I-TASSER results

I-TASSER results for job id Rv1533

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (375 residues)
MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRLESELTWIEEHTGG
KPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVRYGIPAVTDRQRSSSAG
GLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHA
AAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAAGGIARGRQIAAALALGAE
GVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARMLRTAWTDEWDRPDSP
DPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVGSLDRVRSARSVVLDMVE
EFIDTVGQLQGLVQR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAAGGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR
Prediction	CCCHHHHHHCCCCCEEHCCCCHHHHHHHHHCCCCCEHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHCCEEEEHCCCHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEHCCCCCHHHHHHHHHHCCCEEEHCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEHCCCCCCEEEHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	988888998999876865788999999998598544345689999999999999999689986678886899887655555578888888899999888877776887776667777666656688759999999999899999995899989999999998998999759999999999989999999588888888888755799999998799979986888999999999998997588535777678668999999999979998789984556986566467999999986566788885777665568999998756666666554543355788874678899999999999999999999999879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAAGGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR
Prediction	761400520413000000001140000004010000000021205302500540272066300000000013233454434414313421342235204511352504324444444323212233540340021016260300000011025300420272401000001016103301712000000002000113152420000320063047000000000110400020020000000000000004106127401510360564100001001320000000400540372555413524134212442432144232544432231000000000110561520340053205203400530360178
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHCCCCCEEHCCCCHHHHHHHHHCCCCCEHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHCCEEEEHCCCHHHHHHHHHHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEHCCCCCHHHHHHHHHHCCCEEEHCHHHHHCCCCCCCHHHHHHHHHCCCCCEEEEHCCCCCCEEEHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
MRTRVAELLGAEFPICAFSHCRDVVAAVSNAGGFGILGAVAHSPKRLESELTWIEEHTGGKPYGVDVLLPPKYIGAEQGGIDAQQARELIPEGHRTFVDDLLVRYGIPAVTDRQRSSSAGGLHISPKGYQPLLDVAFAHDIRLIASALGPPPPDLVERAHNHDVLVAALAGTAQHARRHAAAGVDLIVAQGTEAGGHTGEVATMVLVPEVVDAVSPTPVLAAGGIARGRQIAAALALGAEGVWCGSVWLTTEEAETPPVVKDKFLAATSSDTVRSRSLTGKPARMLRTAWTDEWDRPDSPDPLGMPLQSALVSDPQLRINQAAGQPGAKARELATYFVGQVVGSLDRVRSARSVVLDMVEEFIDTVGQLQGLVQR

4q4kA

0.25

0.23

0.90

2.76

MUSTER

MTDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEPPVR------LKNIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4q4kA

0.25

0.23

0.90

3.75

dPPAS

MTDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEP------PVRLKNIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4q4kA

0.25

0.23

0.90

4.38

wdPPAS

MTDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEPPVRLK------NIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4q4kA

0.25

0.23

0.90

3.10

wMUSTER

-TDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEPPVRLK------NIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4q4kA

0.25

0.23

0.90

4.41

wPPAS

MTDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEPPVRLK------NIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4q4kA

0.25

0.23

0.90

6.40

dPPAS2

MTDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEP------PVRLKNIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4q4kA

0.25

0.23

0.90

4.10

PPAS

MTDRFTRLLGIQQPIIQAPMTPALAAAVSNAGGLGSIAITGSAAEKGRALIREVRGLTD-KPFNVNLFCHRPGQAD-----------PARERAWLDYLKPLFAEFGAEP------PVRLKNIYLSFLEDPTLLPMLLEERPAAVSFHFGAPPRDQVRALQAVGIRVLVCATTPEEAALVEAAGADAVVAQGIEAGGHRGAIGTLALVRLLAARG-SLPVVAAGGIMDGRGIRAALELGASAVQMGTAFVLCPESSANAAYREALKGPRAARTALTVTMSGRSARGLPNRMFFDAAAPGVPPLPDYPFVYDATKALQTAALAR------GNHDFAAQWAGQGAALAREL-PAAELLRTLVEELRG-----------

4iqlA

0.31

0.25

0.82

6.15

Env-PPAS

M-NRICELLGIEHPIISGGMGWKLASAVSNGG-LGLIGAGSMHPDNLEHHIRSCKAATD-KPFGVNVPLL-------------------------------------------------------YPEMDKIMEIIMREHVPVVVTSAGSPK-VWTAKLKAAGSKVIHVVSSATFARKSEAAGVDAIVAEGFEAGGHNGETTTLCLIPEVVDAVN-IPVVAAGGIASGRAVAAALALGADAVQVGTRFALSEESSAHEDFKAHCRRSVEGDTMLSL-KAVSPTRLLKNKFYQDVFAAEQRGASVEELRELLGRGRAKQGIFE------GDLHEGELEIGQAVSQISHAETVAEIMVDLVDGYKRSLAGMPTEI--

3bw3A

0.28

0.25

0.88

2.60

MUSTER

--SALTDLFPL--PIVQAPMVPQLAAAVCEAGGLGFLAAGYKTADGMYQEIKRLRGLTG-RPFGVNVFMPQPEL--------------GAVEVYAHQLAGEAAWYETELGDPDGG---------RDDGYDAKLAVLLDDPVPVVSFHFGVPDREVIARLRRAGTLTLVTATTPEEARAVEAAGADAVIAQGVEAGGDQGGIGLLSLLAQVREAV-DIPVVAAGGIMRGGQIAAVLAAGADAAQLGTAFLATDESGAPGPHKRALTDPLFARTRLTRAFTGRPARSLVNRFLREHGPYA---PAAYPDVHHLTSPLRKAAAKA------GDAQGMALWAGQGHRMAREL-PAGRLVEVLAAELAEARTAL------

3bw3A

0.28

0.25

0.88

3.51

dPPAS

--SALTDLFPL--PIVQAPMVPQLAAAVCEAGGLGFLAAGYKTADGMYQEIKRLRGLTG-RPFGVNVFMPQPEL--------------GAVEVYAHQLAGEAAWYET---------ELGDPDGGRDDGYDAKLAVLLDDPVPVVSFHFGVPDREVIARLRRAGTLTLVTATTPEEARAVEAAGADAVIAQGVEAGGDQGTIGLLSLLAQVREAV-DIPVVAAGGIMRGGQIAAVLAAGADAAQLGTAFLATDESGAPGPHKRALTDPLFARTRLTRAFTGRPARSLVNRFLREHGPYA---PAAYPDVHHLTSPLRKAAAKA------GDAQGMALWAGQGHRMAREL-PAGRLVEVLAAELAEARTAL------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.13

Estimated TM-score = 0.87±0.07

Estimated RMSD = 4.3±2.9Å

Download Model 2

C-score=-0.89

Download Model 3

C-score=-4.95

Download Model 4

C-score=-2.31

Download Model 5

C-score=-1.42

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4q4kA	0.885	0.98	0.251	0.901
2	3bw3A	0.817	2.17	0.273	0.880
3	2gjlA	0.741	3.06	0.284	0.835
4	4z9rA	0.734	3.30	0.160	0.848
5	4z38A	0.731	3.13	0.175	0.837
6	4iqlA	0.724	2.92	0.304	0.808
7	3hmjG	0.718	3.22	0.151	0.829
8	3bo9A	0.716	2.56	0.348	0.787
9	2uvcG	0.716	3.31	0.157	0.835
10	2z6iB	0.715	2.96	0.281	0.797

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.64	30	3bw2A	FMN	Rep, Mult	17,18,19,66,68,147,190,194,195,196,223,224,243,245,246,249,337,339
2	0.06	4	2z6jA	TUI	Rep, Mult	68,70,148,149,169,171,175,190,197
3	0.04	2	4qitA	NIE	Rep, Mult	68,196,197,337
4	0.03	2	4qiuB	N1P	Rep, Mult	68,123,197,309,337
5	0.03	2	2z6iA	CA	Rep, Mult	211,214,215
6	0.02	2	1b3oA	SAE	Rep, Mult	172,173,189,190,191,206,222,245
7	0.02	1	2z6iA	CA	Rep, Mult	190,197
8	0.01	1	3bw3A	NIE	Rep, Mult	41,309,316,337

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.380	2gjlA	0.741	3.06	0.284	0.835	1.13.12.16	196,199,245,249,283
2	0.160	1xi3B	0.451	2.82	0.172	0.512	2.5.1.3	66,223
3	0.153	1xi3A	0.452	2.79	0.172	0.512	2.5.1.3	NA
4	0.104	2v81A	0.457	2.95	0.184	0.523	4.1.2.21	NA
5	0.087	1vlwB	0.450	2.96	0.117	0.517	4.1.3.16	NA
6	0.066	1g69B	0.461	3.15	0.147	0.536	2.5.1.3	NA
7	0.060	2z1kA	0.506	5.00	0.052	0.685	3.2.1.41	NA
8	0.060	2a1yA	0.539	3.43	0.148	0.629	1.7.1.7	223,227,246,336
9	0.060	3gbdA	0.544	5.39	0.050	0.749	5.4.99.11	NA
10	0.060	1eh9A	0.508	5.30	0.081	0.696	3.2.1.141	185
11	0.060	1izjA	0.508	4.93	0.037	0.675	3.2.1.135,3.2.1.1	142
12	0.060	3bw4A	0.822	2.11	0.275	0.883	1.7.3.1	190,194,196,222,225,230,239,245,249,272
13	0.060	2pffB	0.692	3.43	0.086	0.816	2.3.1.86	171,183
14	0.060	3a47A	0.544	5.44	0.058	0.757	3.2.1.10	NA
15	0.060	2cu0A	0.568	4.08	0.141	0.680	1.1.1.205	147,223,225
16	0.060	2fhbA	0.509	5.67	0.092	0.725	3.2.1.41	NA
17	0.060	2uv8G	0.719	3.44	0.151	0.837	2.3.1.86	NA
18	0.060	2c6qG	0.555	3.89	0.125	0.669	1.7.1.7	198,223
19	0.060	1eepB	0.544	3.66	0.140	0.637	1.1.1.205	146,223
20	0.060	2z6iB	0.715	2.96	0.281	0.797	1.3.1.9	38,194,196,203,223,225,245,340
21	0.060	2wkgA	0.518	4.96	0.040	0.696	3.2.1.54	NA
22	0.060	1s46A	0.517	5.30	0.060	0.715	2.4.1.4	185
23	0.060	2vkzG	0.718	3.22	0.151	0.829	2.3.1.38,3.1.2.14	147,196,246
24	0.060	1g5aA	0.518	5.50	0.060	0.733	2.4.1.4	NA
25	0.060	1jcnB	0.539	2.86	0.185	0.605	1.1.1.205	223,246

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.41	0.735	2.66	0.34	0.81	3bo9A	GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0055114
1	0.40	0.885	0.98	0.25	0.90	4q4kA	GO:0000166 GO:0003824 GO:0018580 GO:0055114
2	0.39	0.821	2.13	0.28	0.88	3bw2A	GO:0000166 GO:0003824 GO:0018580 GO:0051213 GO:0055114
3	0.35	0.724	2.92	0.30	0.81	4iqlA	GO:0000166 GO:0003824 GO:0018580 GO:0055114
4	0.28	0.735	3.05	0.28	0.82	2z6iB	GO:0000166 GO:0003824 GO:0004318 GO:0016491 GO:0018580 GO:0051213 GO:0055114
5	0.26	0.741	3.06	0.28	0.83	2gjlA	GO:0003824 GO:0004497 GO:0016491 GO:0018580 GO:0055114
6	0.25	0.709	3.09	0.18	0.81	4cw5B	GO:0000166 GO:0003824 GO:0004314 GO:0008152 GO:0016740 GO:0018580 GO:0055114
7	0.21	0.576	3.90	0.17	0.69	1zfjA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
8	0.16	0.581	3.68	0.17	0.69	1nf7A	GO:0000166 GO:0003677 GO:0003723 GO:0003824 GO:0003938 GO:0005634 GO:0005737 GO:0005778 GO:0005829 GO:0006164 GO:0006177 GO:0009168 GO:0016020 GO:0016491 GO:0046651 GO:0046872 GO:0051289 GO:0055114 GO:0060041 GO:0070062 GO:0071353
9	0.15	0.522	2.73	0.19	0.58	1b3oA	GO:0000166 GO:0003677 GO:0003723 GO:0003824 GO:0003938 GO:0005634 GO:0005737 GO:0005778 GO:0005829 GO:0006164 GO:0006177 GO:0009168 GO:0016020 GO:0016491 GO:0046651 GO:0046872 GO:0051289 GO:0055114 GO:0060041 GO:0070062 GO:0071353
10	0.14	0.573	3.65	0.18	0.67	4mz1C	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
11	0.13	0.384	4.47	0.08	0.49	4qq3A	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0009152 GO:0016491 GO:0046872 GO:0055114
12	0.12	0.561	3.28	0.17	0.65	1nfbA	GO:0000166 GO:0003677 GO:0003723 GO:0003824 GO:0003938 GO:0005634 GO:0005737 GO:0005778 GO:0005829 GO:0006164 GO:0006177 GO:0009168 GO:0016020 GO:0016491 GO:0046651 GO:0046872 GO:0051289 GO:0055114 GO:0060041 GO:0070062 GO:0071353
13	0.12	0.539	3.57	0.17	0.63	4avfD	GO:0000166 GO:0003824 GO:0003938 GO:0005524 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
14	0.11	0.553	3.67	0.19	0.65	1vrdA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
15	0.07	0.491	3.09	0.22	0.56	2cdh0
16	0.07	0.539	3.43	0.15	0.63	2a1yA	GO:0003824 GO:0003920 GO:0004152 GO:0006163 GO:0006207 GO:0016491 GO:0055114 GO:1902560
17	0.07	0.582	3.59	0.17	0.68	1jr1B	GO:0000166 GO:0003824 GO:0003938 GO:0005634 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
18	0.07	0.603	4.09	0.15	0.73	4af0A	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
19	0.07	0.585	3.83	0.15	0.69	4z0gB	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0005829 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
20	0.07	0.574	3.52	0.18	0.67	5ahmA	GO:0000166 GO:0003824 GO:0003938 GO:0005524 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
21	0.07	0.524	3.73	0.15	0.61	3ffsB	GO:0003824 GO:0003938 GO:0005737 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
22	0.07	0.582	3.58	0.14	0.68	4z87A	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0005829 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0018580	GO:0000166	GO:0004318	GO:0051213
GO-Score	0.90	0.83	0.57	0.56
Biological Processes	GO:0055114
GO-Score	0.90
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.