I-TASSER results

I-TASSER results for job id Rv1639c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (489 residues)
MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLVLAAGWRSRHWQRRWLP
TAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAATVLILGWRSARWWRRGAS
LLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQADQAAVAALAHSGVRPSHGT
LLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPPPQLPTVMMIGGQFNTPADWARA
GNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTECVNGRRGNAADHLTKDVVPYMVSKF
GVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSAFVDIAGDFYPNAGNKTQTIVRLFGGN
EDAWSAFDPTTVITRHGSYTGLSGWFAISSPGPPSPDNAVADTTTMRLAGRDAAANPGNQ
AAAANALCALGRANGIYCAVVPQPGKHDWPFADRVFAAALPWLAGQLATPGVPKIPLPGT
TQQIAGTGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLVLAAGWRSRHWQRRWLPTAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAATVLILGWRSARWWRRGASLLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQADQAAVAALAHSGVRPSHGTLLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPPPQLPTVMMIGGQFNTPADWARAGNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTECVNGRRGNAADHLTKDVVPYMVSKFGVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSAFVDIAGDFYPNAGNKTQTIVRLFGGNEDAWSAFDPTTVITRHGSYTGLSGWFAISSPGPPSPDNAVADTTTMRLAGRDAAANPGNQAAAANALCALGRANGIYCAVVPQPGKHDWPFADRVFAAALPWLAGQLATPGVPKIPLPGTTQQIAGTGR
Prediction	CCCCCCCCCCCCCCCCCCEEHCCCEHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	988777778888877664444465545776899999999999999998656654678999999999999999999875445677877589999999999999999998755655789999999999999999987666545689888765677888877777777776667788888877999999856779974689998897556777666678888985999969999996888877678999999999879998599996999999999887889998678899999999999987999887775899977756899999998988555466537877899987678899985999999998599999998777788679999678988765455666456676555665555569999999999999989988999869988868999999999999999989999888888888888888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLVLAAGWRSRHWQRRWLPTAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAATVLILGWRSARWWRRGASLLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQADQAAVAALAHSGVRPSHGTLLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPPPQLPTVMMIGGQFNTPADWARAGNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTECVNGRRGNAADHLTKDVVPYMVSKFGVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSAFVDIAGDFYPNAGNKTQTIVRLFGGNEDAWSAFDPTTVITRHGSYTGLSGWFAISSPGPPSPDNAVADTTTMRLAGRDAAANPGNQAAAANALCALGRANGIYCAVVPQPGKHDWPFADRVFAAALPWLAGQLATPGVPKIPLPGTTQQIAGTGR
Prediction	725443134231311221120040001011001000010101011000223332100000000000000010000001222002211010000010101200000000012222000000000000000000000112111112022013324343224435424345144454424413124030304325144130000000002444343455652200000000000020100023130230022004446031000000001111221010111641300100052014103730414543410000000000100000001002100000000000002333334102301232351033110230044246143020000012323433433243131011003102122211220042015105736040201124221315103510440151007312235224323245445546668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCEEHCCCEHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCCHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
MAQNELVTASTPPAATQPLAVGHTSLMHGWVPLAVQVVTAVVLVLAAGWRSRHWQRRWLPTAAAIGATLAWGTRWYVTGNGLANERPPSTLWIWVALTGAAATVLILGWRSARWWRRGASLLAVPLCLLSATLTLNLWVGYFPTVQTAWNQLTSGPLPDQADQAAVAALAHSGVRPSHGTLLPVVIPSDASHFKHRGELVYLPPAWFDREHRSENPPPPQLPTVMMIGGQFNTPADWARAGNAVKTLDDFAAAHSGNAPVVVFVDSGGAFNNDTECVNGRRGNAADHLTKDVVPYMVSKFGVSPEQTSWGIVGWSMGGTCAVDLTVMHPTLFSAFVDIAGDFYPNAGNKTQTIVRLFGGNEDAWSAFDPTTVITRHGSYTGLSGWFAISSPGPPSPDNAVADTTTMRLAGRDAAANPGNQAAAANALCALGRANGIYCAVVPQPGKHDWPFADRVFAAALPWLAGQLATPGVPKIPLPGTTQQIAGTGR

4h18A

0.13

0.08

0.59

1.33

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------------AEVTPADVAGDTALSTISDSAPADEASAPRWRAHNAADERVKEMWAYSPSMD-RNVPLVVITAD-----------ESAGPRPVIYLLNGGDGGEANWVMQTDVLDFYLEKN-------VNVVIPMEGFSYYTDWVEENGGKQMWETFLVKELPGPLEEKLNTDG---QRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRGGEYNIYNDALINSDKL---RGTELYVSNASGLAGEWE---------------GGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSWGWWQDDLRGSWTTFARAFELE-------------------

1jjfA

0.18

0.09

0.52

1.56

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------SLPTMPPSGYDQVRNGVPRGQVVNISYFSTATN-STRPARVYLPPGY---------SKDKKYSVLYLLHGIGGSENDWFEGGRANVIADNLIAEGKIKPLIIVTPNTNAAGPG----IADGYENFTKDLLNSLIPYIESNYSVYTDREHRAIAGLSMGGGQSFNIGLTNLDKFAYIGPISAAPNTYP------NERLFPDGGKAAREKL-------------KLLFIACGTNDSL--------------------------IGFGQRVHEYCVANNINHVYWLIQGGHDFNVWKPGLWNFLQMADEAGLTRD------------------

4rgyA

0.20

0.10

0.48

2.60

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMALFQCDFFSDVLG-LSTSMTVILPQ--------------EEHPTLFLLHGLSDDHTIWLRRTSIERYVAE-------MGLAVVMPAVHRSFYTDM----AHGLQYWTFISEELPALARSFFPLATAREDTFVAGLSMGGYGALKLGMRHPERFAAAASLSGALDITV--WVAEQRNIFGDAALPGSDHDLFALAERMAQSDG-------------------PVPKLYQCCGTEDF-----LYEDNVRFRDHVRGLGLDFMYEESPGEHEWGYWDAQIQRVLAWL----PL--------------------

4rgyA

0.20

0.10

0.48

1.75

wMUSTER

----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MALFQCDFFSDVLG-LSTSMTVILPQ--------------EEHPTLFLLHGLSDDHTIWLRRTSIERYVAE-------MGLAVVMPAVHRSFYTDM----AHGLQYWTFISEELPALARSFFPLATAREDTFVAGLSMGGYGALKLGMRHPERFAAAASLSGALDIT--VWVAEQRNIFGDLAALGSDHDLFALAERMAQSDG-------------------PVPKLYQCCGTEDF-----LYEDNVRFRDHVRGLGLDFMYEESPGEHEWGYWDAQIQRVLAWL------------PL------------

4rgyA

0.20

0.10

0.48

3.01

wPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMALFQCDFFSDVLG-LSTSMTVILPQ--------------EEHPTLFLLHGLSDDHTIWLRRTSIERYVAE-------MGLAVVMPAVHRSFYTDM----AHGLQYWTFISEELPALARSFFPLATAREDTFVAGLSMGGYGALKLGMRHPERFAAAASLSGALDIT--VWVAEQRNIFGDAALPGSDHDLFALAERMAQSDG-------------------PVPKLYQCCGTEDF-----LYEDNVRFRDHVRGLGLDFMYEESPGEHEWGYWDAQIQRVLAWL---L----------------------

4rgyA

0.19

0.09

0.47

2.93

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMALFQCDFFSDVLG-LSTSMTVILPQ--------------EEHPTLFLLHGLSDDHTIWLRRTSIERYVAE-------MGLAVVMPAVHRSFYTDM----AHGLQYWTFISEELPALARSFFPLATAREDTFVAGLSMGGYGALKLGMRHPERFAAAASLSGALDIT--VWVAEQRNIFGDAALPGSDHDLFALAERMAQSDGPKLYQCCGTEDF--------------------------LYEDNVRFRDHVRGLGLDFMYEESPGEHEWGYWDAQIQRVLAW---------------------------

1jjfA

0.18

0.09

0.52

2.53

PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------SLPTMPPSGYDQVRNGVPRGQVVNISYFSTATN-STRPARVYLPPGY---------SKDKKYSVLYLLHGIGGSENDWFEGGGANVIADNLIAEGKIKPLIIVTPNTNAAGPGIA----DGYENFTKDLLNSLIPYIESNYSVYTDREHRAIAGLSMGGGQSFNIGLTNLDKFAYIGPISAAPNTYP------NERLFPDGGKAAREKLK-------------LLFIACGTNDSL--------------------------IGFGQRVHEYCVANNINHVYWLIQGGHDFNVWKPGLWNFLQMADEAGLTRD------------------

4rgyA

0.20

0.09

0.48

3.90

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMALFQCDFFSDVLG-LSTSMTVILPQ--------------EEHPTLFLLHGLSDDHTIWLRRTSIERYVAEM-------GLAVVMPAVHRSFYTDM----AHGLQYWTFISEELPALARSFFPLATAREDTFVAGLSMGGYGALKLGMRHPERFAAAASLSGALDIT--VWVAEQRNIFGDLAALGSDHDLFALAERMAQSDGPKLYQCCGTEDF--------------------------LYEDNVRFRDHVRGLGLDFMYEESPGEHEWGYWDAQIQRVLAWL----PL--------------------

4rgyA

0.21

0.10

0.48

1.33

MUSTER

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HMALFQCDFFSDVLG-LSTSMTVILPQ--------------EEHPTLFLLHGLSDDHTIWLRRTSIERYVAE-------MGLAVVMPAVHRSFYTDM----AHGLQYWTFISEELPALARSFFPLATAREDTFVAGLSMGGYGALKLGMRHPERFAAAASLSGALDIT--VWVAEQRNIFGDLAALGSDHDLFALAERMAQSDG-------------------PVPKLYQCCGTEDF-----LYEDNVRFRDHVRGLGLDFMYEESPGEHEWGYWDAQIQRVLAWL------------PL------------

5cxuA

0.13

0.07

0.53

1.55

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------KLQISNTCPDKYRTKQEGVEYPTAKKITYYSKVTE-TERKMNVILPVGY---------DENKKYPVVYYLHGLMSYEDSMLEDDSTLAIPTNLLKEGRAKEMIIVLPDVYAPKPGTAVTPDFNPDNFINELIEVIMPYMEEHYSILTGRENTALCGFSMGARTSLYIGYMRSDLIGYVGAFAPAPGITPGEGK------------------------------------HEGLISEDEFRAEIQPIVSLIDCGTNDSVVG----QFPKSYHEILTRNNQEHIWFEVPGDHDWNAISAGFYNFIQTTFGALN---------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.43

Estimated TM-score = 0.33±0.11

Estimated RMSD = 15.9±3.2Å

Download Model 2

C-score=-3.65

Download Model 3

C-score=-3.60

Download Model 4

C-score=-4.02

Download Model 5

C-score=-4.26

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1h2xA	0.545	5.08	0.074	0.699
2	3azoA	0.544	5.28	0.102	0.712
3	5l8sA	0.539	4.88	0.083	0.673
4	2bklB	0.537	4.99	0.100	0.677
5	4hvtA	0.536	5.23	0.097	0.689
6	1ve6A	0.536	4.71	0.125	0.665
7	2xe4A	0.535	5.37	0.088	0.695
8	4hxeB	0.533	4.86	0.085	0.665
9	3g0bB	0.529	4.87	0.079	0.663
10	1z68A	0.527	4.81	0.089	0.656

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.14	5	2hu5A	UUU	Rep, Mult	229,230,315,316,344,447
2	0.11	4	1wb4A	SXX	Rep, Mult	315,316,319,340,341,343,394,395,398
3	0.06	2	3hrhA	GOL	Rep, Mult	229,230,231,315,449
4	0.06	2	2bgrA	UUU	Rep, Mult	180,200,259,261,262,263
5	0.06	2	2bgrB	UUU	Rep, Mult	184,195,197,198,199
6	0.03	1	1f0nA	MPD	Rep, Mult	315,316,352,353,420
7	0.03	1	1f0pA	TRE	Rep, Mult	229,230,231,315,413,416,447,449,452
8	0.03	1	1gklA	FER	Rep, Mult	315,319,340,341,343,410

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.171	1wb4B	0.469	2.92	0.146	0.517	3.2.1.8	179,202,217,299
2	0.074	3fcxB	0.477	2.63	0.169	0.519	3.1.2.12	291
3	0.067	1qz3A	0.470	3.77	0.106	0.556	3.1.1.1	315,447
4	0.060	3c6bA	0.483	2.93	0.161	0.534	3.1.2.12	233,316,447
5	0.060	1hlgB	0.423	3.86	0.099	0.499	3.1.1.3	290,331
6	0.060	2d5lA	0.498	4.73	0.090	0.609	3.4.14.-	315,447
7	0.060	1k8qA	0.433	4.08	0.107	0.519	3.1.1.3	315
8	0.060	2bklB	0.537	4.99	0.100	0.677	3.4.21.26	447
9	0.060	2c7bA	0.454	3.43	0.161	0.521	3.1.1.1	NA
10	0.060	3g0bB	0.529	4.87	0.079	0.663	3.4.14.5	455
11	0.060	3fakA	0.464	3.61	0.098	0.540	3.1.1.-	NA
12	0.060	1orvA	0.527	4.77	0.081	0.652	3.4.14.5	315,447
13	0.060	1yr2A	0.470	4.90	0.088	0.589	3.4.21.26	315
14	0.060	2gbcA	0.531	4.96	0.089	0.667	3.4.14.5,3.4.15.5	315,447
15	0.060	1b41A	0.431	5.04	0.095	0.558	3.1.1.7	NA
16	0.060	1thgA	0.444	4.97	0.079	0.560	3.1.1.3	317
17	0.060	3k2iA	0.431	4.56	0.107	0.526	3.1.2.2	NA
18	0.060	1ac5A	0.440	4.54	0.087	0.540	3.4.16.6	201
19	0.060	2o7rA	0.447	4.15	0.147	0.538	3.1.1.1	315,447
20	0.060	1jjfA	0.483	2.18	0.171	0.513	3.2.1.8	236,316,448
21	0.060	1hlgA	0.423	3.50	0.097	0.489	3.1.1.3	NA
22	0.060	1r9mB	0.530	4.94	0.080	0.665	3.4.14.5	315,447

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.469	2.39	0.17	0.51	1dqyA	GO:0004144 GO:0005576 GO:0005618 GO:0006869 GO:0009247 GO:0016740 GO:0016746 GO:0016747 GO:0046677 GO:0050348 GO:0071769
1	0.24	0.469	2.47	0.16	0.51	1f0nA	GO:0004144 GO:0005576 GO:0005618 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0040007 GO:0044119 GO:0046677 GO:0050348 GO:0052572
2	0.23	0.483	2.18	0.17	0.51	1jjfA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0031176 GO:0033905 GO:0045493
3	0.21	0.485	2.65	0.13	0.53	5cxxB	GO:0016787 GO:0030600
4	0.21	0.525	4.99	0.07	0.67	1xfdA	GO:0005886 GO:0006508 GO:0008076 GO:0008236 GO:0008239 GO:0009986 GO:0015459 GO:0016020 GO:0016021 GO:0043025 GO:0043268 GO:0070062 GO:0072659 GO:1901379
5	0.21	0.486	2.62	0.15	0.53	3i6yA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
6	0.15	0.477	2.63	0.17	0.52	3fcxB	GO:0005737 GO:0005788 GO:0016023 GO:0016787 GO:0016788 GO:0018738 GO:0031410 GO:0046294 GO:0047374 GO:0052689 GO:0070062 GO:1901687
7	0.14	0.487	3.01	0.17	0.54	1pv1A	GO:0005737 GO:0005829 GO:0016787 GO:0018738 GO:0046294 GO:0052689
8	0.11	0.548	4.78	0.10	0.69	3munA	GO:0004252 GO:0006508 GO:0008236 GO:0070008
9	0.09	0.487	2.54	0.14	0.53	3ls2A	GO:0016787 GO:0018738 GO:0046294 GO:0052689
10	0.07	0.483	2.85	0.14	0.53	4b6gA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
11	0.07	0.478	2.73	0.16	0.52	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
12	0.07	0.494	4.53	0.13	0.60	3mgaA	GO:0005506 GO:0005737 GO:0006826 GO:0008849
13	0.07	0.475	2.55	0.16	0.52	1sfrA	GO:0004144 GO:0005576 GO:0005618 GO:0005737 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0044119 GO:0044121 GO:0050348
14	0.07	0.548	5.15	0.11	0.71	3azoA	GO:0004177 GO:0006508 GO:0008236
15	0.07	0.494	4.65	0.10	0.60	2b20A	GO:0005506 GO:0005737 GO:0006826 GO:0008849 GO:0016787
16	0.07	0.545	5.05	0.08	0.70	4amyA	GO:0004252 GO:0005737 GO:0006508 GO:0008233 GO:0008236 GO:0016787 GO:0070008
17	0.07	0.536	4.69	0.13	0.66	3o4jC	GO:0005737 GO:0006508 GO:0008236 GO:0016787
18	0.07	0.537	4.99	0.10	0.68	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
19	0.07	0.536	5.23	0.10	0.69	4hvtA	GO:0004252 GO:0006508 GO:0008236 GO:0016787 GO:0070008
20	0.07	0.536	4.90	0.08	0.67	4hxgF	GO:0006508 GO:0008236 GO:0046872
21	0.07	0.535	5.37	0.09	0.70	2xe4A	GO:0004252 GO:0005737 GO:0005829 GO:0006508 GO:0008236 GO:0016787 GO:0070008 GO:0070012
22	0.07	0.521	4.93	0.11	0.66	2ecfA	GO:0006508 GO:0008236
23	0.07	0.528	5.03	0.07	0.67	4n8eB	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
24	0.07	0.527	4.81	0.09	0.66	1z68A	GO:0001525 GO:0002020 GO:0004175 GO:0004222 GO:0004252 GO:0005178 GO:0005576 GO:0005615 GO:0005737 GO:0005886 GO:0005925 GO:0006508 GO:0006915 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0009986 GO:0010710 GO:0010716 GO:0016020 GO:0016021 GO:0016787 GO:0030027 GO:0030054 GO:0031258 GO:0032587 GO:0042803 GO:0042995 GO:0043542 GO:0045177 GO:0045178 GO:0046983 GO:0051603 GO:0051917 GO:0060244 GO:0071158 GO:0071438 GO:0071850 GO:0097325 GO:1900119 GO:1902362 GO:1903054
25	0.07	0.526	4.94	0.08	0.66	4wjlB	GO:0005886 GO:0006508 GO:0008236 GO:0008239 GO:0015459 GO:0016020 GO:0016021 GO:0072659 GO:0090004 GO:1901379
26	0.07	0.531	4.96	0.09	0.67	2gbcA	GO:0002020 GO:0002709 GO:0004177 GO:0004252 GO:0005102 GO:0005518 GO:0005576 GO:0005783 GO:0005794 GO:0005886 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0042277 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0051234 GO:0071438
27	0.07	0.528	4.85	0.08	0.66	2aj8A	GO:0001618 GO:0001662 GO:0001666 GO:0002020 GO:0004177 GO:0004252 GO:0005102 GO:0005576 GO:0005765 GO:0005886 GO:0005925 GO:0006508 GO:0007155 GO:0008233 GO:0008236 GO:0008239 GO:0008284 GO:0009986 GO:0010716 GO:0016020 GO:0016021 GO:0016324 GO:0016787 GO:0030027 GO:0030054 GO:0030139 GO:0031258 GO:0031295 GO:0033632 GO:0035641 GO:0036343 GO:0042110 GO:0042802 GO:0042803 GO:0042995 GO:0043542 GO:0045121 GO:0046581 GO:0046718 GO:0070062 GO:0071438
28	0.07	0.510	5.15	0.09	0.64	4q1vA	GO:0006508 GO:0008236 GO:0016787 GO:0046872
29	0.07	0.498	4.73	0.09	0.61	2d5lA	GO:0004177 GO:0006508 GO:0008233 GO:0008236 GO:0016787
30	0.07	0.491	5.55	0.09	0.64	4bp8A	GO:0004252 GO:0006508 GO:0008236 GO:0070008
31	0.07	0.470	4.90	0.09	0.59	1yr2A	GO:0004252 GO:0006508 GO:0008236 GO:0016787 GO:0070008

Consensus prediction of GO terms

Molecular Function	GO:0004144	GO:0050348	GO:0097599	GO:0052689	GO:0016247	GO:0004177	GO:0017171	GO:0005488
GO-Score	0.48	0.48	0.46	0.42	0.42	0.42	0.42	0.37
Biological Processes	GO:0052200	GO:0052564	GO:0044117	GO:0046677	GO:0045491	GO:0016052	GO:0009057	GO:0043270	GO:0019538	GO:0043266	GO:1904062	GO:0007009	GO:1990778	GO:0071805	GO:0072657	GO:0009247	GO:0006869	GO:0071769
GO-Score	0.49	0.49	0.49	0.48	0.46	0.46	0.46	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.31	0.31	0.31
Cellular Component	GO:0005618	GO:0098797	GO:0036477	GO:0005887	GO:0044297	GO:0031988	GO:1903561	GO:0034705
GO-Score	0.48	0.42	0.42	0.42	0.42	0.42	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.