I-TASSER results

I-TASSER results for job id Rv1509

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (293 residues)
MFALSNNLNRVNACMDGFLARIRSHVDAHAPELRSLFDTMAAEARFARDWLSEDLARLPV
GAALLEVGGGVLLLSCQLAAEGFDITAIEPTGEGFGKFRQLGDIVLELAAARPTIAPCKA
EDFISEKRFDFAFSLNVMEHIDLPDEAVRRVSEVLKPGASYHFLCPNYVFPYEPHFNIPT
FFTKELTCRVMRHRIEGNTGMDDPKGVWRSLNWITVPKVKRFAAKDATLTLRFHRAMLVW
MLERALTDKEFAGRRAQWMVAAIRSAVKLRVHHLAGYVPATLQPIMDVRLTKR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFALSNNLNRVNACMDGFLARIRSHVDAHAPELRSLFDTMAAEARFARDWLSEDLARLPVGAALLEVGGGVLLLSCQLAAEGFDITAIEPTGEGFGKFRQLGDIVLELAAARPTIAPCKAEDFISEKRFDFAFSLNVMEHIDLPDEAVRRVSEVLKPGASYHFLCPNYVFPYEPHFNIPTFFTKELTCRVMRHRIEGNTGMDDPKGVWRSLNWITVPKVKRFAAKDATLTLRFHRAMLVWMLERALTDKEFAGRRAQWMVAAIRSAVKLRVHHLAGYVPATLQPIMDVRLTKR
Prediction	CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHCCCCCCCEEEEHCHHHCCCCCCCCEEEEEHCCCHHHCCCHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEHCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEHCC
Conf.Score	98877788756899999999999976998857888876577889999999999985589998589978988889999999899699986899999999999887577655446875456546788898479986476666889999999999976999499999878878887544454556778888999988755777788654444444445678888775556755665455455566665665678876555544444445554655678876554445578876479
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFALSNNLNRVNACMDGFLARIRSHVDAHAPELRSLFDTMAAEARFARDWLSEDLARLPVGAALLEVGGGVLLLSCQLAAEGFDITAIEPTGEGFGKFRQLGDIVLELAAARPTIAPCKAEDFISEKRFDFAFSLNVMEHIDLPDEAVRRVSEVLKPGASYHFLCPNYVFPYEPHFNIPTFFTKELTCRVMRHRIEGNTGMDDPKGVWRSLNWITVPKVKRFAAKDATLTLRFHRAMLVWMLERALTDKEFAGRRAQWMVAAIRSAVKLRVHHLAGYVPATLQPIMDVRLTKR
Prediction	74223441542442054025104610266065034114224330420141036105513653542423130121013106240301004206600530362076435143340212304323226663200200110011042044003000200223000000010120122212301211243012310332154445244342214212202144134222733414132323212200230241440243435202320200242411400320240010012030358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEHCCCCCHHHHHHHHHCCEEEEEHCCHHHHHHHHHHHHHCCCCCCCEEEEHCHHHCCCCCCCCEEEEEHCCCHHHCCCHHHHHHHHHHHCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHHHHHHHHHCCCCCEEEEHCCHHHHHHHHCCCCHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEHCC
MFALSNNLNRVNACMDGFLARIRSHVDAHAPELRSLFDTMAAEARFARDWLSEDLARLPVGAALLEVGGGVLLLSCQLAAEGFDITAIEPTGEGFGKFRQLGDIVLELAAARPTIAPCKAEDFISEKRFDFAFSLNVMEHIDLPDEAVRRVSEVLKPGASYHFLCPNYVFPYEPHFNIPTFFTKELTCRVMRHRIEGNTGMDDPKGVWRSLNWITVPKVKRFAAKDATLTLRFHRAMLVWMLERALTDKEFAGRRAQWMVAAIRSAVKLRVHHLAGYVPATLQPIMDVRLTKR

4kdcA

0.16

0.12

0.74

1.76

MUSTER

-------------EIAKFEAVASRWWDLEG-EFKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGK----SWLMAVVGAEYILRMV------------PK-------FIKPAELLGWVDQTS------------------LKERHITGLHYNPITNTFKLGPGVDVNYMLHTQN--------------

4kdcA

0.14

0.10

0.72

2.12

dPPAS

-------------EIAKFEAVASRWWDLEGE-FKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGKS--------WLMAVVGAEYILRMVPK---------------FIKPAELLGWVDQ-TSLKERHITGLHYNPITNTFKLGPLHTQN--------------------------------------

4kdcA

0.15

0.11

0.72

2.59

wdPPAS

-------------EIAKFEAVASRWWDLEGE-FKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGK----------------SWLMAVVGAEYILRMVPK-------FIKPAELLGWVDQ-TSLKERHITGLHYNPITNTFKLGPLHTQN--------------------------------------

4kdcA

0.16

0.12

0.74

2.03

wMUSTER

-------------EIAKFEAVASRWWDLEG-EFKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGK----SWLMAVVGAEYILRMV------------PK-------FIKPAELLGWVDQTS-LKERHITGL-----------------HYNPITNTFKLGPGVDVNYMLHTQN--------------

4kdcA

0.15

0.11

0.72

2.83

wPPAS

-------------EIAKFEAVASRWWDLEGE-FKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGK---SWLMAVVGAEYILRMV-------------PK-------FIKPAELLGWVDQ-TSLKERHITGLHYNPITNTFKLGPLHTQN--------------------------------------

4kdcA

0.15

0.10

0.68

4.00

dPPAS2

-------------EIAKFEAVASRWWDLEGE-FKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRN---GKSWLMAVVGAEYILRMVPK--------------------FIKPAELLGWVDQ-TSLKERHITGLHYNPITN-------------------------------------------------

4kdcA

0.14

0.10

0.71

2.44

PPAS

-------------EIAKFEAVASRWWDLEGE-FKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRN---GKSWLMAVVGAEYILRMVPK--------------------FIKPAELLGWVDQ-TSLKERHITGLHYNPITNGPGVD-LHTQN--------------------------------------

4kdcA

0.15

0.11

0.74

3.10

Env-PPAS

-------------EIAKFEAVASRWWDLEGE-FKPLHRINPLRLGYIAERAG-----GLFGKKVLDVGCGGGILAESMAREGATVTGLDMGFEPLQVAKLHALESGI--QVDYVQETVEEHAAKHAGQYDVVTCMEMLEHVPDPQSVVRACAQLVKPGGDVFFSTLNRNGK---SWLMAVVGAEYILRMVPK--------------------FIKPAELLGWVDQ-TSLKERHITGLHYN-----PITNTF--KLGPGVD----VNYMLHTQN--------------------

4kwcA

0.12

0.10

0.84

1.59

MUSTER

M------IQEKIKELEVKRALAQSWFSDP-DKRKISSNYDNRETPFTRFLSAETFTSYKTPVSILDIGCGQGQMLEYISKQLADLTGIDSSEEAIHCANKL--------NIKANFICTDIKNFSHAKIYDVILIHLCFGLFENPIELLEQLLPYLSNESMIYIVDLNRDS--------IESGLSSVQSKEEELYIY--------DQYHASLTLSEFEQLLTYITKPRDMMYKIGTSIIGG---------------FSPFSMEFLSLIGNGLQQTLRQAPDVL--LHAWLIKNR

4kwcA

0.11

0.10

0.85

1.96

dPPAS

-----GMIQEKIKELEVKRALAQSWFSDP-DKRKISSNYDNRETPFTRFLSAETFTSKKTPVSILDIGCGQGQMLEYISKQLADLTGIDSSEEAIHCANK------LNIKANFICTDIKN-FSSHAKIYDVILIHLCFGLFENPIELLEQLLPYLSNESMIYIVDLNRD-------SIESGLSSVQSKEEELYIYD---------QYHASLTLSEFEQLLTYITKPREDMMYKIGTSIIGG--------------FSPFSMEFLSLIGNGLQQTLRQAPDVLLHAWLIKNR--

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.70

Estimated TM-score = 0.62±0.14

Estimated RMSD = 7.7±4.3Å

Download Model 2

C-score=-1.90

Download Model 3

C-score=-3.27

Download Model 4

C-score=-4.86

Download Model 5

C-score=-2.69

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4kvzA	0.750	2.38	0.089	0.846
2	4kwcA	0.736	2.52	0.109	0.843
3	1d2gA	0.633	3.61	0.114	0.771
4	4ckbA	0.632	4.57	0.074	0.836
5	2vdwA	0.629	3.98	0.091	0.802
6	4f3nA	0.624	4.02	0.104	0.802
7	4krgA	0.617	4.01	0.089	0.782
8	4gekA	0.612	3.05	0.066	0.724
9	3bgvC	0.611	3.56	0.124	0.744
10	5hyzA	0.609	3.83	0.087	0.775

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.40	31	3px3D	SAH	Rep, Mult	26,34,44,68,69,70,74,89,90,91,94,117,118,135,137,140
2	0.03	2	5dm2A	5D9	Rep, Mult	26,39,40,47,136,137,139,140,165,166,194,195,206,210,283,284
3	0.01	1	3htxA	MG	Rep, Mult	136,139,140,175
4	0.01	1	2uyqA	SAM	Rep, Mult	68,70,89,116,117,118,119
5	0.01	1	3jwgA	MG	Rep, Mult	68,135
6	0.01	1	3sm3A	CA	Rep, Mult	202,209

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.201	2iftA	0.453	3.13	0.128	0.532	2.1.1.52	NA
2	0.178	2h11B	0.565	3.24	0.090	0.672	2.1.1.67	NA
3	0.160	3bgdA	0.571	3.30	0.089	0.683	2.1.1.67	37
4	0.137	3e05D	0.494	2.94	0.106	0.577	2.1.1.132	101
5	0.136	3lccA	0.558	3.36	0.100	0.669	2.1.1.-	68
6	0.132	1susD	0.532	3.01	0.098	0.625	2.1.1.104	68
7	0.104	2ex4A	0.599	3.40	0.114	0.720	2.1.1.-	NA
8	0.081	3hnrA	0.528	3.38	0.117	0.635	2.1.1.-	NA
9	0.072	1ri5A	0.592	3.77	0.096	0.741	2.1.1.56	NA
10	0.067	1f38A	0.492	3.02	0.113	0.577	2.1.1.-	NA
11	0.067	2pxxA	0.524	3.26	0.131	0.621	3.4.24.71	NA
12	0.067	3e05B	0.492	2.93	0.105	0.573	2.1.1.132	NA
13	0.067	3c3yA	0.528	2.91	0.113	0.618	2.1.1.104	NA
14	0.067	3cbgA	0.513	2.88	0.092	0.594	2.1.1.-	NA
15	0.066	3grzB	0.475	2.93	0.099	0.546	2.1.1.-	NA
16	0.060	1kpgA	0.551	4.02	0.108	0.696	2.1.1.79	NA
17	0.060	1ri1A	0.594	3.69	0.101	0.741	2.1.1.56	68
18	0.060	1jq3A	0.523	4.52	0.092	0.683	2.5.1.16	68,92
19	0.060	2a14A	0.560	3.57	0.141	0.693	2.1.1.49	68,70,135
20	0.060	2aovA	0.548	4.08	0.081	0.693	2.1.1.8	69,90,97
21	0.060	1xcjA	0.537	3.78	0.120	0.665	2.1.1.2	95,113
22	0.060	2ytzA	0.563	4.53	0.099	0.737	2.1.1.32	NA
23	0.060	2i62C	0.561	3.34	0.138	0.683	2.1.1.1	68,70
24	0.060	1wznA	0.601	3.13	0.128	0.707	2.1.1.-	NA
25	0.060	1suiA	0.533	3.05	0.099	0.625	2.1.1.104	NA
26	0.060	2vdwG	0.601	3.93	0.080	0.758	2.7.7.50	90
27	0.060	1bhjA	0.635	3.44	0.127	0.764	2.1.1.20	NA
28	0.060	1tw2B	0.586	3.90	0.101	0.737	2.1.1.-	NA
29	0.060	3i58A	0.557	3.85	0.097	0.700	2.1.1.-	NA
30	0.060	1kpiA	0.566	4.21	0.103	0.720	2.1.1.79	NA
31	0.060	2ip2A	0.554	3.67	0.119	0.686	2.1.1.-	NA
32	0.060	1fp2A	0.550	3.79	0.071	0.686	2.1.1.150	NA
33	0.060	2iipA	0.564	3.60	0.106	0.703	2.1.1.1	68,70
34	0.060	2fk8A	0.556	3.88	0.078	0.689	2.1.1.-	146

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.475	2.93	0.10	0.55	3grzB	GO:0005737 GO:0006479 GO:0008168 GO:0008276 GO:0016740 GO:0032259
1	0.28	0.551	3.40	0.12	0.66	1vlmA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0032259
2	0.25	0.733	2.59	0.10	0.84	5dm2A	GO:0008168 GO:0016740 GO:0032259
3	0.22	0.492	3.49	0.15	0.59	3cggA	GO:0008168 GO:0016740 GO:0032259
4	0.21	0.588	3.44	0.11	0.71	4necB	GO:0008168 GO:0016740 GO:0032259
5	0.20	0.511	3.24	0.10	0.60	2p8jB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
6	0.20	0.569	3.39	0.12	0.69	3bxoA	GO:0008168 GO:0008757 GO:0016740 GO:0017000 GO:0032259 GO:0042803
7	0.19	0.601	3.13	0.13	0.71	1wznA
8	0.18	0.575	3.19	0.10	0.68	3dlcA	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
9	0.18	0.532	3.10	0.10	0.62	2gluA	GO:0005737 GO:0008152 GO:0008168 GO:0008757 GO:0016740 GO:0032259
10	0.17	0.483	3.44	0.09	0.58	2ipxA	GO:0000494 GO:0001094 GO:0001649 GO:0001651 GO:0001652 GO:0003723 GO:0005634 GO:0005654 GO:0005730 GO:0006364 GO:0006396 GO:0008033 GO:0008168 GO:0008649 GO:0015030 GO:0016020 GO:0016074 GO:0016740 GO:0030529 GO:0031167 GO:0031428 GO:0032040 GO:0032259 GO:0044822 GO:0048254 GO:0051117 GO:0070062 GO:1990258 GO:1990259
11	0.17	0.529	3.45	0.10	0.63	3l8dA	GO:0008152 GO:0008168 GO:0016740 GO:0032259
12	0.17	0.583	3.13	0.14	0.69	1ve3B	GO:0046872 GO:0051536 GO:0051539
13	0.16	0.537	3.62	0.18	0.66	3mggB	GO:0008168 GO:0016740 GO:0032259
14	0.16	0.550	4.15	0.13	0.70	2yqzA	GO:0008152 GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
15	0.15	0.493	2.94	0.13	0.57	2xvaA	GO:0005737 GO:0005829 GO:0008168 GO:0008757 GO:0009636 GO:0016740 GO:0032259 GO:0046677 GO:0046690
16	0.15	0.510	3.36	0.08	0.61	3g8bB	GO:0005737 GO:0006364 GO:0008168 GO:0008649 GO:0016740 GO:0031167 GO:0032259 GO:0070043 GO:0070476
17	0.15	0.592	3.27	0.15	0.70	4oqdC	GO:0008168 GO:0008757 GO:0016740 GO:0017000 GO:0032259 GO:0042803
18	0.15	0.567	3.03	0.09	0.67	3dtnA	GO:0046872
19	0.15	0.576	3.78	0.08	0.71	4kifB	GO:0008168 GO:0016740 GO:0017000 GO:0032259
20	0.15	0.526	3.10	0.10	0.62	3egeA	GO:0008152 GO:0008168 GO:0032259
21	0.14	0.524	3.43	0.08	0.62	3duwA	GO:0008168 GO:0008171 GO:0016740 GO:0032259
22	0.14	0.529	3.38	0.13	0.63	3sm3A	GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872
23	0.14	0.598	3.28	0.13	0.71	4pneB	GO:0008152 GO:0008168 GO:0016740 GO:0032259
24	0.13	0.515	3.11	0.09	0.60	2hnkB	GO:0008168 GO:0008171 GO:0016740 GO:0032259
25	0.13	0.545	3.66	0.11	0.67	1l1eA	GO:0005737 GO:0006629 GO:0008168 GO:0008610 GO:0008825 GO:0009405 GO:0016740 GO:0032259 GO:0042783 GO:0046500 GO:0052167 GO:0071768
26	0.13	0.531	2.94	0.11	0.62	1vl5A	GO:0008152 GO:0008168 GO:0016740 GO:0032259
27	0.13	0.527	3.10	0.13	0.61	3jwhA	GO:0001510 GO:0008171 GO:0008173
28	0.12	0.543	3.30	0.11	0.65	3g5lA
29	0.12	0.543	3.19	0.09	0.65	4ymgB	GO:0008171 GO:0032259 GO:0046872 GO:0051536 GO:0051539
30	0.11	0.555	2.55	0.13	0.63	3dh0B	GO:0005737 GO:0008757 GO:0032259 GO:0046872 GO:0051536 GO:0051539
31	0.11	0.564	3.55	0.11	0.68	2o57A
32	0.11	0.538	2.96	0.12	0.62	3jwgA	GO:0001510 GO:0008168 GO:0008171 GO:0008173 GO:0016740 GO:0032259
33	0.11	0.572	3.38	0.08	0.68	4iv8A	GO:0000234 GO:0008152 GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
34	0.11	0.493	3.08	0.06	0.58	3eeyA	GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
35	0.10	0.594	3.28	0.07	0.71	5egpA	GO:0008168 GO:0016740 GO:0032259
36	0.09	0.480	3.72	0.12	0.59	4hg2B	GO:0008152 GO:0008168 GO:0016740 GO:0032259
37	0.09	0.601	3.55	0.10	0.73	5je1A	GO:0008168 GO:0016740 GO:0032259
38	0.07	0.591	3.58	0.08	0.72	3uj7A	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
39	0.07	0.475	3.29	0.10	0.57	3mtiB	GO:0008168 GO:0016740 GO:0032259
40	0.07	0.472	3.13	0.10	0.56	4pooA	GO:0008168 GO:0032259 GO:0046872 GO:0051536 GO:0051539
41	0.07	0.465	2.92	0.09	0.55	3i9fB	GO:0008152 GO:0008168 GO:0032259 GO:0046872
42	0.07	0.599	3.67	0.08	0.73	4mwzB	GO:0008168 GO:0016740 GO:0032259 GO:0046872 GO:0051536 GO:0051539
43	0.07	0.592	3.55	0.08	0.72	3d2lC	GO:0008168 GO:0016740 GO:0032259
44	0.07	0.572	3.28	0.12	0.68	4kdcA	GO:0005829 GO:0006744 GO:0008168 GO:0008425 GO:0008689 GO:0008757 GO:0016740 GO:0032259 GO:0043431 GO:0061542 GO:0102004
45	0.07	0.505	4.22	0.09	0.66	1nkvC	GO:0005737 GO:0008757 GO:0016020 GO:0016021 GO:0032259
46	0.07	0.523	3.56	0.09	0.62	1p91A	GO:0005737 GO:0006364 GO:0008168 GO:0008270 GO:0008989 GO:0016740 GO:0032259 GO:0046872 GO:0052911 GO:0070475
47	0.07	0.470	3.70	0.09	0.57	4by9E	GO:0003723 GO:0006364 GO:0008033 GO:0008168 GO:0016740 GO:0032259

Consensus prediction of GO terms

Molecular Function	GO:0008168
GO-Score	0.77
Biological Processes	GO:0043414	GO:0008213
GO-Score	0.60	0.60
Cellular Component	GO:0005737
GO-Score	0.49

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.