I-TASSER results

I-TASSER results for job id Rv1481

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (335 residues)
MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRMLRFANMELLESVAPKR
PSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLVIDVSQSMRATDVEPSRMV
AAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKNALDKLQFADRTATGEAI
FTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNPKGAYTAARTAKDQGVPIS
TISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNAATLAELRAVYSSLQQQIGY
ETIKGDASVGWLRLGALALALAALAALLINRRLPT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRMLRFANMELLESVAPKRPSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLVIDVSQSMRATDVEPSRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKNALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNPKGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNAATLAELRAVYSSLQQQIGYETIKGDASVGWLRLGALALALAALAALLINRRLPT
Prediction	CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCEEEHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCCCCCEEHCCCCHHHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHHCCCEEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
Conf.Score	98754556545557779999999999999999999887655555445899999987577764667899999999999999999698888655678865999998888888778999999999999999999889998799999889669986898999999999997887888758999999999999965765788888875899997999888988875556999999999989969999986898866678865655689999999999979979995999999999999998666445544445788999999999999999999855899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRMLRFANMELLESVAPKRPSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLVIDVSQSMRATDVEPSRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKNALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNPKGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNAATLAELRAVYSSLQQQIGYETIKGDASVGWLRLGALALALAALAALLINRRLPT
Prediction	45231030031010230121111222222001100233444430240032410440256344222201110212021010000010326363555300000000002003163364310520150034006613750100000114402200101412630351056044643231040033005204723354445564210000000002323444454443024005303747020000000153223445344232511371044007526142140533720450054037525454455523220121122102223233223313328
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHCCCEEEHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEHCCCCCCCCCCCCEEHCCCCHHHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHHCCCEEEHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MTLPLLGPMTLSGFAHSWFFLFLFVVAGLVALYILMQLARQRRMLRFANMELLESVAPKRPSRWRHVPAILLVLSLLLFTIAMAGPTHDVRIPRNRAVVMLVIDVSQSMRATDVEPSRMVAAQEAAKQFADELTPGINLGLIAYAGTATVLVSPTTNREATKNALDKLQFADRTATGEAIFTALQAIATVGAVIGGGDTPPPARIVLFSDGKETMPTNPDNPKGAYTAARTAKDQGVPISTISFGTPYGFVEINDQRQPVPVDDETMKKVAQLSGGNSYNAATLAELRAVYSSLQQQIGYETIKGDASVGWLRLGALALALAALAALLINRRLPT

4rckA

0.26

0.14

0.56

1.45

MUSTER

----------------------------------------------------------------------------------------------EH--RDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQ-RKGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLVTAIGEGLGLATKTFIESN--------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGVNTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.15

0.56

2.25

dPPAS

------------------------------------------------------------------------------------------------EHRDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQR-KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLRTAIGEGLGLATKTFIESN--------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGKQTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.14

0.56

2.82

wdPPAS

------------------------------------------------------------------------------------------------EHRDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQ-RKGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLVTAIGEGLGLATKTFIES---------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGVNTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.14

0.56

1.82

wMUSTER

--------------------------------------------------------------------------------------------------RDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQ-RKGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLVTAIGEGLGLATKTFIESN--------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGVNTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.15

0.56

3.01

wPPAS

----------------------------------------------------------------------------------------------EH--RDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQ-RKGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLRTAIGEGLGLATKTFIES---------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFTVNTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.15

0.56

6.01

dPPAS2

------------------------------------------------------------------------------------------------EHRDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQR-KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLRTAIGEGLGLATKTFIESN--------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGKQTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.15

0.56

2.53

PPAS

----------------------------------------------------------------------------------------------EH--RDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQR-KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLRTAIGEGLGLATKTFIESN--------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGVNTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

4rckA

0.26

0.15

0.56

3.83

Env-PPAS

----------------------------------------------------------------------------------------------EH--RDLVVDLSGSAEEDKTSNDRLTAVKQVVSDFIDQR-KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRTVLNLRTAIGEGLGLATKTFIESN--------APQRTIILLSDGANTAGVLE-----PLEAAQLAKDNHAKIYTVGIGAGEQVRGFFGKQTARDLDEDTLTKIATT-GGQYFRARNADELAEIYQTIDALEP------------------------------------

3ibsA

0.22

0.12

0.56

1.40

MUSTER

----------------------------------------------------------------------------------------------KGVEVIIALDISNSL-AQDVQPSRLEKAKRLISRLVDEL-DNDKVGIVFA-GDAFTQLPITSDYISAKFLSPSLISKQGTAIGEAINLATRSFT--------PQEGVGRAIIVITDGENHEG-------GAVEAAKAAAEKGIQVSVLGVGPEGARRDREGNVIVTRLNEG-CQEIAKDGKGIYVRVDSNSAQKAISQEISKAKS------------------------------------

3ibsA

0.22

0.12

0.56

1.92

dPPAS

----------------------------------------------------------------------------------------------KGVEVIIALDISNSL-AQDVQPSRLEKAKRLISRLVDEL-DNDKVGIVFA-GDAFTQLPITSDYISAKFLEPSLISKQGTAIGEAINLATRSF--------TPQEGVGRAIIVITDGENHEGG-------AVEAAKAAAEKGIQVSVLGVGPEGARRDREGNVIVTRLNE-GCQEIAKDGKGIYVRVDSNSAQKAISQEISKAKS------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.10

Estimated TM-score = 0.37±0.12

Estimated RMSD = 14.0±3.9Å

Download Model 2

C-score=-3.14

Download Model 3

C-score=-3.42

Download Model 4

C-score=-3.73

Download Model 5

C-score=-3.77

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5gjvF	0.549	4.13	0.120	0.675
2	3jbrF	0.549	4.07	0.099	0.675
3	3ibsA	0.522	1.77	0.227	0.552
4	2ww8A	0.520	3.55	0.125	0.621
5	1jeyB	0.517	3.85	0.121	0.624
6	1jeqA1	0.517	3.66	0.142	0.612
7	4cn8A	0.516	3.67	0.146	0.609
8	1pcxA	0.514	4.14	0.084	0.636
9	3efoB	0.511	4.34	0.127	0.645
10	3eh2A	0.510	4.34	0.139	0.642

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.74	34	5e6rA	MG	Rep, Mult	104,106,108,174,210
2	0.01	1	1n9zA	MG	Rep, Mult	103,123,141
3	0.01	1	1oak1	III	Rep, Mult	216,222,225,228,229,230,266,267,270

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vz9B	0.450	5.76	0.041	0.672	2.3.1.85	208
2	0.060	1lnsA	0.435	5.93	0.072	0.660	3.4.14.11	NA
3	0.060	3cmmC	0.476	5.76	0.078	0.705	6.3.2.19	177,213,222,229,242
4	0.060	2ok5A	0.460	4.37	0.102	0.573	3.4.21.47	NA
5	0.060	2x42A	0.443	6.13	0.093	0.693	3.2.1.21	240,265
6	0.060	1w6uA	0.443	5.03	0.061	0.615	1.3.1.34	262
7	0.060	1b0pA	0.460	5.98	0.070	0.708	1.2.7.1	NA
8	0.060	3igyB	0.431	5.39	0.074	0.636	5.4.2.1	210
9	0.060	2qt3B	0.430	6.18	0.071	0.669	3.5.99.4	NA
10	0.060	2et6A	0.462	5.86	0.057	0.705	1.1.1.-	NA
11	0.060	1kzhB	0.429	5.42	0.072	0.609	2.7.1.90	210
12	0.060	1ga1A	0.450	4.58	0.099	0.594	3.4.21.100,3.4.23.37	NA
13	0.060	1f76A	0.437	6.28	0.045	0.696	1.3.3.1	NA
14	0.060	1q0pA	0.435	2.90	0.170	0.490	3.4.21.47	274
15	0.060	1thgA	0.427	5.74	0.069	0.651	3.1.1.3	NA
16	0.060	2pffD	0.470	6.13	0.058	0.743	2.3.1.86	126,205,208,239
17	0.060	2gkoA	0.430	4.79	0.086	0.582	3.4.21.14	NA
18	0.060	2e1pA	0.459	5.13	0.098	0.636	3.4.21.62	NA
19	0.060	2prmA	0.434	6.57	0.043	0.705	1.3.5.2	214

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.38	0.483	2.66	0.14	0.54	1pt6B	GO:0000187 GO:0001669 GO:0005102 GO:0005518 GO:0005886 GO:0005925 GO:0006936 GO:0007155 GO:0007160 GO:0007229 GO:0008285 GO:0008305 GO:0009897 GO:0009986 GO:0016020 GO:0016021 GO:0019903 GO:0030198 GO:0030593 GO:0032516 GO:0034665 GO:0042059 GO:0042311 GO:0043005 GO:0043204 GO:0043525 GO:0045121 GO:0045123 GO:0045178 GO:0046872 GO:0048812 GO:0060326 GO:0070062 GO:0098639
1	0.30	0.538	1.74	0.23	0.57	3ibsA	GO:0016020 GO:0016021
2	0.30	0.516	2.05	0.23	0.56	4jduA	GO:0016020 GO:0016021 GO:0046872
3	0.27	0.475	2.76	0.20	0.55	5a5bW	GO:0000502 GO:0005198 GO:0005634 GO:0005829 GO:0006511 GO:0008540 GO:0031593 GO:0043161 GO:0043248
4	0.26	0.491	2.21	0.13	0.54	4wfqA	GO:0000112 GO:0000439 GO:0000990 GO:0005634 GO:0005675 GO:0006281 GO:0006289 GO:0006351 GO:0006355 GO:0006366 GO:0006974 GO:0008270 GO:0016567 GO:0046872 GO:0061630 GO:0070816
5	0.26	0.477	2.34	0.18	0.52	1shuX	GO:0004872 GO:0005576 GO:0005783 GO:0005789 GO:0005886 GO:0009897 GO:0009986 GO:0010008 GO:0016020 GO:0016021 GO:0022414 GO:0046872 GO:1901998
6	0.24	0.486	2.36	0.15	0.54	5ivw0	GO:0000439 GO:0000717 GO:0002031 GO:0003676 GO:0003700 GO:0004672 GO:0005634 GO:0005654 GO:0005675 GO:0006281 GO:0006283 GO:0006289 GO:0006293 GO:0006294 GO:0006295 GO:0006296 GO:0006351 GO:0006355 GO:0006361 GO:0006362 GO:0006363 GO:0006366 GO:0006367 GO:0006368 GO:0006370 GO:0006412 GO:0006468 GO:0006974 GO:0008094 GO:0008135 GO:0008270 GO:0008353 GO:0009411 GO:0033683 GO:0046872 GO:0047485 GO:0070911
7	0.24	0.469	2.26	0.19	0.51	2x5nA	GO:0000502 GO:0005634 GO:0005829 GO:0006511 GO:0008540 GO:0036435 GO:0043161 GO:0043248 GO:0045842
8	0.18	0.511	3.63	0.13	0.61	4cn9A	GO:0046872
9	0.15	0.549	4.07	0.10	0.67	3jbrF	GO:0005244 GO:0005262 GO:0006810 GO:0006811 GO:0006816 GO:0016020 GO:0016021 GO:0034765 GO:0046872 GO:0070588
10	0.13	0.485	2.58	0.15	0.54	4f1jA	GO:0046872
11	0.12	0.469	2.98	0.11	0.53	4hqoB	GO:0016020 GO:0016021 GO:0046872
12	0.08	0.471	2.71	0.15	0.53	1n9zA	GO:0001948 GO:0005615 GO:0005886 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0010668 GO:0016020 GO:0016021 GO:0030198 GO:0034142 GO:0046872 GO:0050900 GO:0070062
13	0.08	0.457	2.67	0.14	0.51	3qa3I	GO:0001948 GO:0005615 GO:0005886 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0010668 GO:0016020 GO:0016021 GO:0030198 GO:0034142 GO:0046872 GO:0050900 GO:0070062
14	0.08	0.475	2.80	0.15	0.53	3n2nA	GO:0004872 GO:0004888 GO:0005518 GO:0005886 GO:0007165 GO:0009986 GO:0010008 GO:0016020 GO:0016021 GO:0022414 GO:0031258 GO:0031527 GO:0031532 GO:0034446 GO:0042995 GO:0046872 GO:0051015 GO:0070062
15	0.07	0.506	3.49	0.12	0.60	3txaA	GO:0016020 GO:0016021 GO:0046872
16	0.07	0.520	3.55	0.12	0.62	2ww8A	GO:0016020 GO:0016021
17	0.07	0.511	4.34	0.13	0.64	3efoB	GO:0000139 GO:0001701 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0048208 GO:0048471
18	0.06	0.403	5.63	0.08	0.60	1npdB	GO:0000166 GO:0004764 GO:0008652 GO:0009073 GO:0009423 GO:0016491 GO:0030266 GO:0050661 GO:0051287 GO:0052733 GO:0052734 GO:0055114
19	0.06	0.365	6.38	0.07	0.59	3mjmA	GO:0004151 GO:0006221 GO:0008270 GO:0016787 GO:0016812 GO:0019856 GO:0044205 GO:0046872
20	0.06	0.361	5.07	0.06	0.52	3c3yA	GO:0008168 GO:0008171 GO:0016740 GO:0032259 GO:0042409 GO:0046872
21	0.06	0.416	5.63	0.08	0.61	4l4xA	GO:0000166 GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0048037
22	0.06	0.367	6.11	0.05	0.59	2h6eA	GO:0004022 GO:0008270 GO:0016491 GO:0046872 GO:0055114
23	0.06	0.345	4.26	0.03	0.45	2k5uA	GO:0000166 GO:0003924 GO:0005525 GO:0005622 GO:0005794 GO:0006810 GO:0006888 GO:0006893 GO:0007264 GO:0015031 GO:0016192 GO:0016236
24	0.06	0.389	5.82	0.07	0.60	2bklB	GO:0004252 GO:0006508 GO:0008236 GO:0070008
25	0.06	0.325	5.75	0.05	0.48	4lk3B	GO:0005739 GO:0005794 GO:0016020 GO:0016021 GO:0016829 GO:0016831 GO:0032580 GO:0033320 GO:0042803 GO:0048040 GO:0051262 GO:0070062 GO:0070403

Consensus prediction of GO terms

Molecular Function	GO:0043130	GO:0046914	GO:0004842	GO:0000988	GO:0061659	GO:0098639	GO:0005102	GO:0019903
GO-Score	0.53	0.52	0.52	0.52	0.52	0.39	0.39	0.39
Biological Processes	GO:0006511	GO:0043623	GO:0010498	GO:0032446	GO:0006357	GO:0033554	GO:0006259	GO:0006936	GO:0007229	GO:0030198	GO:0042059	GO:0043525	GO:0042311	GO:0007160	GO:0032516	GO:0030593	GO:0000187	GO:0048812	GO:0008285	GO:0045123
GO-Score	0.53	0.53	0.53	0.52	0.52	0.52	0.52	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39
Cellular Component	GO:0005838	GO:0032806	GO:0090575	GO:0000109	GO:0016591	GO:0005925	GO:0034665	GO:0045121	GO:0001669	GO:0070062	GO:0043204	GO:0045178	GO:0009897	GO:0043005
GO-Score	0.53	0.52	0.52	0.52	0.52	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39	0.39

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.