I-TASSER results

I-TASSER results for job id Rv1682

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (305 residues)
MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQRTRSGYDPVAVNHYIAELVLRQQA
QHCEIETLKAEIASLKDENAALKDTSPSAQAVTDRMAKMLRLAVDEVFQMQSEARAEAAT
LVSAARDEAEAVRTQKREMLADMNARQRALESEHADVMRRAREEAEQLVAQATAEVERMR
VIDARRREKAEQELDAEIIRLRTDAQFQIDDQLQATQQECEKRLGEAKIEADRRLHVADE
QIEHGLSEARRTLEEISQRRVGILEQLARIHAQLENIPALLESARHSETEPLQSINGAVA
ELRAI

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQRTRSGYDPVAVNHYIAELVLRQQAQHCEIETLKAEIASLKDENAALKDTSPSAQAVTDRMAKMLRLAVDEVFQMQSEARAEAATLVSAARDEAEAVRTQKREMLADMNARQRALESEHADVMRRAREEAEQLVAQATAEVERMRVIDARRREKAEQELDAEIIRLRTDAQFQIDDQLQATQQECEKRLGEAKIEADRRLHVADEQIEHGLSEARRTLEEISQRRVGILEQLARIHAQLENIPALLESARHSETEPLQSINGAVAELRAI
Prediction	CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	98887557777776788899999988887656778888876589999999999999999999999999999999999999999978879999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQRTRSGYDPVAVNHYIAELVLRQQAQHCEIETLKAEIASLKDENAALKDTSPSAQAVTDRMAKMLRLAVDEVFQMQSEARAEAATLVSAARDEAEAVRTQKREMLADMNARQRALESEHADVMRRAREEAEQLVAQATAEVERMRVIDARRREKAEQELDAEIIRLRTDAQFQIDDQLQATQQECEKRLGEAKIEADRRLHVADEQIEHGLSEARRTLEEISQRRVGILEQLARIHAQLENIPALLESARHSETEPLQSINGAVAELRAI
Prediction	73343640142043545334532332135553551430242133630352055035425414531551454155146415524644543641353045125414531553355045415532551454155225515533551553355245415532651453155335514542553454355325533551554145335534543553355255415533551454155335514541553354155335524532551354146135415513541553355445336526423542476
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MLPQRPNCTKLFRPRRGVSERYRVTTAHNGSAPRFQRTRSGYDPVAVNHYIAELVLRQQAQHCEIETLKAEIASLKDENAALKDTSPSAQAVTDRMAKMLRLAVDEVFQMQSEARAEAATLVSAARDEAEAVRTQKREMLADMNARQRALESEHADVMRRAREEAEQLVAQATAEVERMRVIDARRREKAEQELDAEIIRLRTDAQFQIDDQLQATQQECEKRLGEAKIEADRRLHVADEQIEHGLSEARRTLEEISQRRVGILEQLARIHAQLENIPALLESARHSETEPLQSINGAVAELRAI

5j1iA

0.10

1.00

1.33

MUSTER

IRLQLEACETRTVHRLRLPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGEEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMDSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEKVQSGSESVIQEYVDLRTHYSEL

5cwmA

0.10

0.08

0.74

1.37

dPPAS

-------------------------------------------------------------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER------

4tqlA

0.10

0.07

0.74

1.93

wdPPAS

--------------------------------------------------------------------------YKQMVQELEKARDRMEKLYKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGGKQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDELLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLK----

5j1iA

0.10

1.00

1.82

wMUSTER

IRLQLEACETRTVHRLRLPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLAAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGEEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMDSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEKVQSGSESVIQEYVDLRTHYSEL

4tqlA

0.10

0.07

0.74

2.40

wPPAS

--------------------------------------------------------------------------YKQMVQELEKARDRMEKLYKEMVELIQKAIELMRKIFQEVKQEVEKAIEEMKKLYDEAKKKIEQMIQQIKQGDKQKMEELLKRAKEEMKKVKDKMEKLLEKLKQIMQEAKQKMEKLLKQLKEEMKKMKEKMEKLLKEMKQRMEEVKKKMDDELLEKIKKNIDDLKKIAEDLIKKAEENIKEAKKIAEQLVKRAKQLIEKAKQVAEELIKKILQLIEKAKEIAEKVLK----

5cwmA

0.10

0.08

0.74

2.47

dPPAS2

-------------------------------------------------------------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGSEEAKERAERVREEARELQERVKELRER------

5cwmA

0.11

0.08

0.74

2.07

PPAS

---------------------------------------------DPEDELKRVEKLVKEAEELLRQAKEKGSEEDLEKALRTAEEAAREAKKVLEQAEKEGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVALRAVELVVRVAELLLRIAKESGSEEALERALRVAEEAARLAKRVLELAEKQGDPEVARRAVELVKRVAELLERIARESGS--EEAKERAERVREEARELQERVKELRER--------------------------------

3obyA

0.11

0.10

0.93

0.62

Env-PPAS

LIPETLDDLWHLRFIIEKGDVV-----------------FATTKVTVRLG---IEVEKVEFHRFANRLRVSGKIVAGGYHTLNITVGKELSIIKKWKPEQLERLRRAVEDSNRPEI-VMLTIEEGYAVAGVLRQWGVEEIFEERMSRKEFFGEVAAKLESFDFKYLIVAGPGFAKNDFLDFLKERYPEMAKNAVVVDVSSVGSRGFIEILKRRVVDKIVGEVRLAEEAEYIDRLLEGIAKGERVALDEVREAHNYRAIEVLLVADEFLLEEREKWDVDGLLREVEESGGKVVSTEFEPGKRLMSL

4uxvA

0.10

1.00

1.31

MUSTER

HLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAKKANQVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKYSHLYGELYDSLEKDLDEIWYITARKVLLEQDRNLERLQSYIDDVPKLLADCKQTVPGQIAKLKDGYGEMKEKGYKLEHQLDKELENLSNQLKRAEHVLMTELDIDEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDLLVEEVASIEKQIEEVKKEHAEY

5cwqA

0.10

0.08

0.75

1.35

dPPAS

----------------------------------------------------------------------------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.15

Estimated TM-score = 0.36±0.12

Estimated RMSD = 13.8±3.9Å

Download Model 2

C-score=-3.79

Download Model 3

C-score=-4.00

Download Model 4

C-score=-4.02

Download Model 5

C-score=-4.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4tqlA	0.720	1.32	0.096	0.748
2	1vw1A	0.473	5.15	0.048	0.675
3	4ut1A	0.467	3.89	0.074	0.593
4	2d4yA	0.465	4.12	0.058	0.597
5	4f4cA	0.462	5.66	0.049	0.689
6	2w6dA	0.456	5.41	0.068	0.679
7	1jadA	0.450	4.59	0.101	0.610
8	5sv0B	0.447	4.55	0.099	0.613
9	4dylA	0.443	3.28	0.055	0.521
10	4ke2A	0.442	3.09	0.120	0.525

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	3ojaB	MAN	Rep, Mult	255,258
2	0.04	2	3qmkB	SO4	Rep, Mult	188,257,261
3	0.04	2	3ijoE	B4D	Rep, Mult	99,102,103,249,253,256,257
4	0.04	2	4ev6E	MG	Rep, Mult	100,252
5	0.02	1	3j000	PEV	Rep, Mult	159,162,166
6	0.02	1	3lsfE	PZI	Rep, Mult	74,75,227,231,232
7	0.02	1	3umkA	CU	Rep, Mult	202,243
8	0.02	1	3j001	PEV	Rep, Mult	181,184
9	0.02	1	2w6dB	CPL	Rep, Mult	192,193,194,195,196,214,215,217
10	0.02	1	2w6dA	CPL	Rep, Mult	193,194,214,215,217,218
11	0.02	1	1g1iA	CA	Rep, Mult	290,293
12	0.02	1	2w6dB	CPL	Rep, Mult	188,189,191
13	0.02	1	2d4cA	CA	Rep, Mult	248,252
14	0.02	1	2w6dB	CPL	Rep, Mult	143,144,145,154,155,157
15	0.02	1	4eotA	NUC	Rep, Mult	166,167,171,174,175,178
16	0.02	1	3k2sB	POV	Rep, Mult	192,198,202
17	0.02	1	3mq7E	CA	Rep, Mult	240,243
18	0.02	1	2w6dA	GDP	Rep, Mult	135,136,138,139
19	0.02	1	3hd7A	GGG	Rep, Mult	265,266
20	0.02	1	3qmkB	SGN	Rep, Mult	195,250

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3btaA	0.369	6.31	0.014	0.597	3.4.24.69	NA
2	0.060	3ffzA	0.400	5.54	0.036	0.600	3.4.24.69	NA
3	0.060	3b8eC	0.336	5.87	0.039	0.538	3.6.3.9	NA
4	0.060	3fg3A	0.284	6.00	0.041	0.446	4.2.1.92,1.13.11.40	NA
5	0.060	3dy5A	0.339	5.57	0.026	0.488	1.13.11.40,4.2.1.92	NA
6	0.060	3hmjA	0.397	5.54	0.058	0.597	2.3.1.86	NA
7	0.060	1eulA	0.285	5.33	0.021	0.413	3.6.3.8	NA
8	0.060	2cseW	0.322	6.59	0.069	0.561	3.6.4.13	NA
9	0.060	3b8eA	0.338	5.77	0.035	0.531	3.6.3.9	NA
10	0.060	3ikmD	0.326	5.42	0.025	0.475	2.7.7.7	114
11	0.060	1w27A	0.328	6.67	0.034	0.564	4.3.1.24	111
12	0.060	3g61A	0.438	5.43	0.048	0.629	3.6.3.44	NA
13	0.060	2vumA	0.264	6.28	0.040	0.439	2.7.7.6	NA
14	0.060	1mo7A	0.162	5.29	0.060	0.243	3.6.3.9	NA
15	0.060	2fhbA	0.334	6.71	0.041	0.597	3.2.1.41	NA
16	0.060	2p0mB	0.348	5.88	0.022	0.525	1.13.11.33	94
17	0.060	2np0A	0.388	5.60	0.037	0.584	3.4.24.69	NA
18	0.060	2pffD	0.386	5.49	0.045	0.577	2.3.1.86	182
19	0.060	2uv8G	0.322	6.66	0.066	0.567	2.3.1.86	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.348	4.85	0.04	0.49	3haiA	GO:0005543 GO:0005737 GO:0005768 GO:0005829 GO:0005886 GO:0006897 GO:0007015 GO:0008092 GO:0008289 GO:0016020 GO:0030054 GO:0030100 GO:0030137 GO:0030659 GO:0031410 GO:0032587 GO:0042995 GO:0043005 GO:0043209 GO:0043679 GO:0045202 GO:0045806 GO:0048471 GO:0048488 GO:0048666 GO:0048812 GO:0072657 GO:0090002 GO:0097320 GO:1900006
1	0.06	0.379	5.25	0.08	0.55	4bneA	GO:0005737 GO:0005768 GO:0005769 GO:0005802 GO:0005829 GO:0005856 GO:0005886 GO:0005901 GO:0005925 GO:0006897 GO:0008092 GO:0008289 GO:0016020 GO:0030036 GO:0030054 GO:0030100 GO:0030659 GO:0031410 GO:0032587 GO:0042995 GO:0045806 GO:0055038 GO:0070300 GO:0070836 GO:0097320
2	0.06	0.355	5.41	0.06	0.52	3q0kD	GO:0005215 GO:0005654 GO:0005737 GO:0005768 GO:0005769 GO:0005829 GO:0005856 GO:0005886 GO:0005901 GO:0005911 GO:0005913 GO:0005925 GO:0006897 GO:0008092 GO:0008289 GO:0016020 GO:0019898 GO:0030036 GO:0030100 GO:0030659 GO:0031410 GO:0032587 GO:0036010 GO:0042802 GO:0042995 GO:0043231 GO:0045806 GO:0048858 GO:0055038 GO:0070062 GO:0070300 GO:0070836 GO:0072584 GO:0097320 GO:0098609 GO:0098641
3	0.06	0.380	5.33	0.07	0.57	3qniA	GO:0005543 GO:0005737 GO:0005768 GO:0005829 GO:0005886 GO:0006897 GO:0007015 GO:0008092 GO:0008289 GO:0016020 GO:0030054 GO:0030100 GO:0030137 GO:0030659 GO:0031410 GO:0032587 GO:0042995 GO:0043005 GO:0043209 GO:0043679 GO:0045202 GO:0045806 GO:0048471 GO:0048488 GO:0048666 GO:0048812 GO:0072657 GO:0090002 GO:0097320 GO:1900006
4	0.06	0.322	4.11	0.06	0.42	2lemA	GO:0001523 GO:0001540 GO:0001932 GO:0001935 GO:0002740 GO:0005319 GO:0005543 GO:0005548 GO:0005576 GO:0005615 GO:0005634 GO:0005829 GO:0006629 GO:0006644 GO:0006656 GO:0006695 GO:0006810 GO:0006869 GO:0006898 GO:0007186 GO:0007229 GO:0007584 GO:0008035 GO:0008104 GO:0008202 GO:0008203 GO:0008211 GO:0008289 GO:0009986 GO:0010804 GO:0010873 GO:0010898 GO:0010903 GO:0015485 GO:0015914 GO:0017127 GO:0018158 GO:0018206 GO:0019433 GO:0019899 GO:0019915 GO:0030139 GO:0030300 GO:0030301 GO:0030325 GO:0031100 GO:0031103 GO:0031210 GO:0031410 GO:0032489 GO:0033344 GO:0033700 GO:0034115 GO:0034190 GO:0034191 GO:0034361 GO:0034364 GO:0034365 GO:0034366 GO:0034372 GO:0034375 GO:0034380 GO:0035025 GO:0042157 GO:0042158 GO:0042493 GO:0042627 GO:0042632 GO:0042802 GO:0043534 GO:0043627 GO:0043691 GO:0045499 GO:0045723 GO:0046470 GO:0050713 GO:0050728 GO:0050821 GO:0050919 GO:0051006 GO:0051180 GO:0051345 GO:0051346 GO:0051496 GO:0055091 GO:0055102 GO:0060192 GO:0060228 GO:0060354 GO:0060761 GO:0070062 GO:0070328 GO:0070508 GO:0070653 GO:0071813 GO:0072562 GO:1900026 GO:1903561
5	0.06	0.274	5.80	0.03	0.42	3cfoA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0039693 GO:0071897 GO:0090305
6	0.06	0.233	6.74	0.03	0.40	2y51A	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114
7	0.06	0.235	6.60	0.03	0.41	5d0uA	GO:0000166 GO:0003676 GO:0004386 GO:0005524 GO:0008026 GO:0016787
8	0.06	0.203	5.69	0.03	0.31	3vz2B	GO:0000166 GO:0008152 GO:0016491 GO:0016620 GO:0055114
9	0.06	0.232	5.67	0.04	0.37	1m1cA	GO:0019012 GO:0019028
10	0.06	0.221	6.11	0.03	0.36	3wsyA	GO:0000042 GO:0001540 GO:0004888 GO:0005576 GO:0005615 GO:0005641 GO:0005768 GO:0005769 GO:0005783 GO:0005794 GO:0005802 GO:0005887 GO:0006605 GO:0006622 GO:0006629 GO:0006810 GO:0006869 GO:0006892 GO:0006897 GO:0006898 GO:0007165 GO:0008202 GO:0008203 GO:0014910 GO:0016020 GO:0016021 GO:0030169 GO:0030306 GO:0031985 GO:0032091 GO:0032460 GO:0034362 GO:0043407 GO:0045053 GO:0045732 GO:0050768 GO:0051604 GO:0055037 GO:0070062 GO:0070863 GO:1901215 GO:1902430 GO:1902771 GO:1902948 GO:1902953 GO:1902955 GO:1902960 GO:1902963 GO:1902966 GO:1902997 GO:2001137
11	0.06	0.170	6.56	0.03	0.29	2qv7A	GO:0000166 GO:0003951 GO:0004143 GO:0005524 GO:0006629 GO:0008152 GO:0008654 GO:0016301 GO:0016310 GO:0016740 GO:0046872
12	0.06	0.255	5.83	0.05	0.40	4ojjC	GO:0000290 GO:0000776 GO:0000932 GO:0001731 GO:0003682 GO:0003723 GO:0003729 GO:0005634 GO:0005737 GO:0006397 GO:0006417 GO:0006446 GO:0007049 GO:0007059 GO:0010494 GO:0022627 GO:0033962 GO:0045947 GO:0051301 GO:0061641 GO:1990726
13	0.06	0.183	6.17	0.01	0.31	1igiH
14	0.06	0.183	5.36	0.04	0.28	4f8xA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493
15	0.06	0.170	4.10	0.03	0.21	4g59B	GO:0001913 GO:0003823 GO:0005886 GO:0006955 GO:0009897 GO:0016020 GO:0019882 GO:0031225 GO:0042267 GO:0042742 GO:0046658 GO:0046703 GO:0071222 GO:0071360
16	0.06	0.168	5.76	0.04	0.26	3nr8B	GO:0001958 GO:0002376 GO:0003779 GO:0005737 GO:0005794 GO:0005829 GO:0005856 GO:0005886 GO:0006006 GO:0006661 GO:0006897 GO:0007015 GO:0007155 GO:0008285 GO:0009791 GO:0010629 GO:0016020 GO:0016787 GO:0017124 GO:0030027 GO:0030175 GO:0032868 GO:0034485 GO:0042169 GO:0042995 GO:0043647 GO:0044255 GO:0046856 GO:0052659 GO:0097178
17	0.06	0.213	3.67	0.00	0.26	3kwoA	GO:0005737 GO:0006879 GO:0006950 GO:0008199 GO:0016491 GO:0042262 GO:0046872 GO:0055114
18	0.06	0.176	6.36	0.07	0.29	3lm8A	GO:0000166 GO:0004788 GO:0005524 GO:0006772 GO:0009229 GO:0016301 GO:0016310 GO:0016740 GO:0030975

Consensus prediction of GO terms

Molecular Function	GO:0005515
GO-Score	0.47
Biological Processes	GO:0051129	GO:0007009	GO:0051051	GO:0030100
GO-Score	0.47	0.47	0.47	0.47
Cellular Component	GO:0031256	GO:0001726	GO:0012506	GO:0012505	GO:0044433	GO:0031253	GO:0016023	GO:0005773
GO-Score	0.47	0.47	0.47	0.47	0.47	0.47	0.47	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.