I-TASSER results

I-TASSER results for job id Rv1540

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (308 residues)
MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNGVPAGKSDRLVSGALL
QVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAHASVGWTGPTVLGGLAAAG
YRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKRAFKYRTVDKRYHALVQGHPD
PSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEAFVAASLLDVHLETGRTHQIRVH
FAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSPYPADLQHA
LKILRGEG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNGVPAGKSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAHASVGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEAFVAASLLDVHLETGRTHQIRVHFAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSPYPADLQHALKILRGEG
Prediction	CCEEEEEHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCEEHCCEEHCHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCEEEHCCCEEEEHCCCCCEHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHCCEEEEEEEEEEEHCCCCCCEEHCCCCCCCCCCEEEEHCCCCEEEEEHHHEHHHHCCCEEEEEEHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEHCCCHHHHHHHHHHHHHC
Conf.Score	98699997876588749999999759999999999998997889898675436789889999958999888888877889867877696899977898655789999998799999998655555789888776666778997799998899999999999998975899999999555788767867888999887689985898654655565677599869999956898558899999879986787889998876556899874687767746589999789999689799999999999979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNGVPAGKSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAHASVGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEAFVAASLLDVHLETGRTHQIRVHFAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSPYPADLQHALKILRGEG
Prediction	76626150467324210130027227202420240066340304644043623044413030403446664624326067040000041000001134000310331441000000011044067365432120231433500000000124401522251056360533110001030667513050101436734320102770340200030042156001010315144214120000103000001423144652366350610010024041411346440404041161045006404768
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEHCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCEEHCCEEHCHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCEEEHCCCEEEEHCCCCCEHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHCCEEEEEEEEEEEHCCCCCCEEHCCCCCCCCCCEEEEHCCCCEEEEEHHHEHHHHCCCEEEEEEHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEHCCCHHHHHHHHHHHHHC
MADRSMPVPDGLAGMRVDTGLARLLGLSRTAAAALAEEGAVELNGVPAGKSDRLVSGALLQVRLPEAPAPLQNTPIDIEGMTILYSDDDIVAVDKPAAVAAHASVGWTGPTVLGGLAAAGYRITTSGVHERQGIVHRLDVGTSGVMVVAISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEWKFAITKNGRHSLTHYDTLEAFVAASLLDVHLETGRTHQIRVHFAALHHPCCGDLVYGADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSPYPADLQHALKILRGEG

2istA

0.34

0.33

0.97

5.12

MUSTER

V-QLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

15.00

dPPAS

RVQLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

13.13

wdPPAS

RVQLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

5.68

wMUSTER

V-QLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

5.45

wPPAS

V-QLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

14.23

dPPAS2

V-QLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

5.34

PPAS

V-QLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA

0.34

0.33

0.97

8.68

Env-PPAS

V-QLTATVSENQLGQRLDQALAEMFDYSRSRIKEWILDQRVLVNGKVCKPKEKVLGGEQVAINAEIE----RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA2

0.39

0.29

0.75

4.17

MUSTER

-----------------------------------------------------------------------RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

2istA2

0.39

0.29

0.75

12.35

dPPAS

-----------------------------------------------------------------------RFEPQDIP-LDIVYEDEDIIIINKPRDLVVHPGAGNPDGTVLNALLHYY---PPIADVPRAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTA-GGTVDEPISRHPTKRTHMAVHPMGKPAVTHYRIMEHFRVHTRLRLRLETGRTHQIRVHMAHITHPLVGDPVYGGRPRPPKGASFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIEVMRADF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=2.00

Estimated TM-score = 0.99±0.04

Estimated RMSD = 2.3±1.8Å

Download Model 2

C-score=-2.89

Download Model 3

C-score=-2.87

Download Model 4

C-score=-4.09

Download Model 5

C-score=-4.40

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2istA	0.935	1.34	0.341	0.971
2	1xpiA	0.653	2.48	0.332	0.718
3	2i82A	0.589	2.50	0.333	0.653
4	4iqmA	0.473	4.38	0.104	0.620
5	1dj0A	0.448	4.05	0.092	0.575
6	2v9kA	0.440	4.39	0.088	0.575
7	1k8wA	0.433	3.42	0.130	0.519
8	1ze1A	0.433	3.49	0.114	0.519
9	1vs3A	0.422	4.19	0.105	0.545
10	1vioA	0.418	4.39	0.115	0.545

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.57	12	1kskA	URA	Rep, Mult	139,142,171,235,236,237,271
2	0.23	8	2i82D	NUC	Rep, Mult	100,102,103,104,105,108,133,136,137,138,139,140,152,155,156,159,162,163,165,169,197,200,207,232,233,234,235,252,253
3	0.09	5	3hjwA	RQA	Rep, Mult	102,134,135,136,137,139,140,169,171,231,232,236,237,238,249,271,273
4	0.03	1	2istA	BCT	Rep, Mult	79,81
5	0.03	1	2istA	BCT	Rep, Mult	302,305
6	0.02	1	1n38A	CH1	Rep, Mult	171,172,173,174
7	0.02	1	3lwrA	RQA	Rep, Mult	102,137,139

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.122	1ze2B	0.209	5.42	0.017	0.321	4.2.1.70	139,171
2	0.121	1s71B	0.405	3.38	0.178	0.480	4.2.1.70	139,171
3	0.113	1k8wA	0.433	3.42	0.130	0.519	4.2.1.70	139,171
4	0.060	3k1dA	0.398	7.15	0.039	0.731	2.4.1.18	NA
5	0.060	1dj0A	0.448	4.05	0.092	0.575	5.4.99.12	139
6	0.060	1pj6A	0.368	6.35	0.057	0.614	1.5.3.10	NA
7	0.060	1m7xB	0.392	6.95	0.034	0.724	2.4.1.18	38
8	0.060	1r3fA	0.395	3.17	0.136	0.468	4.2.1.70	171
9	0.060	2fhbA	0.390	7.08	0.056	0.737	3.2.1.41	NA
10	0.060	1s0kA	0.383	6.05	0.044	0.627	3.2.1.18	NA
11	0.060	2fhcA	0.396	6.58	0.060	0.688	3.2.1.41	137
12	0.060	1hwxA	0.362	6.36	0.027	0.610	1.4.1.3	NA
13	0.060	1vs3A	0.422	4.19	0.105	0.545	5.4.99.12	139
14	0.060	1l5jA	0.377	6.48	0.050	0.646	4.2.1.3	82,97,141
15	0.060	3ctzA	0.370	6.39	0.073	0.633	3.4.11.9	NA
16	0.060	1rp5A	0.395	6.30	0.038	0.656	3.4.-.-	NA
17	0.060	1yq2A	0.369	6.61	0.066	0.646	3.2.1.23	NA
18	0.060	3fwmA	0.372	6.33	0.053	0.617	2.4.1.129,	NA
19	0.060	2vr5A	0.370	6.61	0.038	0.659	3.2.1.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.56	0.935	1.34	0.34	0.97	2istA	GO:0000027 GO:0000455 GO:0001522 GO:0003723 GO:0005829 GO:0006364 GO:0009451 GO:0009982 GO:0016853 GO:0019239
1	0.46	0.608	2.50	0.33	0.67	2i82A	GO:0000455 GO:0001522 GO:0003723 GO:0006364 GO:0008033 GO:0009451 GO:0009982 GO:0016853 GO:0019239 GO:0031118 GO:0031119
2	0.37	0.653	2.48	0.33	0.72	1xpiA	GO:0000455 GO:0001522 GO:0003723 GO:0005829 GO:0006364 GO:0009451 GO:0009982 GO:0016853 GO:0019239
3	0.36	0.414	3.47	0.10	0.50	1kskA	GO:0000455 GO:0001522 GO:0003723 GO:0005829 GO:0006364 GO:0009451 GO:0009982 GO:0016853 GO:0016866
4	0.07	0.473	4.38	0.10	0.62	4iqmA	GO:0001522 GO:0003723 GO:0004730 GO:0005634 GO:0005739 GO:0005759 GO:0008033 GO:0009451 GO:0009982 GO:0016853 GO:0044822 GO:0070902
5	0.07	0.448	4.05	0.09	0.57	1dj0A	GO:0000049 GO:0001522 GO:0003723 GO:0008033 GO:0009451 GO:0009982 GO:0016853 GO:0031119
6	0.06	0.422	4.19	0.10	0.55	1vs3A	GO:0001522 GO:0003723 GO:0008033 GO:0009451 GO:0009982 GO:0016853 GO:0031119
7	0.06	0.401	3.61	0.17	0.49	2omlA	GO:0000455 GO:0001522 GO:0003723 GO:0005829 GO:0006364 GO:0009451 GO:0009982 GO:0016853 GO:0016866
8	0.06	0.291	7.09	0.05	0.55	3a2fA	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0004518 GO:0004519 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0071897 GO:0090305
9	0.06	0.319	6.70	0.04	0.56	1tgoA	GO:0000166 GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008152 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0071897 GO:0090305
10	0.06	0.310	6.92	0.05	0.56	1d5aA	GO:0000166 GO:0003676 GO:0003677 GO:0003824 GO:0003887 GO:0004518 GO:0004527 GO:0006260 GO:0008152 GO:0008408 GO:0016740 GO:0016779 GO:0016787 GO:0046872 GO:0071897 GO:0090305
11	0.06	0.300	5.83	0.04	0.47	1wn7A	GO:0000166 GO:0003676 GO:0003677 GO:0003887 GO:0006260 GO:0008408 GO:0016740 GO:0016779 GO:0071897 GO:0090305
12	0.06	0.293	6.25	0.06	0.48	3cuzA	GO:0003824 GO:0004474 GO:0005737 GO:0006097 GO:0006099 GO:0016740
13	0.06	0.255	6.82	0.05	0.46	2rh4B	GO:0016491 GO:0017000 GO:0055114
14	0.06	0.283	6.79	0.04	0.50	3n5mA	GO:0003824 GO:0008483 GO:0016740 GO:0030170
15	0.06	0.258	7.13	0.05	0.48	2qpxA	GO:0016787 GO:0046872
16	0.06	0.234	5.71	0.07	0.36	1q7rA	GO:0004359 GO:0006541 GO:0006543 GO:0016787 GO:0016829 GO:0036381 GO:0042819 GO:0042823
17	0.06	0.251	6.63	0.03	0.44	4cukB	GO:0000166 GO:0008152 GO:0008720 GO:0016491 GO:0016616 GO:0051287 GO:0055114
18	0.06	0.224	5.61	0.06	0.34	4aqyD	GO:0003723 GO:0003735 GO:0005622 GO:0005840 GO:0006412 GO:0015935 GO:0019843 GO:0030529 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0009982	GO:0003723	GO:0019239
GO-Score	0.91	0.91	0.85
Biological Processes	GO:0000455	GO:0000027	GO:0031119
GO-Score	0.90	0.56	0.46
Cellular Component	GO:0005829
GO-Score	0.82

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.