I-TASSER results

I-TASSER results for job id Rv1514c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (262 residues)
MTSAPTVSVITISFNDLDGLQRTVKSVRAQRYRGRIEHIVIDGGSGDDVVAYLSGCEPGF
AYWQSEPDGGRYDAMNQGIAHASGDLLWFLHSADRFSGPDVVAQAVEALSGKGPVSELWG
FGMDRLVGLDRVRGPIPFSLRKFLAGKQVVPHQASFFGSSLVAKIGGYDLDFGIAADQEF
ILRAALVCEPVTIRCVLCEFDTTGVGSHREPSAVFGDLRRMGDLHRRYPFGGRRISHAYL
RGREFYAYNSRFWENVFTRMSK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MTSAPTVSVITISFNDLDGLQRTVKSVRAQRYRGRIEHIVIDGGSGDDVVAYLSGCEPGFAYWQSEPDGGRYDAMNQGIAHASGDLLWFLHSADRFSGPDVVAQAVEALSGKGPVSELWGFGMDRLVGLDRVRGPIPFSLRKFLAGKQVVPHQASFFGSSLVAKIGGYDLDFGIAADQEFILRAALVCEPVTIRCVLCEFDTTGVGSHREPSAVFGDLRRMGDLHRRYPFGGRRISHAYLRGREFYAYNSRFWENVFTRMSK
Prediction	CCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEHCCCEEEHCCCCCCHHHHHHCCCCCCCCEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEHCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
Conf.Score	9999977999987888789999999999888999879999879999875999999799879999889998899999999987998999975888767987999999999989996999987688757867887688899999987598877765666588999989999988756769999999997988995856899756887777668999999999999999856656789999999999999877899999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MTSAPTVSVITISFNDLDGLQRTVKSVRAQRYRGRIEHIVIDGGSGDDVVAYLSGCEPGFAYWQSEPDGGRYDAMNQGIAHASGDLLWFLHSADRFSGPDVVAQAVEALSGKGPVSELWGFGMDRLVGLDRVRGPIPFSLRKFLAGKQVVPHQASFFGSSLVAKIGGYDLDFGIAADQEFILRAALVCEPVTIRCVLCEFDTTGVGSHREPSAVFGDLRRMGDLHRRYPFGGRRISHAYLRGREFYAYNSRFWENVFTRMSK
Prediction	8555245213000222260464045130402142503020014012430240056157401101026444102000200430444110000010101365103300510473420000000012434546323434513032102431200000000013005614123350320030030022045242120410001012222134442541254143025015312213320230102022123223310440043068
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCEEEEEHCCCCHHHHHHHHHHHHHCCCCCCEEEEEHCCCCCCCHHHHHHHHCCCEEEEEHCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEEEHCCCEEEHCCCCCCHHHHHHCCCCCCCCEEEEEHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCEEEHCCEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MTSAPTVSVITISFNDLDGLQRTVKSVRAQRYRGRIEHIVIDGGSGDDVVAYLSGCEPGFAYWQSEPDGGRYDAMNQGIAHASGDLLWFLHSADRFSGPDVVAQAVEALSGKGPVSELWGFGMDRLVGLDRVRGPIPFSLRKFLAGKQVVPHQASFFGSSLVAKIGGYDLDFGIAADQEFILRAALVCEPVTIRCVLCEFDTTGVGSHREPSAVFGDLRRMGDLHRRYPFGGRRISHAYLRGREFYAYNSRFWENVFTRMSK

1h7qA

0.17

0.15

0.85

2.53

MUSTER

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLNRVRFYQSDEKTRYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKYWDESFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPP-QRNCRELRESLKKLGMG-------------------------------

1h7qA

0.17

0.14

0.85

4.86

dPPAS

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLDNRVRFYQSDISGYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKYWDESFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPPQR-NCRELRESLKKLGMG-------------------------------

1h7qA

0.16

0.13

0.85

7.57

wdPPAS

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLDNRVRFYQSDKTRYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKEESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPPQRN-CRELRESLKKLGMG-------------------------------

1h7qA

0.17

0.14

0.85

3.52

wMUSTER

-----KVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLNRVRFYQSDEKTRYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKYWDESFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPP-QRNCRELRESLKKLGMG-------------------------------

1h7qA

0.16

0.13

0.85

4.63

wPPAS

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLDNRVRFYQSDKTRYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKEESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPP-QRNCRELRESLKKLGMG-------------------------------

1h7qA

0.17

0.15

0.84

10.85

dPPAS2

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLDNRVRFYQSDISGYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDETVRPAAQVTW----NAPCAIDHCSVMHRYSVLEKVKYWDESFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPPQR-NCRELRESLKKLGMG-------------------------------

1h7qA

0.16

0.14

0.85

3.66

PPAS

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLDNRVRFYQSDKTRYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKYWDESFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPP-QRNCRELRESLKKLGMG-------------------------------

1h7qA

0.17

0.14

0.85

4.14

Env-PPAS

----PKVSVIMTSYNKSDYVAKSISSILSQTFSD-FELFIMDDNSNEETLNVIRPFLDNRVRFYQSDISGYAALINQAIEMAEGEYITYATDDNIYM-PDRLLKMVRELDTHPEKAVIYSASKTYHLNDIVKETVRPAA-QVTWNAPCAIDHCSVMHRYSVLEKVKYWDESFYRIGDARFFWRVNHFYPFYPLDEELDLNYITDNEFVRNLPPQR-NCRELRESLKKLGMG-------------------------------

2z86C2

0.16

0.15

0.95

2.24

MUSTER

LKRVPLVSIYIPAYNCSKYIVRCVESALNQTITD-LEVCICDDGSTDDTLRILQEHYHPRVRFISQKNKGIGSASNTAVRLCRGFYIGQLDSDDFLE-PDAVELCLDEFRKDLSLACVYTTNRNIDREGNLISNGYNWIYSREKLTSAMICHHFRMFTARAWNLTEGFNESISNAVDYDMYLKLSEVGPFKHINKICYNRVLHGENTSILDIQKENHFKVVNESLSRLGIKKYK----YSPLTNLNECRKYTWEKI------

2z86C2

0.16

0.15

0.96

4.71

dPPAS

LKRVPLVSIYIPAYNCSKYIVRCVESALNQTITD-LEVCICDDGSTDDTLRILQEHYHPRVRFISQKNKGIGSASNTAVRLCRGFYIGQLDSDDFLE-PDAVELCLDEFRKDLSLACVYTTNRNIDEGNLISNGYNWPIYSREKLTSAMICHHFRMFTARAWNLTEGFNESISNAVDYDMYLKLSEVGPFKHINKICYNRVLHGENTSI--KKLDIQKENHFKVVNESLSRLGIKKYKYSPLTNLNECRKYTWEKI------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.41

Estimated TM-score = 0.77±0.10

Estimated RMSD = 5.1±3.3Å

Download Model 2

C-score=-1.32

Download Model 3

C-score=-1.92

Download Model 4

C-score=-2.42

Download Model 5

C-score=-2.73

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2z86C2	0.811	2.86	0.148	0.931
2	1h7qA	0.773	2.19	0.157	0.840
3	4hg6A	0.752	3.85	0.120	0.947
4	2d7rA	0.741	4.14	0.125	0.943
5	4fixA	0.733	3.43	0.116	0.893
6	1xhbA	0.731	3.78	0.141	0.920
7	2ffuA1	0.716	3.59	0.145	0.893
8	2bo8A	0.708	4.07	0.102	0.916
9	2wvkA	0.666	3.91	0.084	0.859
10	3ckqA	0.650	3.93	0.146	0.813

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.41	31	4d11B	UDP	Rep, Mult	12,13,14,43,68,70,71,91,92,93,200,205
2	0.30	24	2z86B	UGA	Rep, Mult	12,13,14,43,68,70,71,74,91,92,93,174,175,176,177,200,205
3	0.03	3	4fiyA	MN	Rep, Mult	16,91,93,200
4	0.02	2	2z86C	MN	Rep, Mult	93,94,203
5	0.01	1	1h7qA	MG	Rep, Mult	112,114
6	0.01	1	1yp2A	PMB	Rep, Mult	11,13,40,41,42,63,64

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.149	1vgwB	0.543	3.34	0.092	0.660	2.7.7.60	71,95,99,153
2	0.067	2px7A	0.512	3.48	0.156	0.626	2.7.7.60	23,71,96,202
3	0.066	1i52A	0.546	3.49	0.101	0.676	2.7.7.60,2.7.7.-	31
4	0.066	1vpaA	0.535	3.24	0.063	0.649	2.7.7.60	31
5	0.066	2vsiB	0.535	3.70	0.080	0.672	2.7.7.60	95
6	0.066	3lw6A	0.543	3.32	0.092	0.664	2.4.1.133	177
7	0.066	1h7eA	0.548	3.97	0.071	0.702	2.7.7.38	31
8	0.066	2agdA	0.561	3.73	0.102	0.695	2.4.1.90	95
9	0.066	3k8dA	0.544	4.00	0.076	0.714	2.7.7.38	31
10	0.066	2pa4B	0.575	3.88	0.065	0.741	2.7.7.9	31
11	0.066	1wvcA	0.535	3.60	0.095	0.679	2.7.7.33	NA
12	0.066	3f1cB	0.533	3.87	0.068	0.679	2.7.7.60	95,202
13	0.066	1vicA	0.529	3.91	0.088	0.679	2.7.7.38	31
14	0.060	2vs4A	0.550	3.69	0.070	0.699	2.4.1.87	57
15	0.060	1on8A	0.619	3.95	0.079	0.801	2.4.1.223	159
16	0.060	1hm8A	0.572	3.71	0.044	0.725	2.7.7.23	31
17	0.060	2ux8G	0.550	4.15	0.076	0.729	2.7.7.9	226
18	0.060	3hl3A	0.570	3.52	0.130	0.714	2.7.7.24	22
19	0.060	1kwsA	0.585	3.40	0.072	0.710	2.4.1.135	97,197
20	0.060	3fwwA	0.564	3.79	0.081	0.721	2.3.1.157,2.7.7.23	31
21	0.060	2d0jA	0.584	3.48	0.112	0.714	2.4.1.135	NA
22	0.060	2cu2A	0.561	4.16	0.099	0.748	2.7.7.13	NA
23	0.060	1foaA	0.620	4.41	0.053	0.817	2.4.1.101	NA
24	0.060	1fggA	0.584	3.42	0.072	0.710	2.4.1.135	NA
25	0.060	2d0jC	0.583	3.57	0.112	0.718	2.4.1.135	97
26	0.060	1h7tA	0.549	3.96	0.071	0.702	2.7.7.38	NA
27	0.060	1fxoB	0.549	3.83	0.082	0.714	2.7.7.24	NA
28	0.060	3dk5A	0.581	3.30	0.071	0.702	2.3.1.157	31
29	0.060	2yqjA	0.566	4.07	0.039	0.741	2.7.7.23	44,76
30	0.060	2e3dC	0.569	3.73	0.059	0.721	2.7.7.9	NA
31	0.060	2oi6B	0.577	3.80	0.089	0.729	2.3.1.157,2.7.7.23	NA
32	0.060	1v82A	0.583	3.50	0.083	0.714	2.4.1.135	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.31	0.811	2.86	0.15	0.93	2z86C	GO:0016740 GO:0016757 GO:0047238 GO:0050510
1	0.26	0.773	2.19	0.16	0.84	1h7qA	GO:0016740 GO:0016757
2	0.19	0.593	3.65	0.10	0.73	5ekeC	GO:0005886 GO:0016020 GO:0016021 GO:0016740 GO:0016757
3	0.19	0.592	2.41	0.20	0.66	3bcvA	GO:0016740
4	0.19	0.739	4.00	0.12	0.94	2d7iA	GO:0000139 GO:0004653 GO:0005794 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016266 GO:0016740 GO:0016757 GO:0030246 GO:0046872
5	0.14	0.752	3.85	0.12	0.95	4hg6A	GO:0000166 GO:0006011 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0016759 GO:0016760 GO:0030244 GO:0035438
6	0.09	0.561	3.73	0.10	0.69	2agdA	GO:0000138 GO:0000139 GO:0002064 GO:0002526 GO:0003831 GO:0003945 GO:0004461 GO:0005576 GO:0005615 GO:0005794 GO:0005886 GO:0005975 GO:0005989 GO:0006012 GO:0006486 GO:0006487 GO:0007155 GO:0007339 GO:0007341 GO:0008092 GO:0008285 GO:0008378 GO:0009101 GO:0009312 GO:0009611 GO:0009897 GO:0009986 GO:0016020 GO:0016021 GO:0016323 GO:0016740 GO:0016757 GO:0018146 GO:0019901 GO:0030057 GO:0030112 GO:0030145 GO:0030175 GO:0030198 GO:0030879 GO:0031526 GO:0032580 GO:0035250 GO:0042060 GO:0042127 GO:0042803 GO:0042995 GO:0043014 GO:0043065 GO:0045136 GO:0046872 GO:0048487 GO:0048754 GO:0050900 GO:0051270 GO:0060046 GO:0060054 GO:0060055 GO:0060058 GO:0070062
7	0.09	0.545	3.54	0.10	0.67	1fgxB	GO:0000138 GO:0002064 GO:0002526 GO:0003831 GO:0003945 GO:0004461 GO:0005576 GO:0005615 GO:0005794 GO:0005886 GO:0005975 GO:0005989 GO:0006012 GO:0006486 GO:0006487 GO:0007155 GO:0007339 GO:0007341 GO:0008092 GO:0008285 GO:0008378 GO:0009101 GO:0009312 GO:0009897 GO:0009986 GO:0016020 GO:0016021 GO:0016323 GO:0016740 GO:0016757 GO:0030057 GO:0030112 GO:0030145 GO:0030175 GO:0030198 GO:0030879 GO:0031526 GO:0032580 GO:0035250 GO:0042060 GO:0042127 GO:0042803 GO:0042995 GO:0043014 GO:0043065 GO:0045136 GO:0046872 GO:0048487 GO:0048754 GO:0050900 GO:0051270 GO:0060046 GO:0060054 GO:0060055 GO:0060058 GO:0070062
8	0.07	0.731	3.78	0.14	0.92	1xhbA	GO:0004653 GO:0005576 GO:0005794 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016740 GO:0016757 GO:0018242 GO:0018243 GO:0030145 GO:0030246 GO:0032580 GO:0046872 GO:0048471
9	0.07	0.536	3.01	0.11	0.63	2we9B	GO:0046872
10	0.07	0.508	2.67	0.14	0.58	3d5nA
11	0.07	0.535	2.88	0.12	0.63	2wawA
12	0.07	0.717	3.72	0.13	0.90	4d11C	GO:0000139 GO:0002378 GO:0004653 GO:0005576 GO:0005789 GO:0005794 GO:0005795 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016266 GO:0016740 GO:0016757 GO:0018242 GO:0018243 GO:0030145 GO:0030173 GO:0030246 GO:0032580 GO:0046872 GO:0048471 GO:0070062
13	0.07	0.484	3.32	0.07	0.60	2e8bA	GO:0000166 GO:0003824 GO:0005525 GO:0005737 GO:0006777 GO:0016740 GO:0019720 GO:0046872 GO:0061603 GO:0070568
14	0.07	0.731	3.90	0.13	0.93	4d0tA	GO:0000139 GO:0002378 GO:0004653 GO:0005576 GO:0005789 GO:0005794 GO:0005795 GO:0006486 GO:0006493 GO:0016020 GO:0016021 GO:0016266 GO:0016740 GO:0016757 GO:0018242 GO:0018243 GO:0030145 GO:0030173 GO:0030246 GO:0032580 GO:0046872 GO:0048471 GO:0070062
15	0.06	0.345	5.56	0.06	0.57	1vknA	GO:0003942 GO:0005737 GO:0006526 GO:0008652 GO:0016491 GO:0016620 GO:0046983 GO:0051287 GO:0055114
16	0.06	0.327	5.06	0.03	0.49	1cydA	GO:0004090 GO:0005739 GO:0005759 GO:0006116 GO:0016491 GO:0043621 GO:0051262 GO:0055114
17	0.06	0.302	4.75	0.08	0.44	3eozB	GO:0004614 GO:0004619 GO:0006096 GO:0016020 GO:0016021 GO:0016853
18	0.06	0.297	5.70	0.03	0.47	2hpsA	GO:0005509 GO:0046872
19	0.06	0.289	6.46	0.04	0.51	1yxaA	GO:0004867 GO:0005576 GO:0005615 GO:0006953 GO:0010466 GO:0010951 GO:0030414 GO:0034097 GO:0043434 GO:0070062 GO:0072562
20	0.06	0.283	5.29	0.04	0.42	3hs3A	GO:0003677 GO:0003700 GO:0006351 GO:0006355
21	0.06	0.253	5.26	0.04	0.39	5a52A	GO:0005096 GO:0005543 GO:0005634 GO:0005886 GO:0008289 GO:0009738 GO:0009789 GO:0016020 GO:0043547 GO:0046872
22	0.06	0.248	5.53	0.05	0.39	2xt2A	GO:0016746
23	0.06	0.256	6.21	0.05	0.46	4u9wB	GO:0006629 GO:0008080 GO:0016740 GO:0016746
24	0.06	0.235	6.29	0.04	0.42	4prhD	GO:0005886 GO:0016020 GO:0016021 GO:0031295 GO:0050776 GO:0050852
25	0.06	0.222	5.30	0.04	0.35	3fouA	GO:0016020 GO:0016021 GO:0016491 GO:0016679 GO:0046872 GO:0051536 GO:0051537 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0050510	GO:0047238
GO-Score	0.38	0.31	0.31
Biological Processes	GO:0006493
GO-Score	0.38
Cellular Component	GO:0071944	GO:0098588	GO:0044431	GO:0016021
GO-Score	0.39	0.38	0.38	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.