I-TASSER results

I-TASSER results for job id Rv1534

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (225 residues)
MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADIAKQAGLAYGLIYWYF
DSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVK
LLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQL
AHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Prediction	CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
Conf.Score	999999999998656799999999999999999988655789999999899877877767999999999999999999999999999789997777999999999999999997757888888766668999999999999999999999999999989999889999999999999999999866899999999999999999998757888887788877889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART
Prediction	866566666544576535523633450146051432124034564453463243045244541243123203410440252035115736654454024002200310031036233102000100442464025204501540251045015302743504723030002021110001021113476513143003101402551543544366675666668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MSRASARRRRAVSDEDKSQRRDEILAAAKIVFAHKGFHATTVADIAKQAGLAYGLIYWYFDSKDDLFHALMAGEEEALRAHVAAELARVGGSTEAPLRALLQAAVQATFEFFETDKATVKLLFRDAYALGGRFEEHLGGIYERFIDDIEAVVVAAQRRGEVVEAPSRMAAYTLAALVGQLAHRRLNTDDNVTAAQVADFVVSLVLDGLRPRALAVGARGGRAART

3himB

0.19

0.16

0.85

2.26

MUSTER

LGTS--------------KAAARIRAAAIEVFAAKGYGATTTREIAASLDMSPGAVYPHYKTKESLLYAISLEGHHSVLAAITAAD-----FPDIAAPDRLMSTVTAYVTWHADNRASARVGQYELRSLSPEHFAIIADIRRSTTKVFTRIIEAGATAGDFHPFDIEAAALAITSLGIDVSRWF-PSHTYSDPRIIAARYVELALRMVGCAD-------------

4w97A

0.24

0.21

0.87

2.29

dPPAS

-----------RVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTAN-----PLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLSQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPDLDVDLVYRFIRDTTWVSVRWYRPGGPLTAQQVGQQYLAIVLGGITKE--------------

3himB

0.19

0.16

0.85

2.63

wdPPAS

LGTS--------------KAAARIRAAAIEVFAAKGYGATTTREIAASLDMSPGAVYPHYKTKESLLYAISLEGHHSVLAAITAAD-----FPDIAAPDRLMSTVTAYVTWHADNRASARVGQYELRSLSPEHFAIIADIRRSTTKVFTRIIEAGATAGDFHPFDIEAAALAITSLGIDVSRWF-PSHTYSDPRIIAARYVELALRMVGCAD-------------

3himB

0.19

0.16

0.85

2.58

wMUSTER

--------------LGTSKAAARIRAAAIEVFAAKGYGATTTREIAASLDMSPGAVYPHYKTKESLLYAISLEGHHSVLAAITAAD-----FPDIAAPDRLMSTVTAYVTWHADNRASARVGQYELRSLSPEHFAIIADIRRSTTKVFTRIIEAGATAGDFHPFDIEAAALAITSLGIDVSRWF-PSHTYSDPRIIAARYVELALRMVGCAD-------------

3himB

0.19

0.16

0.85

2.72

wPPAS

LGTS--------------KAAARIRAAAIEVFAAKGYGATTTREIAASLDMSPGAVYPHYKTKESLLYAISLEGHHSVLAAITAAD-----FPDIAAPDRLMSTVTAYVTWHADNRASARVGQYELRSLSPEHFAIIADIRRSTTKVFTRIIEAGATAGDFHPFDIEAAALAITSLGIDVSRWF-PSHTYSDPRIIAARYVELALRMVGCAD-------------

4w97A

0.23

0.20

0.86

3.02

dPPAS2

-----------RVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTAN-----PLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLSQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPLDVDLVYRFIRDTTWVSVRW-YRPGGPLTAQQVGQQYLAIVLGGITKE--------------

4w97A

0.23

0.20

0.86

2.49

PPAS

-----------RVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTAN-----PLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLSQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPLDVDLVYRFIRDTTWVSVR--YRPGGPLTAQQVGQQYLAIVLGGITKE--------------

4w97A

0.23

0.20

0.86

3.31

Env-PPAS

-----------RVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTAN-----PLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLSQPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPLDVDLVYRFIRDTTWVSVRW-YRPGGPLTAQQVGQQYLAIVLGGITKE--------------

4w97A

0.23

0.20

0.86

2.24

MUSTER

-----------RVAGQVNSRRGELLELAAAMFAERGLRATTVRDIADGAGILSGSLYHHFASKEEMVDELLRGFLDWLFARYRDIVDSTAN-----PLERLQGLFMASFEAIEHHHAQVVIYQDEAQRLASPRFSYIEDRNKQQRKMWVDVLNQGIEEGYFRPLDVDLVYRFIRDTTWVSVR--YRPGGPLTAQQVGQQYLAIVLGGITKE--------------

3himB

0.19

0.16

0.85

2.29

dPPAS

--------------LGTSKAAARIRAAAIEVFAAKGYGATTTREIAASLDMSPGAVYPHYKTKESLLYAISLEGHHSVLAAITAAD-----FPDIAAPDRLMSTVTAYVTWHADNRASARVGQYELRSLSPEHFAIIADIRRSTTKVFTRIIEAGATAGDFHPFDIEAAALAITSLGIDVSRWF-PSHTYSDPRIIAARYVELALRMVGCAD-------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.47

Estimated TM-score = 0.65±0.13

Estimated RMSD = 6.6±4.0Å

Download Model 2

C-score=-0.84

Download Model 3

C-score=-2.62

Download Model 4

C-score=-0.88

Download Model 5

C-score=-3.02

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3himB	0.794	1.62	0.193	0.853
2	4w97A	0.761	2.27	0.237	0.862
3	3vprA	0.730	2.35	0.212	0.813
4	5e57A	0.719	2.79	0.195	0.858
5	3e7qB	0.695	3.16	0.164	0.844
6	3ccyA	0.695	2.72	0.189	0.796
7	4g12A	0.695	2.72	0.234	0.813
8	4udsA	0.690	2.41	0.254	0.782
9	5dxzA	0.688	2.79	0.193	0.818
10	4mo7A	0.687	2.89	0.188	0.827

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.18	44	3q3sA	O8B	Rep, Mult	82,101,104,105,108,112,119,123,137,141,144,147,148,174,177,178,181,182,204
2	0.07	18	4dw6A	0MN	Rep, Mult	82,101,104,105,108,112,137,141,147,148,151,174,177,178,181,182,204
3	0.07	16	3br5A	RHQ	Rep, Mult	71,74,75,78,81,112,119,140,144,177
4	0.06	14	5eyrA	5T0	Rep, Mult	82,85,100,101,104,105,108,141,144,147,174,177,204
5	0.04	9	1vi0A	DCC	Rep, Mult	71,74,75,108,111,120,125,138,141,142,145,167,168,170,171,174
6	0.03	5	1jt0C	QNA	Rep, Mult	40,41,42,53,57,62,63
7	0.03	6	3angD	DCC	Rep, Mult	179,183,187,188,190,191
8	0.03	6	1jt0D	QNA	Rep, Mult	19,20,50,51,52,53,54,55,58,59
9	0.02	5	1qvuA	ET	Rep, Mult	120,123,127,141,144,174
10	0.02	5	1rkwA	PNT	Rep, Mult	74,77,78,81,104,108,111,112,115,148,174,177,178
11	0.01	3	3btjB	DEQ	Rep, Mult	118,121,182,183
12	0.01	2	3qqaA	TCH	Rep, Mult	71,78,112,122,135,140
13	0.01	3	2i10B	NPO	Rep, Mult	141,142,171
14	0.01	2	3lsjA	COA	Rep, Mult	97,100,157,205,206,209
15	0.01	2	2nx40	III	Rep, Mult	29,117,120,121,127,128,138,145,165,167,168,171,172,175,176,179,180,182,183,195,198,199,202,203
16	0.00	1	2eh3A	MG	Rep, Mult	103,106
17	0.00	1	3btjB	DEQ	Rep, Mult	28,31,66,67
18	0.00	1	1vi0B	DCC	Rep, Mult	168,171,172,175,176,201
19	0.00	1	2np5C	NDS	Rep, Mult	46,47,49,52
20	0.00	1	3locA	URA	Rep, Mult	183

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3hmkB	0.440	5.10	0.060	0.689	5.1.1.18	152,216
2	0.060	1f2dA	0.451	5.56	0.038	0.760	3.5.99.7	57
3	0.060	2gn0C	0.435	5.13	0.102	0.689	4.3.1.19	NA
4	0.060	1y7lA	0.434	5.29	0.066	0.693	2.5.1.47	NA
5	0.060	1z7wA	0.445	5.06	0.049	0.689	2.5.1.47	NA
6	0.060	1ygpA	0.441	5.78	0.054	0.742	2.4.1.1	NA
7	0.060	1ve1A	0.443	5.04	0.075	0.689	2.5.1.47	NA
8	0.060	1ve5A	0.445	4.88	0.085	0.684	4.3.1.19	NA
9	0.060	3djlA	0.440	4.75	0.092	0.644	1.3.99.-	NA
10	0.060	1s6yA	0.449	4.97	0.038	0.680	3.2.1.86	82
11	0.060	1up7A	0.445	5.00	0.052	0.698	3.2.1.86	123
12	0.060	2i2xA	0.467	4.59	0.096	0.680	2.1.1.90	36
13	0.060	2q3dA	0.440	5.10	0.067	0.684	2.5.1.47	NA
14	0.060	1tzmC	0.457	5.69	0.048	0.769	3.5.99.7	32
15	0.060	2dh6A	0.403	5.83	0.048	0.680	4.2.1.20	NA
16	0.060	1x1qB	0.432	5.96	0.074	0.756	4.2.1.20	35
17	0.060	1p5jA	0.449	5.36	0.071	0.716	4.3.1.17	NA
18	0.060	1ve5D	0.429	5.04	0.093	0.662	4.3.1.19	NA
19	0.060	1b8fA	0.447	5.56	0.042	0.707	4.3.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.44	0.626	3.65	0.18	0.82	4l62A	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355
1	0.40	0.579	4.11	0.14	0.81	3hggA	GO:0003677 GO:0006351 GO:0006355
2	0.40	0.638	3.23	0.17	0.81	3ppbA	GO:0003677 GO:0006351 GO:0006355
3	0.39	0.625	3.58	0.18	0.82	3vibC	GO:0003677 GO:0006351 GO:0006355
4	0.39	0.677	2.78	0.18	0.82	1jt0A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0045892
5	0.38	0.751	2.33	0.21	0.84	3vprA	GO:0003677 GO:0006351 GO:0006355 GO:0042802
6	0.37	0.673	2.94	0.19	0.83	3bcgA	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0008144 GO:0042493 GO:0043565 GO:0045892
7	0.37	0.696	2.34	0.23	0.80	3f1bA	GO:0003677 GO:0006351 GO:0006355
8	0.36	0.492	4.56	0.13	0.71	2np3B	GO:0003677 GO:0006351 GO:0006355
9	0.34	0.676	2.90	0.20	0.82	3whcA	GO:0003677 GO:0005737 GO:0006351 GO:0006355 GO:0006629 GO:0006631 GO:0016042
10	0.34	0.716	2.95	0.18	0.83	3ccyA	GO:0003677 GO:0006351 GO:0006355
11	0.33	0.650	3.24	0.18	0.82	2wuiA	GO:0003677 GO:0006351 GO:0006355
12	0.33	0.761	2.27	0.24	0.86	4w97A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0010468 GO:0019217
13	0.32	0.648	3.14	0.15	0.81	3dewA	GO:0003677 GO:0006351 GO:0006355 GO:0016020 GO:0016021
14	0.32	0.693	2.89	0.18	0.84	3lhqA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
15	0.32	0.712	2.97	0.20	0.86	4pxiB	GO:0003677 GO:0006351 GO:0006355
16	0.31	0.658	2.78	0.18	0.79	2iaiA	GO:0003677 GO:0006351 GO:0006355
17	0.30	0.705	2.95	0.17	0.83	4mxmA	GO:0003677 GO:0006351 GO:0006355
18	0.30	0.634	3.47	0.15	0.82	3lwjA	GO:0003677 GO:0006351 GO:0006355
19	0.30	0.641	3.41	0.18	0.81	3on4A	GO:0003677 GO:0006351 GO:0006355
20	0.29	0.528	4.00	0.17	0.72	4hkuA	GO:0003677 GO:0006351 GO:0006355
21	0.29	0.647	3.41	0.19	0.83	2uxhA	GO:0003677 GO:0006351 GO:0006355
22	0.29	0.584	3.29	0.16	0.75	4aciB	GO:0000287 GO:0003677 GO:0006351 GO:0006355 GO:0046872
23	0.28	0.794	1.62	0.19	0.85	3himB	GO:0003677 GO:0006351 GO:0006355
24	0.28	0.652	2.88	0.13	0.80	2zcnD	GO:0003677 GO:0006351 GO:0006355
25	0.28	0.614	3.50	0.17	0.79	3mvpA	GO:0003677 GO:0006351 GO:0006355
26	0.28	0.647	3.29	0.20	0.81	3dcfA	GO:0003677 GO:0006351 GO:0006355
27	0.27	0.594	3.65	0.13	0.78	3f0cA	GO:0003677 GO:0006351 GO:0006355
28	0.27	0.643	3.19	0.20	0.81	4me9A	GO:0003677 GO:0006351 GO:0006355
29	0.27	0.666	3.32	0.16	0.84	5dy0A	GO:0003677 GO:0006351 GO:0006355
30	0.26	0.614	3.40	0.12	0.78	2hytA	GO:0003677 GO:0006351 GO:0006355
31	0.26	0.681	2.87	0.27	0.82	2ibdA	GO:0003677 GO:0006351 GO:0006355
32	0.26	0.519	3.96	0.19	0.71	2qwtA	GO:0003677 GO:0006351 GO:0006355
33	0.26	0.695	3.11	0.12	0.85	3nnrA	GO:0003677 GO:0006351 GO:0006355
34	0.26	0.657	3.02	0.20	0.82	2genA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
35	0.24	0.659	3.36	0.17	0.84	2id6A	GO:0003677 GO:0006351 GO:0006355
36	0.24	0.658	3.33	0.19	0.83	3s5rA	GO:0003677 GO:0006351 GO:0006355
37	0.24	0.649	3.47	0.17	0.84	3qbmA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
38	0.24	0.573	4.47	0.18	0.83	1rktA	GO:0003677 GO:0006351 GO:0006355
39	0.23	0.667	2.85	0.18	0.80	2np5A	GO:0003677 GO:0006351 GO:0006355
40	0.23	0.586	3.65	0.10	0.77	3ni7A	GO:0003677 GO:0006351 GO:0006355
41	0.23	0.629	3.54	0.13	0.82	3eupA	GO:0003677 GO:0006351 GO:0006355
42	0.23	0.500	4.34	0.11	0.72	2of7A	GO:0003677 GO:0006351 GO:0006355
43	0.23	0.642	2.57	0.16	0.75	2eh3A	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0046872
44	0.22	0.696	3.41	0.18	0.88	3p9tA	GO:0003677 GO:0006351 GO:0006355
45	0.22	0.600	3.53	0.17	0.78	3cdlB	GO:0003677 GO:0006351 GO:0006355
46	0.22	0.534	3.72	0.14	0.72	3bniA	GO:0003677 GO:0006351 GO:0006355
47	0.21	0.538	4.23	0.11	0.74	3b81A	GO:0003677 GO:0006351 GO:0006355
48	0.21	0.561	3.42	0.13	0.72	3cjdA	GO:0003677 GO:0006351 GO:0006355
49	0.21	0.672	3.49	0.17	0.85	3rh2A	GO:0003677 GO:0006351 GO:0006355
50	0.20	0.601	3.88	0.13	0.81	3bhqA	GO:0003677 GO:0006351 GO:0006355
51	0.20	0.593	3.84	0.12	0.80	5d18A	GO:0003677 GO:0006351 GO:0006355
52	0.19	0.585	4.10	0.13	0.82	3gziA	GO:0003677 GO:0006351 GO:0006355
53	0.19	0.651	3.16	0.12	0.82	3geuA	GO:0003677 GO:0006351 GO:0006355
54	0.19	0.527	3.95	0.09	0.73	3zqfA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
55	0.18	0.557	3.81	0.09	0.76	3zqgA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
56	0.18	0.597	3.94	0.14	0.80	3angC	GO:0003677 GO:0006351 GO:0006355
57	0.17	0.535	3.81	0.10	0.73	4auxA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
58	0.16	0.653	3.16	0.15	0.82	2hyjA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
59	0.15	0.553	4.37	0.13	0.79	2rasB	GO:0003677 GO:0006351 GO:0006355
60	0.14	0.594	3.56	0.14	0.78	2jj7B	GO:0003677 GO:0006351 GO:0006355 GO:0042802
61	0.10	0.510	4.04	0.10	0.69	2hxiB	GO:0003677 GO:0006351 GO:0006355 GO:0045892
62	0.07	0.597	3.55	0.11	0.78	2zcxA	GO:0003677 GO:0006351 GO:0006355
63	0.07	0.613	3.75	0.20	0.83	2fbqA	GO:0000976 GO:0003677 GO:0003700 GO:0005829 GO:0006351 GO:0006355 GO:0044212 GO:0045893 GO:0050714
64	0.07	0.592	3.93	0.15	0.80	3dpjA	GO:0003677 GO:0006351 GO:0006355
65	0.07	0.563	4.08	0.21	0.78	2raeA	GO:0003677 GO:0006351 GO:0006355

Consensus prediction of GO terms

Molecular Function	GO:0003700	GO:0000976
GO-Score	0.66	0.44
Biological Processes	GO:0045892
GO-Score	0.39
Cellular Component	GO:0005829
GO-Score	0.44

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.