I-TASSER results

I-TASSER results for job id Rv1548c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (678 residues)
MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGP
ASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAATVHPGAVSANRGRLRSL
VASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVALSLTPFTPSPSAAATPGG
AVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANTGSVNLGNANIGDLNLGSG
NIGSYNLGGGNTGDLNPDSGNTGTLNWGSGNIGSYNLGGGNLGSYNLGSGNTGDTNFGGG
NTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSGNLGSGNIGFGNKGSHNIGFG
NSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNIGFFNSGNNNIGMGNSGNGVGA
LSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNSATTSTGWFNSGTTNTGWFNSGT
TNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTGFF
NSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFDNNARDEHAEFVTGNSGL
ANVGNYNAGIINVGDHLSGFRNSVPTITGTANISGFVNAGTSISGFFNFGSLMSGFANFD
DEVSGYLNGDSRASGWIH

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGPASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAATVHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVALSLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANTGSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPDSGNTGTLNWGSGNIGSYNLGGGNLGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSGNLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNIGFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNSATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSVPTITGTANISGFVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH
Prediction	CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEHCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	985558865677654578997789999999999999999999999999988646777875899999999989999999999999999999999999987654688846666677655445446778887555555654666654566655566777776655677888888877888877777777887777777888777777777888877778888888888877788888888888898888888888888888888998888888998888888899888888889999998888999888888889999998889998899889999889998899988888888998998888889888888889888888888899888888889998888888999898888899888888888888888889888889988888889999998888998888888888888888888888888888988888888888889988888888988899888899889988889998999888998899988888899988898899998999889999899998998888988888888888888888988888888888888988888888888888899988888888888888888889998887888888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGPASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAATVHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVALSLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANTGSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPDSGNTGTLNWGSGNIGSYNLGGGNLGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSGNLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNIGFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNSATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSVPTITGTANISGFVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH
Prediction	431001000000010100000000100010021003001100300100000000111101000000000000020012003103300310200010022012021211203111200000001111212001004141324422143112012132212102122321233332222232212121123232322222222221212422213221232221232113323314323122131331313343133121211213333232131431313213133130311313313022131442404213144131220313413022131441313213144120311314413132131432313323344421413213143130421414433112131431303213144444444342443442312213143010211214323143141442313314143121221313413122131444443341321314312031241421103113142121301313311022131431102113254333120321312212032141421313214143441422321312314143230211313313033141431413324413103143110221314311121131331102113134110220
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEHCCCCCCCCHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MNFSVLPPEINSALMFAGAGPGPMLAAASAWTGLAGDLGSAAASFSAVTSQLATGSWQGPASAAMTGVAASYARWLTTAAAQAEQAAGQAQAAVSAFEAALAATVHPGAVSANRGRLRSLVASNLLGQNAPAIAAVEAVYEQMWAADVAAMLGYHGEASAVALSLTPFTPSPSAAATPGGAVIIAGFPFLDLGNVTIGGFNLASGNLGLGNLGSFNPGSANTGSVNLGNANIGDLNLGSGNIGSYNLGGGNTGDLNPDSGNTGTLNWGSGNIGSYNLGGGNLGSYNLGSGNTGDTNFGGGNTGNLNVGGGNTGNSNFGFGNTGNVNFGNGNTGDTNFGSGNLGSGNIGFGNKGSHNIGFGNSGNNNIGFGLTGDNQIGFGALNSGSGNLGFGNSGNGNIGFFNSGNNNIGMGNSGNGVGALSVEFGSSAERSSGFGNSGELSTGIGNSGQLSTGWFNSATTSTGWFNSGTTNTGWFNSGTTNTGIGNSGGNLVTGSMGLFNSGHTNTGSFNAGSMNTGDFNSGNVNTGYFNSGNINTGFFNSGDLNTGLFNSVNQPVQNSGWLHTGTNNSGYANAGTFNSGFDNNARDEHAEFVTGNSGLANVGNYNAGIINVGDHLSGFRNSVPTITGTANISGFVNAGTSISGFFNFGSLMSGFANFDDEVSGYLNGDSRASGWIH

5ak1A

0.13

0.99

1.53

MUSTER

APGSKAPGRTRELGLYNGANNGNAQWARDFWKFYAPRYA---VAWGPPYSSSTANPPGAVDEIDVYRIIRTYVFGGKGGAAEALKDIRAFNKAVFAVAFHGYAGWQETTIAVEELLKAPCFTEYAGGAWGSGGGLDVELTYELERLGVSWLTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVKTSDTGGGYNVGWISEGVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTATRQVFLGAGLQKLRINALSGGFNLNWIELSPISTGTIPDGTYKFLNRANGKTLQEVTGNNSIITADYKGITEQHWKIQHIGGGQYRISSAGRGWNWNWWGFGTVGWWGTGSSTCFIISPTGDGYYRIVLVGDGTNLQISSGDPSKIEGKAFHGGANQQWAILPVSAPAFPTGLSAVLDSSGNLTWNAAPGANSSTKSGGPYTTIATNITSTNYTDTGVATGTKYSNGVETLNSAEAILQYPKLTGTVIGTQGSWNNIGNTIHKAFDGDLNTFFDGPTANGCWLGLDFGEGVRNVITQ-CPRSGYEQRIGGIFQGANKEDFSDAVTLFTITSLPGSGTLTSVDVDNPTGFRY---SPDGSNGN

2ocwA

0.07

0.06

0.78

1.73

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNK-KNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQ-ALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYG

2g38B

0.33

0.08

0.26

2.90

wdPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4om9A

0.10

1.00

1.48

MUSTER

TSFNYNENNQNIIDRYGVIIGFRVGSGNTTFSGIKTSQTYQADLLSASLFHFTNLTTNGDSGSGVYVFDNKEDKWVLQKTYVTPFDSKTTNELKQLFIQNVNIDNNTATIGGGKITNKDLVFSGIFDENKKYTVSAEGNNNVTFKGAGIDIGKGSTVDWNIKYASNDALHGEGSLNVIQAQNTNLKTGNGTVILGAQKTFNNIYVAGGPGTVQLNAENALGEGDYAGIFFTENGGKLDLNGHNQTFKKIAATDSGTTITNSNTTKESVLSVNNQNNYIYHGNVDGNVRLEHHLDTKQDNARDGDIQANSISIKNAPLVMQGHATDHAIFRTTKTNNCPEFLCGVDWVKTTYKSNNQVSDLSQPDWETRKFRFDNLNIEDSSLSIARNADVEGNGDKTAYIDLYSGKNITGAGFTFRQDIKSGDSIGESMATDGSISIGDKAIVTLNTVSSLDRTALTIHKGANVTASSSLFTTSNIKSGGDLTLTGATESTGEITPSMFYAAGGYEL-TEDGANFTAKNQASVTGDIKSEKAAKLSFGSADKDNSATRYSQFALAMLDGFDTSYQGSIKAAQSSLAMNNALWKVTGNSELKKLNSTGSMVLFNGGKNIFNTLTVDELTTSNSAFVMRTNTQQADQLKLEGANNLLLVDFIEKKGNDKNLENTSKDVFKTETQTIGFSD

2g38B

0.33

0.08

0.25

1.73

wMUSTER

--FEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3chnS

0.08

0.06

0.78

1.72

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------KSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNK-KNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQE------GSPIQAWQLFVNEESTIPRSPTVVKGVAGSSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQ

2g38B

0.33

0.08

0.26

3.99

wPPAS

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5ak1A

0.12

0.98

1.57

wMUSTER

VELGFLYPGYAVNEIDKGANNGNAQWARDFWKFYAPRYA----KETHVLVAWGPPYSSSTANPPGAVDEIDVYRIIRTYAPGGKGGAAEALKDIRAFNKAVFAGWQETTIAVEELLKACFTEGGAWGSGGGLDVELTYELERLGVS--LTFQYIPPTGVSDDVTKPEYFSALVENSGLSWTPDYGNWPAARGVYGNGGLARETATWINNFLTGTTRIEAEDFDWGGNGVSYYDTDSVNVGGQYRPDEGVDIEKTSDTGGGNVGWISEGVRNPGYYNLSLRVAGISGSRVQVSFGNQDKTGVWELPATGGFQTWTTGAGLQKRINALSGGFNLNWIELSPISTGTIPDGTYKFLNRANGKTLQEVTGNNSIITADYKGITEQHWKIQHIGGGQYRISSAGRGWNWNWWGFGTVGWWGTGSSTCFIISPTGDGYYRIVLVGDGTNLQISSGDPSKIEGKAFHGGANQQWAILPVSAPAFPTGLSAVLDSSGNTANLTWNAAPGANSYNVKRSTKSGGPYTTIATNITSTNYTDTGVATGTKYSNGVETLNSAEAILQYPKLTGTVIGTQGSWNNIGNTIHKAFDGDLNTFFDGPTANGCWLGLDFGEGVRNVITQ-CPRSGYEQRIGGIFQGANKEDFSDAVTLFTITSLPGSGTLTSVDVDNPTGFR----SPDGSNGN

2g38B

0.33

0.08

0.26

4.35

dPPAS2

-AFEAYPPEVNSANIYAGPGPDSMLAAARAWRSLDVEMTAVQRSFNRTLLSL-MDAWAGPVVMQLMEAAKPFVRWLTDLCVQLSEVERQIHEIVRAYEWAHHDMVPLAQIYNNRAERQILIDNNALGQFTAQIADLDQEYDDFWDEDGEVMRDYRLRVSDALSKLTPWKAPPPIA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4uicA

0.11

0.99

1.09

Env-PPAS

TETGQFPDIKDVYAAYNKA-KQAYANAVAVVNKAGAKKDAYLADLQAIYETYVFKAKSGEARVATYIDAYNYATKLDKMRQELKAAVDALKKAEELYHKISYELKTRTVILDRQSTRELLRSTKADAQALRDRLIYDTVAMKAREAQDAVKAGNLDKAKAALDQVNQYVSKVTDAFKAELQKAAQDAKAAYEAALTPKVESVSAIDSTSFKTFTKPVDKATAIPKNFSITLKGTETKLYPKSVEVSESGLTATVTLYDTLVDGKTYTVVTSGLKDTAGKEFETSTNEFTYNKPVPASITFNFNKLPEDSAVDLTKYVTVKDAAGNVIKSGFELEFTSSEKLTQGKFINTTGKKSVIVNATVKGTNVTTGNVILAVEDEKAAEVSELKLTKDNKEVVTLYANGNAFDKDGNQISSGTLTLTAKFKDQYGNELTGKVAGTDYTFESLNPEVLVVAPDGSVTPIVPGTALVKVKYGEVTKTIPVTVKANPVLETIAVDSTGVSVAKGQKATFKVTLKDQYGNKFTGNVNVTSDKTETATVSVSNSGIGQSEYTVTVNGVAEGSTTITIKSGTKEVKVPVNVVAGGPVANYQIKVLVQLKVYAVDANGNIVGDITNDVTITSGVIVNASKSTANGDTVYVIT--DNETLTVKLGTVTLGTVDVEVLKATVVTKKADLIEL--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.72

Estimated TM-score = 0.62±0.14

Estimated RMSD = 9.7±4.6Å

Download Model 2

C-score=-0.83

Download Model 3

C-score=-1.05

Download Model 4

C-score=-2.24

Download Model 5

C-score=-1.67

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5ak1A	0.907	3.18	0.098	0.988
2	2y8kA	0.455	3.40	0.094	0.504
3	5kf6A	0.361	8.47	0.059	0.597
4	1llwA	0.361	8.63	0.033	0.612
5	1yq2A	0.358	6.89	0.040	0.510
6	2iwhB	0.354	8.32	0.056	0.575
7	2vdcA	0.353	8.77	0.039	0.603
8	4cvuA	0.353	8.73	0.056	0.609
9	3ob8A	0.350	6.95	0.046	0.497
10	2xvgA	0.349	8.03	0.050	0.555

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	7	5ak1A	CA	Rep, Mult	220,222,260,341
2	0.07	3	1af0A	CA	Rep, Mult	551,552,553,559,571,576,577,589
3	0.04	2	3huzP	MG	Rep, Mult	574,576
4	0.02	1	2g38B	MN	Rep, Mult	149,152,153
5	0.02	1	1ofeA	ONL	Rep, Mult	489,504,505,530,545,546,547
6	0.02	1	1rzoD	GAL	Rep, Mult	357,480
7	0.02	1	5la0A	ARA	Rep, Mult	254,263,264,339
8	0.02	1	3huxP	MG	Rep, Mult	576,587
9	0.02	1	3ca5A	NAG	Rep, Mult	357,406,409,480
10	0.02	1	2z8xA	CA	Rep, Mult	614,630,632,633
11	0.02	1	1ktwA	CA	Rep, Mult	362,398,400
12	0.02	1	2y8kA	NA	Rep, Mult	236,239,240,241,242,250,251,252
13	0.02	1	3a23B	GAL	Rep, Mult	453,455,464,472
14	0.02	1	3n85A	UUU	Rep, Mult	334,336

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3lxuX	0.315	8.20	0.062	0.504	3.4.14.10	270
2	0.060	1a1qA	0.113	5.63	0.052	0.149	3.4.21.98	270
3	0.060	2uv8G	0.325	8.38	0.029	0.538	2.3.1.86	NA
4	0.060	2je8B	0.343	8.54	0.045	0.583	3.2.1.25	NA
5	0.060	3b9jI	0.125	5.47	0.027	0.162	1.17.1.4,1.17.3.2	312
6	0.060	2vkzG	0.320	8.46	0.042	0.519	2.3.1.38,3.1.2.14	220
7	0.060	1bxrA	0.336	8.22	0.038	0.546	6.3.5.5	223,232
8	0.060	1fo4A	0.328	8.14	0.048	0.532	1.17.1.4	NA
9	0.060	3h0gA	0.312	8.33	0.052	0.512	2.7.7.6	NA
10	0.060	3ffzA	0.332	8.36	0.025	0.553	3.4.24.69	NA
11	0.060	3b9jJ	0.174	6.41	0.050	0.243	1.17.1.4,1.17.3.2	361
12	0.060	1e1yA	0.313	8.42	0.039	0.518	2.4.1.1	NA
13	0.060	2vdcA	0.353	8.77	0.039	0.603	1.4.1.13	NA
14	0.060	1ea0A	0.352	8.47	0.031	0.587	1.4.1.13	68
15	0.060	2r7oA	0.313	8.11	0.045	0.501	2.7.7.48	431
16	0.060	1cu1A	0.311	8.02	0.055	0.497	3.6.1.15	NA
17	0.060	1fa9A	0.283	8.25	0.043	0.463	2.4.1.1	NA
18	0.060	8ohmA	0.215	6.85	0.072	0.305	2.7.7.48	NA
19	0.060	3gpbA	0.311	8.48	0.043	0.516	2.4.1.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.909	3.13	0.10	0.99	5ak1A	GO:0000272 GO:0004553 GO:0005975 GO:0030246 GO:0046872
1	0.06	0.280	7.87	0.05	0.44	5awoA	GO:0003824 GO:0004553 GO:0005975 GO:0030246
2	0.06	0.240	5.79	0.03	0.31	3zm8A	GO:0004553 GO:0005975 GO:0006080 GO:0008152 GO:0016787 GO:0016798 GO:0016985 GO:0030246 GO:0046872
3	0.06	0.206	7.24	0.02	0.31	3vsfC	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246
4	0.06	0.237	6.66	0.05	0.34	1a0eA	GO:0000287 GO:0005737 GO:0005975 GO:0006098 GO:0009045 GO:0016853 GO:0042732 GO:0046872
5	0.06	0.236	7.48	0.04	0.36	3c7gA	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0030246 GO:0045493 GO:0046556 GO:0046872
6	0.06	0.215	4.32	0.06	0.26	3pzvA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030248
7	0.06	0.219	4.45	0.07	0.26	5a8mA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798
8	0.06	0.221	4.55	0.05	0.27	2jepA	GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0033946
9	0.06	0.217	4.91	0.08	0.27	5fipB	GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016020 GO:0016021 GO:0016787 GO:0016798 GO:0030245
10	0.06	0.218	4.90	0.07	0.27	4xzbA	GO:0003860 GO:0004553 GO:0005975 GO:0008152 GO:0016020 GO:0016021 GO:0016787 GO:0016798
11	0.06	0.179	7.24	0.05	0.27	2hihA	GO:0004620 GO:0004806 GO:0005509 GO:0005576 GO:0006629 GO:0008970 GO:0016020 GO:0016042 GO:0016787 GO:0019433 GO:0034638 GO:0046872 GO:0052739 GO:0052740
12	0.06	0.198	5.23	0.04	0.25	3amdB	GO:0004553 GO:0005576 GO:0005975 GO:0006073 GO:0008152 GO:0008422 GO:0009251 GO:0009986 GO:0016787 GO:0016798
13	0.06	0.218	4.52	0.06	0.26	1egzA	GO:0000272 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246
14	0.06	0.206	4.64	0.06	0.25	2cksB	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030246 GO:0030247
15	0.06	0.216	4.43	0.10	0.26	1tvnA	GO:0004553 GO:0005509 GO:0005576 GO:0005975 GO:0007155 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030246
16	0.06	0.208	5.50	0.05	0.27	4im4A	GO:0000272 GO:0003824 GO:0004553 GO:0005576 GO:0005975 GO:0008152 GO:0008810 GO:0016787 GO:0016798 GO:0030245 GO:0030248 GO:0045493 GO:0046555 GO:0046872 GO:2000884
17	0.06	0.154	7.14	0.02	0.23	4yh7A	GO:0004721 GO:0004725 GO:0005102 GO:0006470 GO:0007157 GO:0016020 GO:0016021 GO:0016311 GO:0016787 GO:0016791 GO:0030182 GO:0035335 GO:0046426 GO:0050775 GO:0050776 GO:0050839 GO:0097105
18	0.06	0.174	7.33	0.05	0.27	1zl0A	GO:0004180 GO:0005737 GO:0006508 GO:0008233 GO:0008236 GO:0008360 GO:0009252 GO:0009254 GO:0016787 GO:0071555

Consensus prediction of GO terms

Molecular Function	GO:0030246	GO:0004553	GO:0046872
GO-Score	0.43	0.43	0.39
Biological Processes	GO:0000272
GO-Score	0.35
Cellular Component	GO:0005737
GO-Score	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.