I-TASSER results

I-TASSER results for job id Rv1680

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (274 residues)
MSTEPLVVGAVAYTPNVVPIWEGIRGYFQDSESPDTQMDFVLYSNYARLVDSLIAGHIDI
AWNTNLAYVRTVLQTGGRCTPLAQRDTDVDYTTVFVAHAGSDLHGAKDIAGKRLALGSAD
SAHAAILPLYYLRRAGIAESDLQVIRFDTDIGKHGDTGRSELDAVDAVLAGEADVAAIGS
STWAAMGAAELMGESLTEVWRTDGYCHCMFTALDTLPAERYQPWLDRLLAMSWDDSEHRK
ILELEGLRRWVPPHLDGYKPLFEAVQEQGIDPRW

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSTEPLVVGAVAYTPNVVPIWEGIRGYFQDSESPDTQMDFVLYSNYARLVDSLIAGHIDIAWNTNLAYVRTVLQTGGRCTPLAQRDTDVDYTTVFVAHAGSDLHGAKDIAGKRLALGSADSAHAAILPLYYLRRAGIAESDLQVIRFDTDIGKHGDTGRSELDAVDAVLAGEADVAAIGSSTWAAMGAAELMGESLTEVWRTDGYCHCMFTALDTLPAERYQPWLDRLLAMSWDDSEHRKILELEGLRRWVPPHLDGYKPLFEAVQEQGIDPRW
Prediction	CCCCEEEEEEHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHCCEEEEEEEHCCCCCEEEEEEHCCCCCCCCHHHHCCCEEEHCCCCCCCHHHHHHHHHHHHCCCHHHCEEEEHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHCHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCEEHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEHCCHHHHHHHHHHHHHHCCCCCC
Conf.Score	9998589999858885788999999999998678986999986999999999998996599968889999999859969999975888876899999699999998996689699858998745599999999989997774456545666665556677799999999899989986568999999869875476899985899998699879999999999999999889899999999998698785658887899999999998999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MSTEPLVVGAVAYTPNVVPIWEGIRGYFQDSESPDTQMDFVLYSNYARLVDSLIAGHIDIAWNTNLAYVRTVLQTGGRCTPLAQRDTDVDYTTVFVAHAGSDLHGAKDIAGKRLALGSADSAHAAILPLYYLRRAGIAESDLQVIRFDTDIGKHGDTGRSELDAVDAVLAGEADVAAIGSSTWAAMGAAELMGESLTEVWRTDGYCHCMFTALDTLPAERYQPWLDRLLAMSWDDSEHRKILELEGLRRWVPPHLDGYKPLFEAVQEQGIDPRW
Prediction	8464402000002345234104202510563573715032230641440041045450200000211001013437030100013544440100000147461540540462300111430100100012104736053740442413443333343334232002103433000000224003304757423750210040451240000004503661153025003503563640341054261640240437205302500662716378
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCEEEEEEHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHCCCHHHHHHHHHHCCCEEEEHCCHHHHHHHHHHCCEEEEEEEHCCCCCEEEEEEHCCCCCCCCHHHHCCCEEEHCCCCCCCHHHHHHHHHHHHCCCHHHCEEEEHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEHCHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCEEHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEHCCHHHHHHHHHHHHHHCCCCCC
MSTEPLVVGAVAYTPNVVPIWEGIRGYFQDSESPDTQMDFVLYSNYARLVDSLIAGHIDIAWNTNLAYVRTVLQTGGRCTPLAQRDTDVDYTTVFVAHAGSDLHGAKDIAGKRLALGSADSAHAAILPLYYLRRAGIAESDLQVIRFDTDIGKHGDTGRSELDAVDAVLAGEADVAAIGSSTWAAMGAAELMGESLTEVWRTDGYCHCMFTALDTLPAERYQPWLDRLLAMSWDDSEHRKILELEGLRRWVPPHLDGYKPLFEAVQEQGIDPRW

3p7iA

0.17

0.16

0.94

2.12

MUSTER

---KALNFGIISTESNLKPQWTPFLQDMEKKL--GVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVADGSPGYWSVLIVNKDSPINNLNDLLAKTFGNGDPNSTSGFLVPGYYVAKNNISASDFKRTVN-----------AGHETNALAVANKQVDVATNNTENLDKLKTSAPKLKELKVIWKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYGK-TPEEKAVLERLGWAPFRASSDLQLVPIRQLALFKEMQSKG

3p7iA

0.17

0.16

0.94

2.70

dPPAS

---KALNFGIISTESNLKPQWTPFLQDMEKKL--GVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVADGSPGYWSVLIVNKDSPINNLNDLLALTFGNGDPNSTSGFLVPGYYVAKNNISASDFKRTVN-----------AGHETNALAVANKQVDVATNNTENLDKLKTSAEKLKELKVIWKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYGK-TPEEKAVLERLGWAPFRASSDLQLVPIRQLALFKEMDNKG

3p7iA

0.15

0.14

0.94

3.34

wdPPAS

---KALNFGIISTESNLKPQWTPFLQDMEKKL--GVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVADGSPGYWSVLIVNKDSPINNLNDLLDLTFGNGDPNSTSGFLVPGYYVFAKNNISAS----------DFKRTVNAGHETNALAVANKQVDVATNNTENLDKLKTSAEKLKELKVIWKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYGK-TPEEKAVLERLGWAPFRASSDLQLVPIRQLALFKEMQSKG

3p7iA

0.17

0.16

0.93

2.58

wMUSTER

----ALNFGIISTESNLKPQWTPFLQDMEKKL--GVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVADGSPGYWSVLIVNKDSPINNLNDLLAKTFGNGDPNSTSGFLVPGYYVAKNNISASDFKRTVN-----------AGHETNALAVANKQVDVATNNTENLDKLKTSAPKLKELKVIWKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYG-KTPEEKAVLERLGWAPFRASSDLQLVPIRQLALFKEMQSKG

3n5lA

0.16

0.15

0.94

3.61

wPPAS

-DQPVINFGIISTESNLKSIWEPFLKDSQQ---TGYQVKAFFAPDYAGIIQGR-FDKVDIAWYGNKAAEAVDRAHGEIFAQTVAASGAPGYWSLLIANKDSKIDSLEDLASLTFGNGDPNSTSGYLVPGYYVFAKNVDPVKA----------FKRTLNSSHEVNALAVANKQVDVATFNTEGERLELTQPEKARQLKVIWKSPLIPGDPLVWRNNLSDEQKNKLRDFFFKYGA-NAEQKKVLADLQWSKFQASDDDQLLPIRQLELFKQRNANL

3p7iA

0.17

0.16

0.92

6.30

dPPAS2

---KALNFGIISTESNLKPQWTPFLQDMEKKL--GVKVNAFFAPDYAGIIQGMRFNKVDIAWYGNLSAMEAVDRANGQVFAQTVADGSPGYWSVLIVNKDSPINNLNDLLAKTFGNGDPNSTSGFLVPGYYVAKNNISASDFKRTVN-----------AGHETNALAVANKQVDVATNNTENLDKLKTSAEKLKELKVIWKSPLIPGDPIVWRKNLSETTKDKIYDFFMNYGK-TPEEKAVLERLGWAPFRASSDLQLVPIRQLALFK------

3n5lA

0.16

0.15

0.94

3.16

PPAS

-DQPVINFGIISTESNLKSIWEPFLKDSQQ---TGYQVKAFFAPDYAGIIQGR-FDKVDIAWYGNKAAEAVDRAHGEIFAQTVAASGAPGYWSLLIANKDSKIDSLEDLASLTFGNGDPNSTSGYLVPGYYVFAKNVDPVKAFKRTL----------NSSHEVNALAVANKQVDVATFNTEGERLELTQPEKARQLKVIWKSPLIPGDPLVWRNNLSDEQKNKLRDFFFKYGA-NAEQKKVLADLQWSKFQASDDDQLLPIRQLELFKQRNANL

3n5lA

0.16

0.15

0.94

3.65

Env-PPAS

-DQPVINFGIISTESNLKSIWEPFLKDSQQ---TGYQVKAFFAPDYAGIIQGR-FDKVDIAWYGNKAAEAVDRAHGEIFAQTVAASGAPGYWSLLIANKDSKIDSLEDLASLTFGNGDPNSTSGYLVPGYYVFAKNVDPVKAFKRTL----------NSSHEVNALAVANKQVDVATFNTEGERLELTQPEKARQLKVIWKSPLIPGDPLVWRNNLSDEQKNKLRDFFFKYGA-NAEQKKVLADLQWSKFQASDDDQLLPIRQLELFKQRNANL

3n5lA

0.16

0.15

0.94

2.07

MUSTER

-DQPVINFGIISTESNLKSIWEPFLKDSQQ---TGYQVKAFFAPDYAGIIQGR-FDKVDIAWYGNKAAEAVDRAHGEIFAQTVAASGAPGYWSLLIANKDSKIDSLEDLASLTFGNGDPNSTSGYLVPGYYVFAKNVDPVKA----------FKRTLNSSHEVNALAVANKQVDVATFNTEGERLELTQPEKARQLKVIWKSPLIPGDPLVWRNNLSDEQKNKLRDFFFKYGA-NAEQKKVLADLQWSKFQASDDDQLLPIRQLELFKQRNNAN

3n5lA

0.17

0.16

0.95

2.68

dPPAS

-DQPVINFGIISTESNLKSIWEPFLKDSQQ---TGYQVKAFFAPDYAGIIQGR-FDKVDIAWYGNKAAEAVDRAHGEIFAQTVAASGAPGYWSLLIANKDSKIDSLEDLASLTFGNGDPNSTSGYLVPGYYVFAKNN---------VDPVKAFKRTLNSSHEVNALAVANKQVDVATFNTEGERLELTQPEKARQLKVIWKSPLIPGDPLVWRNNLSDEQKNKLRDFFFKYGA-NAEQKKVLADLQWSKFQASDDDQLLPIRQLELFKQRNANL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.94

Estimated TM-score = 0.84±0.08

Estimated RMSD = 4.1±2.7Å

Download Model 2

C-score=-1.95

Download Model 3

C-score=0.73

Download Model 4

C-score=-2.26

Download Model 5

C-score=-3.19

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3p7iA	0.907	1.31	0.151	0.942
2	3n5lA	0.894	1.31	0.165	0.931
3	1d4nA	0.753	3.62	0.103	0.953
4	3mc2A	0.741	3.67	0.095	0.945
5	1b1xA	0.737	3.80	0.103	0.949
6	4eswA	0.736	3.45	0.099	0.905
7	3ix1A	0.722	3.33	0.077	0.890
8	3ekiA	0.716	3.71	0.088	0.909
9	3myuA	0.712	3.50	0.089	0.898
10	4dddA	0.708	3.07	0.116	0.854

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.61	27	3qk6A	UNL	Rep, Mult	10,46,64,91,121,122,123,161,208
2	0.03	2	2h4iA	UUU	Rep, Mult	130,131,260,263,264,267
3	0.02	1	2dwaA	FUC	Rep, Mult	90,204,205,206,207,258
4	0.02	1	2aluA	UUU	Rep, Mult	125,126,127,128,130
5	0.02	1	3ugwA	DCZ	Rep, Mult	85,89,90,91,92

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.137	2vd2A	0.536	4.04	0.105	0.697	2.4.2.17	158,181
2	0.077	3kbrA	0.593	3.55	0.088	0.745	4.2.1.91,4.2.1.51	8
3	0.067	1ve4A	0.505	3.77	0.110	0.653	2.4.2.17	NA
4	0.067	1o64A	0.518	3.76	0.119	0.668	2.4.2.17	178
5	0.060	1z7mH	0.496	3.99	0.100	0.657	2.4.2.17	160,199
6	0.060	2vhyB	0.332	6.15	0.061	0.562	1.4.1.1	165,178
7	0.060	3h9uC	0.435	5.93	0.059	0.712	3.3.1.1	NA
8	0.060	1thgA	0.413	5.68	0.046	0.668	3.1.1.3	122
9	0.060	2rgyA	0.455	5.63	0.063	0.726	5.1.1.1	202
10	0.060	1a7aA	0.429	5.91	0.059	0.697	3.3.1.1	NA
11	0.060	2vhwE	0.427	5.64	0.070	0.690	1.4.1.1	178
12	0.060	3hnoA	0.427	6.23	0.072	0.726	2.7.1.90	NA
13	0.060	1t34A	0.445	6.00	0.040	0.726	4.6.1.2	NA
14	0.060	2vd3A	0.518	4.35	0.085	0.708	2.4.2.17	181,202
15	0.060	1nh7A	0.505	4.28	0.071	0.686	2.4.2.17	12,47,70
16	0.060	3ceaA	0.413	5.99	0.044	0.682	1.1.1.18	71
17	0.060	3c3kB	0.452	5.50	0.096	0.693	5.1.1.1	NA
18	0.060	3bblA	0.431	5.65	0.065	0.679	5.1.1.1	131,196
19	0.060	1ii0B	0.447	5.74	0.064	0.715	3.6.3.16	NA
20	0.060	3k2qA	0.419	5.87	0.046	0.690	2.7.1.90	NA
21	0.060	3ecrA	0.563	4.61	0.064	0.799	2.5.1.61	NA
22	0.060	2de3B	0.668	4.39	0.094	0.887	3.13.1.3	62,124
23	0.060	3beoA	0.414	5.38	0.036	0.635	5.1.3.14	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.911	1.23	0.16	0.95	3n5lA	GO:0015604 GO:0015716 GO:0042916 GO:0042917 GO:0043190 GO:0055085
1	0.35	0.905	1.22	0.16	0.94	3qk6B	GO:0015604 GO:0015716 GO:0043190 GO:0055085
2	0.23	0.747	3.61	0.10	0.95	1h76A	GO:0005576 GO:0005615 GO:0005623 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008199 GO:0015091 GO:0015682 GO:0046872 GO:0055072
3	0.23	0.737	3.80	0.10	0.95	1b1xA	GO:0001503 GO:0001817 GO:0002227 GO:0002376 GO:0005576 GO:0005615 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008236 GO:0016787 GO:0019731 GO:0019732 GO:0031665 GO:0032680 GO:0033690 GO:0042581 GO:0043066 GO:0045669 GO:0046872 GO:0055072 GO:0060349 GO:1900159 GO:1900229 GO:1902732 GO:2000308 GO:2001205
4	0.20	0.757	3.69	0.11	0.96	1jnfA	GO:0005576 GO:0005615 GO:0005623 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008199 GO:0015091 GO:0015682 GO:0046872 GO:0055072
5	0.20	0.635	4.00	0.07	0.83	3s9nD	GO:0001895 GO:0002576 GO:0005576 GO:0005615 GO:0005769 GO:0005770 GO:0005905 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008198 GO:0008199 GO:0009925 GO:0009986 GO:0010008 GO:0015091 GO:0016023 GO:0016324 GO:0030139 GO:0031232 GO:0031647 GO:0031982 GO:0033572 GO:0034774 GO:0045178 GO:0046872 GO:0048260 GO:0048471 GO:0055037 GO:0055072 GO:0070062 GO:0071281 GO:0072562 GO:0097460 GO:1990459 GO:1990712
6	0.20	0.753	3.74	0.09	0.96	1biyA	GO:0001503 GO:0001817 GO:0002227 GO:0002376 GO:0004252 GO:0005506 GO:0005576 GO:0005615 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008236 GO:0016787 GO:0019731 GO:0019732 GO:0031665 GO:0032680 GO:0033690 GO:0042581 GO:0043066 GO:0045669 GO:0046872 GO:0055072 GO:0060349 GO:1900159 GO:1900229 GO:1902732 GO:2000308 GO:2001205
7	0.19	0.732	4.05	0.12	0.96	2bjjX	GO:0001503 GO:0001817 GO:0001895 GO:0002227 GO:0002376 GO:0003677 GO:0004252 GO:0005506 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0006351 GO:0006355 GO:0006508 GO:0006810 GO:0006811 GO:0006959 GO:0008201 GO:0008233 GO:0008236 GO:0009986 GO:0016787 GO:0019731 GO:0019732 GO:0030141 GO:0031665 GO:0032680 GO:0032780 GO:0033214 GO:0033690 GO:0034145 GO:0042581 GO:0042742 GO:0043066 GO:0043123 GO:0043234 GO:0043539 GO:0044267 GO:0044793 GO:0045071 GO:0045454 GO:0045669 GO:0046872 GO:0048525 GO:0051092 GO:0055072 GO:0060349 GO:0070062 GO:0071902 GO:0097013 GO:1900159 GO:1900229 GO:1902732 GO:2000308 GO:2001205
8	0.13	0.740	3.96	0.09	0.96	3s9mC	GO:0001895 GO:0002576 GO:0005576 GO:0005615 GO:0005769 GO:0005770 GO:0005905 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008198 GO:0008199 GO:0009925 GO:0009986 GO:0010008 GO:0015091 GO:0016023 GO:0016324 GO:0030139 GO:0031232 GO:0031647 GO:0031982 GO:0033572 GO:0034774 GO:0045178 GO:0046872 GO:0048260 GO:0048471 GO:0055037 GO:0055072 GO:0070062 GO:0071281 GO:0072562 GO:0097460 GO:1990459 GO:1990712
9	0.13	0.741	3.67	0.10	0.95	3mc2A	GO:0004857 GO:0005506 GO:0005576 GO:0005615 GO:0043086
10	0.13	0.683	3.71	0.10	0.88	3s9mD	GO:0001895 GO:0002576 GO:0005576 GO:0005615 GO:0005769 GO:0005770 GO:0005905 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008198 GO:0008199 GO:0009925 GO:0009986 GO:0010008 GO:0015091 GO:0016023 GO:0016324 GO:0030139 GO:0031232 GO:0031647 GO:0031982 GO:0033572 GO:0034774 GO:0045178 GO:0046872 GO:0048260 GO:0048471 GO:0055037 GO:0055072 GO:0070062 GO:0071281 GO:0072562 GO:0097460 GO:1990459 GO:1990712
11	0.09	0.686	4.02	0.15	0.90	3e4rA	GO:0006790 GO:0006810 GO:0016020
12	0.09	0.641	3.29	0.11	0.79	1xt8B
13	0.08	0.678	3.93	0.13	0.88	2x26A	GO:0006790 GO:0006810 GO:0016020 GO:0042597 GO:0055052
14	0.07	0.632	3.01	0.10	0.76	4ymxA	GO:0004970 GO:0005215 GO:0006810 GO:0016020 GO:0035235
15	0.07	0.557	5.21	0.08	0.84	1aovA	GO:0005576 GO:0005615 GO:0006810 GO:0006811 GO:0046872 GO:0055072
16	0.07	0.729	3.94	0.09	0.94	4h0wA	GO:0001895 GO:0002576 GO:0005576 GO:0005615 GO:0005769 GO:0005770 GO:0005905 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008198 GO:0008199 GO:0009925 GO:0009986 GO:0010008 GO:0015091 GO:0016023 GO:0016324 GO:0030139 GO:0031232 GO:0031647 GO:0031982 GO:0033572 GO:0034774 GO:0045178 GO:0046872 GO:0048260 GO:0048471 GO:0055037 GO:0055072 GO:0070062 GO:0071281 GO:0072562 GO:0097460 GO:1990459 GO:1990712
17	0.07	0.555	5.31	0.11	0.86	1aivA	GO:0005576 GO:0005615 GO:0006810 GO:0006811 GO:0006953 GO:0031012 GO:0032496 GO:0046872 GO:0055072
18	0.07	0.552	5.03	0.08	0.81	1dtzA	GO:0001503 GO:0001817 GO:0002227 GO:0002376 GO:0004252 GO:0005506 GO:0005576 GO:0005615 GO:0006508 GO:0006810 GO:0006811 GO:0008233 GO:0008236 GO:0016787 GO:0019731 GO:0019732 GO:0031665 GO:0032680 GO:0033690 GO:0042581 GO:0043066 GO:0045669 GO:0046872 GO:0055072 GO:0060349 GO:1900159 GO:1900229 GO:1902732 GO:2000308 GO:2001205
19	0.07	0.694	4.03	0.09	0.92	4x1bA	GO:0001895 GO:0002576 GO:0005576 GO:0005615 GO:0005769 GO:0005770 GO:0005905 GO:0006810 GO:0006811 GO:0006826 GO:0006879 GO:0008198 GO:0008199 GO:0009925 GO:0009986 GO:0010008 GO:0015091 GO:0016023 GO:0016324 GO:0030139 GO:0031232 GO:0031647 GO:0031982 GO:0033572 GO:0034774 GO:0045178 GO:0046872 GO:0048260 GO:0048471 GO:0055037 GO:0055072 GO:0070062 GO:0071281 GO:0072562 GO:0097460 GO:1990459 GO:1990712
20	0.06	0.321	6.22	0.04	0.53	1lluA	GO:0000166 GO:0008270 GO:0016491 GO:0046872 GO:0055114
21	0.06	0.357	6.09	0.04	0.60	3hemA	GO:0001666 GO:0005737 GO:0005829 GO:0005886 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0016740 GO:0032259 GO:0046500 GO:0052167 GO:0071766 GO:0071768 GO:0071769

Consensus prediction of GO terms

Molecular Function	GO:0070011	GO:0017171	GO:0015091	GO:0008199	GO:0042917
GO-Score	0.46	0.46	0.39	0.39	0.36
Biological Processes	GO:0055085	GO:0043069	GO:0045087	GO:0050832	GO:0031664	GO:1900157	GO:0019538	GO:0002385	GO:1903011	GO:1903556	GO:0010721	GO:1900191	GO:1900228	GO:2000307	GO:0033688	GO:0032102	GO:0045597	GO:0032640	GO:0019730	GO:0009968	GO:0035988	GO:0002832	GO:0030501	GO:2001204	GO:0048705	GO:0045667	GO:0045671	GO:0042742	GO:0042981	GO:1903012	GO:0008284	GO:0006879	GO:0015682	GO:0042916
GO-Score	0.58	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.39	0.39	0.36
Cellular Component	GO:0043190	GO:0005615	GO:0030141
GO-Score	0.58	0.53	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.