I-TASSER results

I-TASSER results for job id Rv1510

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (432 residues)
MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATALAVACVYTVIYLAARDL
PPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIVAGHRTHPLRVAGMIGTVA
AVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATLLGALAGVDRWTQYGSLMVTD
AVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMASPTARSAASLLTPGGIATFVRG
AAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAVILAVTLTRAPLLVPLSAMQGNLIA
HFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLTGPWLLRVGFGPDYQTGGALLAWLTAA
AVAIAMLTLTGAAAVAAALHRAYLLGWVSATVASTLLLLLPMPLETRTVIALLFGPTVGI
AIHVAALARRPD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATALAVACVYTVIYLAARDLPPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIVAGHRTHPLRVAGMIGTVAAVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATLLGALAGVDRWTQYGSLMVTDAVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMASPTARSAASLLTPGGIATFVRGAAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAVILAVTLTRAPLLVPLSAMQGNLIAHFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLTGPWLLRVGFGPDYQTGGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYLLGWVSATVASTLLLLLPMPLETRTVIALLFGPTVGIAIHVAALARRPD
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	988888887777777888887777887766457899999999999999999999999668988889999999999999999998999998888877665566655444567899999999999999988777665578756899999999999999999999998665667889999999999999999999997789999999999999999999964565566565566666788888999999999999999876777765468756678999999999988899999888889999987555567999999999999999999999999978889986477655446899999999999999999999999977655688999999999999999747668999999999999999999999975589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATALAVACVYTVIYLAARDLPPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIVAGHRTHPLRVAGMIGTVAAVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATLLGALAGVDRWTQYGSLMVTDAVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMASPTARSAASLLTPGGIATFVRGAAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAVILAVTLTRAPLLVPLSAMQGNLIAHFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLTGPWLLRVGFGPDYQTGGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYLLGWVSATVASTLLLLLPMPLETRTVIALLFGPTVGIAIHVAALARRPD
Prediction	733357442334442544645544554443333100000000011121111000000000336200100011122212010130112200220232344545533211001000010001000000001000120135320000000010000000000000001024303100000010001000000000000121111000000010000000010232243242434132330011000000000000001001100010114434210000000000130001000110100000211444642220002001100010011022010011100000023512111100001011001100000100000012221000000000000000000011312100000000000000000000015358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
MYERRHERGMCDRAVEMTDVGATAAPTGPIARGSVARVGAATALAVACVYTVIYLAARDLPPACFSIFAVFWGALGIATGATHGLLQETTREVRWVRSTQIVAGHRTHPLRVAGMIGTVAAVVIAGSSPLWSRQLFVEGRWLSVGLLSVGVAGFCAQATLLGALAGVDRWTQYGSLMVTDAVIRLAVAAAAVVIGWGLAGYLWAATAGAVAWLLMLMASPTARSAASLLTPGGIATFVRGAAHSITAAGASAILVMGFPVLLKVTSDQLGAKGGAVILAVTLTRAPLLVPLSAMQGNLIAHFVDRRTQRLRALIAPALVVGGIGAVGMLAAGLTGPWLLRVGFGPDYQTGGALLAWLTAAAVAIAMLTLTGAAAVAAALHRAYLLGWVSATVASTLLLLLPMPLETRTVIALLFGPTVGIAIHVAALARRPD

5ezmA

0.10

0.09

0.93

1.17

MUSTER

MFASGDWVTIRYNALKYFEKP-VTVVGYELFGLGEWQARLAVALSGLLGIGVSMMAARRWFGARAAAFTGLALLAAPMWSVAAHF------------------------NTLDMTLAGVMSCVLAFMLMGQHPDASVAARRGWMVACWAAMGVAILTKGLVGIALPGLVLVVYTLVTRDWGLWRRLHLALGVVVMLVITVPWFYLVSVRNPEFPNFFFIHEHWQRRSGSVFYFLPLVIGGFLPWAGIFPKLWTAMRARFRPALMAGIWAIAIFVFFSISRSKLPGYIVPVIPALGILAGVALDRLSPRSWGKQLIGMAIVAACGLLASPVVATLNANHIPNSF-------YRAYAVWVAVAFVVMLLGIAVARLLLRRGVLPSVAVYAMGMYLGFTVALLGHETVGRPASGADIAPQIAQKLMPLYGVQMLD

4z3nA

0.11

0.10

0.94

1.08

dPPAS

--------------------FTVAGMFDGSLYKLLLRMALPMFVGMLTQVTYAIADIFWLSHGIIAGVGLVFPVGMGLFAIANGIQIGMGSLLSRAIGMQRLDRILSVGIIIALFFAIVITVLGYVYAQPLLRSLGATKSTEFYYYSLLTVFSIMLIGVMMGLFQGAGKIMVIMKASLLGALVNIMLDPIMIFFDFGVKGVALASFLAQLSMVAYFIYTLMGSWKI-------YREFLSVGMAQMLMQLIIAVGIVIYNFFIVRLDVNAMAAFTLTGRIDYFIITPMLAIATALLTVVGQNWGHGNTRTLNAYWAAVALAFSIVLVLAVMHIVLAPWMYPLFTRVVSDYAVLQTRIMALALPFVAISLLASEYYQAIGKPWYSVLLTLMRHVFISVPVVYLEMRITGVYFGAMSGTFVAALLAWRLLRLSPR

3vvnA

0.12

0.11

0.95

1.39

wdPPAS

---------------KTTKG--LRGDPKKAIVRLSIPMMIGMSVQTLYNLADGIWVSG-LGPESLAAVGLFFPVFMGIIALAAGLGVGTSSAIARRIGARDKEG-AVHSLILSLILGVTITITMLPAIDSLFRSMGAEAVIEYARVLLAGAFIIVFNNVGNGILRGEGDANRAMLAMVLGSGLNIVLDPIFIYLGFGVVGAAYATLLSMVVTSLFIAYWLFVKRDTYVDITLRLKDILRVGLPSSLSQLSMSIAMFFLNSVAITAGGENGVAVFTSAWRITMLGIVPILGMAAATTSVTGAAYGEREKLETAYLYAIKIAFMIELAVVAFIMLFAPQVAYLFTAQV-GDLISALRTLPVFLVLTPFGMMTSAMFQGIGEGEKSLILTIFRTLVMQVGFAYIFV-LRGVWIGIVIGNMVAAIVGFLWGRMRIS

3vvnA

0.12

0.95

1.52

wMUSTER

-------------TTKGVQ---LRGDPKKAIVRLSIPMMIGMSVQTLYNLADGIWVSG-LGPESLAAVGLFFPVFMGIIALAAGLGVGTSSAIARRIGARDKEGVAVHSLILSLILGVTITITMLPAIDSLFRSM--ELAIEYARVLLAGAFIIVFNNVGNGILRGEGDANRAMLAMVLGSGLNIVLDPIFIYLGFGVVGAAYATLLSMVVTSLFIAYWLFVKRDTYVDITLRLKDILRVGLPSSLSQLSMSIAMFFLNSVAITAGGNGVAVFTSAWRITMLGIVPILGMAAATTSVTGAAYGERNEKLETAYLYAIKIAFMIELAVVAFIMLFAPQVAYLFTAQVIKGLISALRTLPVFLVLTPFGMMTSAMFQGIGEGEKSLILTIFRTLVMQVGFAYIFV-LRGVWIGIVIGNMVAAIVGFLWGRMRIS

5aymA

0.09

0.08

0.85

2.29

wPPAS

-------------------------------LRIETQLLLGRLLTRSGDQAWDFVVPFALKLQVAAFYYLIVKIGTFLLTPSSGKWIDTHPRIQVVKWG---------VWLQFFAILAGMVFFGMLDGLVRAGGRESWLLSVLFIALALSGVMASLGSQITDISVGN-LTHFNSWLRRIDLATEVGAPILAGALFAGLFLIGLWNLVSFVPEYFLLRNV---RSGLKIKVLGSFSD--PIFWLILSYALLWLSVLSPHGVLLAAY--KDEMRLPETEIGLFRGLGAVFGLISTVSFPYLVRRLG----LISSSRWHLGFQGVTLGIAVTAFA----------MGS-TASVYVFLGCILLSRVGLYGFSNGEFELRQRLRGELNSLSSLTTTSATLILFSAGSTEDFKYLVYVSLAAVLLANVVFIKWSSR--

5aymA

0.09

0.08

0.87

1.76

dPPAS2

---------------------------LRIETQLLLGRLLTRSGDQAWDFVVPFALLVIFPLQVAAFYYLIVKIGTFLLTPSSGKWIDTHPRIQVVKWG---------VWLQFFAILAGMVFFGMLDGLVRAGGRESWLLSVLFIALALSGVMASLGSQITDISVGNDLTHFNSWLRRIDLATEVGAPILAGALFAGLFLIGLWNLVSFVPEYFLLRNVIRSGLKIKVLGSFSDPIFWLILSYALLWLSVLSPHGVLLAAYLKDEMRLPETEIGLFRGLGAVFGLISTVSFPYLVRRLG---------LISSSRWHLGFQGVTLGIAVTAFAM-----------GSTASVYVFLGCILLSRVGLYGFSNGEFELRQRLIPLSSLTTTSATLILFSAGSLLPQTEDFKYLVYVSLAAVLLANVVFIKWSSR--

5aymA

0.09

0.07

0.86

2.09

PPAS

---------------------------LRIETQLLLGRLLTRSGDQAWDFVVPFALLVIFKLQVAAFYYLIVKIGTFLLTPSSGKWIDTHPRIQVVKWG---------VWLQFFAILAGMVFFGMLDGLVRAGGRESWLLSVLFIALALSGVMASLGSQITDISVGN-LTHFNSWLRRIDLATEVGAPILAGALFAGLFLIGLWNLVSFVPEYFLLRNVIRSGLKIKVLGSFSDPIFWLILSYALLWLSVLSPHGVLLAAYLKDEMRLPETEIGLFRGLGAVFGLISTVSFPYLVRRL---------------------LISSSRWHLGFQGVTLGIAVTAFAMGSTASVYVFLGCILLSRVGLYGFSNGEFELRQRLNSLSSLTTTSATLILFSAGSLLPQTEDFKYLVYVSLAAVLLANVVFIKWSSR--

4z3nA

0.11

0.10

0.94

2.94

Env-PPAS

--------------------FTVAGMFDGSLYKLLLRMALPMFVGMLTQVTYAIADIFWLSHGIIAGVGLVFPVGMGLFAIANGIQIGMGSLLSRAIGMQRLDRILSVGIIIALFFAIVITVLGYVYAQPLLRSLGATKSTEFYYYSLLTVFSIMLIGVMMGLFQGAGKIMVIMKASLLGALVNIMLDPIMIFFDFGVKGVALASFLAQLSMVAYFIYTLMGSWKI-------YREFLSVGMAQMLMQLIIAVGIVIYNFFIVRLDVNAMAAFTLTGRIDYFIITPMLAIATALLTVVGQNWGHGNTRTLNAYWAAVALAFSIVLVLAVMHIVLAPWMYPLFTRVVSDYAVLQTRIMALALPFVAISLLASEYYQAIGKPWYSVLLTLMRHVFISVPVVYLLAIITGVYFGAMSGTFVAALLAWRLLRLSPR

3vvnA

0.12

0.96

1.14

MUSTER

---------------KTTKGVQLRGDPKKAIVRLSIPMMIGMSVQTLYNLADGIWVSG-LGPESLAAVGLFFPVFMGIIALAAGLGVGTSSAIARRIGARDKEGVAVHSLILSLILGVTITITMLPAIDSLFRSM--ELAIEYARVLLAGAFIIVFNNVGNGILRGEGDANRAMLAMVLGSGLNIVLDPIFIYLGFGVVGAAYATLLSMVVTSLFIAYWLDTYVDITLRDFSPSREILKDILRVGLPSSLSQLSMSIAMFFLNSVAITAVAVFTSAWRITMLGIVPILGMAAATTSVTGAAYGERNEKLETAYLYAIKIAFMIELAVVAFIMLFAPQVAYLFTAQVIKGLISALRTLPVFLVLTPFGMMTSAMFQGIGEGEKSLILTIFRTLVMQVGFAYIFV-LRGVWIGIVIGNMVAAIVGFLWGRMRIS

5aymA

0.09

0.08

0.87

1.08

dPPAS

---------------------------LRIETQLLLGRLLTRSGDQAWDFVVPFALLVIFPLQVAAFYYLIVKIGTFLLTPSSGKWIDTHPRIQVVKWG---------VWLQFFAILAGMVFFGMLDGLVRAGGRESWLLSVLFIALALSGVMASLGSQITDISVGNDFNSWLRRIDLATEVGAPILAGALFPLAGLFLIGLWNLVSFVPEYFLLRNVIQRSGLKIKVLGSFSDPIFWLILSYALLWLSVLSPHGVLLAAYLKDEMRLPETEIGLFRGLGAVFGLISTVSFPYLVRRLG---------LISSSRWHLGFQGVTLGIAVTAFAM-----------GSTASVYVFLGCILLSRVGLYGFSNGEFELRQRLIPLSSLTTTSATLILFSAGSLLPQTEDFKYLVYVSLAAVLLANVVFIKWSSR--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 2 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.53

Estimated TM-score = 0.65±0.13

Estimated RMSD = 8.2±4.5Å

Download Model 2

C-score=-1.19

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3vvnA	0.898	2.16	0.118	0.965
2	4z3nA	0.895	1.77	0.104	0.938
3	4lz6A	0.861	2.95	0.105	0.961
4	3mktA	0.839	2.73	0.088	0.935
5	4hukA	0.807	3.09	0.083	0.919
6	3o7pA	0.449	7.20	0.080	0.755
7	4gbyA	0.448	7.35	0.051	0.757
8	4cl4A	0.440	7.32	0.095	0.743
9	4w6vA	0.438	7.37	0.095	0.743
10	4ikvA	0.437	7.32	0.073	0.741

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.06	3	1oaoA	SF4	Rep, Mult	317,321,322,323,366
2	0.06	3	4hukA	P4P	Rep, Mult	49,68,72,255,274,277,278
3	0.04	2	3vvqA	III	Rep, Mult	62,65,66,69,70,73,253,256,257,259,260,263,270
4	0.04	2	3vvsA	III	Rep, Mult	45,48,49,72,75,76,79,83,154,157,158,161,177,205,209,212,248,251,274,278,281
5	0.04	2	1jqkB	SF4	Rep, Mult	372,375,380
6	0.02	1	3rg2A	PNS	Rep, Mult	34,35
7	0.02	1	3vvrA	III	Rep, Mult	42,45,48,49,72,75,76,79,83,157,158,176,177,184,205,209,212,248
8	0.02	1	3vvpA	BNU	Rep, Mult	45,48,157,161,176,177,180,184,205,208,209,212,216
9	0.02	1	2xtvA	MC3	Rep, Mult	326,329
10	0.02	1	2dwdC	L2C	Rep, Mult	404,407
11	0.02	1	1n38A	CH1	Rep, Mult	324,325,361,364,365,366
12	0.02	1	1lghA	DET	Rep, Mult	421,428
13	0.02	1	3mkuA	RB	Rep, Mult	254,360,412
14	0.02	1	3kziT	CLA	Rep, Mult	414,418
15	0.02	1	3arcJ	III	Rep, Mult	387,388
16	0.02	1	3o8lB	PO4	Rep, Mult	332,336,355,356,358
17	0.02	1	2zt9G	III	Rep, Mult	404,412
18	0.02	1	2o01I	CLA	Rep, Mult	339,343

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2occN	0.356	7.24	0.057	0.595	1.9.3.1	339
2	0.060	1n1hA	0.391	7.28	0.041	0.655	2.7.7.48	279
3	0.060	2vk1A	0.345	6.40	0.061	0.518	4.1.1.1	NA
4	0.060	3b9jI	0.158	5.40	0.038	0.222	1.17.1.4,1.17.3.2	269
5	0.060	1q16A	0.357	7.01	0.062	0.593	1.7.99.4	NA
6	0.060	1dmrA	0.373	7.06	0.086	0.618	1.7.2.3	72,79,80
7	0.060	3h7fB	0.354	6.52	0.061	0.551	2.1.2.1	NA
8	0.060	3b9jC	0.295	7.48	0.053	0.500	1.17.3.2,1.17.1.4	NA
9	0.060	1i1iP	0.374	6.71	0.072	0.574	3.4.24.16	NA
10	0.060	1occA	0.356	7.33	0.050	0.600	1.9.3.1	NA
11	0.060	3b9jJ	0.240	6.33	0.045	0.361	1.17.1.4,1.17.3.2	275
12	0.060	1mhsA	0.354	6.28	0.038	0.523	3.6.3.6	NA
13	0.060	1tgoA	0.355	6.78	0.054	0.565	2.7.7.7	36
14	0.060	2ckjA	0.335	7.19	0.052	0.560	1.17.1.4,1.17.3.2	NA
15	0.060	2ipyA	0.285	7.34	0.062	0.481	4.2.1.3	NA
16	0.060	1fo4A	0.357	7.25	0.059	0.611	1.17.1.4	NA
17	0.060	1t3tA	0.365	7.32	0.059	0.627	6.3.5.3	NA
18	0.060	1y791	0.374	6.88	0.069	0.593	3.4.15.5	NA
19	0.060	3ig5A	0.349	7.48	0.055	0.609	6.3.2.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.895	1.77	0.10	0.94	4z3nA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
1	0.28	0.859	3.10	0.10	0.97	5c6nA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
2	0.27	0.819	2.97	0.11	0.92	3vvpA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
3	0.23	0.815	2.96	0.08	0.92	5c6pA	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
4	0.22	0.887	2.39	0.12	0.97	4mlbB	GO:0006855 GO:0015238 GO:0015297 GO:0016020 GO:0016021 GO:0055085
5	0.18	0.839	2.73	0.09	0.94	3mktA
6	0.06	0.324	6.89	0.07	0.53	4ffcA	GO:0003824 GO:0003867 GO:0008483 GO:0009448 GO:0016740 GO:0030170
7	0.06	0.293	7.28	0.05	0.48	1j0hA	GO:0003824 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031216 GO:0046872
8	0.06	0.228	5.73	0.07	0.33	4wsoA	GO:0000166 GO:0003824 GO:0004515 GO:0005524 GO:0009058 GO:0009435 GO:0016740 GO:0016779 GO:0019363
9	0.06	0.218	5.96	0.03	0.32	2i9eB	GO:0003824 GO:0004807 GO:0006094 GO:0006096 GO:0006098 GO:0008152 GO:0016853
10	0.06	0.135	4.79	0.02	0.18	2ejeA	GO:0000981 GO:0003677 GO:0003700 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006351 GO:0006355 GO:0006357 GO:0006366 GO:0006367 GO:0007165 GO:0014886 GO:0016020 GO:0016525 GO:0042995 GO:0043025 GO:0051019 GO:0051481
11	0.06	0.118	4.20	0.07	0.15	3a0bE	GO:0005506 GO:0009055 GO:0009523 GO:0009539 GO:0009579 GO:0009767 GO:0015979 GO:0016020 GO:0016021 GO:0019684 GO:0020037 GO:0042651 GO:0046872 GO:0055114
12	0.06	0.102	5.02	0.04	0.14	5a9zAS	GO:0003723 GO:0003735 GO:0005622 GO:0005840 GO:0006412 GO:0019843 GO:0030529
13	0.06	0.106	4.22	0.08	0.13	3jcuE	GO:0005506 GO:0009055 GO:0009507 GO:0009523 GO:0009535 GO:0009536 GO:0009539 GO:0009579 GO:0009767 GO:0015979 GO:0016020 GO:0016021 GO:0019684 GO:0020037 GO:0046872 GO:0055114

Consensus prediction of GO terms

Molecular Function	GO:0015297	GO:0015238
GO-Score	0.78	0.78
Biological Processes	GO:0006855
GO-Score	0.78
Cellular Component	GO:0016021
GO-Score	0.78

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.