I-TASSER results

I-TASSER results for job id Rv1610

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (235 residues)
MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIGSFDELGPPKEVTLTGA
SWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAVGYLGISLWVVPDVAARGA
DLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSSAAIRGSAGEDMARYAAPRAR
RSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALDEGRDPTDREQESDTEGR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIGSFDELGPPKEVTLTGASWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAVGYLGISLWVVPDVAARGADLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSSAAIRGSAGEDMARYAAPRARRSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALDEGRDPTDREQESDTEGR
Prediction	CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCEEEEEHCCEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
Conf.Score	9988887666667874689999999999999999857858999995788887589986774436899999999999999999866999999999999999999998888637855899998864676456555787588999999999999999999998566777776666567857888888888766555554556788888899866889988769999999988888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIGSFDELGPPKEVTLTGASWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAVGYLGISLWVVPDVAARGADLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSSAAIRGSAGEDMARYAAPRARRSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALDEGRDPTDREQESDTEGR
Prediction	7456555554545443121001001231111003113121130323344446343404334022002000001201210020034202200000001111110131111003453353034215243333243433311100000000001000000021033344445444415435444552455355455444545544555543322100301354431255676556658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCCEEEEEHCCEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCC
MAANAGSVRPNRRARPMIGIAQLLLVVAAGALWMAARLPWVVIGSFDELGPPKEVTLTGASWSTALLPLALLMLAAAVAALAVRGWPLRALAVLLAAASFAVGYLGISLWVVPDVAARGADLAHVPVVTLVGSARHYWGAVAAVLAAVCALLAAVFLMSSAAIRGSAGEDMARYAAPRARRSIARRQHSNAAGRAAPQDDGPDMGPRMSERMIWEALDEGRDPTDREQESDTEGR

3x29A

0.11

0.07

0.60

1.03

wPPAS

------------SG--LQLLGYFLALGGWVGIIASTALPWKQSSYAGDAIITAVGLYEGGHIALMVVAVLLGFVAMVLSVVGMK--NPTAKSRVAISGGALFLLAGLCTLTA--YATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLAAT---------------------------------------------------------------------------

4ke2A

0.17

0.14

0.83

1.49

dPPAS2

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASA-------------ASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP--------------------------

4ke2A

0.17

0.14

0.83

1.20

PPAS

MNIDPAARAAAAAAASKAAVTAADAAAAAATIAASA--------------------------ASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAA-AVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP------------

4xu4A

0.15

0.11

0.77

1.01

dPPAS2

------------MRLRISEAVVLFLLGAVAALIGDHSHVVTGTTVYHTDAVPFVWS------SPFWFPILVGAATASLAELRLHVTARQALGGVAAVVGTYVTTALVH----AFPVVPVTALVCAAAAITWCVLGDGPGAACGVVIAVIGPAVEIALVQLGVFAYHPDSDGLFGVAPFLAPLYFAFGVVAALLGELAVARRPQL-------------------------------

5b2gA2

0.12

0.07

0.59

0.97

wPPAS

---------------GLQVMGIALAVLGWLAVMLCCALPWRVTAFIGSNIVTSQTIWEGAARALVIISIIVAALGVLLSVVGDESAKTMIVAGVVFLLAGLMVIVPVSWTA---HNIIQDFYNPLVASGQKREM---ASLYVGWAASGLLLLGGGLLCCS---------------------------------------------------------------------------

3x29A

0.14

0.09

0.62

1.03

dPPAS2

--------------SGLQLLGYFLALGGWVGIIASTALPWKQSSYAGDAIITAVGLYEGIQSARALMVVAVLLGFVAMVLSVVGMKNPTAKSRVAISGGALFLLAGLCTLTASWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLAAT---------------------------------------------------------------------------

3jbrE

0.22

0.12

0.56

0.93

wPPAS

MSPTEAP---------KVRVTLFCILVGIVLAMTAVVSDWAVLSEFT----QKEYSISAA--AISVFSLGFLIMGTICALMAFR----KKRDYLLRPASMFYVFAGLCLFVS--EVMRQSVKR----------YYYSWSFACACAAFVLLFLGGISLLLFS----------PR--------------------------------------------------------------

5cwqA

0.15

0.14

0.97

0.86

MUSTER

ERESEEAERRLQEARKRSEEARERLKELAEALIEEARAVQELARVACERGNSEEAE-------RASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH

4ke2A

0.15

0.13

0.83

0.86

dPPAS

------------MNIDPAARAAAAAAASKAAVTAADAA--AAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETINVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------------------------

3x29A

0.11

0.07

0.60

0.98

wdPPAS

--------------SGLQLLGYFLALGGWVGIIASTALPWKQSSYAGDAIITAVGLYEGSARALMVVAVLLGFVAMVLSVVGMK--NPTAKSRVAISGGALFLLAGLCTLTA--YATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLAAT---------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.58

Estimated TM-score = 0.32±0.11

Estimated RMSD = 14.3±3.8Å

Download Model 2

C-score=-3.91

Download Model 3

C-score=-4.09

Download Model 4

C-score=-3.19

Download Model 5

C-score=-4.92

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4av3A	0.562	4.99	0.083	0.834
2	1m56A	0.556	4.55	0.080	0.821
3	1ocrN	0.555	4.79	0.079	0.834
4	2yevA	0.552	5.68	0.082	0.923
5	1xmeA	0.544	5.03	0.080	0.838
6	1fftA	0.537	4.85	0.047	0.826
7	3ayxA	0.525	4.53	0.076	0.723
8	4he8L	0.523	4.82	0.086	0.766
9	3x29A	0.520	2.63	0.120	0.604
10	3mk7A	0.516	4.51	0.069	0.753

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	3rl3A	MN	Rep, Mult	220,222
2	0.08	4	5fnyB	O	Rep, Mult	29,71,75,149,153
3	0.07	3	2jstB	HLT	Rep, Mult	71,74,101
4	0.04	2	3ty8A	TAR	Rep, Mult	207,211,224
5	0.04	2	3ag4A	CDL	Rep, Mult	71,74,77,90,94,97,101,104
6	0.04	2	5arnA	CU1	Rep, Mult	76,98,102,153
7	0.02	1	1ebeA	O	Rep, Mult	37,40
8	0.02	1	1xmeC	HAS	Rep, Mult	141,145
9	0.02	1	3dtuC	DMU	Rep, Mult	71,74,75,78
10	0.02	1	1izlL	CLA	Rep, Mult	25,75,79
11	0.02	1	1rwtB	CHL	Rep, Mult	62,64
12	0.02	1	2bhwA	CLA	Rep, Mult	65,74
13	0.02	1	1e86A	CMO	Rep, Mult	69,72,110
14	0.02	1	4xxjA	MPG	Rep, Mult	64,101,104

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1fftA	0.537	4.85	0.047	0.826	1.10.3.-	NA
2	0.060	1frvB	0.501	4.59	0.085	0.706	1.12.2.1	NA
3	0.060	1vdkA	0.479	5.38	0.068	0.749	4.2.1.2	NA
4	0.060	1i0aA	0.453	5.17	0.057	0.685	4.3.2.1	NA
5	0.060	2occN	0.549	4.62	0.085	0.826	1.9.3.1	NA
6	0.060	3crlB	0.496	4.90	0.036	0.723	2.7.11.2	104,105,107
7	0.060	1yfeA	0.478	5.33	0.092	0.736	4.2.1.2	NA
8	0.060	1xmeA	0.544	5.03	0.080	0.838	1.9.3.1	NA
9	0.060	3no9A	0.477	5.18	0.064	0.728	4.2.1.2	33
10	0.060	3gtdA	0.475	5.10	0.055	0.723	4.2.1.2	NA
11	0.060	1b8fA	0.466	5.50	0.070	0.728	4.3.1.3	NA
12	0.060	2hvgA	0.467	5.23	0.066	0.723	4.3.2.2	NA
13	0.060	1jswB	0.473	5.43	0.060	0.740	4.3.1.1	NA
14	0.060	1y8pA	0.487	4.51	0.058	0.694	2.7.11.2	NA
15	0.060	3gzhA	0.472	5.17	0.033	0.719	4.3.2.2	NA
16	0.060	1m56A	0.556	4.55	0.080	0.821	1.9.3.1	NA
17	0.060	2zdxA	0.469	4.50	0.045	0.655	2.7.11.2	NA
18	0.060	1jtnA	0.238	5.68	0.012	0.396	3.2.1.17	NA
19	0.060	2pfdB	0.489	3.90	0.120	0.630	2.1.2.5,4.3.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.556	4.55	0.08	0.82	1m56A	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
1	0.25	0.548	4.68	0.08	0.83	1occA	GO:0004129 GO:0005506 GO:0005739 GO:0005743 GO:0006119 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0045277 GO:0046872 GO:0055114 GO:0070469 GO:1902600
2	0.10	0.399	5.04	0.04	0.56	1occC	GO:0004129 GO:0005739 GO:0005743 GO:0008535 GO:0015002 GO:0016020 GO:0016021 GO:0019646 GO:0022904 GO:0045277 GO:1902600
3	0.09	0.511	4.94	0.08	0.77	3o0rB	GO:0004129 GO:0005506 GO:0005886 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0019333 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
4	0.07	0.552	5.68	0.08	0.92	2yevA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015002 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0046872 GO:0055114 GO:0070469 GO:1902600
5	0.07	0.537	4.85	0.05	0.83	1fftA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006811 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015078 GO:0015453 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016682 GO:0019646 GO:0020037 GO:0046872 GO:0048039 GO:0055114 GO:0070469
6	0.07	0.543	5.02	0.08	0.84	3eh3A	GO:0004129 GO:0005506 GO:0005886 GO:0006119 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
7	0.07	0.552	4.64	0.07	0.83	1qleA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
8	0.07	0.517	4.51	0.07	0.75	5djqA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006119 GO:0009055 GO:0009060 GO:0015078 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016705 GO:0019411 GO:0019646 GO:0019825 GO:0020037 GO:0045154 GO:0045278 GO:0046872 GO:0055114 GO:0070069 GO:0070469 GO:0070470 GO:1902600
9	0.07	0.556	4.82	0.07	0.82	4av3B	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
10	0.07	0.514	4.80	0.09	0.77	4xydA	GO:0004129 GO:0005506 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0020037 GO:0055114 GO:0070469 GO:1902600
11	0.07	0.529	5.16	0.07	0.80	4av6A	GO:0000287 GO:0004427 GO:0005509 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006814 GO:0009678 GO:0015081 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030955 GO:0035725 GO:0042803 GO:0046872
12	0.06	0.494	5.47	0.09	0.78	4a01A	GO:0004427 GO:0005773 GO:0005774 GO:0006810 GO:0006811 GO:0009678 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0055085
13	0.06	0.400	4.33	0.08	0.53	1fftC	GO:0004129 GO:0005886 GO:0005887 GO:0008827 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015002 GO:0015078 GO:0015453 GO:0015990 GO:0016020 GO:0016021 GO:0016491 GO:0019646 GO:0022904 GO:0055114
14	0.06	0.461	4.70	0.07	0.68	1f88B	GO:0000139 GO:0001750 GO:0001917 GO:0004871 GO:0004930 GO:0005085 GO:0005794 GO:0005886 GO:0005887 GO:0005911 GO:0006468 GO:0007165 GO:0007186 GO:0007601 GO:0007602 GO:0007603 GO:0008020 GO:0009416 GO:0009583 GO:0009881 GO:0016020 GO:0016021 GO:0016038 GO:0016056 GO:0018298 GO:0022400 GO:0042622 GO:0043547 GO:0045494 GO:0046872 GO:0050896 GO:0050953 GO:0060041 GO:0060342 GO:0071482 GO:0097381
15	0.06	0.399	4.73	0.06	0.54	1qleC	GO:0004129 GO:0005886 GO:0015002 GO:0016020 GO:0016021 GO:0016491 GO:0019646 GO:0022904 GO:0055114 GO:1902600
16	0.06	0.401	4.88	0.07	0.55	1m56C	GO:0004129 GO:0015002 GO:0016020 GO:0019646 GO:0022904 GO:1902600
17	0.06	0.281	4.96	0.04	0.40	3l0mA	GO:0000166 GO:0003824 GO:0005085 GO:0005524 GO:0005576 GO:0005622 GO:0006612 GO:0008152 GO:0008289 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0017137 GO:0018117 GO:0018260 GO:0033644 GO:0043087 GO:0043547 GO:0044161 GO:0044162 GO:0044600 GO:0070273 GO:0070733
18	0.06	0.292	4.37	0.03	0.42	3l0iC	GO:0000166 GO:0003824 GO:0005085 GO:0005524 GO:0005576 GO:0005622 GO:0006612 GO:0008152 GO:0008289 GO:0009405 GO:0016020 GO:0016740 GO:0016779 GO:0017137 GO:0018117 GO:0018260 GO:0033644 GO:0043087 GO:0043547 GO:0044161 GO:0044162 GO:0044600 GO:0070273 GO:0070733

Consensus prediction of GO terms

Molecular Function	GO:0004129	GO:0005506	GO:0020037	GO:0005507
GO-Score	0.60	0.55	0.55	0.34
Biological Processes	GO:1902600	GO:0009060	GO:0006119	GO:0022900
GO-Score	0.60	0.55	0.51	0.34
Cellular Component	GO:0016021	GO:0005886	GO:0005743	GO:0045277
GO-Score	0.60	0.40	0.33	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.