I-TASSER results

I-TASSER results for job id Rv1486c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (288 residues)
MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAVAAGHTGLPWPDVHDAG
TVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEHDALAAGEAVIVANPEDPG
SAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGAPVLEHYELGDAEYALRSAVR
SAAEALSTIGLGSSDVAKPRGLVEQLLESSRQHRVPDHAPSRALRVLENAAHVDAIIAVS
AGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMSAVTAILHSAWPD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAVAAGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEHDALAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGAPVLEHYELGDAEYALRSAVRSAAEALSTIGLGSSDVAKPRGLVEQLLESSRQHRVPDHAPSRALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMSAVTAILHSAWPD
Prediction	CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCEEEEHCEEHCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
Conf.Score	998745789999999978999589999999858875765677766666788888888876899999999986566788859998689999899999959999999989889995789988669995767657887766666667887568999998799999889998999999999999999999996888788767899999988756889999999979999999999999999999865789876679999999999999999999999999999999998669
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAVAAGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEHDALAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGAPVLEHYELGDAEYALRSAVRSAAEALSTIGLGSSDVAKPRGLVEQLLESSRQHRVPDHAPSRALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMSAVTAILHSAWPD
Prediction	710110200000000010202222012003724442314434443444442424434442023003102423444454210000001201046023446024201400000000134444100000021434434443434443452220201014146233263231330142035003400410441523434163134204412552643411442331033004205302100200343464422223133143045102403400230100002210452278
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEHCCCCCCCCCCCCCHHHHHHHHHHCCEEEEHCCCCCCCEEEEHCEEHCCCCCCCCCCCCCCCCCCEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MWCPSVSLSIWANAWLAGKAAPDDVLDALSLWAPTQSVAAYDAVAAGHTGLPWPDVHDAGTVSLLQTLRAAVGRRRLRGTINVVLPVPGDVRGLAAGTQFEHDALAAGEAVIVANPEDPGSAVGLVPEFSYGDVDEAAQSEPLTPELCALSWMVYSLPGAPVLEHYELGDAEYALRSAVRSAAEALSTIGLGSSDVAKPRGLVEQLLESSRQHRVPDHAPSRALRVLENAAHVDAIIAVSAGLSRLPIGTQSLSDAQRATDALRPLTAVVRSARMSAVTAILHSAWPD

3wj8A

0.12

0.11

0.88

0.62

MUSTER

MRVPWVAFGIRVMS----PHFIPHAWAALKPNIETRYAEDGADLIRLNSIVPGPVMPN-----PTPKLLRLGWTESKIEELK---------------TALDLLNYGNPKYLILI--------TAFNEAWHERDTGGRAPQKLRGRDAERIPYGL--PNSVEKFNLLDIEKASDRTQTVLRDIRDAFLHHGPASN-GVWPDYLEIALRDSLAPVALSAEYDETARRIRKIAREHVKGFDKAGVAWRDMTEKLSAEQIAGLTGLLFMYNRFIADITIAIIRLKQAFSGPE

5gaoE

0.16

0.99

0.72

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--

3sttA

0.13

0.11

0.83

0.67

wdPPAS

V-KKHFVL-------VHTAFHWYKIVALMRSSG--HNVTALDLGASGIN--PKQALQIPNFSDYLSPLMEFMASLPANEKIILV----GHALG---GLAISKAMETFPEVAVFLSGLMPGPNIDATTVCTKAGSAVLGQLDNCVTYENG-------PTNPPTTLIAGPKFLATNVYHLSPIEDLALATALVRPLYLYLAEDISKEVLSSKRYGSVKDALKKEFLKLMIEKNPPDEVKEI-----EGSDHVTMMSKPQQLFTTLLSIANKYK-----------------

3sttA

0.14

0.11

0.84

0.75

wMUSTER

V-KKHFVLV---TAF-HGAWCWYKIVALMRSSG--HNVTALDLGASGIN--PKQALQIPNFSDYLSPLMEFMASLPANEKIILV----GHALG---GLAISKAMETFPSVAVFLSG--------LMPGPNIDATTVCTKAGSAVLGQLDNCVTYENGPTNPPTTIAGPKFLATNVYHLSPIEDLALATALVRPLYLYLAEDISKEVLSSKRYGSVKDALKKEFLKLMIEKNPPDEVKEI-----EGSDHVTMMSKPQQLFTTLLSIANKYK-----------------

3sttA

0.14

0.11

0.82

0.75

wPPAS

V-KKH--LV---TAF-HGAWCWYKIVALMRSSG--HNVTALDLGASGIN--PKQALQIPNFSDYLSPLMEFMASLPANEKIILV----GHALG---GLAISKAMETFPEVAVFLSGLMPGPNIDATTVCTKAGSAVLGQLDNCVTYENG-------PTNPPTTLIAGPKFLATNVYHLSPIEDLALATALVRPLYLYLAEDISKEVLSSKRYGSVKDALKKEFLKLMIEKDEVKEI----------EGSD--VTMMSKPQQLFTTLLSIANKYK--------------

5gaoE

0.16

0.99

0.98

dPPAS2

--AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--

5gaoE

0.16

0.99

1.00

PPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYKKLSQKFHGTKSNKK--

3zjcA

0.10

0.09

0.93

0.76

Env-PPAS

VGKTGSGKSATANTILGEEIF--DSRIAAQAVTKNCQKASREWQGRDLLVVDTPGLFDSLDTTCKEISRCIISSCPGPHAIVLVLQLGRY-------TEEEQKTVALIKAVFGKSAMKH--MVILFTRKEELEGQSFHDFIADADVGLKSIVKECGNRCCAFSNSTSKAEKESQVQELVELIEKMVQCNEGAYFSDDIYKDTEERLKQREE---------VLRKIYTDQLNEEIKLVEEDKHKSEEEKEKEIKLLKLKYDEKIKNIREEAERNIFKDVFNRIWKMLSE

4ui9O

0.08

0.07

0.95

0.62

MUSTER

PDFAEAHYLSYLNNLRVQD--VFSSTHSLLHY----RLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRI--------AQESNDHVCLQHCLSWLYVLGQKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLEQQNNT-ESFAVALCHLAELHAEQFAAASEVKERFPPNSQHAQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITAL

4wj1A

0.09

0.08

0.89

0.62

dPPAS

---------------EELQYELPGLERKAHECESTRPEGPGDATKPDELATTASVYSKLASAAKLKATFAAGDREGERIAAAIRAAA----GAYQKIEEQKAAELSRQN----GSDAPPPAAEAVVPDSGIPGPLAIPSEYPSAAAAADEDWEAAARIIHSGDTQALSKYFRDQWRDYQSTLEGHGRHFANPAEGWAGAAAETCAEAQRRLS--------TWWADGAECGRLAQEATTFVDAHDKLVANHPTLENVREFEETEWEWDRQNAWALQEQSEDALEAYANG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.22

Estimated TM-score = 0.45±0.15

Estimated RMSD = 11.3±4.5Å

Download Model 2

C-score=-4.86

Download Model 3

C-score=-5.00

Download Model 4

C-score=-5.00

Download Model 5

C-score=-4.16

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3sttA	0.686	3.36	0.099	0.830
2	3wwoA	0.669	3.58	0.099	0.830
3	1sciA	0.664	3.70	0.095	0.833
4	3dqzA	0.663	3.73	0.110	0.840
5	2wflA	0.658	3.78	0.090	0.837
6	1y7iB	0.651	3.91	0.119	0.837
7	5hk8A	0.629	3.27	0.095	0.757
8	2cjpA	0.607	4.51	0.095	0.823
9	2qvbB	0.601	4.45	0.080	0.819
10	2zjfA	0.601	4.78	0.122	0.830

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	5	3c6yA	ACN	Rep, Mult	91,166,175,250
2	0.05	3	3v1nA	HPK	Rep, Mult	11,17,18,21,22,175,179,183,187,250,253
3	0.05	3	1scqA	CNH	Rep, Mult	13,91,93,166,250
4	0.03	2	3wwoA	CA	Rep, Mult	13,17,91,249,250
5	0.03	2	3a2mA	SUC	Rep, Mult	264,267,268
6	0.03	2	1y66C	DIO	Rep, Mult	152,172,175
7	0.03	2	1s2vB	MG	Rep, Mult	55,90
8	0.02	1	3a2mB	SUC	Rep, Mult	25,27,28,86
9	0.02	1	3stwA	2TD	Rep, Mult	91,136,137,194,197,202,250
10	0.02	1	3bwxA	CA	Rep, Mult	216,219
11	0.02	1	2o2hA	DCE	Rep, Mult	122,123,223,227
12	0.02	1	3a2mA	SUC	Rep, Mult	172,176,182,183,186
13	0.02	1	2wpnA	SBY	Rep, Mult	4,6,82,84,263,267
14	0.02	1	3c700	III	Rep, Mult	19,20,23,26,52,182,185,186,189,190
15	0.02	1	3hi4A	ACT	Rep, Mult	94,95,206
16	0.02	1	3c9iB	XE	Rep, Mult	233,236
17	0.02	1	2yasA	SCN	Rep, Mult	91,175,249,250
18	0.02	1	1xklC	STH	Rep, Mult	164,166,170,196
19	0.02	1	1bjeA	AZI	Rep, Mult	113,269
20	0.02	1	2ckrA	ZN	Rep, Mult	23,27

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.105	1qj4A	0.664	3.70	0.095	0.833	4.1.2.37	NA
2	0.067	1va4A	0.571	4.55	0.091	0.771	3.1.1.2	NA
3	0.067	1a88A	0.572	4.60	0.103	0.774	1.11.1.10	NA
4	0.067	3a2lA	0.594	4.35	0.097	0.812	3.8.1.5	256
5	0.067	2qvbB	0.601	4.45	0.080	0.819	3.8.1.5	NA
6	0.067	1a8qA	0.570	4.74	0.115	0.785	1.11.1.10	NA
7	0.066	1a8sA	0.566	4.89	0.086	0.785	1.11.1.10	NA
8	0.066	1mj5A	0.592	4.32	0.085	0.799	3.8.1.5	NA
9	0.066	1j1iA	0.532	4.36	0.105	0.715	3.7.1.8	17
10	0.060	3nwoA	0.568	4.38	0.111	0.767	3.4.11.5	66
11	0.060	1cpyA	0.562	4.80	0.074	0.802	3.4.16.5	NA
12	0.060	2cjpA	0.607	4.51	0.095	0.823	3.3.2.3	NA
13	0.060	2v9zA	0.588	4.37	0.077	0.802	3.8.1.5	58
14	0.060	1qtrA	0.592	4.47	0.071	0.806	3.4.11.5	NA
15	0.060	1u2eA	0.555	4.61	0.096	0.767	3.7.1.-	NA
16	0.060	3n2zB	0.563	4.99	0.066	0.812	3.4.16.2	NA
17	0.060	1b6gA	0.598	4.38	0.100	0.806	3.8.1.5	NA
18	0.060	1yscA	0.561	4.71	0.075	0.795	3.4.16.5	47
19	0.060	1zoiA	0.570	4.88	0.091	0.785	3.1.1.-	NA
20	0.060	1k8qA	0.574	4.55	0.085	0.788	3.1.1.3	NA
21	0.060	1a88B	0.571	4.65	0.091	0.778	1.11.1.10	240,246
22	0.060	1azwA	0.592	4.48	0.088	0.806	3.4.11.5	NA
23	0.060	1cqzB	0.595	4.35	0.097	0.802	3.3.2.10,3.3.2.3	NA
24	0.060	1mt3A	0.565	4.51	0.077	0.778	3.4.11.5	NA
25	0.060	1vj5A	0.600	4.48	0.092	0.819	3.3.2.10,3.3.2.3	NA
26	0.060	1hlgA	0.580	4.76	0.092	0.819	3.1.1.3	NA
27	0.060	1a7uA	0.568	4.66	0.121	0.774	1.11.1.10	NA
28	0.060	2pu5A	0.553	4.81	0.095	0.781	3.7.1.8	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.22	0.599	4.37	0.10	0.81	1be0A	GO:0003824 GO:0009636 GO:0016787 GO:0018786 GO:0019260
1	0.10	0.674	3.83	0.08	0.86	3wwpA	GO:0016829 GO:0046872
2	0.10	0.663	3.70	0.11	0.83	1dwoA	GO:0016829 GO:0052891 GO:0052892
3	0.09	0.675	3.84	0.12	0.86	1y7iB	GO:0002376 GO:0006952 GO:0008152 GO:0009862 GO:0016298 GO:0016787 GO:0045087 GO:0080031
4	0.09	0.664	3.71	0.10	0.83	3c6xA	GO:0016829 GO:0052891 GO:0052892
5	0.09	0.663	3.73	0.11	0.84	3dqzA	GO:0009611 GO:0016139 GO:0016787 GO:0016829 GO:0046593
6	0.09	0.662	3.75	0.09	0.84	2wfmA	GO:0009820 GO:0016787 GO:0050529 GO:0052689
7	0.07	0.602	4.38	0.08	0.82	3u1tB	GO:0003824
8	0.07	0.629	3.27	0.10	0.76	5hk8A	GO:0005737 GO:0005829 GO:0010150 GO:0015996 GO:0016787 GO:0016788 GO:0033310 GO:0035560 GO:0042803 GO:0052689 GO:0070988 GO:0080030 GO:0080032
9	0.07	0.601	4.63	0.09	0.83	4k2aC	GO:0003824 GO:0016787 GO:0018786
10	0.07	0.586	4.49	0.10	0.80	5aljA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
11	0.07	0.591	4.55	0.10	0.80	4rncA	GO:0016787 GO:0052689
12	0.07	0.595	4.32	0.12	0.81	5esrA	GO:0003824 GO:0016787 GO:0018786
13	0.07	0.575	4.38	0.12	0.77	2xt0A	GO:0003824
14	0.07	0.600	4.48	0.09	0.82	4haiA	GO:0000287 GO:0003824 GO:0004301 GO:0005102 GO:0005737 GO:0005777 GO:0005829 GO:0006629 GO:0006805 GO:0006874 GO:0006954 GO:0008152 GO:0008217 GO:0009636 GO:0010628 GO:0015643 GO:0016311 GO:0016787 GO:0016791 GO:0017144 GO:0019373 GO:0019439 GO:0033885 GO:0042577 GO:0042632 GO:0042803 GO:0045909 GO:0046272 GO:0046839 GO:0046872 GO:0070062 GO:0072593 GO:0090181
15	0.07	0.581	4.33	0.10	0.78	4x00A	GO:0016787
16	0.07	0.582	4.43	0.12	0.80	4mj3B	GO:0003824 GO:0016787 GO:0018786
17	0.07	0.572	4.53	0.09	0.77	3heaA	GO:0003824 GO:0004064 GO:0004601 GO:0016491 GO:0016787 GO:0055114 GO:0098869
18	0.07	0.564	4.39	0.13	0.76	4f0jA	GO:0003824 GO:0016787
19	0.07	0.572	4.80	0.11	0.79	3fobA	GO:0003824 GO:0004601 GO:0009636 GO:0016491 GO:0016691 GO:0016787 GO:0019806 GO:0055114 GO:0098869
20	0.07	0.573	4.77	0.11	0.79	1hkhA	GO:0003824 GO:0004601 GO:0098869
21	0.07	0.566	4.89	0.09	0.78	1a8sA	GO:0003824 GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
22	0.07	0.583	4.62	0.08	0.80	4dlnB	GO:0016787
23	0.07	0.552	4.47	0.09	0.75	1iunB	GO:0003824 GO:0016787
24	0.07	0.502	4.60	0.09	0.69	3dkrA	GO:0052689
25	0.07	0.557	4.69	0.09	0.78	2vf2A	GO:0005618 GO:0005886 GO:0006629 GO:0006694 GO:0016042 GO:0016787 GO:0018774 GO:0019439 GO:0034820 GO:0044117 GO:0102296
26	0.07	0.537	4.69	0.10	0.74	3qitB	GO:0003824 GO:0008152 GO:0016740 GO:0031177
27	0.07	0.539	4.41	0.11	0.73	3kxpA	GO:0016787 GO:0042803 GO:0042820 GO:0047411
28	0.07	0.532	4.36	0.10	0.72	1j1iA	GO:0016787

Consensus prediction of GO terms

Molecular Function	GO:0019120	GO:0016832
GO-Score	0.44	0.36
Biological Processes	GO:0018899	GO:0042205
GO-Score	0.44	0.44
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.