I-TASSER results

I-TASSER results for job id Rv1525

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (261 residues)
MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDYPRIGTERVSTPGENLG
WAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRLPADAGMVGPMFDVGFPFA
VADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGGMDLSTFGRYGWGLDLDLALR
ARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGASAAMIRGLRRTHGWPAAMGILRE
MGMAHHRKWHKSFPLTCPASC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDYPRIGTERVSTPGENLGWAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRLPADAGMVGPMFDVGFPFAVADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGGMDLSTFGRYGWGLDLDLALRARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGASAAMIRGLRRTHGWPAAMGILREMGMAHHRKWHKSFPLTCPASC
Prediction	CCCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHCCCCEEEEHCCCEHCCCCHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCEEHCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCEEEHCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
Conf.Score	999998689999769999999999999996998699986999998777589996899887647899999999847998899985985658999999999998999868866546788654567788765567887656645344457777599999988999777665545546799999999899899968689999767558998876889999999999999746555679999999999999988764676567889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDYPRIGTERVSTPGENLGWAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRLPADAGMVGPMFDVGFPFAVADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGGMDLSTFGRYGWGLDLDLALRARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGASAAMIRGLRRTHGWPAAMGILREMGMAHHRKWHKSFPLTCPASC
Prediction	875241500000012432520340050234451534423410537314303003175221001001200320475613000001030203540035305114534000000002112010103324424422554423301000032254315037506140340002101000000002234240300001402011333222445343212112202200220243431300000021002012230343130304357
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCEEEEHCCCCCCCCHHHHHHHHHHHHCCCCEEEEHCCCEHCCCCHHHHHHHHHHCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCEEHCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHCCEEEHCCCEEEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
MYAPLVSLMITVPVFGQHEYTHALVADLEREGADYLIVDNRGDYPRIGTERVSTPGENLGWAGGSELGFRLAFAEGYSHAMTLNNDTRVSKGFVAALLDSRLPADAGMVGPMFDVGFPFAVADEKPDAESYVPRARYRKVPAVEGTALVMSRDCWDAVGGMDLSTFGRYGWGLDLDLALRARKSGYGLYTTEMAYINHFGRKTANTHFGGHRYHWGASAAMIRGLRRTHGWPAAMGILREMGMAHHRKWHKSFPLTCPASC

4fixA

0.15

0.14

0.98

1.83

MUSTER

TSPAPANIAVGIPTFNRPADCVNALRELTADPLAVIVPDQGERHPDFPRLSIHDQ-PNLGGSGGYSRVMYEALKNDCQQILFMDDDIRLEPDSILRVLAMHRFKAPMLVGGQMLNLQEPSHAPHAEYDHDFAEYPRRIDVDYNGWWTCMIPRQVAEELGQPLPLF----IKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKDDAID-WQAYFHLRNRLVVAAMHWDGPKQVIGLVRSHLKATLKHLACLEYSTVAIQN

2z86C1

0.13

0.10

0.77

3.18

dPPAS

DQLIIDGLSIVIPTYNRAKILAITLACLCNYDYEVIVADDGSKENSLLNIKYVRQKYGYQLCAVRNLGLRAAKY---NYVAILDCDMAPNPLWVQSYMELLAVDNVALIGPRKYIDTSKHTYLDFLSQKSLINEIPEIITNFFSGGNVAFAKKWLFRAGWFDEEF--THWGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPPGKE--------------------------------------------------------

4fixA3

0.18

0.14

0.76

4.91

wdPPAS

---GTANIAVGIPTFNRPADCVNALRELTADPLAVIVPDQGERKVRLGSRLSIHDQPNLGGSGGYSRVMYEALKNDCQQILFMDDDIRLEPDSILRVLAMHRFKAPMLVGGQMLNLQEPAPHAEYDHDFAEYPLNDRIDVDYNGWWTCMIPRQVAEELG-QPLPLF---IKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKD--------------------------------------------------------

4fixA

0.16

0.98

2.45

wMUSTER

SPAPTANIAVGIPTFNRPADCVNALRELTADPLAVIVPDQGERKPDFPRLSIHDQ-PNLGGSGGYSRVMYEALKNDCQQILFMDDDIRLEPDSILRVLAMHRFKAPMLVGGQMLNLQEPSHAPHAEYDHDFAEYPRRIDVDYNGWWTCMIPRQVAEELG-QPLPLF---IKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKDDAID-WQAYFHLRNRLVVAAMHWDGPKQVIGLVRSHLKATLKHLACLEYSTVAIQN

2z86C1

0.14

0.11

0.77

3.33

wPPAS

LDDQIDGLSIVIPTYNRAKILAITLACLCNQDYEVIVADDGSKENILLNIKYVRQKYGYQLCAVRNLGLRAAKY---NYVAILDCDMAPNPLWVQSYMELLAVDNVALIGPRKYIDTSKSLINEIPEIITNQNRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFTH--WGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPPGKE--------------------------------------------------------

2z86C1

0.13

0.10

0.76

6.71

dPPAS2

LI--IDGLSIVIPTYNRAKILAITLACLCNYDYEVIVADDGSKENSLLNIKYVRQKYGYQLCAVRNLGLRAAKY---NYVAILDCDMAPNPLWVQSYMELLAVDNVALIGPRKYKSLINEIPEIITNQNKDNLRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEF--THWGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPP--GKE------------------------------------------------------

2z86C1

0.13

0.10

0.77

2.53

PPAS

LDDQIDGLSIVIPTYNRAKILAITLACLCNYDYEVIVADDGSKENSLLNIKYVRQKYGYQLCAVRNLGLRAAKY---NYVAILDCDMAPNPLWVQSYMELLAVDNVALIGPRKYKSLINEIPEIITNQNKDNLRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFTH--WGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPPGKE--------------------------------------------------------

2z86C1

0.14

0.11

0.77

2.69

Env-PPAS

LDDQIDGLSIVIPTYNRAKILAITLACLCNYDYEVIVADDGSKENSLLNIKYVRQKYGYQLCAVRNLGLRAAKY---NYVAILDCDMAPNPLWVQSYMELLAVDNVALIGPRKYIDTSKSLINEIPEIITDNLRLCNTPFRFFSGGNVAFAKKWLFRAGWFDEEFT--HWGGEDNEFGYRLYREGCYFRSVEGAMAYHQEPPGKE--------------------------------------------------------

2ffuA

0.16

0.15

0.96

1.72

MUSTER

WRVDLPATSVVITFHNARSALLRTVVSVLKKSPEIILVDDYSNDPKIEKVRVLRNDRREGLMRSRVRGADAA---QAKVLTFLDSHCECNEHWLEPLLERVAEDRTRVVSPIIDVINMDNFQYVGASADLKGNPVAPIKTPMIAGGLFVMDKFYFEELGKYDMMMDV--WGGENLEISFRVWQCGGSLEIIPCSRVGHVFRKQHPYTFPGGSGTVFARNTRRAAEVWMDEYKNFYYAAVPSAIQSRLELRKKL------SC

4fixA3

0.17

0.13

0.75

3.06

dPPAS

---GTANIAVGIPTFNRPADCVNALRELTADPGAVIVPDQGERKVRDHPLSIHDQP-NLGGSGGYSRVMYEALKNDCQQILFMDDDIRLEPDSILRVLAMHRFKAPMLVGGQMLNLQPHAEYDHDFAEYPLNDNNRRIDVDYNGWWTCMIPRQVAEELGQPL----PLFIKWDDADYGLRAAEHGYPTVTLPGAAIWHMAWSDKD--------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.11

Estimated TM-score = 0.73±0.11

Estimated RMSD = 5.7±3.6Å

Download Model 2

C-score=-1.12

Download Model 3

C-score=-2.44

Download Model 4

C-score=-3.53

Download Model 5

C-score=-3.73

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ffuA	0.858	2.65	0.150	0.973
2	2d7rA1	0.852	2.46	0.140	0.958
3	1xhbA	0.810	2.73	0.116	0.923
4	4fixA	0.808	2.56	0.137	0.916
5	2z86C	0.744	3.80	0.128	0.919
6	4hg6A	0.691	4.02	0.143	0.870
7	5heaA	0.669	3.15	0.082	0.805
8	1h7qA	0.658	3.59	0.079	0.816
9	3f1yA	0.651	4.09	0.077	0.835
10	2wvkA	0.648	3.95	0.107	0.828

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.41	68	2d7iA	UDP	Rep, Mult	13,14,15,17,40,58,60,61,84,85,86,169,170,198,201,206
2	0.12	18	4fiyA	MN	Rep, Mult	17,84,86,198
3	0.03	6	2y4kA	GDP	Rep, Mult	13,14,15,17,38,40,60,61,64,84,85,86
4	0.01	2	2z86A	UGA	Rep, Mult	13,15,40,58,61,82,84,85,148,171,172,173,174
5	0.01	3	2fydD	NGA	Rep, Mult	61,84,87,113,142,144,145,171,173,174,198
6	0.01	1	4fiyB	UDP	Rep, Mult	15,17,40,58,60,61,169,170,171,198
7	0.01	3	3ee5A	UUU	Rep, Mult	142,143,170,171,172,174,175,219
8	0.00	1	1fgxB	U5P	Rep, Mult	15,16,17,60
9	0.00	1	2z86A	MN	Rep, Mult	86,201

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.134	1kwsA	0.562	3.76	0.068	0.701	2.4.1.135	24,86,90
2	0.130	1on8A	0.619	3.84	0.082	0.774	2.4.1.223	94
3	0.096	3f1cB	0.526	3.83	0.096	0.663	2.7.7.60	NA
4	0.067	2agdA	0.615	3.04	0.117	0.728	2.4.1.90	46
5	0.067	2px7A	0.514	3.54	0.129	0.632	2.7.7.60	13,16
6	0.067	1v82A	0.558	3.58	0.074	0.697	2.4.1.135	NA
7	0.067	1fggA	0.559	3.58	0.068	0.694	2.4.1.135	NA
8	0.067	1vgwB	0.531	3.59	0.109	0.655	2.7.7.60	17
9	0.066	1vpaA	0.534	3.35	0.086	0.647	2.7.7.60	NA
10	0.066	2vsiB	0.527	3.79	0.071	0.663	2.7.7.60	195
11	0.066	1fgxB	0.579	3.31	0.120	0.697	2.4.1.38	66
12	0.066	1h7tA	0.526	3.99	0.096	0.674	2.7.7.38	63
13	0.066	1h7eA	0.526	4.06	0.091	0.678	2.7.7.38	NA
14	0.066	2j0aA	0.527	3.67	0.095	0.659	2.4.1.222	69,86,188
15	0.066	1i52A	0.531	3.46	0.120	0.651	2.7.7.60,2.7.7.-	NA
16	0.066	3hl3A	0.541	3.39	0.086	0.667	2.7.7.24	101
17	0.066	3k8dA	0.534	3.84	0.090	0.674	2.7.7.38	101
18	0.060	1hm8A	0.555	3.70	0.071	0.694	2.7.7.23	NA
19	0.060	2d7iA	0.852	2.44	0.140	0.958	2.4.1.41	115,198
20	0.060	2d0jC	0.563	3.59	0.074	0.697	2.4.1.135	13,24,86,90,198
21	0.060	1yp3C	0.575	3.47	0.078	0.709	2.7.7.27	NA
22	0.060	3lw6A	0.574	3.74	0.122	0.713	2.4.1.133	171,173,174
23	0.060	2pa4B	0.547	3.68	0.091	0.686	2.7.7.9	NA
24	0.060	2oi6B	0.560	3.59	0.092	0.686	2.3.1.157,2.7.7.23	NA
25	0.060	2rj7A	0.554	3.69	0.069	0.697	2.4.1.37,2.4.1.40	50,88
26	0.060	2icyB	0.546	3.92	0.049	0.701	2.7.7.9	NA
27	0.060	1jv3A	0.540	3.84	0.053	0.694	2.7.7.23	NA
28	0.060	2vd4A	0.548	3.56	0.096	0.678	2.3.1.157,2.7.7.23	42,86
29	0.060	1fxoB	0.532	3.73	0.072	0.670	2.7.7.24	70
30	0.060	1hm9B	0.555	3.54	0.079	0.686	2.3.1.157,2.7.7.23	57,59,86
31	0.060	2d0jA	0.566	3.62	0.074	0.701	2.4.1.135	NA
32	0.060	2vs4A	0.566	3.47	0.075	0.701	2.4.1.87	NA
33	0.060	2i5kB	0.540	3.96	0.053	0.697	2.7.7.9	43
34	0.060	2v0hA	0.549	3.55	0.092	0.678	2.3.1.157,2.7.7.23	NA
35	0.060	2zu8A	0.619	3.87	0.100	0.793	2.4.1.217	100
36	0.060	2ffvA	0.815	2.91	0.127	0.939	2.4.1.41	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.852	2.44	0.14	0.96	2d7iA	GO:0000139 GO:0004653 GO:0005794 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016266 GO:0016740 GO:0016757 GO:0030246 GO:0046872
1	0.29	0.857	2.66	0.14	0.97	4d0tA	GO:0000139 GO:0002378 GO:0004653 GO:0005576 GO:0005789 GO:0005794 GO:0005795 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016266 GO:0016740 GO:0016757 GO:0018242 GO:0018243 GO:0030145 GO:0030173 GO:0030246 GO:0032580 GO:0046872 GO:0048471 GO:0070062
2	0.28	0.810	2.73	0.12	0.92	1xhbA	GO:0004653 GO:0005576 GO:0005794 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0046872 GO:0048471
3	0.28	0.744	3.80	0.13	0.92	2z86C	GO:0016740 GO:0016757 GO:0047238 GO:0050510
4	0.26	0.837	2.60	0.13	0.94	4d11C	GO:0000139 GO:0002378 GO:0004653 GO:0005576 GO:0005789 GO:0005794 GO:0005795 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016266 GO:0016740 GO:0016757 GO:0018242 GO:0018243 GO:0030145 GO:0030173 GO:0030246 GO:0032580 GO:0046872 GO:0048471 GO:0070062
5	0.20	0.808	2.56	0.14	0.92	4fixA	GO:0005829 GO:0005886 GO:0008921 GO:0009103 GO:0016020 GO:0016740 GO:0016757 GO:0035250 GO:0035496 GO:0040007 GO:0044038 GO:0045227 GO:0046872 GO:0052573 GO:0070592 GO:0071555 GO:0071769
6	0.18	0.587	3.90	0.11	0.75	5ekeC	GO:0005886 GO:0016020 GO:0016021 GO:0016740 GO:0016757
7	0.12	0.524	2.90	0.11	0.61	3bcvA	GO:0016740
8	0.07	0.509	3.24	0.09	0.62	2we9B	GO:0046872
9	0.07	0.496	3.36	0.09	0.61	2e8bA	GO:0000166 GO:0003824 GO:0005525 GO:0005737 GO:0006777 GO:0016740 GO:0019720 GO:0046872 GO:0061603 GO:0070568
10	0.07	0.499	2.82	0.13	0.59	3d5nA
11	0.07	0.519	3.20	0.09	0.62	2wawA
12	0.06	0.294	6.33	0.04	0.51	4z8sB	GO:0006952 GO:0016787 GO:0017148 GO:0030598
13	0.06	0.299	6.98	0.03	0.60	4eb2B	GO:0006952 GO:0016787 GO:0017148 GO:0030246 GO:0030598
14	0.06	0.289	7.18	0.04	0.58	1vclA	GO:0030246 GO:0046872
15	0.06	0.342	6.32	0.07	0.61	3a21A	GO:0003824 GO:0004553 GO:0004557 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0052692
16	0.06	0.301	6.90	0.03	0.60	1abrB	GO:0005534 GO:0006952 GO:0016787 GO:0017148 GO:0030246 GO:0030598 GO:0045807
17	0.06	0.299	6.93	0.05	0.59	1onkB	GO:0006952 GO:0016787 GO:0017148 GO:0030246 GO:0030598
18	0.06	0.293	6.89	0.04	0.59	4hr6C	GO:0017148 GO:0030246 GO:0030598
19	0.06	0.303	6.95	0.05	0.61	2zr1B	GO:0005829 GO:0006952 GO:0007157 GO:0016787 GO:0017148 GO:0030246 GO:0030598 GO:0044533
20	0.06	0.299	6.85	0.03	0.59	2aaiB	GO:0000166 GO:0005783 GO:0006952 GO:0016787 GO:0017148 GO:0030246 GO:0030598 GO:0031640
21	0.06	0.294	6.84	0.06	0.59	3c9zA	GO:0006952 GO:0016787 GO:0017148 GO:0030246 GO:0030598
22	0.06	0.293	6.37	0.03	0.52	1unbA	GO:0005506 GO:0009058 GO:0016491 GO:0017000 GO:0031418 GO:0050599 GO:0055114
23	0.06	0.305	6.65	0.05	0.57	1rzoB	GO:0000166 GO:0005783 GO:0006952 GO:0016787 GO:0017148 GO:0030246 GO:0030598

Consensus prediction of GO terms

Molecular Function	GO:0004653	GO:0030246	GO:0030145	GO:0015020
GO-Score	0.74	0.74	0.62	0.55
Biological Processes	GO:0016266	GO:0018242	GO:0018243	GO:0002378
GO-Score	0.64	0.62	0.62	0.47
Cellular Component	GO:0048471	GO:0032580	GO:0030173	GO:0070062	GO:0005789
GO-Score	0.62	0.62	0.47	0.47	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.