I-TASSER results

I-TASSER results for job id Rv1646

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (310 residues)
MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAADRVSAVVAAMLGAYAR
DFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNAVNAPAQALLGHPLIGPET
VGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGPVTMTLNGSFDPLTQQVVFDS
GSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQSGNLLGAAGALLQAPGNAVTGF
LFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQPVTVTLTPTSGMPTAIQLSGTQFG
GLLPALLNGF

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAADRVSAVVAAMLGAYARDFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNAVNAPAQALLGHPLIGPETVGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGPVTMTLNGSFDPLTQQVVFDSGSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQSGNLLGAAGALLQAPGNAVTGFLFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQPVTVTLTPTSGMPTAIQLSGTQFGGLLPALLNGF
Prediction	CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCEEEHCHHHCCCHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEHCCCCCCCCCCCEHCCCCCCCCCCCCCEEHCCCCCCCCCEEEHCCCCCCCHHHHHHCCC
Conf.Score	9767645799999999999998899999887777765445666665678999999999999999999999999999999999999999888888999999876667888877788888888888777777877567657888888877666666777776656677766777766666655555677644555555775778776466654543333346667888888766754544556788876555545788888876555567885568886556657899987557766776654566766589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAADRVSAVVAAMLGAYARDFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNAVNAPAQALLGHPLIGPETVGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGPVTMTLNGSFDPLTQQVVFDSGSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQSGNLLGAAGALLQAPGNAVTGFLFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQPVTVTLTPTSGMPTAIQLSGTQFGGLLPALLNGF
Prediction	4210403022021003203403200320221001101211212332011000110230142021003201300320041022013102212133134301410101011001110234444343334343433111112233244332433342443323233323332334434334333323343332311321333231131223333112211332333211101143423101011336332424130345242330202221210202333120223333623231304213000001032647
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCEEEHCHHHCCCHHHHHHHHHHCCCHHHCCCCCCCCCCCCCEHCCCCCCCCCCCEHCCCCCCCCCCCCCEEHCCCCCCCCCEEEHCCCCCCCHHHHHHCCC
MSFLTVAPDMVTAAAGNLESVGSALNEAAAAAAPATVGLAAPAADRVSAVVAAMLGAYARDFQGISAQIAGFHNQFVGALRGGAAAYASAEAANVQQTVVNAVNAPAQALLGHPLIGPETVGSSAAAVSFGFGPLLLAGSDPLLAVPFSYPASLPTPFGPVTMTLNGSFDPLTQQVVFDSGSLTAPAPFVYGLGAVGPALTTMTALQNSGTAFSGAVQSGNLLGAAGALLQAPGNAVTGFLFGQTAISQSIPGPSNLGYESVGISVPVGGLLAPLQPVTVTLTPTSGMPTAIQLSGTQFGGLLPALLNGF

5gaoE

0.19

0.98

1.01

dPPAS

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKF

5gaoE

0.19

0.98

1.72

dPPAS2

-----AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKF

5gaoE

0.19

0.98

1.70

PPAS

------AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKF

4ut1A3

0.09

0.99

0.88

MUSTER

LNAAQTQGSSLSTYYTLVAQLNNYVAGIATAITNYFTGLQTVANNAADPSARQTAMSNAQTLASQLVAAGQQYSQLRGGALGGLLAFRSQTLDPAQAQLGALAVSFASQVNAQNALGVDMSGNPGGSLFAVGAPAVYANQNNTGSATLSVSFVDGTQPTTSDYALSYDGAKYTLTDRATGSVVGTATPSSTPPTMTIGGLKLSLSSTPNAGDSFTVLPTRGALDGFSLATANGSAIAAASPVANKGTNDGRNALALSQLVNSKTMN--NGTTTLTGAYAGYVNAIGNAASQLKASSAAQTALVGQITQAQ

2g38C

0.33

0.08

0.25

1.30

wdPPAS

-------PEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4ut1A

0.17

0.99

0.75

wMUSTER

GSSLSTYYTLVAQLNNYVGSPTAGIATAITNYFTGLQTVANNAADSNAQTLASQLVAAGQQYSQLRQSVNSQLTDTVTQINSYTSQIAQLNEQIASASSPNQLLDQRDLAVSK-LAGVQVVQSNGNYS-SGGQPLVVGNASYQLATVASPSDPSELTIVSKGVAGSAQPGPTQYLPDVSLTGGALGGLLAFRSQTLDPAQAQLGALAVSASQVNAQNALGDMSGNPGSLFAVGAPAVYANQNNTGSATLSVSFVDGTQPTTSDYALSYDGLTDRATGSVVGTATPSSTPPKLSLSSTPNAGVLPT-LDGF

2g38C

0.33

0.08

0.25

1.49

wPPAS

-------PEALTVAATEVRRIRDRAIQSDAQVAPMTTAVRPPAADLVSEKAATFLVEYARKYRQTIAAAAVVLEEFAHALTTG-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5b04A

0.12

0.11

0.91

Env-PPAS

KKFLQDDPE-ITMPVAAIEALVQLLSRSQAKTISEFMDILQNGSNTLKEGNISLSAGCDIFQRFVTRSLHDVFEQCKRHLVENGKLFIQRARACRQRIAHLGYPLI----------RDGSVILTHGFSRGVAAVLLAAAKRHVRFKVFVTESRPSGSGCLMTRTLKNACIPT---------CMVLDSAVSFTMNRVDLVLVGAEGVVENGGLINQIGTF--QLAVFAKHAHKPFYAVAESHKFVRMFPLS-QYDIPFSRPILEFDDPSPETPTPSDAI----HNELIMNEEQIRNNPTLDVTPPEFVSGL

2vsgA

0.12

0.99

0.79

MUSTER

CELTAELRKTAGVAKMKVNSDLNSFKTLELTKMKLLTFAAKFPESKEALTLRALEAALNTDLRALRDNIANGIDRAVRATAYASEAAGALFSGIQTLHDASNGNAAMASQGCKPLALPELLTEDSYNTDTNAQGQGKSGEQAASGAQATNTGVQFSGGSRINLGLGAIVASAAQQPTRPDLSDFSGTARNQLYGKAHASITELLQLAQGPKPGQTEVETMKLLAQKTAALDSIKFQLAASTGKKTDYKEDENLKTEYFGKTESNIEA---LWNKVKEEKVKGADPEDPSKESKISDLNTEEQLQRVLDYY

4ke2A

0.20

0.13

0.63

0.76

dPPAS

---------------MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALE----------------------------TINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-----------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.69

Estimated TM-score = 0.31±0.10

Estimated RMSD = 15.4±3.4Å

Download Model 2

C-score=-4.22

Download Model 3

C-score=-4.81

Download Model 4

C-score=-4.97

Download Model 5

C-score=-3.03

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ut1A	0.682	4.52	0.088	0.926
2	2d4yA	0.679	4.51	0.086	0.916
3	4a01A	0.473	5.31	0.031	0.684
4	4av3A	0.466	5.96	0.041	0.726
5	2p7nA	0.466	6.00	0.084	0.745
6	4akkA	0.448	5.01	0.073	0.635
7	4d8mA	0.444	5.41	0.022	0.639
8	1w99A	0.443	5.59	0.061	0.658
9	1ciyA	0.431	5.55	0.068	0.642
10	4w8jA	0.426	5.08	0.050	0.594

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1mz9E	VDY	Rep, Mult	14,18,21
2	0.06	3	2j9tA	BO3	Rep, Mult	41,42,45,50,51,54
3	0.06	3	1mz9B	VDY	Rep, Mult	18,21,25
4	0.06	3	3lw5K	CLA	Rep, Mult	28,32
5	0.04	2	3e1aC	NUC	Rep, Mult	46,47
6	0.02	1	3rkoL	LFA	Rep, Mult	34,37,38,55
7	0.02	1	3s6lA	ZN	Rep, Mult	45,73
8	0.02	1	2xquB	CVM	Rep, Mult	105,109
9	0.02	1	2dyrK	PGV	Rep, Mult	72,73
10	0.02	1	3hykA	MG	Rep, Mult	45,91
11	0.02	1	3f1eT	MG	Rep, Mult	2,15
12	0.02	1	1vd5A	GLY	Rep, Mult	39,55
13	0.02	1	2wsf3	CLA	Rep, Mult	91,94
14	0.02	1	3bvvA	MPD	Rep, Mult	28,96,99
15	0.02	1	3ri5A	RI5	Rep, Mult	8,12

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2occN	0.385	6.31	0.049	0.629	1.9.3.1	NA
2	0.060	2z5xA	0.386	6.58	0.053	0.655	1.4.3.4	NA
3	0.060	1o5wC	0.391	6.15	0.039	0.648	1.4.3.4	NA
4	0.060	2q8gA	0.377	5.94	0.058	0.594	2.7.11.2	NA
5	0.060	1m56A	0.387	6.31	0.051	0.626	1.9.3.1	19
6	0.060	3g61A	0.395	5.87	0.041	0.587	3.6.3.44	NA
7	0.060	2frvD	0.377	6.19	0.065	0.613	1.12.2.1	NA
8	0.060	1frvB	0.380	6.17	0.062	0.616	1.12.2.1	NA
9	0.060	1itwB	0.314	6.43	0.034	0.529	1.1.1.42	56,57,234
10	0.060	1fftA	0.388	6.21	0.055	0.626	1.10.3.-	NA
11	0.060	2ow6A	0.398	6.22	0.056	0.652	3.2.1.114	NA
12	0.060	1y8pA	0.388	6.11	0.050	0.623	2.7.11.2	NA
13	0.060	1i1iP	0.374	4.91	0.041	0.526	3.4.24.16	NA
14	0.060	1occA	0.385	6.23	0.049	0.623	1.9.3.1	19
15	0.060	1cc1L	0.373	5.98	0.061	0.581	1.12.99.6	223
16	0.060	1yqwR	0.381	6.36	0.067	0.629	1.12.2.1	NA
17	0.060	1qleA	0.357	6.92	0.064	0.629	1.9.3.1	NA
18	0.060	3crlB	0.386	5.63	0.045	0.594	2.7.11.2	81,140
19	0.060	3cxhN	0.377	5.18	0.043	0.532	1.10.2.2	39,111

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.11	0.679	4.51	0.09	0.92	2d4yA	GO:0005198 GO:0005576 GO:0009288 GO:0009424 GO:0044780 GO:0071973
1	0.11	0.682	4.52	0.09	0.93	4ut1A	GO:0005198 GO:0009424 GO:0044780
2	0.07	0.473	5.31	0.03	0.68	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
3	0.07	0.466	5.90	0.05	0.72	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
4	0.06	0.430	5.24	0.06	0.63	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
5	0.06	0.287	6.59	0.04	0.49	3peiA	GO:0004177 GO:0005622 GO:0005737 GO:0006508 GO:0008233 GO:0008235 GO:0016787 GO:0019538 GO:0030145 GO:0046872
6	0.06	0.247	6.66	0.05	0.43	2wssA	GO:0000166 GO:0005524 GO:0005739 GO:0005743 GO:0005753 GO:0005886 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016820 GO:0033178 GO:0045261 GO:0046034 GO:0046933 GO:0046961
7	0.06	0.305	5.96	0.05	0.50	1n8pA	GO:0003824 GO:0003962 GO:0004123 GO:0005737 GO:0008652 GO:0016829 GO:0019343 GO:0019344 GO:0019346 GO:0030170 GO:0042802 GO:0044540 GO:0071266 GO:0080146
8	0.06	0.308	6.30	0.04	0.52	5bv7A	GO:0004607 GO:0004623 GO:0005576 GO:0005615 GO:0006629 GO:0006644 GO:0006656 GO:0008202 GO:0008203 GO:0008374 GO:0016740 GO:0016746 GO:0030301 GO:0034186 GO:0034364 GO:0034372 GO:0034375 GO:0034435 GO:0042157 GO:0042158 GO:0042632 GO:0043691 GO:0046470 GO:0046688 GO:0051384 GO:0070062 GO:0090107
9	0.06	0.282	6.94	0.04	0.50	3k5pA	GO:0004617 GO:0006564 GO:0008152 GO:0016491 GO:0016597 GO:0016616 GO:0051287 GO:0055114
10	0.06	0.296	4.73	0.03	0.41	2aekA	GO:0016106 GO:0016829 GO:0045482
11	0.06	0.288	6.73	0.04	0.50	4n0rA	GO:0005975
12	0.06	0.270	5.41	0.07	0.40	3l0mA	GO:0000166 GO:0003824 GO:0005085 GO:0005524 GO:0005576 GO:0005622 GO:0006612 GO:0008152 GO:0008289 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0017137 GO:0018117 GO:0018260 GO:0033644 GO:0043087 GO:0043547 GO:0044161 GO:0044162 GO:0044600 GO:0070273 GO:0070733
13	0.06	0.269	6.74	0.04	0.48	3v7dB	GO:0000082 GO:0000086 GO:0004842 GO:0005634 GO:0007049 GO:0007067 GO:0007126 GO:0016363 GO:0016567 GO:0019005 GO:0030435 GO:0031146 GO:0042787 GO:0043130 GO:0043224 GO:0050815 GO:0051301 GO:0061630
14	0.06	0.238	6.85	0.06	0.42	4gmvB	GO:0005737 GO:0005856 GO:0005886 GO:0007165 GO:0016020 GO:0030027 GO:0030175 GO:0031252 GO:0042995 GO:0048675
15	0.06	0.198	6.59	0.06	0.33	2wlkA	GO:0005242 GO:0005244 GO:0006810 GO:0006811 GO:0006813 GO:0016020 GO:0016021 GO:0034765 GO:0071805
16	0.06	0.166	5.73	0.03	0.26	2q1zB	GO:0003677 GO:0006351 GO:0006355 GO:0046872
17	0.06	0.147	4.49	0.04	0.20	2ipaB	GO:0004725 GO:0016491 GO:0016787 GO:0030612 GO:0035335 GO:0046685 GO:0055114
18	0.06	0.196	5.54	0.04	0.30	2v9qA	GO:0002042 GO:0005737 GO:0005886 GO:0005887 GO:0006919 GO:0006935 GO:0007155 GO:0007156 GO:0007275 GO:0007399 GO:0007411 GO:0007507 GO:0008046 GO:0009986 GO:0016020 GO:0016021 GO:0016199 GO:0021836 GO:0030154 GO:0030275 GO:0030336 GO:0030424 GO:0033600 GO:0035025 GO:0035385 GO:0042802 GO:0042995 GO:0050772 GO:0050925 GO:0070100

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0016462	GO:0015405
GO-Score	0.36	0.36	0.36
Biological Processes	GO:0070925	GO:0030031	GO:0044781	GO:0015672	GO:0006818
GO-Score	0.42	0.42	0.42	0.36	0.36
Cellular Component	GO:0044461
GO-Score	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.