I-TASSER results

I-TASSER results for job id Rv1678

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (300 residues)
MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWKVPPDFGERGRRDLYHF
THLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVLLLTGTAVRLAALIGIGQS
VAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVDAVRAAATGSAARTAAQRLLA
GWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEYNLRGALALIAIALAMLAAAKRG
WRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTTAAVFVCAAVVSLATEFRIGRVEGA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWKVPPDFGERGRRDLYHFTHLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVLLLTGTAVRLAALIGIGQSVAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVDAVRAAATGSAARTAAQRLLAGWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEYNLRGALALIAIALAMLAAAKRGWRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTTAAVFVCAAVVSLATEFRIGRVEGA
Prediction	CCCCCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCEEEEEEHHHHHHCCCCEHCCCCCC
Conf.Score	987655544545889998766547789999999999999999974787666778765666765466777648999999987555788999999999999999999999999999999999999998765899865789999999999996566546764455545457776669999998766667889899888766888887546664343334455789999999999999999886677899999999999998877646876887689884688765455554455445445689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWKVPPDFGERGRRDLYHFTHLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVLLLTGTAVRLAALIGIGQSVAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVDAVRAAATGSAARTAAQRLLAGWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEYNLRGALALIAIALAMLAAAKRGWRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTTAAVFVCAAVVSLATEFRIGRVEGA
Prediction	753243024101433444430210000201330031012200230334124434310110033316431140022002100113123100111301131121223123133112100313211100003245312010000010100001022111100110022114445432032003121320000010120221235321211131021102422020000000001110000334130000010000000001010213421000122421000000000011034231243658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCEEEEEEHHHHHHCCCCEHCCCCCC
MARVRRGTELLLSPQSPPATGGLIVLTGLRLLAGLIWLYNVVWKVPPDFGERGRRDLYHFTHLAVEHPVFTPFSWVIEHAVLPYFTAFGWGVLFAESALAVLLLTGTAVRLAALIGIGQSVAIGLSVAESPGEWPWAYAMLLGIHVVLLFTCSTRYAAVDAVRAAATGSAARTAAQRLLAGWGIVLGLIGLVAVWRGLGDDRPAYVGIRALEFSLGEYNLRGALALIAIALAMLAAAKRGWRTVALVAAVVAVAAAAAIYLQVGRTAVWLGGTNTTAAVFVCAAVVSLATEFRIGRVEGA

4kjsA

0.12

0.95

0.86

MUSTER

AAGV-----SVIGSLMHWPSAVLFAVYCVTIIALASYMGRATESLSIRIG-----GLLNATFGN------AVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKSGVATIVLFAATIVVAYISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLVFTLLVAMVSAVLLMIAISNDGDSNWFEGA

4w6vA2

0.11

0.09

0.82

0.66

dPPAS

---------------------GRWVTAIMAVVVVIIALISQGVIP---------INPVMIASLLVYVIAASVTLYFIYLFAFAKMSRKDRARLLVCFILLVSAAFFWSAFEQKPTSFNLFANDYTDRMVMGFEIPTVWFQSINALFIILL-------------APVFSWAPSSITKFVIGILCAAAGFAVMMYAAQHVLSSGGAGV---SPLWLVMSILLLTLGELCLSPIGLATMTLLRMRGQVMGLWFCASSLGNLAAGLIG-GHVKADQLDMLPTLFARCSIALVIC--------AA

5i20A

0.12

0.10

0.85

0.76

wdPPAS

LALATSST----------GAVPPFLLTALTFTIGGAVGIAAGLARGVSVLRQPWPVWVHGIGG-----LFGYHFFYFSALKL-EAGLVAYLWPLLIVLFSAFLPAHVAGALMGLAGTVVLLGARAGGFGFAPEYVPGYLAAAACAVIWSVYS---------VASRRFARVPT----EVVAGFCLATAALSALCHILFEPSVWPVG--------EWLAVVALGIGPGIAFYTWDIGMKRGDVRLLGVLSYAAPVLSTLLLVVAGFAAALAIA------CALIVGGAAVATLLAR--RLES-

4kjsA

0.13

0.12

0.90

0.88

wMUSTER

IGSLMHWPSAV-----------LFAVYCVTIIALASYMGRATESLSIRIG-----GLLNATFGNAVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGFNIHDARHNSGLLIFAIIVAFVISVGMGNASKLNLSIGISIIMILL--------YVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSVAEQ----FGWS--ELFI-GVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPLLVAMVSAVLLMINDGDSNWFEGA

5i20A

0.13

0.10

0.80

0.85

wPPAS

LALATSSTGAV----------PPFLLTALTFTIGGAVGIAAGLA-----GVSVLRQPWPVWVH-------GIGGLFGYHFFYPEAGLVAYLWPLLIVLFSAFLPAHVAGALMGLAGTVVLLGARAGGFGFAPEYVPGYLAAAACAVIWSV------YSV---ASRRFARVPT----EVVAGFCLATAALSALCHILFEPSVWPV---------------GSEWLAVVALGIGVGIAFYTWDIGMKRG----VRLLGVLSYAAP--STLAGFAAPSGACALIVGGAAVATLLAR--RLE-S

4kjsA

0.12

0.11

0.91

0.83

dPPAS2

IGSL-----MHWPSAV------LFAVYCVTIIALASYMGRATESLSIRIG-----GLLNATFGN------AVELIISMFALKEGLTGIVLASLTGSVLGNLLLVAGLSFFVGGIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSIGISIIMILLYVAALYFKSGKVATIVLFAATIVVAYISENLVHTFHSV---AEQFGWSE---LFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAVGSTLQIAMFVAPVLVICSIFFPTSMPAMVSAVLLMIAISNDGDSNWFEGA

5doqB

0.13

0.12

0.93

0.94

PPAS

VA----SIDFFFSVYSHWANQQHILHRIIQRYLSPVWEVTNVFLV---FFFVGIVGFFPKTAYYYGSILLVPASIAIVLLAIGSYYAFHTYGETERNWYLLAYGLTGLFIPASLSIVLTISEGGFVEENAAGVFASPLSWSVVLLSVTSVL----YISA-VFLTYYADAAGDEQARALLRRYALLWSPTMLSALLIIYQ----LRYHNPEHYDNLWNVAWMLVISFLFFVITVWLLGRQRFGWAFIALLFQYAFAFYAYGISHPYLTIY-FTNETMAMAFIAGLLLLIPS-FLFNK----

4h54A

0.17

0.12

0.71

0.66

Env-PPAS

------------------------------------------------------TTEIDAILLNLNKAIDAHYQWLVSMFH--SVVAFGRWIDHLGPLD--NDELPYVRLMDSAHQHMHNCGRELMLAIVENHWQDAHFDAFQEGLLSFT-------------AAL-----TDYKIYLLTIRSNRRVLDESFDHQLRNAEPLNLYL----MLLDIDTYHLIGDVVLRTLATYLASWT----RTVYIANDEEACRAGVRICQLVDNHAITHSEGNITVTAGVSRAFPEEPLDVVIGR---A

5ezmA1

0.14

0.13

0.94

0.79

MUSTER

VALVVWFVSLDMRHLVGPGRYAEISREMFAS-PFHMWVTVVGYEL---FGLGEWQARLAVALSGL--LGIGVSMMAARRWFGARAAAFTGLALLAAPMWSVAAHFNTLDMTLAGVMSCVLAFMLMGQHPDASVRGWMVACWAAMGVAILTKGLVGIALPGLVLVVYTVTRDWGLWRRLHLALGVVVMLVITVPWFYLVSVRNPFFFIHEHWQRRSGSYFLPLVIGGFLPWAGIFPKLWTAMR---FRPALMAGIWAIAIFVFF-----SISRSKLPGYIVPVIPALGILAGVALDRL---

4tq3A

0.15

0.12

0.84

0.65

dPPAS

----------------------SKYLRLLRPVAWLCFLLPYAVGFGFGITPNASLQHAVLGLLSFLHDGLNLSMQPLVTGEISVREAWLYCIAFLALSLATAAAINEKFFLAMLGANIIGYVYSA--PPRFKAWPVMDVICNALAAVLAFYAG----------LSIGGAEVPIAIYPAAFFLAATFYIPTAVSDYEFD-----KKAGLKNTPVFFGERALKSLYPLSAITVILWAYVFLMAERIEIKVISPLIIAYTLIYTFIINSRWDGEKLNVSSALFIAYGFAVISV----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.04

Estimated TM-score = 0.37±0.13

Estimated RMSD = 13.5±4.0Å

Download Model 2

C-score=-3.74

Download Model 3

C-score=-3.50

Download Model 4

C-score=-4.24

Download Model 5

C-score=-4.27

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4k1cA	0.738	3.96	0.087	0.957
2	4kjsA	0.734	3.84	0.079	0.920
3	4kppA	0.716	4.35	0.094	0.953
4	3v5sA	0.588	5.07	0.077	0.853
5	5j65A	0.411	6.13	0.051	0.660
6	2pulA	0.404	5.67	0.053	0.603
7	4a01A	0.399	6.42	0.066	0.663
8	4acoA	0.399	6.44	0.053	0.687
9	5jm7A2	0.395	5.04	0.076	0.567
10	2w02B	0.390	5.45	0.080	0.580

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	4	2xqtE	CVM	Rep, Mult	39,42
2	0.05	3	1hx9A	MG	Rep, Mult	102,106,291
3	0.05	3	2xqsA	CVM	Rep, Mult	38,42,45
4	0.02	1	2yl8A	MN	Rep, Mult	96,159
5	0.02	1	2w02B	SER	Rep, Mult	42,46,166,167
6	0.02	1	1xvbA	BHL	Rep, Mult	35,39,184,185
7	0.02	1	1gw9A	IOD	Rep, Mult	77,78,83,155
8	0.02	1	1xvbA	BHL	Rep, Mult	35,38,39,65,97
9	0.02	1	1xvgA	BRJ	Rep, Mult	29,32,33,36
10	0.02	1	2avu2	III	Rep, Mult	97,101,104,111,118,119,120,121,279,280,281,282
11	0.02	1	1m34A	SF4	Rep, Mult	114,115
12	0.02	1	1fz8B	2BM	Rep, Mult	46,49,50,163
13	0.02	1	1xvgA	BRJ	Rep, Mult	139,142,143
14	0.02	1	4b5sB	3GR	Rep, Mult	111,112,131
15	0.02	1	2o012	CLA	Rep, Mult	289,293
16	0.02	1	1xvfA	3CL	Rep, Mult	35,229,232,233
17	0.02	1	1pmmA	PLP	Rep, Mult	213,214
18	0.02	1	1xvgB	BRJ	Rep, Mult	94,98,99,102
19	0.02	1	3g0zA	MN	Rep, Mult	160,280
20	0.02	1	5dwkB	78N	Rep, Mult	38,177

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ig8A	0.353	6.00	0.072	0.567	2.7.1.1	130
2	0.060	2vdcA	0.371	5.94	0.035	0.600	1.4.1.13	NA
3	0.060	2zalA	0.229	4.97	0.093	0.330	3.5.1.1	161
4	0.060	1jn9D	0.199	4.02	0.050	0.260	3.4.19.5,3.5.1.1	NA
5	0.060	1otwA	0.363	5.24	0.076	0.543	1.3.3.11	29,34,186
6	0.060	1aupA	0.283	6.81	0.041	0.507	1.4.1.2	201
7	0.060	1bdgA	0.372	5.72	0.030	0.583	2.7.1.1	NA
8	0.060	5coxA	0.299	7.03	0.068	0.550	1.14.99.1	NA
9	0.060	3f9mA	0.341	6.29	0.050	0.563	2.7.1.2	NA
10	0.060	2bmaA	0.363	5.94	0.035	0.573	1.4.1.4	NA
11	0.060	1ea0A	0.371	5.94	0.035	0.600	1.4.1.13	250
12	0.060	2vdcF	0.371	6.24	0.038	0.617	1.4.1.13	NA
13	0.060	2wghB	0.367	5.12	0.073	0.530	1.17.4.1	66
14	0.060	2cvtA	0.365	5.37	0.066	0.540	1.17.4.1	NA
15	0.060	1seoD	0.203	4.23	0.076	0.273	3.4.19.5	226
16	0.060	1w4xA	0.370	6.43	0.036	0.637	1.14.13.92	NA
17	0.060	1qleC	0.374	6.28	0.069	0.603	1.9.3.1	194
18	0.060	3gqbA	0.366	6.44	0.036	0.603	3.6.3.14	198
19	0.060	2pulA	0.404	5.67	0.053	0.603	2.7.1.100	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.739	3.91	0.08	0.93	4kjrA	GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0008324 GO:0015297 GO:0015369 GO:0016020 GO:0016021 GO:0055085 GO:0070588
1	0.14	0.738	3.96	0.09	0.96	4k1cA	GO:0000324 GO:0000329 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0006812 GO:0006816 GO:0006828 GO:0006874 GO:0008324 GO:0015085 GO:0015369 GO:0015386 GO:0016020 GO:0016021 GO:0046872 GO:0055085 GO:0070588 GO:0071805 GO:0098655
2	0.13	0.716	4.35	0.09	0.95	4kppA	GO:0016020 GO:0016021 GO:0046872 GO:0055085
3	0.07	0.596	4.84	0.11	0.86	5hwyA	GO:0005262 GO:0005509 GO:0005886 GO:0005887 GO:0006874 GO:0008273 GO:0016020 GO:0016021 GO:0030955 GO:0031402 GO:0035725 GO:0055085 GO:0070588
4	0.06	0.357	4.98	0.04	0.51	2pywA	GO:0000166 GO:0005524 GO:0005829 GO:0008652 GO:0009086 GO:0016301 GO:0016310 GO:0016740 GO:0019509 GO:0042802 GO:0046522 GO:0071281 GO:0071369 GO:0071732
5	0.06	0.399	6.42	0.07	0.66	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
6	0.06	0.374	6.56	0.06	0.65	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
7	0.06	0.380	6.42	0.07	0.62	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
8	0.06	0.348	5.83	0.04	0.55	1w07B	GO:0000062 GO:0001676 GO:0003995 GO:0003997 GO:0005777 GO:0005829 GO:0006629 GO:0006631 GO:0006635 GO:0008152 GO:0009055 GO:0009506 GO:0009611 GO:0009620 GO:0009695 GO:0016491 GO:0016627 GO:0033539 GO:0046686 GO:0050660 GO:0052890 GO:0055088 GO:0055114
9	0.06	0.341	5.83	0.06	0.54	2ckpB	GO:0000166 GO:0004103 GO:0004104 GO:0004305 GO:0004871 GO:0005524 GO:0005737 GO:0005829 GO:0006580 GO:0006629 GO:0006646 GO:0006656 GO:0006657 GO:0006869 GO:0007165 GO:0008144 GO:0008654 GO:0009636 GO:0016301 GO:0016310 GO:0016740 GO:0019695 GO:0033265 GO:0042803 GO:1904681
10	0.06	0.404	5.67	0.05	0.60	2pulA	GO:0000166 GO:0005524 GO:0008652 GO:0009086 GO:0016301 GO:0016310 GO:0016740 GO:0019284 GO:0019509 GO:0046522
11	0.06	0.314	6.35	0.05	0.50	3i0oA	GO:0000166 GO:0016740
12	0.06	0.306	6.11	0.04	0.49	4v7oA5	GO:0000502 GO:0005634 GO:0005737 GO:0005839 GO:0006281 GO:0006974 GO:0010499 GO:0010952 GO:0016504 GO:0034515 GO:0043248 GO:0043486 GO:0061136 GO:0070577 GO:0070628 GO:1990236 GO:1990237
13	0.06	0.282	6.29	0.07	0.46	1us2A	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0009279 GO:0016020 GO:0016787 GO:0016798 GO:0031176 GO:0045493
14	0.06	0.300	5.55	0.06	0.45	3eafA	GO:0016020 GO:0016021 GO:0046872
15	0.06	0.291	6.16	0.03	0.47	4gmvB	GO:0005737 GO:0005856 GO:0005886 GO:0007165 GO:0016020 GO:0030027 GO:0030175 GO:0031252 GO:0042995 GO:0048675
16	0.06	0.411	6.13	0.05	0.66	5j65A	GO:0030435
17	0.06	0.277	6.75	0.07	0.50	3ic1A	GO:0005829 GO:0006508 GO:0008152 GO:0008237 GO:0008270 GO:0008652 GO:0009014 GO:0009085 GO:0009089 GO:0016787 GO:0019877 GO:0043171 GO:0046872 GO:0050897 GO:0070573
18	0.06	0.248	6.31	0.03	0.42	3k5pA	GO:0004617 GO:0006564 GO:0008152 GO:0016491 GO:0016597 GO:0016616 GO:0051287 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0015369
GO-Score	0.50	0.33
Biological Processes	GO:0055074	GO:0072503	GO:0006875	GO:0070588
GO-Score	0.40	0.40	0.40	0.37
Cellular Component	GO:0031226	GO:0016021
GO-Score	0.54	0.45

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.