHCCEEEEHCHHHHHHHHHCCCCCEEHCCCCCCCHHHHHHCCEEEHCCCCCCCCHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	998765678888998579998688766778647999499986788769999999998897899856677888766669999998996986789999998679959999999899898899987997999999999999999999999999999999999766654788898766656898599996998689999999999987598899977889999998999979986898887889887778998578998865789999989975887689988999999999989988999778898999988655788757888887546645478899998756777689999999999999999986478669999999999999999998769
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRMSALLSRNTSRPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLDLDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPEIFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAHLEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDLKSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGAQVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALLVTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHISGGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS
Prediction	752443244546314030202114504500520563100002064033300430163402000000412123102200210061401000302460053045344030453201243420040341337303520540364035203400310041046134001660504605450561300000315404610540351056230000000100300262602000000104423550031003000102422324025204715041331304423200000002234042000010303022003403652100000000200430111500140134424120000002113211000000012122002000310120021033107
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCEEEEEEHCCCHHHHHHHCCCCCEEEEHCCCCCHHHHHHHHHHCCCEEEHCCCCCCCCCCCHHHHHHHHHCCEEEHCCCHHHHHHCCCCEEEEEHCCEEEHCCEEEEEEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHCCEEEEHCHHHHHHHHHCCCCCEEHCCCCCCCHHHHHHCCEEEHCCCCCCCCHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
MRMSALLSRNTSRPGLIGIARVDRNIDRLLRRVCPGDIVVLDVLDLDRITADALVEAEIAAVVNASSSVSGRYPNLGPEVLVTNGVTLIDETGPEIFKKVKDGAKVRLYEGGVYAGDRRLIRGTERTDHDIADLMREAKSGLVAHLEAFAGNTIEFIRSESPLLIDGIGIPDVDVDLRRRHVVIVADEPSGPDDLKSLKPFIKEYQPVLVGVGTGADVLRKAGYRPQLIVGDPDQISTEVLKCGAQVVLPADADGHAPGLERIQDLGVGAMTFPAAGSATDLALLLADHHGAALLVTAGHAANIETFFDRTRVQSNPSTFLTRLRVGEKLVDAKAVATLYRNHISGGAIALLALTMLIAIIVALWVSRTDGVVLHWIIDYWNRFSLWVQHLVS

3x2eA

0.15

0.13

0.88

0.64

MUSTER

NKIAEEYSREKPLSGVGMSIHLEAKTAYLAITLSKGKVVITGPLSTQDDVAEALRSKGI--TVYARRTHDESIYRENLMKVLDERPFIIDDGGDLTVISHTEREEVL----------ENLKGVSEETTTGVRRLKALEETGKDSKMKYLFDNRYGTGQSTWDAIMRNTNL-----LVAGKNVVVAGYGWCGRGIALRAAGL---ARVIVTEVDVKAVEAIMDGF----TVMPM----KEAVKI-ADFVITASGNTDVLSKEDILSLKDGAVLANAGHFNVEIPVRVLEEI-AVEKFEARPNVTGYT-LENGKT----------------FLLAEGLVNLAAGDGHPVEIMDLSFALQIFAVLYLLENHRSPKVYMLPDEIDERVARMKLDSLG

3lm8A1

0.23

0.08

0.34

1.01

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTINIVAGGP--KNLIPDLTGYTDE-HTLWIGVDKGTVTLLDAGIIPVEAFGDFDSIT-------------------EQERRRIEKAAPALHVYQAEKTDLDLALDWALEKQPDIIQIFGITGGRADHFLG-----NIQLLYKGVKTNIKLIDKQNHIQ-------------------------------------------------------

3lm8A1

0.23

0.08

0.34

1.34

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTINIVAGGP--KNLIPDLTGYTDE-HTLWIGVDKGTVTLLDAGIIPVEAFGDFDSIT-------------------EQERRRIEKAAPALHVYQADQTDLDLALDWALEKQPDIIQIFGITGGRADHFLG-----NIQLLYKGVKTNIKLIDKQNHIQ-------------------------------------------------------

3x2eA

0.16

0.13

0.83

0.63

wMUSTER

M-LNKIAEESREKPGVGMSIHLEAKTAYLAITLSKGKVVITGPLSTQDDVAEALRSKGI-TVYARRTHDESIY--ENLMKVLDERPFIIDDGGDLTVISHTEREEVL----------ENLKGVSEETTTGVRRLKALEETGKDSKMKYLFDNRYGTGQSTWDAIMRNTNL-----LVAGKNVVVAGYGWCGRGIALRAAGL---ARVIVTEVDVKAVEAIMDGFIADFVITNTDVLSKEDILSGAVLANAGHFNVEIP-VRVLEEIAVEKFEA-------------------PNVTGY---------LENGKT------FL--LAEG-RLVN------LAAGDGHPVEIMDLSFALQIFAVLYLLENHRKYMLPDEIDERVARMKLDSLGVLT

3lm8A1

0.23

0.08

0.34

0.96

wPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTINIVAGGP--KNLIPDLTGYTDE-HTLWIGVDKGTVTLLDAGIIPVEAFGDFDSIT-------------------EQERRRIEKAAPALHVYQADQTDLDLALDWALEKQPDIIQIFGITGGRADHFLG-----NIQLLYKGVKTNIKLIDKQNHIQ-------------------------------------------------------

3lm8A1

0.23

0.08

0.34

2.76

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTINIVAGGP--KNLIPDLTGYTDE-HTLWIGVDKGTVTLLDAGIIPVEAFGDFDSIT-------------------EQERRRIEKAAPALHVYQAEKTDLDLALDWALEKQPDIIQIFGITGGRADHFLG-----NIQLLYKGVKTNIKLIDKQNHIQ-------------------------------------------------------

3lm8A1

0.23

0.08

0.34

0.83

PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTINIVAGGP--KNLIPDLTGYTDE-HTLWIGVDKGTVTLLDAGIIPVEAFGDFDSIT-------------------EQERRRIEKAAPALHVYQAEKTDLDLALDWALEKQPDIIQIFGITGGRADHFLG-----NIQLLYKGVKTNIKLIDKQNHIQ-------------------------------------------------------

3lm8A1

0.23

0.08

0.34

1.49

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTINIVAGGP--KNLIPDLTGYTDE-HTLWIGVDKGTVTLLDAGIIPVEAFGDFDSIT-------------------EQERRRIEKAAPALHVYQAEQTDLDLALDWALEKQPDIIQIFGITGGRADHFLG-----NIQLLYKGVKTNIKLIDKQNHIQ-------------------------------------------------------

3gnhA

0.12

0.11

0.89

0.59

MUSTER

-----------EIKAVSAARLLDVASGKYVDNVTDGRITSIGKKGDAVPAGATAVDLPIDMHVHLDSLAEVGGYNANAKKTLEAGFTTVRNVGVGLREAIDAG---YVPGPRIVTAAISFGTGGHCDSTFFPPSMDQKNPFNSDSPDEARKAVRTLKKYGAQVIICATGGVFSRGNEPGQQQL--------YEEMKAVVDEAHMAGKVAAHAHSGIREAVRAGVD---TIEHASLVDDEGIKLAVQAYFSMDIYNTDYTQAEGKKNGVLEDNLRKDRDLQRENFRKALKAGVK--MVYGTDAGI------YPHGDNAKQFAVMVRYG--ATPLQAIQSA------LTAAEALGRSKDVGQVAVMIAVAGD---LADVTTLEKPVFVMKGGVVK

2omkA1

0.17

0.06

0.35

0.88

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------GVDLGTENLYFQSNAMINEHAIILANGEYPAH--ELPLRLLAEAQFVVCC---AANEYISRGHTPDVIIGDGDSLLPEYKKRFSSIILQIS---------------------DQETNDQTKAVHYLQSKGIRKIAIVGATGKREDHTLG-----NISLLVEYMRSGMEVR--------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.79

Estimated TM-score = 0.30±0.10

Estimated RMSD = 16.3±3.0Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1v8bA	0.785	3.26	0.109	0.911
2	3ondA	0.782	3.31	0.114	0.911
3	3ce6A	0.782	3.31	0.111	0.911
4	5hm8A	0.781	3.25	0.137	0.908
5	3n58A	0.777	3.12	0.099	0.896
6	3x2eA	0.774	3.25	0.116	0.896
7	3glqA	0.774	3.18	0.111	0.896
8	3h9uC	0.773	2.99	0.109	0.885
9	3gvpA	0.735	3.63	0.108	0.888
10	3gg9A	0.554	4.33	0.078	0.707

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.32	32	4pfjA	ADN	Rep, Mult	20,21,23,25,26,91,126,127,151,277,336,339,343,344,345,350,353,354
2	0.10	11	1v8bA	NAD	Rep, Mult	127,128,129,152,156,186,188,189,190,210,211,212,215,251,252,253,254,275,276,277,336,338,345
3	0.05	5	3ihkA	MG	Rep, Mult	232,234
4	0.02	2	1s2oA	MG	Rep, Mult	42,47,232
5	0.01	1	3ztyB	GD	Rep, Mult	45,47,232,237
6	0.01	1	3lm8C	VIB	Rep, Mult	254,278
7	0.01	1	2btdA	MG	Rep, Mult	232,254,299

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.110	3gvpA	0.735	3.63	0.108	0.888	3.3.1.1	NA
2	0.107	3ce6A	0.782	3.31	0.111	0.911	3.3.1.1	127,251,339,342
3	0.107	1v8bC	0.786	3.25	0.109	0.911	3.3.1.1	128,255,281
4	0.081	2dbqA	0.526	4.57	0.107	0.690	1.1.1.26	NA
5	0.069	3ba1A	0.528	4.45	0.079	0.687	1.1.1.237	NA
6	0.066	2dbrB	0.526	4.58	0.107	0.690	1.1.1.26	163
7	0.066	2j6iA	0.549	4.63	0.081	0.720	1.2.1.2	NA
8	0.066	2fssA	0.549	4.69	0.081	0.723	1.2.1.2	NA
9	0.066	2cukA	0.515	4.69	0.124	0.679	1.1.1.-	NA
10	0.066	1xdwA	0.522	4.59	0.069	0.684	1.1.1.-	NA
11	0.066	3ga0A	0.521	4.54	0.073	0.684	1.1.1.-	NA
12	0.066	3n7uA	0.534	4.68	0.115	0.705	1.2.1.2	251,257
13	0.066	2dldA	0.503	5.00	0.085	0.684	1.1.1.28	NA
14	0.066	1dxyA	0.494	4.77	0.067	0.664	1.1.1.-	191
15	0.060	1a7aA	0.774	3.01	0.097	0.888	3.3.1.1	199
16	0.060	2vhyB	0.468	4.68	0.085	0.606	1.4.1.1	186
17	0.060	2g76A	0.488	4.79	0.068	0.651	1.1.1.95	NA
18	0.060	1v8bA	0.785	3.26	0.109	0.911	3.3.1.1	194
19	0.060	2vhxE	0.540	4.81	0.093	0.713	1.4.1.1	NA
20	0.060	3n58A	0.777	3.12	0.099	0.896	3.3.1.1	NA
21	0.060	1pjbA	0.537	4.72	0.082	0.700	1.4.1.1	NA
22	0.060	3h9uC	0.773	2.99	0.109	0.885	3.3.1.1	199
23	0.060	2eklA	0.485	5.00	0.081	0.662	1.1.1.95	204
24	0.060	1j49A	0.500	4.84	0.091	0.672	1.1.1.28	NA
25	0.060	1f8gA	0.525	4.99	0.072	0.710	1.6.1.2	NA
26	0.060	2gcgA	0.528	4.56	0.092	0.690	1.1.1.81,1.1.1.79	NA
27	0.060	3d64A	0.729	3.81	0.123	0.893	3.3.1.1	NA
28	0.060	2vhwE	0.539	4.83	0.093	0.713	1.4.1.1	160,186
29	0.060	3d64B	0.736	3.89	0.114	0.903	3.3.1.1	251
30	0.060	1e5lA	0.460	6.22	0.084	0.707	1.5.1.10	128
31	0.060	3gg9A	0.554	4.33	0.078	0.707	1.1.1.95	NA
32	0.060	3g1uC	0.774	3.03	0.103	0.888	3.3.1.1	NA
33	0.060	1gdhA	0.521	4.69	0.091	0.695	1.1.1.29	187

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.774	3.03	0.10	0.89	3g1uC	GO:0000166 GO:0004013 GO:0005829 GO:0006730 GO:0016787 GO:0033353
1	0.21	0.783	3.29	0.11	0.91	3ondB	GO:0004013 GO:0006730 GO:0016787
2	0.20	0.785	3.26	0.11	0.91	1v8bA	GO:0004013 GO:0005829 GO:0006730 GO:0016787 GO:0033353
3	0.19	0.747	3.75	0.09	0.90	3n58B	GO:0004013 GO:0005737 GO:0006730 GO:0016787
4	0.19	0.729	3.81	0.12	0.89	3d64A	GO:0004013 GO:0005737 GO:0006730 GO:0016787
5	0.19	0.735	3.63	0.11	0.89	3gvpA	GO:0004013 GO:0005737 GO:0005783 GO:0005829 GO:0006730 GO:0016787 GO:0033353 GO:0043005 GO:0043231
6	0.16	0.793	2.96	0.11	0.90	3x2fA	GO:0004013 GO:0005737 GO:0005829 GO:0006730 GO:0016787 GO:0033353
7	0.16	0.774	3.01	0.10	0.89	1a7aA	GO:0000096 GO:0001666 GO:0002439 GO:0004013 GO:0005634 GO:0005737 GO:0005829 GO:0006730 GO:0007584 GO:0016787 GO:0019510 GO:0030554 GO:0032259 GO:0033353 GO:0042470 GO:0042745 GO:0042802 GO:0043005 GO:0051287 GO:0070062 GO:0071268
8	0.15	0.779	3.39	0.12	0.91	5jpiA	GO:0004013 GO:0006730 GO:0016787
9	0.15	0.782	3.31	0.11	0.91	3ce6A	GO:0004013 GO:0005576 GO:0005618 GO:0005737 GO:0005829 GO:0005886 GO:0006730 GO:0009087 GO:0016787 GO:0033353 GO:0040007 GO:0046085 GO:0070403
10	0.14	0.773	2.99	0.11	0.89	3h9uC	GO:0000166 GO:0004013 GO:0005829 GO:0006730 GO:0016787 GO:0033353
11	0.11	0.526	4.57	0.11	0.69	2dbqA	GO:0005737 GO:0008152 GO:0016491 GO:0016616 GO:0047964 GO:0051287 GO:0055114
12	0.07	0.521	4.68	0.11	0.69	5aowA	GO:0005737 GO:0008152 GO:0016491 GO:0016616 GO:0047964 GO:0051287 GO:0055114
13	0.07	0.522	4.59	0.07	0.68	1xdwA
14	0.07	0.539	4.83	0.09	0.71	2vhwE	GO:0000166 GO:0000286 GO:0001666 GO:0005576 GO:0005618 GO:0005829 GO:0005886 GO:0006524 GO:0016491 GO:0042853 GO:0046872 GO:0055114
15	0.07	0.526	4.62	0.08	0.69	3wwzB	GO:0008152 GO:0008720 GO:0016491 GO:0016616 GO:0051287 GO:0055114
16	0.07	0.519	4.74	0.12	0.69	5aovA	GO:0005737 GO:0008152 GO:0016491 GO:0016616 GO:0047964 GO:0051287 GO:0055114
17	0.07	0.532	4.83	0.11	0.70	4zgsA	GO:0008152 GO:0016491 GO:0016616 GO:0051287 GO:0055114
18	0.07	0.500	4.84	0.09	0.67	1j49A	GO:0008152 GO:0008720 GO:0016491 GO:0016616 GO:0051287 GO:0055114
19	0.07	0.503	5.00	0.09	0.68	2dldA	GO:0008152 GO:0008720 GO:0016491 GO:0016616 GO:0051287 GO:0055114
20	0.07	0.499	4.46	0.07	0.64	3d4oB
21	0.07	0.485	5.00	0.08	0.66	2eklA	GO:0000166 GO:0004617 GO:0008152 GO:0016491 GO:0016616 GO:0051287 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0004013	GO:0036094	GO:1901265
GO-Score	0.68	0.43	0.43
Biological Processes	GO:0006730	GO:0033353
GO-Score	0.68	0.38
Cellular Component	GO:0005829
GO-Score	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.