I-TASSER results

I-TASSER results for job id Rv1676

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (234 residues)
MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGVPTRLARGATVPTRRLQ
DINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQEVADSGITEVVFFHSAADA
LRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALWAAVRGSAAMLHRNDPERAGV
GFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSVDQLIDINRSLGGKGTQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGVPTRLARGATVPTRRLQDINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQEVADSGITEVVFFHSAADALRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALWAAVRGSAAMLHRNDPERAGVGFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSVDQLIDINRSLGGKGTQ
Prediction	CCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEHCCCCEEHCCCCCEEHCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHCCCCCEEHCCCCHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHCCCC
Conf.Score	998765455545444555566556678999999999987656666678998658885776899986864656998999985899996768999999999999999899899995899999999998899979977995999998995444554566544444445667777765666656678887766787699988997899999878888899999999999999865789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGVPTRLARGATVPTRRLQDINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQEVADSGITEVVFFHSAADALRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALWAAVRGSAAMLHRNDPERAGVGFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSVDQLIDINRSLGGKGTQ
Prediction	752442414444533532344453144224411451255353634440534450250405146455140533732000000223201202410440361155047350300000323463045237714010002353400431403432433343432332143333333444445344344554331110000000571302001224526421406301400450476678
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEHCCCCEEHCCCCCEEHCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHCCCCCEEHCCCCHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHCCCC
MACPEWEISRSKRTRKPVLRPRHSVSTLTNRFLAEFCHRYGIGVPTRLARGATVPTRRLQDINDQPVDVPAATGRTHLQFRRFAACPICHLHLRSFANRHQEVADSGITEVVFFHSAADALRGYQSLLPFAVIADPDRVQYREFGVEKSLGAITHPRALWAAVRGSAAMLHRNDPERAGVGFGDGTTHLGLPADFLLDADGTVAAVHYGRHADDQWSVDQLIDINRSLGGKGTQ

5epfA

0.20

0.13

0.64

1.93

MUSTER

----------------------------------------------HMKTGDTVADFELPDQTGTPRRLSVLDGPVVLFFYPAAMTPGCTKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVFDYPLLSDAQGTVAAQFGVK---------RGLLGKLMPVKR------------------------TTFVIDTDRKVLDVISSFSMDAH--ADKALATLRAIRS----

5epfA

0.19

0.12

0.64

1.97

dPPAS

----------------------------------------------HMKTGDTVADFELPDQTGTPRRLSVLDGPVVLFFYPAAMTPGCTKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVFDYPLLSDAQGTVAAQFGVKRGL---------------------------------LGKLMPVKRTTFVIDTDRKVLDVISS-EFSMDAHADKALATLRAIRS----

5epfA

0.19

0.12

0.64

2.83

wdPPAS

----------------------------------------------HMKTGDTVADFELPDQTGTPRRLSVLLSPVVLFFYPAAMTPGCTKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVFDYPLLSDAQGTVAAQFGVK---------RGLLGKLMPVKR------------------------TTFVIDTDRKVLDVISEFSMDAH--ADKALATLRAIRS----

5enuA

0.20

0.13

0.66

2.42

wMUSTER

---------------------------------------HHHHMS--VEVDRQVPDFTAPATGGD-ISLSDLKGKLVLYFYPKDNTPGCTTEGLQFRELYPKFKKAGAEIIGVSRDSLRSHDNFKAKLPFPLISDADEALCALFDV------IKMKKMYGKEVRGIER------------------------STFLIDADGVLRQAWRGIKVPGH--VDDVLSAVQAL------

5epfA

0.19

0.12

0.64

3.27

wPPAS

----------------------------------------------HMKTGDTVADFELPDQTGTPRRLSVLLSPVVLFFYPAAMTPGCTKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVFDYPLLSDAQGTVAAQFGVK---------RGLLGKLMPVKR------------------------TTFVIDTDRKVLDVISEFSMDAH--ADKALATLRAIRS----

5epfA

0.21

0.13

0.64

3.31

dPPAS2

----------------------------------------------HMKTGDTVADFELPDQTGTPRRLSVLDGPVVLFFYPAAMTPGCTKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVFDYPLLSDAQGTVAAQFGVKRGL-----LGKLMPVKR----------------------------TTFVIDTDRKVLDVISEFSMDAH--ADKALATLRAIRS----

5epfA

0.20

0.13

0.64

2.66

PPAS

----------------------------------------------HMKTGDTVADFELPDQTGTPRRLSVLLSPVVLFFYPAAMTPGCTKEACHFRDLAKEFAEVRASRVGISTDPVRKQAKFAEVFDYPLLSDAQGTVAAQFGVKRGL-----LGKLMPVKR----------------------------TTFVIDTDRKVLDVISEFSMDAH--ADKALATLRAIRS----

5enuA

0.18

0.12

0.66

3.64

Env-PPAS

-----------------------------------------HHHHMSVEVDRQVPDFTAPATGGD-ISLSDLKGKLVLYFYPKDNTPGCTTEGLQFRELYPKFKKAGAEIIGVSRDSLRSHDNFKAKLPFPLISDADEALCALFDVI--KMKKMYGKEVRGIER----------------------------STFLIDADGVLRQAWRGIKVPGH--VDDVLSAVQAL------

5enuA

0.20

0.13

0.66

1.90

MUSTER

-----------------------------------------HHHHMSVEVDRQVPDFTAPATGGD-ISLSDLKGKLVLYFYPKDNTPGCTTEGLQFRELYPKFKKAGAEIIGVSRDSLRSHDNFKAKLPFPLISDADEALCALFDV------IKMKKMYGKEVRGIER------------------------STFLIDADGVLRQAWRGIKVPGH--VDDVLSAVQAL------

5enuA

0.19

0.13

0.66

1.86

dPPAS

-----------------------------------------HHHHMSVEVDRQVPDFTAPATGGD-ISLSDLKGRLVLYFYPKDNTPGCTTEGLQFRELYPKFKKAGAEIIGVSRDSLRSHDNFKAKLPFPLISDADEALCALFDVIK--MKKMYGKEVRGIER----------------------------STFLIDADGVLRQAWRGIKVPGH--VDDVLSAVQAL------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.59

Estimated TM-score = 0.41±0.14

Estimated RMSD = 11.7±4.5Å

Download Model 2

C-score=-2.78

Download Model 3

C-score=-2.83

Download Model 4

C-score=-3.56

Download Model 5

C-score=-3.73

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5epfA	0.598	1.61	0.193	0.641
2	2a4vA	0.596	1.72	0.146	0.645
3	5enuA	0.592	1.97	0.163	0.645
4	3ixrA	0.591	1.98	0.112	0.650
5	3gknA	0.583	2.46	0.143	0.658
6	4k1fA	0.583	2.23	0.111	0.654
7	2v2gA	0.581	2.61	0.109	0.667
8	3a5wB	0.580	2.30	0.182	0.658
9	2yzhD	0.580	2.84	0.169	0.679
10	1uulA	0.580	2.09	0.132	0.645

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.32	13	3a2xG	ACT	Rep, Mult	82,86,87,88,89,192
2	0.05	2	3cejB	AVF	Rep, Mult	133,134,135,137
3	0.02	1	4grfA	GSH	Rep, Mult	48,49,145,206
4	0.02	1	3hdc0	III	Rep, Mult	44,88,115,140,147,191,196,205,208
5	0.02	1	2p5q0	III	Rep, Mult	95,206,208,209,210,218,220,223,224
6	0.02	1	1q980	III	Rep, Mult	64,83,85,115,116,117,119,120,123,136,163,164
7	0.02	1	3gknB	BIH	Rep, Mult	61,62,109,129,130,131

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.246	1n8jT	0.575	2.08	0.141	0.637	1.11.1.15	97,205,214,221
2	0.239	1zofH	0.572	2.06	0.141	0.637	1.11.1.15	191
3	0.183	1qmvA	0.574	2.21	0.139	0.645	1.11.1.15	217,219
4	0.173	2pn8A	0.570	2.24	0.114	0.637	1.11.1.15	198
5	0.151	1xvwB	0.563	2.55	0.172	0.637	1.11.1.15	NA
6	0.149	2bmxB	0.549	2.44	0.133	0.628	1.11.1.15	163
7	0.066	2p31A	0.479	2.74	0.098	0.568	1.11.1.9	65
8	0.066	2v1mA	0.488	2.99	0.125	0.586	1.11.1.9	NA
9	0.060	1zyeK	0.568	2.10	0.142	0.632	1.11.1.15	217
10	0.060	3i39X	0.435	5.47	0.067	0.679	1.2.99.2	NA
11	0.060	3e0uA	0.458	3.70	0.113	0.586	1.11.1.9	NA
12	0.060	2he3A	0.498	3.82	0.084	0.641	1.11.1.9	65
13	0.060	2dkiA	0.495	3.62	0.104	0.637	1.14.13.23	NA
14	0.060	2z9sJ	0.582	2.14	0.118	0.650	1.11.1.15	217,219,222
15	0.060	2gs3A	0.493	3.35	0.107	0.611	1.11.1.12	NA
16	0.060	2wgrA	0.487	2.88	0.118	0.581	1.11.1.9	NA
17	0.060	2r60A	0.434	4.77	0.040	0.624	2.4.1.14	NA
18	0.060	3cmiA	0.444	2.66	0.119	0.521	1.11.1.15	NA
19	0.060	2f8aA	0.508	3.49	0.084	0.632	1.11.1.9	65
20	0.060	1e1yA	0.423	5.02	0.057	0.632	2.4.1.1	82
21	0.060	2qllA	0.421	4.94	0.051	0.632	2.4.1.1	82
22	0.060	1prxA	0.575	2.27	0.131	0.654	1.11.1.7,1.11.1.15	NA
23	0.060	1kbiA	0.440	5.69	0.039	0.727	1.1.2.3	NA
24	0.060	2p5rA	0.460	3.24	0.145	0.568	1.11.1.-	216
25	0.060	2i3yA	0.500	3.42	0.076	0.620	1.11.1.9	NA
26	0.060	2vl3A	0.570	2.37	0.140	0.641	1.11.1.15	84,136
27	0.060	1ygpA	0.451	5.08	0.049	0.675	2.4.1.1	102

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.592	1.97	0.16	0.65	5enuA	GO:0016209 GO:0016491 GO:0055114 GO:0098869
1	0.30	0.561	2.50	0.16	0.64	4gqfA	GO:0004601 GO:0016209 GO:0016491 GO:0055114 GO:0098869
2	0.29	0.517	2.21	0.21	0.59	3gl3A	GO:0016491 GO:0055114
3	0.28	0.546	2.40	0.17	0.62	4g2eA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
4	0.26	0.561	2.25	0.14	0.63	4kb3B	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
5	0.26	0.574	2.21	0.14	0.65	1qmvA	GO:0000302 GO:0004601 GO:0005737 GO:0005829 GO:0006979 GO:0008379 GO:0016209 GO:0016491 GO:0019430 GO:0034599 GO:0042744 GO:0042981 GO:0043066 GO:0043524 GO:0051920 GO:0055114 GO:0070062
6	0.26	0.585	2.12	0.15	0.65	3hjpA	GO:0016209 GO:0016491 GO:0055114 GO:0098869
7	0.25	0.596	1.72	0.15	0.65	2a4vA	GO:0000781 GO:0004601 GO:0005634 GO:0005694 GO:0006351 GO:0006355 GO:0008379 GO:0016209 GO:0016491 GO:0034599 GO:0045454 GO:0051920 GO:0055114 GO:0098869
8	0.25	0.550	2.43	0.15	0.63	2bmxB	GO:0004601 GO:0005618 GO:0005829 GO:0005886 GO:0008785 GO:0016209 GO:0016491 GO:0032843 GO:0045454 GO:0051409 GO:0051920 GO:0052059 GO:0052060 GO:0055114 GO:0098869
9	0.24	0.567	2.13	0.16	0.63	1we0A	GO:0006979 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
10	0.23	0.574	2.35	0.14	0.65	4kw6A	GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
11	0.22	0.568	2.25	0.14	0.64	4k7iA	GO:0000302 GO:0001016 GO:0004601 GO:0005102 GO:0005615 GO:0005634 GO:0005737 GO:0005739 GO:0005759 GO:0005777 GO:0005782 GO:0005829 GO:0006915 GO:0006954 GO:0006979 GO:0008379 GO:0016209 GO:0016480 GO:0016491 GO:0031410 GO:0032967 GO:0034614 GO:0042744 GO:0043027 GO:0043066 GO:0043154 GO:0043231 GO:0046983 GO:0048471 GO:0051354 GO:0051920 GO:0055114 GO:0060785 GO:0070062 GO:0070995 GO:0072541 GO:0098869 GO:2001057
12	0.21	0.580	1.87	0.12	0.63	3drnA	GO:0016209 GO:0016491 GO:0055114 GO:0098869
13	0.21	0.564	2.11	0.12	0.63	2h01A	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
14	0.21	0.503	2.62	0.17	0.59	4nmuA	GO:0005886 GO:0015036 GO:0016020 GO:0016021 GO:0016209 GO:0016491 GO:0017004 GO:0045454 GO:0055114 GO:0098869
15	0.21	0.567	2.23	0.13	0.64	1e2yG	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
16	0.20	0.582	2.05	0.12	0.65	3ztlB	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
17	0.19	0.573	2.07	0.14	0.64	1zofB	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
18	0.19	0.560	2.37	0.13	0.63	2c0dB	GO:0004601 GO:0005739 GO:0006979 GO:0008379 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
19	0.19	0.563	2.55	0.17	0.64	1xvwB	GO:0004601 GO:0005829 GO:0016209 GO:0016491 GO:0051409 GO:0051920 GO:0052060 GO:0055114 GO:0098869
20	0.19	0.573	2.09	0.16	0.64	3w6gA	GO:0005737 GO:0016209 GO:0016491 GO:0045454 GO:0051920 GO:0055114 GO:0071453 GO:0098869
21	0.18	0.567	2.32	0.15	0.64	4ma9B	GO:0004601 GO:0006979 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
22	0.18	0.579	2.14	0.15	0.65	5jcgA	GO:0000302 GO:0001893 GO:0004601 GO:0005737 GO:0005739 GO:0005759 GO:0005769 GO:0005829 GO:0006915 GO:0006979 GO:0007005 GO:0008022 GO:0008284 GO:0008379 GO:0008385 GO:0008785 GO:0016209 GO:0016491 GO:0018171 GO:0019900 GO:0019901 GO:0030099 GO:0032496 GO:0033673 GO:0034599 GO:0034614 GO:0042542 GO:0042744 GO:0042802 GO:0043027 GO:0043066 GO:0043154 GO:0043209 GO:0051092 GO:0051881 GO:0051920 GO:0055114 GO:0070062 GO:0098869
23	0.18	0.532	3.00	0.11	0.64	2ls5A	GO:0016491 GO:0055114
24	0.16	0.472	2.65	0.20	0.56	1lu4A	GO:0003756 GO:0005576 GO:0005623 GO:0015035 GO:0016209 GO:0016491 GO:0045454 GO:0055114 GO:0098869
25	0.15	0.583	2.09	0.12	0.65	5dvbA	GO:0004601 GO:0005737 GO:0006457 GO:0008379 GO:0016209 GO:0016491 GO:0034599 GO:0045454 GO:0051920 GO:0055114 GO:0098869
26	0.15	0.584	2.06	0.13	0.65	3sbcB	GO:0000077 GO:0001302 GO:0004601 GO:0005737 GO:0005829 GO:0005844 GO:0006457 GO:0008379 GO:0016209 GO:0016491 GO:0033194 GO:0034599 GO:0042262 GO:0043022 GO:0045454 GO:0051082 GO:0051920 GO:0055114 GO:0061077 GO:0098869
27	0.14	0.581	2.61	0.11	0.67	2v2gA	GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
28	0.14	0.579	2.11	0.13	0.65	4llrA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
29	0.14	0.587	2.10	0.11	0.65	3tkpA	GO:0004601 GO:0005576 GO:0005615 GO:0005634 GO:0005737 GO:0005739 GO:0005783 GO:0005790 GO:0005829 GO:0007252 GO:0007283 GO:0008379 GO:0008584 GO:0016209 GO:0016491 GO:0019471 GO:0022417 GO:0030198 GO:0042803 GO:0045454 GO:0051920 GO:0055114 GO:0070062 GO:0072593 GO:0098869 GO:2000255
30	0.12	0.591	1.98	0.11	0.65	3ixrA	GO:0016209 GO:0016491 GO:0055114 GO:0098869
31	0.12	0.583	2.23	0.11	0.65	4k1fA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
32	0.08	0.594	1.61	0.20	0.64	5epfA	GO:0004601 GO:0016209 GO:0016491 GO:0051920 GO:0055114 GO:0098869
33	0.07	0.584	2.24	0.18	0.66	3a2vF	GO:0005737 GO:0016209 GO:0016491 GO:0045454 GO:0051920 GO:0055114 GO:0070301 GO:0098869
34	0.07	0.583	2.46	0.14	0.66	3gknA	GO:0016209 GO:0016491 GO:0055114 GO:0098869

Consensus prediction of GO terms

Molecular Function	GO:0004601	GO:0051920
GO-Score	0.63	0.46
Biological Processes	GO:0055114	GO:0098869
GO-Score	0.82	0.74
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.