I-TASSER results

I-TASSER results for job id Rv1488

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (381 residues)
MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTVSGQLTLLVPFIDR
VRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTT
TLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEK
QMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRMLRAQ
GERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPEMARGDANKVWVVPSDF
NAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDAEVAGWFSTDTDPSIARAVAT
AEAIARKPVEGSLGTPPRLTQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDAEVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ
Prediction	CCCHHHHHHHHHHHHHHHHHHHHHHCEEHCCCEEEEEEHCCEEEEHCCCCEEEEHCCEEEEEEEEHCEEEEEHCCCCEEEHCCCCEEEEEEEEEEEEHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
Conf.Score	987577999999999999999998546765656899887685544449987999454557888886479997679865775577689988999999978888787558999999999999999998668899999999999999999999998646959999997648999999999999999999999999999999999999999999999998899999999999999999999988888999999999999999999975567757899999999999999978998699985959999999999998656667666778888877777788886544566665566899999999998876678877778755479
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDAEVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ
Prediction	340111122222222221222222001004111100000012033023010001000003033302012131604515112425140302010000022033001205203300221012001320363303400550550154025303620551203023020430513740250045125242533041341514352144335054224236154423431342304442443435144322332141315214412531555522311103301510350073751100000021241143024104434654455354553675456456465553554355544553552455355456564575475375358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCHHHHHHHHHHHHHHHHHHHHHHCEEHCCCEEEEEEHCCEEEEHCCCCEEEEHCCEEEEEEEEHCEEEEEHCCCCEEEHCCCCEEEEEEEEEEEEHCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
MQGAVAGLVFLAVLVIFAIIVVAKSVALIPQAEAAVIERLGRYSRTVSGQLTLLVPFIDRVRARVDLRERVVSFPPQPVITEDNLTLNIDTVVYFQVTVPQAAVYEISNYIVGVEQLTTTTLRNVVGGMTLEQTLTSRDQINAQLRGVLDEATGRWGLRVARVELRSIDPPPSIQASMEKQMKADREKRAMILTAEGTREAAIKQAEGQKQAQILAAEGAKQAAILAAEADRQSRMLRAQGERAAAYLQAQGQAKAIEKTFAAIKAGRPTPEMLAYQYLQTLPEMARGDANKVWVVPSDFNAALQGFTRLLGKPGEDGVFRFEPSPVEDQPKHAADGDDAEVAGWFSTDTDPSIARAVATAEAIARKPVEGSLGTPPRLTQ

2rpbA

0.47

0.14

0.30

1.02

MUSTER

------------------------------------------------------------GSDHVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQVIDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINARLREELDKITDRWGVKITRVEIQRIDPPKD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.39

0.17

0.44

1.55

MUSTER

--------------------------------------------------------MIFEKAVIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISE---PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.39

0.17

0.45

1.97

dPPAS

--------------------------------------------------------MIFEKAVIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISEH--PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.38

0.17

0.44

3.29

wdPPAS

------------------------------------------------------M-IFEKA-VIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISE---PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.38

0.17

0.44

2.05

wMUSTER

-----------------------------------------------------MI--FEKA-VIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISE---PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.38

0.17

0.44

3.40

wPPAS

-----------------------------------------------------MI--FEKA-VIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISE---PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.39

0.17

0.45

4.30

dPPAS2

--------------------------------------------------------MIFEKAVIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISEH--PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.39

0.17

0.44

2.70

PPAS

--------------------------------------------------------MIFEKAVIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISE---PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

3bk6A

0.39

0.17

0.45

4.12

Env-PPAS

--------------------------------------------------------MIFEKAVIVDLRTQVLDVPVQETITKDNVPVRVNAVVYFRVVDPVKAVTQVKNYIMATSQISQTTLRSVIGQAHLDELLSERDKLNMQLQRIIDEATDPWGIKVTAVEIKDVELPAGMQKAMARQAEAERERRARITLAEAERQAAEKLREAAEIISEH--PMALQLRTLQT---------------------------------------------------------------------------------------------------------------------------------------------------------

2rpbA

0.47

0.14

0.30

1.35

dPPAS

------------------------------------------------------------GSDHVDLREHVIDVPPQEVICKDNVVVTVDAVVYYQVIDPVKAVYNVSDFLMAIVKLAQTNLRAIIGEMELDETLSGRDIINARLREELDKITDRWGVKITRVEIQRIDPPKD----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-5.00

Estimated TM-score = 0.21±0.05

Estimated RMSD = 19.8±1.8Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-3.88

Download Model 4

C-score=-5.00

Download Model 5

C-score=-3.83

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3bk6A	0.400	2.53	0.375	0.441
2	1kc7A	0.382	6.73	0.044	0.625
3	4r04A	0.377	6.67	0.064	0.606
4	1w27A	0.367	6.80	0.045	0.617
5	4f91B	0.361	7.23	0.042	0.622
6	5ikyA	0.361	6.87	0.061	0.601
7	3nz4A	0.357	6.99	0.052	0.609
8	4w8yA1	0.356	5.50	0.051	0.509
9	3dy5A	0.355	7.49	0.039	0.640
10	1kitA	0.352	7.04	0.074	0.606

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	4b7bA	CO	Rep, Mult	181,185
2	0.06	3	2xulB	MG	Rep, Mult	77,127
3	0.04	2	2ypaB	NUC	Rep, Mult	185,188
4	0.04	2	1gdtA	NUC	Rep, Mult	189,192,193,200
5	0.04	2	2d4cA	CA	Rep, Mult	177,181
6	0.04	2	3b8iB	MG	Rep, Mult	83,90
7	0.02	1	3d5d2	MG	Rep, Mult	132,189
8	0.02	1	1kqfA	SF4	Rep, Mult	122,125,126,127,135,142,379
9	0.02	1	3ddrA	HEM	Rep, Mult	100,102,156,157
10	0.02	1	1w0oA	CA	Rep, Mult	74,90,91
11	0.02	1	1oe4A	3DR	Rep, Mult	183,186
12	0.02	1	3tahA	MG	Rep, Mult	142,150
13	0.02	1	2fpwB	CA	Rep, Mult	83,95
14	0.02	1	3pfdA	IOD	Rep, Mult	179,182,183
15	0.02	1	2qx6A	ML1	Rep, Mult	156,219

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1w27A	0.367	6.80	0.045	0.617	4.3.1.24	NA
2	0.060	3dlaD	0.320	7.03	0.047	0.538	6.3.5.1	NA
3	0.060	2p0mA	0.327	7.00	0.049	0.556	1.13.11.33	NA
4	0.060	2iukB	0.336	7.29	0.048	0.593	1.13.11.12	124,126
5	0.060	2ckjA	0.310	7.15	0.055	0.541	1.17.1.4,1.17.3.2	NA
6	0.060	1kblA	0.379	6.61	0.047	0.617	2.7.9.1	NA
7	0.060	2pdaA	0.326	7.39	0.045	0.593	1.2.7.1	73,141
8	0.060	3fwmA	0.344	6.53	0.059	0.551	2.4.1.129,	NA
9	0.060	1kitA	0.352	7.04	0.074	0.606	3.2.1.18	NA
10	0.060	2fhcA	0.316	6.59	0.061	0.514	3.2.1.41	120
11	0.060	3fg3A	0.270	7.76	0.057	0.509	4.2.1.92,1.13.11.40	NA
12	0.060	2fhbA	0.308	6.69	0.068	0.504	3.2.1.41	NA
13	0.060	3l9oA	0.317	6.84	0.038	0.533	3.6.4.13	33,147
14	0.060	3b9jJ	0.194	6.08	0.034	0.302	1.17.1.4,1.17.3.2	125
15	0.060	1w36C	0.319	7.25	0.039	0.551	3.1.11.5	135
16	0.060	1qbaA	0.326	6.87	0.054	0.554	3.2.1.52	NA
17	0.060	1b0pA	0.325	6.99	0.026	0.549	1.2.7.1	NA
18	0.060	1k32A	0.317	6.79	0.033	0.528	3.4.21.-	NA
19	0.060	1no3A	0.321	7.28	0.017	0.556	1.13.11.12	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.30	0.263	1.93	0.43	0.28	2rpbA	GO:0016020 GO:0016021
1	0.25	0.400	2.53	0.38	0.44	3bk6A	GO:0016020 GO:0016021
2	0.24	0.270	2.42	0.36	0.29	4fvfB	GO:0002230 GO:0005615 GO:0005737 GO:0005739 GO:0005783 GO:0005856 GO:0005886 GO:0005887 GO:0016020 GO:0016023 GO:0031410 GO:0031982 GO:0034765 GO:0042470 GO:0042802 GO:0042803 GO:0044829 GO:0045121 GO:0048471 GO:0048524 GO:0051260 GO:0070062 GO:0070063 GO:0072562 GO:0090314 GO:0098779 GO:0098792 GO:1901585
3	0.06	0.379	6.61	0.05	0.62	1kblA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
4	0.06	0.221	6.47	0.07	0.34	2kx9A	GO:0000287 GO:0003824 GO:0005737 GO:0005829 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0019197 GO:0046872
5	0.06	0.294	7.32	0.04	0.52	1vbgA	GO:0000166 GO:0003824 GO:0005524 GO:0005737 GO:0006090 GO:0009507 GO:0009536 GO:0015979 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872 GO:0050242
6	0.06	0.279	7.47	0.07	0.50	3igyB	GO:0003824 GO:0004619 GO:0005737 GO:0006007 GO:0008152 GO:0016853 GO:0030145 GO:0046872
7	0.06	0.226	7.24	0.04	0.40	2e28A	GO:0000166 GO:0000287 GO:0003824 GO:0004743 GO:0005524 GO:0006096 GO:0008152 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0030955 GO:0046872
8	0.06	0.286	3.24	0.17	0.33	1winA	GO:0001765 GO:0001931 GO:0002020 GO:0002080 GO:0005768 GO:0005886 GO:0005901 GO:0005913 GO:0005925 GO:0007155 GO:0010629 GO:0016020 GO:0016323 GO:0016600 GO:0030027 GO:0030139 GO:0030864 GO:0031410 GO:0031982 GO:0035255 GO:0044291 GO:0044860 GO:0045121 GO:0045661 GO:0046982 GO:0048471 GO:0050821 GO:0070062 GO:0090002 GO:1902992 GO:1903905
9	0.06	0.273	7.20	0.04	0.47	2wqdA	GO:0003824 GO:0005737 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
10	0.06	0.258	6.81	0.05	0.42	5jcpA	GO:0000166 GO:0001726 GO:0003924 GO:0005096 GO:0005525 GO:0005547 GO:0005737 GO:0005768 GO:0005789 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0005938 GO:0007010 GO:0007049 GO:0007165 GO:0007179 GO:0007264 GO:0007266 GO:0008360 GO:0016020 GO:0016032 GO:0016192 GO:0016477 GO:0017022 GO:0021762 GO:0030027 GO:0030036 GO:0030054 GO:0030168 GO:0030334 GO:0030336 GO:0030496 GO:0031234 GO:0031532 GO:0031982 GO:0032154 GO:0032467 GO:0032956 GO:0033688 GO:0035021 GO:0035024 GO:0035385 GO:0036089 GO:0038027 GO:0042346 GO:0042995 GO:0043123 GO:0043149 GO:0043296 GO:0043297 GO:0043325 GO:0043542 GO:0043547 GO:0043931 GO:0044319 GO:0045666 GO:0046872 GO:0048010 GO:0048013 GO:0048015 GO:0050771 GO:0050772 GO:0050919 GO:0051056 GO:0051301 GO:0051496 GO:0060071 GO:0060193 GO:0061383 GO:0070062 GO:0071902 GO:0071944 GO:0090051 GO:0090307 GO:0097498 GO:1902766 GO:1903673 GO:2000145
11	0.06	0.285	6.43	0.06	0.45	2hroA	GO:0003824 GO:0005737 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
12	0.06	0.256	6.81	0.03	0.43	2olsA	GO:0000166 GO:0003824 GO:0005524 GO:0006090 GO:0006094 GO:0008986 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
13	0.06	0.226	7.52	0.04	0.41	1gk8A	GO:0000287 GO:0004497 GO:0009507 GO:0009536 GO:0009853 GO:0015977 GO:0015979 GO:0016491 GO:0016829 GO:0016984 GO:0019253 GO:0046872 GO:0055114
14	0.06	0.220	6.98	0.02	0.37	5c2kA	GO:0000166 GO:0000281 GO:0000915 GO:0001669 GO:0003924 GO:0005096 GO:0005525 GO:0005547 GO:0005634 GO:0005654 GO:0005737 GO:0005768 GO:0005789 GO:0005819 GO:0005829 GO:0005856 GO:0005874 GO:0005886 GO:0005925 GO:0005938 GO:0006810 GO:0006811 GO:0006890 GO:0007018 GO:0007049 GO:0007165 GO:0007179 GO:0007264 GO:0007266 GO:0007275 GO:0007283 GO:0007405 GO:0008017 GO:0008272 GO:0008289 GO:0009790 GO:0016020 GO:0016032 GO:0016477 GO:0017022 GO:0019886 GO:0019901 GO:0021762 GO:0030027 GO:0030036 GO:0030054 GO:0030154 GO:0030168 GO:0030334 GO:0030496 GO:0031234 GO:0031410 GO:0031532 GO:0031982 GO:0032154 GO:0032467 GO:0032956 GO:0033688 GO:0035385 GO:0035556 GO:0036089 GO:0038027 GO:0042346 GO:0042995 GO:0043014 GO:0043015 GO:0043123 GO:0043149 GO:0043296 GO:0043297 GO:0043542 GO:0043547 GO:0043931 GO:0044319 GO:0045666 GO:0046872 GO:0048010 GO:0048013 GO:0048015 GO:0048487 GO:0050771 GO:0050772 GO:0050919 GO:0051056 GO:0051233 GO:0051256 GO:0051301 GO:0051496 GO:0051988 GO:0060071 GO:0060193 GO:0061383 GO:0070062 GO:0071902 GO:0071944 GO:0072686 GO:0090051 GO:0090307 GO:0097149 GO:0097498 GO:1902766 GO:1903673 GO:2000145
15	0.06	0.225	6.96	0.04	0.38	4jicA	GO:0000166 GO:0003824 GO:0010181 GO:0016491 GO:0055114
16	0.06	0.183	4.71	0.03	0.24	5fmgE	GO:0000502 GO:0004175 GO:0004298 GO:0005634 GO:0005737 GO:0005839 GO:0006508 GO:0006511 GO:0008233 GO:0016787 GO:0019773 GO:0051603
17	0.06	0.216	7.12	0.05	0.37	2xz7A	GO:0003824 GO:0005737 GO:0006810 GO:0008643 GO:0008965 GO:0009401 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0046872
18	0.06	0.199	6.55	0.01	0.31	2yyeB	GO:0000166 GO:0000287 GO:0004756 GO:0005524 GO:0016260 GO:0016301 GO:0016310 GO:0016740

Consensus prediction of GO terms

Molecular Function	GO:0046983	GO:0042802	GO:0019899
GO-Score	0.48	0.48	0.48
Biological Processes	GO:0051259	GO:0098780	GO:0050691	GO:2000649	GO:0000423	GO:0045070	GO:0051130	GO:0010469	GO:0090316	GO:0090313	GO:0044794	GO:0044827	GO:2001257
GO-Score	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48	0.48
Cellular Component	GO:1903561	GO:0012505	GO:0098857	GO:0031226	GO:0048770	GO:0043232	GO:0016021
GO-Score	0.48	0.48	0.48	0.48	0.48	0.48	0.47

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.