I-TASSER results

I-TASSER results for job id Rv1592c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (446 residues)
MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAGYQHAVPGTVLRSRDVE
LAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAPGQTCPLLSYQCAIDAMSS
RCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPDHEGPKGLWGSPYEPGYRVLD
GIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEACGEYAPDLDIVGAVLGSPVGDLG
HTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRM
AGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALA
DSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRFAGKPLTDHRVRTTWPTIFNPM
TYAGMARLAVIAAKVITGRKLSRRPL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAPGQTCPLLSYQCAIDAMSSRCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPDHEGPKGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEHCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
Conf.Score	99887544566777777887555455678899989998899999888999879999867877667777885899999999789998789999999859999999985899967767888888876544678888777556789999999998998998589999999887756788999999999998765898899689975575999999999997775898767999977888889999998688865579999999999988765667888879999999999996777889998668888887667755554698999999985888888998689998589986688999999999999899699999589986456665589999999999979889999865567777886678899999999999998777788999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAPGQTCPLLSYQCAIDAMSSRCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPDHEGPKGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL
Prediction	72320200010212201212355146524123156120031157167231020031140324223213231302202020313644210000000002123454310000000000022330000100232332222222201100120143400000000002413121122102000200310240263614462200000000000000000321552245020000000011220330043033220000000000001211241332024101430240042027200110023133230230044314201324202300432403422130000001022010021520240043027351402023133413121210113200410441054421474144332212021301210042013001000434035458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCCCCCCCCEEEEEEEEEHCCCCCEEEEEEEEEHCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHCCHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEHCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
MVEPGNLAGATGAEWIGRPPHEELQRKVRPLLPSDDPFYFPPAGYQHAVPGTVLRSRDVELAFMGLIPQPVTATQLLYRTTNMYGNPEATVTTVIVPAELAPGQTCPLLSYQCAIDAMSSRCFPSYALRRRAKALGSLTQMELLMISAALAEGWAVSVPDHEGPKGLWGSPYEPGYRVLDGIRAALNSERVGLSPATPIGLWGYSGGGLASAWAAEACGEYAPDLDIVGAVLGSPVGDLGHTFRRLNGTLLAGLPALVVAALQHSYPGLARVIKEHANDEGRQLLEQLTEMTTVDAVIRMAGRDMGDFLDEPLEDILSTPEISHVFGDTKLGSAVPTPPVLIVQAVHDYLIDVSDIDALADSYTAGGANVTYHRDLFSEHVSLHPLSAPMTLRWLTDRFAGKPLTDHRVRTTWPTIFNPMTYAGMARLAVIAAKVITGRKLSRRPL

2veoA

0.28

0.25

0.92

2.53

MUSTER

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDIGN--ANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLFGKPFGPTP-

2veoA

0.27

0.25

0.92

2.83

dPPAS

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDI--GNANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLNGKPFGPITP

2veoA

0.28

0.25

0.92

4.06

wdPPAS

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDIG--NANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLNGKPFGPTP-

2veoA

0.28

0.25

0.92

3.22

wMUSTER

----------------------------ALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDIGN--ANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLNGKPFGPTP-

2veoA

0.28

0.25

0.92

5.00

wPPAS

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDIG--NANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLNGKPFGPTP-

2veoA

0.28

0.25

0.92

5.10

dPPAS2

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDI--GNANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLNGKPFGPTP-

2veoA

0.28

0.25

0.92

4.51

PPAS

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDIGN--ANNAASFQLQYRTTNTQNEAVADVATVWIPAK--PASPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLFGKPFGPTP-

2veoA

0.27

0.25

0.92

5.47

Env-PPAS

---------------------------AALPNPYDDPFYTTPSNIGTFAKGQVIQSRKVPTDI--GNANNAASFQLQYRTTNTQNEAVADVATVWIPAKPA--SPPKIFSYQVYEDATALDCAPSYSYLTGLDQPNKVTADTPIIIGWALQQGYYVVSSDHEGFKAAFIAGYEEGMAILDGIRALKNYQN--LPSDSKVALEGYSGGAHATVWATSLADSYAPELNIVGASHGGTPVSAKDTFTFLNGGPFAGFALAGVSGLSLAHPDMESFIEARLNAKGQQTLKQIRGFCLPQVVLTYPFLNVFSLVNDT--NLLNEAPIAGILKQESYTVSVPKFPRFIWHAIPDEIVPYQPAATYVKEQCAKGANINFSPYPIAEHLTAEIFGLVPSLWFIKQAFDGTTPKVICGTPAIAGITTPSADQVLGSDLANQLRSLNGSAFGKPPI

3h2kA

0.18

0.14

0.78

1.64

MUSTER

-----------------------------------------------PARGTLLTSNFLTSYTREQAKCNVRVAEFTYATIGVEGEPATASGVLLIPGGERCSGPYPLLGWGHPTEALRAQEQAKEIRDAKGDD---------PLVTRLASQGYVVVGSDYLGLGKSYLHSASEASATIDAMRAARSVLQHLTPLSGKVMLSGYSGGHTAMATQREIEAHLSKEFHLVASAPISGPYALEQTFLDSWSGFGILLGSYAIVAMQHTYKNIYLEPGQVFQDPWAAKVEPLGKQSLTDMFLNDTLPSVKSYFQPGYSDFPSNPPFRQDLARNNLLEWAPQTPTLLCGSSNDATVPLKNAQTAIASFQQRGSNQVALVDTGTGNAFAHMLTKESCIVVVRDQLLDKQR------------------------------------------

3h2kA

0.17

0.13

0.78

1.82

dPPAS

-----------------------------------------------PARGTLLTSNFLTSSGPEQAKCNVRVAEFTYATIGVEGEPATASGVLLIPGGERCSGPYPLLGWGHPTEALRAQEQAKEIRDAKGDD---------PLVTRLASQGYVVVGSDYLGLGKSNLHSASEASATIDAMRAARSVLQHLTPLSGKVMLSGYSGGHTAMATQREIEAHLSKEFHLVASAPISGPYALEQTFLDSWSGFGILLGSYAIVAMQHTYKNIYLEPGQVFQDPWAAKVEPLGKQSLTDMFLNDTLPSIDKVKSYFQPPSNPANPFRQDLARNNLLEWAPQTPTLLCGSSNDATVPLKNAQTAIASFQQRGSNQVALVDTGTGNAFAHMLTKESCIVVVRDQLLDKQR------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.03

Estimated TM-score = 0.71±0.12

Estimated RMSD = 7.1±4.2Å

Download Model 2

C-score=-1.84

Download Model 3

C-score=-1.95

Download Model 4

C-score=-0.60

Download Model 5

C-score=-1.98

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2veoA	0.907	0.99	0.273	0.921
2	3h2kA	0.679	3.14	0.163	0.769
3	4eziA	0.660	2.89	0.163	0.740
4	3wmtA	0.575	3.83	0.085	0.684
5	4fg5A	0.562	5.16	0.080	0.747
6	1lnsA	0.558	4.73	0.083	0.691
7	4pf1A	0.554	4.57	0.100	0.691
8	1nx9A	0.554	4.52	0.081	0.688
9	3azoA	0.548	3.97	0.117	0.650
10	4hxeB	0.545	3.76	0.092	0.634

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.52	8	2veoB	GOL	Rep, Mult	116,168,205,206,242,246,350,351
2	0.18	3	2veoA	PG4	Rep, Mult	116,168,169,205,239,242,243,246,254,258,259,262,326
3	0.04	1	2veo0	III	Rep, Mult	28,29,31,35,37,60,65,130,131,132,133
4	0.04	1	2jbwA	NA	Rep, Mult	145,146,147,150,152,154,156

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.454	1thtA	0.486	3.94	0.091	0.581	2.3.1.-	205,380
2	0.363	1vlqA	0.510	2.99	0.104	0.574	3.1.1.41	205,348,380
3	0.095	3fcyA	0.510	3.12	0.104	0.579	3.1.1.41	205,348,380
4	0.067	1l7aA	0.513	3.15	0.120	0.581	3.1.1.72,3.1.1.41	205,380
5	0.067	1qz3A	0.497	3.93	0.128	0.594	3.1.1.1	205,352,380
6	0.067	3fakA	0.478	3.57	0.110	0.556	3.1.1.-	NA
7	0.066	3fcxB	0.466	3.35	0.112	0.543	3.1.2.12	348
8	0.063	2jbwD	0.551	3.92	0.142	0.652	3.7.1.-	205,380
9	0.062	1yr2A	0.523	4.08	0.087	0.626	3.4.21.26	205,348
10	0.060	1k4yA	0.522	5.17	0.108	0.691	3.1.1.1	NA
11	0.060	1gz7A	0.522	5.21	0.061	0.695	3.1.1.3	NA
12	0.060	1k8qA	0.516	4.85	0.099	0.659	3.1.1.3	380
13	0.060	1c7jA	0.517	4.93	0.078	0.670	3.1.1.-	205,380
14	0.060	1lpsA	0.523	5.29	0.076	0.700	3.1.1.3	50,92
15	0.060	2bklB	0.525	4.24	0.113	0.634	3.4.21.26	234,348,380
16	0.060	2veoB	0.904	1.09	0.273	0.921	3.1.1.3	163,165,172,221
17	0.060	1thgA	0.515	5.62	0.078	0.704	3.1.1.3	210
18	0.060	1hlgB	0.510	4.40	0.104	0.632	3.1.1.3	263
19	0.060	3fvrA	0.515	3.23	0.109	0.585	3.1.1.6	380
20	0.060	1nx9A	0.554	4.52	0.081	0.688	3.1.1.43	164,181
21	0.060	1e5tA	0.529	4.18	0.093	0.634	3.4.21.26	234,348,380
22	0.060	1orvA	0.526	4.00	0.110	0.619	3.4.14.5	205,348,380
23	0.060	3g0bB	0.525	4.05	0.098	0.619	3.4.14.5	NA
24	0.060	1aknA	0.536	5.12	0.087	0.706	3.1.1.13,3.1.1.3	205
25	0.060	2ecfA	0.526	3.83	0.116	0.612	3.4.14.5	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.678	2.84	0.16	0.76	4eziA	GO:0004806 GO:0016042
1	0.24	0.679	3.14	0.16	0.77	3h2kA	GO:0004177 GO:0004806 GO:0006508 GO:0016042
2	0.22	0.904	1.11	0.27	0.92	3guuA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787
3	0.11	0.405	4.51	0.12	0.50	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
4	0.07	0.470	3.45	0.13	0.55	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
5	0.07	0.575	3.83	0.09	0.68	3wmtA	GO:0000272 GO:0005576 GO:0005975 GO:0016787 GO:0016998 GO:0030600 GO:0045493 GO:0046872 GO:0052689
6	0.07	0.503	4.27	0.12	0.61	4j7aA	GO:0008152 GO:0016787
7	0.07	0.475	3.40	0.12	0.56	3i6yA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
8	0.07	0.473	3.72	0.11	0.56	4b6gA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
9	0.06	0.419	3.89	0.10	0.50	4ns4A	GO:0016787 GO:0016788
10	0.06	0.317	6.72	0.05	0.50	3sqzA	GO:0003824 GO:0004421 GO:0008152 GO:0008299 GO:0016740 GO:0016746
11	0.06	0.348	6.56	0.04	0.54	3egdB	GO:0000139 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0045714 GO:0048208 GO:0048471 GO:0050714 GO:2000189
12	0.06	0.300	6.85	0.07	0.49	4v85AW	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005829 GO:0006412 GO:0006415 GO:0006449 GO:0016149 GO:0016150 GO:0019003
13	0.06	0.287	6.00	0.05	0.41	4q9dB	GO:0000287 GO:0003824 GO:0016829 GO:0030976 GO:0046872 GO:0050695
14	0.06	0.295	7.62	0.03	0.51	2wvaX	GO:0000287 GO:0003824 GO:0004737 GO:0016829 GO:0016831 GO:0030976 GO:0046872
15	0.06	0.276	7.21	0.04	0.46	2xexB	GO:0000166 GO:0003746 GO:0003924 GO:0005525 GO:0005622 GO:0005737 GO:0006412 GO:0006414
16	0.06	0.276	6.46	0.07	0.42	3lehA	GO:0003824 GO:0004421 GO:0008152 GO:0008299 GO:0016740 GO:0016746
17	0.06	0.270	6.63	0.05	0.42	4uxdA	GO:0003824 GO:0005975 GO:0006007 GO:0008152 GO:0008674 GO:0008675 GO:0016829 GO:0016832 GO:0061677
18	0.06	0.268	5.95	0.04	0.39	3qufB	GO:0005215 GO:0006810
19	0.06	0.254	5.45	0.03	0.35	3qh8A	GO:0000166 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0004806	GO:0008238
GO-Score	0.58	0.49
Biological Processes	GO:0016042	GO:0019538
GO-Score	0.58	0.49
Cellular Component	GO:0005576
GO-Score	0.22

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.