I-TASSER results

I-TASSER results for job id Rv1480

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (317 residues)
MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLHGDHLGLIPGPGSEPG
ESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTACCEKRDL
AVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQAPAGVRG
DLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARHEVLAIEVLDPRDVELPDV
GDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTIRGCGAPLLSLRTDRDWLAD
IVRFVASRRRGALAGHQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLHGDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARHEVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTIRGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ
Prediction	CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEHCCCCCEEEEHCCCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCCEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCCEEEEEHCCHHHHCCCCCCCEEEEHCCCCEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHHHHHCCCCC
Conf.Score	99888888888887666555798999985558755443345555786667788999998886578999986447754454589948986434458859999978987677788987799999999999999999799589999869856886899998999999999998675578888999999999999689986999987999977999999999875978999987967756888787899958999599966899999999999999999999999998997899579998999999999999986557889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLHGDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARHEVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTIRGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ
Prediction	84546546434334234441325601530570503043314232324232434144230532142352443230102100232200010223434120000000121021236524112200100000010024341200000014633320304324500230041035045534345220230042026204440000000101236402400220033020000000122035036413130311133231313225400530252055115302510462603204032643225023400421243434448
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCEHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCEEHCCCCCEEEEHCCCCCCEEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEHCCCCEEEHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCHHHHHHHHHHHHCCCEEEEEHCCHHHHCCCCCCCEEEEHCCCCEEEEHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCHHHHHHHHHHHHHHHHCCCCC
MTESKAPAVVHPPSMLRGDIDDPKLAAALRTLELTVKQKLDGVLHGDHLGLIPGPGSEPGESRLYQPGDDVRRMDWAVTARTTHPHVRQMIADRELETWLVVDMSASLDFGTACCEKRDLAVAAAAAITFLNSGGGNRLGALIANGAAMTRVPARTGRQHQHTMLRTIATMPQAPAGVRGDLAVAIDALRRPERRRGMAVIISDFLGPINWMRPLRAIAARHEVLAIEVLDPRDVELPDVGDVVLQDAESGVVREFSIDPALRDDFARAAAAHRADVARTIRGCGAPLLSLRTDRDWLADIVRFVASRRRGALAGHQ

3ibsA

0.12

0.08

0.61

1.14

wdPPAS

---------------------------------------------------------------------------------------------KGVEVIIALDISNSLA-QDVQPSRLEKAKRLISRLVDEL--DNDKVGIVFAGD-AFTQLPITSDYISAKFLESISPSL---ISKQGTAIGEAINLATRSFTPQRAIIVITD-NHEGGAVEAAKAAAEKGQVSVLGVGPEGAPIPVEGTNDYRRDREGNVIVTRLNE----------------GCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS-------

2nvoA2

0.13

0.09

0.70

1.13

wdPPAS

-----------------------SDESRLTRFLVL------GVDGGTFYASAQKHTVQADFVRELVQRDAALALRVTLDVVRGQ------RAPANTRHLLALDVSGSMTCGDVAGVPGLTPNMAAAAMSLIALRTEPDALTMGFAEQFRPLITPRDT---LESAMQKAQSV----SFGGTDCAQPILWAAQERLDVDTFVVYTDWAGQVHPTVALDQYAQKPKLIVVGL---------TATEFSIADPQRRDMLDVVFDAAAPNVMTAFARGEV-------------------------------------------

3ibsA

0.12

0.07

0.60

1.09

wPPAS

---------------------------------------------------------------------------------------------KGVEVIIALDISNSLA-QDVQPSRLEKAKRLISRLVDE---DNDKVGIVFAGD--FTQLPITSDYISAKFLESISPSLIS---KQGTAIGEAINLATRSFTVGRAIIVITD-NHEGGAVEAAKAAAEKGQVSVLGVGPEGAPIPVEGTNDYRRDREGNVIVTRLNE----------------GCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS-------

2nvoA2

0.14

0.09

0.70

1.09

wPPAS

-----------------------SDESRLTRFLV-------GVDGGTFYASAQKHTVQADFVRELVQRDAALALRVTLDVVRGQ------RAPANTRHLLALDVSGSMTCGDVAGVPGLTPNMAAAAMSLIALRTEPDALTMGFAEQFRPLITPRDT---LESAMQKAQSV----SFGGTDCAQPILWAAQERLDVDTFVVYTDWAGQVHPTVALDQYAQKPKLIVVGL-TATEFSIA--------DPQRRDMLDV----------------------------GFD-----------AAAPNVMTAFARGEV----

4fx5A1

0.16

0.09

0.52

1.95

dPPAS2

---------------------------------------------------------------------------------------------SENVEVIIIDCSGSDYPRTK-------AAKEATKVAIDTLTDGAFFAVVAGTEGARVVYPTGGDYQSRAAAKEAVGRLHANGGTAGRWLAQAGRIFDTAPSAIKHAILLTDSETPADLARAIQSSIGNFTADCRGIWEPKELR-------KIADALLGTVGIIRDPATLAEDFRETAKS---------------------------------------------

3ibsA

0.12

0.08

0.61

1.30

Env-PPAS

---------------------------------------------------------------------------------------------KGVEVIIALDISNSL-AQDVQPSRLEKAKRLISRLVDEL--DNDKVGIVFAG-DAFTQLPITSDYISAKFLESISPSLIS---KQGTAIGEAINLATRSFTVGRAIIVITDENHEGGAVEAAKAAAEKGQVSVLGVGPEGAPIPVEGTNDYRRDREGNVIVTRLNE----------------GCQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS-------

3ibsA

0.12

0.08

0.61

1.93

dPPAS2

---------------------------------------------------------------------------------------------KGVEVIIALDISNSLA-QDVQPSRLEKAKRLISRLVDEL--DNDKVGIVFAGD-AFTQLPITSDYISAKFLESISPSL---ISKQGTAIGEAINLATRSFTPQRAIIVITDGENHEGGAVEAAKAAAEKGVSVLGVGPEGAPIPVEGTNDYRRDREGNVIVTRLNEG----------------CQEIAKDGKGIYVRVDNSNSAQKAISQEISKAKS-------

4rckA

0.15

0.09

0.58

1.15

Env-PPAS

-----------------------------------------------------------------------------------------------EHRDLVVDLSGSAESNGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT---VLNLVGQRTALGLATKTFIESNAPQRTIILLSDTAGVLEPLEAAQLAKDNHKIYTVGIGAG--------EQVRGFFGKQTVNTARDLDEDTLTKIATT---------------GGQYFRARN----ADELAEIYQTIDAL------

4rckA

0.16

0.09

0.54

0.93

wPPAS

--------------------------------------------------------------------------------------------E----RDLVVDLSGSAESNGDFVDRLTAVKQVVSDFIDQ---KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT---VLNLVGQRTALGLATKTFIESNAPQRTIILLSD-AGVLEPLEAAQLAKDNH-IYTVGIGAGEQVRGFF--------GKQTVNTARDLDEDTLTKIAT--ARNADELAEIYQTID--------------------------------

4rckA

0.16

0.09

0.54

1.65

dPPAS2

-----------------------------------------------------------------------------------------------EHRDLVVDLSGSAESNGDFVDRLTAVKQVVSDFIDQR--KGDRLGLVLFGDHAYLQTPLTFDRNTVREQLDRT---VLNLVGQRTALGLATKTFIESNAPQRTIILLSDTAGVLEPLEAAQLAKDNHKIYTVGIGAGEQVRGFFGKQTVNTARDGGQYFRARNADELAEIYQTIDAL---------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.77

Estimated TM-score = 0.31±0.10

Estimated RMSD = 15.6±3.3Å

Download Model 2

C-score=-3.93

Download Model 3

C-score=-4.37

Download Model 4

C-score=-4.44

Download Model 5

C-score=-4.33

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ibsA	0.575	1.78	0.129	0.612
2	4cn8A	0.532	3.70	0.076	0.640
3	1pcxA	0.523	4.35	0.081	0.662
4	3eh1A	0.517	4.25	0.080	0.659
5	3jbrF	0.512	3.65	0.073	0.622
6	3eh2A	0.511	4.13	0.078	0.650
7	3efoB	0.510	4.16	0.084	0.650
8	2ww8A	0.509	4.25	0.077	0.634
9	3txaA	0.507	4.07	0.059	0.625
10	1jeqA	0.503	3.08	0.065	0.584

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.40	34	1v7pC	MN	Rep, Mult	103,105,107,204
2	0.11	11	3bqmB	BQM	Rep, Mult	98,124,128,137,200,223,225,226,227,287,288,289
3	0.01	1	1t6b1	III	Rep, Mult	104,105,106,107,146,147,179,180,181,184,210
4	0.01	1	2ww8A	CA	Rep, Mult	139,153,155,157,162
5	0.01	1	2winK	UUU	Rep, Mult	108,116,117
6	0.01	1	1n9zA	MG	Rep, Mult	102,122,141,168
7	0.01	1	1oak1	III	Rep, Mult	208,209,210,213,214,215,216,217,276,277,280
8	0.01	1	2b0qA	MG	Rep, Mult	204,231

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1v9cB	0.422	4.47	0.063	0.571	5.4.1.2	NA
2	0.060	3efvA	0.432	5.20	0.058	0.606	1.2.1.-	NA
3	0.060	1e5tA	0.414	5.70	0.048	0.622	3.4.21.26	NA
4	0.060	2ok5A	0.487	4.34	0.079	0.615	3.4.21.47	NA
5	0.060	3fg0C	0.433	5.08	0.056	0.603	1.2.1.8	NA
6	0.060	1cvrA	0.427	4.83	0.062	0.596	3.4.22.37	NA
7	0.060	1ua4A	0.416	5.59	0.067	0.618	2.7.1.147	118,301
8	0.060	2pffD	0.435	6.59	0.022	0.710	2.3.1.86	125,131
9	0.060	2jc9A	0.428	5.55	0.034	0.631	3.1.3.5	NA
10	0.060	2d4eC	0.434	5.33	0.057	0.618	1.2.1.60	223
11	0.060	1gc5A	0.417	5.75	0.069	0.625	2.7.1.147	NA
12	0.060	2pffA	0.433	6.30	0.064	0.710	2.3.1.41,2.3.1.86	NA
13	0.060	2prlA	0.415	6.54	0.095	0.697	1.3.3.1,1.3.99.11	NA
14	0.060	1uuoA	0.402	6.51	0.070	0.672	1.3.3.1,1.3.99.11	NA
15	0.060	2afvA	0.418	4.65	0.052	0.574	5.4.1.2	NA
16	0.060	1ky8A	0.426	5.35	0.059	0.603	1.2.1.9	223
17	0.060	2iw5A	0.424	5.47	0.086	0.622	1.-.-.-	NA
18	0.060	1pixA	0.436	5.81	0.057	0.672	4.1.1.70	NA
19	0.060	1a4sA	0.431	5.16	0.051	0.603	1.2.1.8,1.2.1.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.490	2.36	0.12	0.54	1shuX	GO:0004872 GO:0005576 GO:0005783 GO:0005789 GO:0005886 GO:0009897 GO:0009986 GO:0010008 GO:0016020 GO:0016021 GO:0022414 GO:0046872 GO:1901998
1	0.31	0.494	2.98	0.09	0.57	1aoxA	GO:0001618 GO:0001666 GO:0002687 GO:0005178 GO:0005518 GO:0005634 GO:0005886 GO:0005925 GO:0006929 GO:0006971 GO:0007155 GO:0007160 GO:0007229 GO:0007565 GO:0007596 GO:0008283 GO:0008305 GO:0009887 GO:0009897 GO:0009986 GO:0010634 GO:0010694 GO:0014070 GO:0014075 GO:0014850 GO:0014911 GO:0016020 GO:0016021 GO:0016032 GO:0030198 GO:0030424 GO:0030879 GO:0031346 GO:0031589 GO:0032403 GO:0032967 GO:0033343 GO:0033591 GO:0033627 GO:0034666 GO:0038064 GO:0038065 GO:0042060 GO:0042493 GO:0042995 GO:0043236 GO:0043388 GO:0043589 GO:0043679 GO:0045178 GO:0045184 GO:0045727 GO:0045785 GO:0045987 GO:0046718 GO:0046872 GO:0046982 GO:0048041 GO:0048333 GO:0048471 GO:0048661 GO:0050729 GO:0050927 GO:0050966 GO:0051971 GO:0060100 GO:0070365 GO:0071107 GO:0071260 GO:0071392 GO:0071407 GO:0098639
2	0.30	0.490	2.70	0.09	0.55	1na5A	GO:0001948 GO:0005615 GO:0005886 GO:0007155 GO:0007229 GO:0008305 GO:0009986 GO:0010668 GO:0016020 GO:0016021 GO:0030198 GO:0034142 GO:0046872 GO:0050900 GO:0070062
3	0.28	0.480	2.96	0.12	0.55	1pt6B	GO:0000187 GO:0001669 GO:0005102 GO:0005518 GO:0005886 GO:0005925 GO:0006936 GO:0007155 GO:0007160 GO:0007229 GO:0008285 GO:0008305 GO:0009897 GO:0009986 GO:0016020 GO:0016021 GO:0019903 GO:0030198 GO:0030593 GO:0032516 GO:0034665 GO:0042059 GO:0042311 GO:0043005 GO:0043204 GO:0043525 GO:0045121 GO:0045123 GO:0045178 GO:0046872 GO:0048812 GO:0060326 GO:0070062 GO:0098639
4	0.23	0.565	1.95	0.13	0.61	4jduA	GO:0016020 GO:0016021 GO:0046872
5	0.22	0.496	2.86	0.09	0.57	2i6qA	GO:0004252 GO:0005576 GO:0006508 GO:0006956 GO:0008233 GO:0008236 GO:0016787 GO:0046872
6	0.22	0.475	2.82	0.13	0.55	5a5bW	GO:0000502 GO:0005198 GO:0005634 GO:0005829 GO:0006511 GO:0008540 GO:0031593 GO:0043161 GO:0043248
7	0.14	0.475	2.33	0.10	0.52	2x5nA	GO:0000502 GO:0005634 GO:0005829 GO:0006511 GO:0008540 GO:0036435 GO:0043161 GO:0043248 GO:0045842
8	0.11	0.535	3.58	0.08	0.64	4cn9A	GO:0046872
9	0.10	0.493	2.77	0.11	0.56	5ivw0	GO:0000439 GO:0000717 GO:0002031 GO:0003676 GO:0003700 GO:0004672 GO:0005634 GO:0005654 GO:0005675 GO:0006281 GO:0006283 GO:0006289 GO:0006293 GO:0006294 GO:0006295 GO:0006296 GO:0006351 GO:0006355 GO:0006361 GO:0006362 GO:0006363 GO:0006366 GO:0006367 GO:0006368 GO:0006370 GO:0006412 GO:0006468 GO:0006974 GO:0008094 GO:0008135 GO:0008270 GO:0008353 GO:0009411 GO:0033683 GO:0046872 GO:0047485 GO:0070911
10	0.07	0.480	2.78	0.12	0.54	3n2nA	GO:0004872 GO:0004888 GO:0005518 GO:0005886 GO:0007165 GO:0009986 GO:0010008 GO:0016020 GO:0016021 GO:0022414 GO:0031258 GO:0031527 GO:0031532 GO:0034446 GO:0042995 GO:0046872 GO:0051015 GO:0070062
11	0.07	0.591	1.74	0.13	0.63	3ibsA	GO:0016020 GO:0016021
12	0.07	0.492	2.67	0.10	0.55	4wfqA	GO:0000112 GO:0000439 GO:0000990 GO:0005634 GO:0005675 GO:0006281 GO:0006289 GO:0006351 GO:0006355 GO:0006366 GO:0006974 GO:0008270 GO:0016567 GO:0046872 GO:0061630 GO:0070816
13	0.07	0.469	2.35	0.10	0.52	2iueA	GO:0001948 GO:0005886 GO:0006954 GO:0007159 GO:0007160 GO:0007229 GO:0009986 GO:0016020 GO:0016021 GO:0019901 GO:0030141 GO:0030369 GO:0030593 GO:0034113 GO:0034687 GO:0035987 GO:0043113 GO:0043235 GO:0050730 GO:0050839 GO:0070062 GO:1903561
14	0.07	0.517	4.25	0.08	0.66	3eh1A	GO:0000139 GO:0001843 GO:0002093 GO:0002474 GO:0003151 GO:0005215 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0021747 GO:0030127 GO:0030134 GO:0035909 GO:0048208 GO:0048471 GO:0060088 GO:0060425 GO:0060463 GO:0060982 GO:0061156 GO:0072358 GO:0090178 GO:1901301
15	0.07	0.525	4.13	0.09	0.66	1m2vB	GO:0000139 GO:0005048 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0030127 GO:0031410 GO:0046872 GO:0090110
16	0.07	0.518	4.16	0.08	0.66	3egdB	GO:0000139 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0045714 GO:0048208 GO:0048471 GO:0050714 GO:2000189
17	0.07	0.304	6.89	0.05	0.54	3eg9A	GO:0000139 GO:0002474 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0030134 GO:0030868 GO:0048208 GO:0048471
18	0.07	0.510	4.16	0.08	0.65	3efoB	GO:0000139 GO:0001701 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0048208 GO:0048471
19	0.07	0.523	4.35	0.08	0.66	1pcxA	GO:0000139 GO:0005048 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0030127 GO:0031410 GO:0046872 GO:0090110
20	0.07	0.511	4.13	0.08	0.65	3eh2A	GO:0000139 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0048208 GO:0048471
21	0.07	0.503	4.17	0.08	0.63	4bziA	GO:0000139 GO:0003400 GO:0005096 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0016236 GO:0030127 GO:0031410 GO:0043547 GO:0046872
22	0.07	0.500	3.56	0.07	0.59	5e6uA	GO:0002291 GO:0005886 GO:0006928 GO:0006954 GO:0007155 GO:0007157 GO:0007159 GO:0007160 GO:0007165 GO:0007229 GO:0008305 GO:0009986 GO:0016020 GO:0016021 GO:0016337 GO:0030198 GO:0030369 GO:0032403 GO:0034687 GO:0043113 GO:0046872 GO:0046982 GO:0050776 GO:0050839 GO:0050900 GO:0070062
23	0.07	0.475	2.88	0.16	0.55	4dmuJ	GO:0001948 GO:0002020 GO:0002576 GO:0005178 GO:0005518 GO:0005576 GO:0005578 GO:0005783 GO:0007155 GO:0007596 GO:0007597 GO:0007599 GO:0009611 GO:0019865 GO:0030168 GO:0030198 GO:0031012 GO:0031091 GO:0031093 GO:0031589 GO:0033093 GO:0035902 GO:0042802 GO:0042803 GO:0047485 GO:0051087 GO:0051260 GO:0070062
24	0.07	0.480	2.56	0.09	0.54	4igiA	GO:0004867 GO:0005578 GO:0005581 GO:0005615 GO:0010951 GO:0031012 GO:0042383 GO:0070062 GO:1903561
25	0.07	0.486	2.96	0.13	0.56	4f1jA	GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0097367	GO:0019902	GO:0098639	GO:0043236	GO:0046982	GO:0005178	GO:0001618	GO:0038064
GO-Score	0.83	0.60	0.55	0.50	0.31	0.31	0.31	0.31	0.31
Biological Processes	GO:0030198	GO:0007229	GO:0002224	GO:0007398	GO:0042058	GO:0043666	GO:0043065	GO:0048858	GO:0043406	GO:1990266	GO:0043523	GO:1901185	GO:0032147	GO:1901216	GO:0050880	GO:0035307	GO:0031175	GO:0071621	GO:1901998	GO:0033627	GO:0071260	GO:0006929	GO:0071107	GO:0050729	GO:0042493	GO:0043589	GO:0006971	GO:0045727	GO:0051971	GO:0010694	GO:0043388	GO:0048333	GO:0002687	GO:0033591	GO:0007565	GO:0048041	GO:0038065	GO:0001666	GO:0010634	GO:0048661	GO:0050966	GO:0071392	GO:0014850	GO:0046718	GO:0032967	GO:0070365	GO:0030879	GO:0031346	GO:0045987	GO:0050927	GO:0014075	GO:0045785	GO:0033343	GO:0007596	GO:0045184	GO:0060100	GO:0014911
GO-Score	0.65	0.65	0.60	0.60	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.55	0.36	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31	0.31
Cellular Component	GO:0009897	GO:0097223	GO:0043025	GO:0098857	GO:0030141	GO:0005925	GO:0045178	GO:0070062	GO:0005789	GO:0010008	GO:0043679	GO:0005634	GO:0034666	GO:0048471
GO-Score	0.68	0.55	0.55	0.55	0.55	0.50	0.50	0.49	0.36	0.36	0.31	0.31	0.31	0.31

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.