I-TASSER results

I-TASSER results for job id Rv1461

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (846 residues)
MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISA
KKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDI
RNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFK
EYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLII
ADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGE
LFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKD
VAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVE
DVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDE
TFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGP
GVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPD
SYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAE
AGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTS
SNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDV
TMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQ
MEGAVG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
Prediction	CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCHHHHHHHCCCEEEEHCCEEEEHCCCHHHHHHCEEHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEHCCCCHCCCCEEEEEEHCCCCCCEEEEEEEEHCCCCEEEEEEEHCCCCCCCCCCCCEEEEEEEEHCCCEEEEEHCCCEEEEEEEEEHCCCCEEEEEEEEHCCCCHCCCCCCEEEEHCCCCCEEEEEHCCCCCCCCCCHHHCCCCCCCCCCCHCCCCEEEEHCCCCCCCCCCCCHHHHHHHCCEHCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEHCCHCHHHHHHHHHHHHHHCCEEEEEEEHCCCCCEEEHCCCCCCCHHHHHHHCCCCEEEEEHCCCEEEEEHCCEEEHCCCCCEEEEEEEHCCCEEEEEEEEEEHCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEEEHCCCCEEEEEEEEEEHCCCCEEEEEEEEHCCCEEEHCEEEEEHCCCCEEEEEEEEEHCCCEEEHCCEEEEEHCCCCEEEEEEEEEHCCCCEEEEEEEEEHCCCCCCCCCCCCCCEEEHCCCCEEHCCCEEEEHCCCEEEEEEHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
Conf.Score	998888777778887655546788999876556787677765445457999999999999979959999999999999998899988888876787466776467776778877799999999998798867887754565899878677654657777759699699999999899999998545788876788888876579689998798565885677888668987466679999879979999986578765444556467777777646556776466657876776647788589999875776444677858998678865478887477766666544456666655554445776888756777777777878877765355577765677876588857888599999999999998588887655567775678875656788899987556777776555547888899999887545676544456665444444448999999999999797678887646776456644577765566665458867898747767999845444544555546899997699699999987646677777776345568999869959999999857998799865799987896899999996885567655899976897899999999679869856579998679867888888888699679998899977888777765444658858998465665567766867898765456788899999998799999999999999999999978869999999999999856689
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG
Prediction	744446445546445445435545315304513120334524344034302360044006536104002500340052047261142455134020420211033445434415402550351054040243144312100000011210113035504542000020430055134003500231143652210000000000000000056140420000000013531200100000004401000012123231111202010100010112310102223201001001232241300010232322131011000000234504323244442434133330442333114154044120101021361464341244000000000000001234323101001444134004202400361254622224434443130101121003002410343153441354115244520220030003132303344423243132004201430331023101101022323635431243424533302121142110020214020101011412344423310100012244020100010111122334110000000000013403010000021242000001110202330301000010103201120102020640402010000026311000101010104404021000001234032002020203540640413340200001560322010101041420401410010304541110000021437303300030003300740244014103400443054548
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840

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Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHCCCHHHHHHHCCCEEEEHCCEEEEHCCCHHHHHHCEEHCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCEEEEHCCCCHCCCCEEEEEEHCCCCCCEEEEEEEEHCCCCEEEEEEEHCCCCCCCCCCCCEEEEEEEEHCCCEEEEEHCCCEEEEEEEEEHCCCCEEEEEEEEHCCCCHCCCCCCEEEEHCCCCCEEEEEHCCCCCCCCCCHHHCCCCCCCCCCCHCCCCEEEEHCCCCCCCCCCCCHHHHHHHCCEHCCCCCCCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEHCCCHHHHHHHHHHCCCCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEHCCHCHHHHHHHHHHHHHHCCEEEEEEEHCCCCCEEEHCCCCCCCHHHHHHHCCCCEEEEEHCCCEEEEEHCCEEEHCCCCCEEEEEEEHCCCEEEEEEEEEEHCCCCCCCCCCCEEEEEEEEHCCCCEEEEEEEEHCCCCEEEEEEEEEEHCCCCEEEEEEEEHCCCEEEHCEEEEEHCCCCEEEEEEEEEHCCCEEEHCCEEEEEHCCCCEEEEEEEEEHCCCCEEEEEEEEEHCCCCCCCCCCCCCCEEEHCCCCEEHCCCEEEEHCCCEEEEEEHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCC
MTLTPEASKSVAQPPTQAPLTQEEAIASLGRYGYGWADSDVAGANAQRGLSEAVVRDISAKKNEPDWMLQSRLKALRIFDRKPIPKWGSNLDGIDFDNIKYFVRSTEKQAASWDDLPEDIRNTYDRLGIPEAEKQRLVAGVAAQYESEVVYHQIREDLEAQGVIFLDTDTGLREHPDIFKEYFGTVIPAGDNKFSALNTAVWSGGSFIYVPPGVHVDIPLQAYFRINTENMGQFERTLIIADEGSYVHYVEGCLPAGELITTADGDLRPIESIRVGDFVTGHDGRPHRVTAVQVRDLDGELFTFTPMSPANAFSVTAEHPLLAIPRDEVRVMRKERNGWKAEVNSTKLRSAEPRWIAAKDVAEGDFLIYPKPKPIPHRTVLPLEFARLAGYYLAEGHACLTNGCESLIFSFHSDEFEYVEDVRQACKSLYEKSGSVLIEEHKHSARVTVYTKAGYAAMRDNVGIGSSNKKLSDLLMRQDETFLRELVDAYVNGDGNVTRRNGAVWKRVHTTSRLWAFQLQSILARLGHYATVELRRPGGPGVIMGRNVVRKDIYQVQWTEGGRGPKQARDCGDYFAVPIKKRAVREAHEPVYNLDVENPDSYLAYGFAVHNCTAPIYKSDSLHSAVVEIIVKPHARVRYTTIQNWSNNVYNLVTKRARAEAGATMEWIDGNIGSKVTMKYPAVWMTGEHAKGEVLSVAFAGEDQHQDTGAKMLHLAPNTSSNIVSKSVARGGGRTSYRGLVQVNKGAHGSRSSVKCDALLVDTVSRSDTYPYVDIREDDVTMGHEATVSKVSENQLFYLMSRGLTEDEAMAMVVRGFVEPIAKELPMEYALELNRLIELQMEGAVG

5awfA

0.44

0.20

0.45

2.12

MUSTER

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHW----------------------------------------------------------------LKAHEKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWTGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

2zu0A

0.17

0.08

0.48

2.92

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SNALQQWHHLFEAEGTKRSPQAQQHLQQLLRTGLPTRKHENWK-----YTPLEGLINSQFVSIAG----------EISPQQRDALA------LTLDSVRLVFVDGRYV-------PALSDATEGSGYEVSINDDRQGLP-------DAIQAEVFLHLTEAQSVTHIAVKRGLLMHITQGVAGEEVNTAHYRHHLDLAEGAEATVIEHFVS----LNDARHFTGARFTINVAANAHLQHIKLAFENPLSHHFAHNDLLLAEDATAFSHSFLLGGAVLRHNTSTQLNGENSTLRINSLAMPVKNEVCDTRTWLEHNKGFCNSRQLHKTIVSDKGRAVFNGLINVAQHAIKTDGQMTNNNLLMGKLAEVDTKPQLEIYADDVKCSHGATVGRIDDEQIFYLRSRGINQQDAQQMIIYAFAAELTEALREGLKQQVLARIGQRLPGGAR

5awfA

0.44

0.20

0.45

6.07

wdPPAS

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHWL----------------------------------------------------------------KAHEKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWFGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

5awfA

0.44

0.20

0.45

2.63

wMUSTER

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHW----------------------------------------------------------------LKAHEKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWTGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

5awfA

0.44

0.20

0.45

5.48

wPPAS

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHW----------------------------------------------------------------LKAHEKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWFGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

5awfA

0.44

0.20

0.45

8.20

dPPAS2

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHWL----------------------------------------------------------------KAHEKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWTGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

5awfA

0.44

0.20

0.45

4.57

PPAS

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHWL----------------------------------------------------------------KAHEKLAEQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWTGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

5awfA

0.44

0.20

0.45

8.05

Env-PPAS

---------------------------------------------LAKGINEEVVRAISAKRNEPEWMLEFRLNAYRAWLEMEEPHWLKAHEKLA----------------------------------------------------------------EQGIIFCSFGEAIHDHPELVRKYLGTVVPGNDNFFAALNAAVASDGTFIYVPKGVRCPMELSTYFRINAEKTGQFERTILVADEDSYVSYIEGCSAPV-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RDSYQLHAAVVEVIIHKNAEVKYSTVQNWFPGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

2zu0A

0.18

0.09

0.49

1.97

MUSTER

--------------------------------------------------SNALQQWHHLFEAEGTKRSPQAQQHLQQLLRTGLPT--RKHENWKYTPLEGLINSQFVSIAG--EIS---PQQRDALALT-------LDSVRLVFVDGRYVPALSDATEGSGYEVS-INDDRQGLPD----------AIQAEVFLHLTESLAQSVTHIAVKRGQRPAKPLLLMHITQGEVNTAHYRHHLDLAEGAEATVIEHFVSLN------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DARHFTGARFTINVAANAHLQHIKLAFENPLSHHFAHNDLLLAEDATAFSHSFLLGGAVLRHNTSTQLNGENSTLRINSLAMPVKNEVCDTRTWLEHNKGFCNSRQLHKTIVSDKGRAVFNGLINVAQHAIKTDGQMTNNNLLMGKLAEVDTKPQLEIYADDVKCSHGATVGRIDDEQIFYLRSRGINQQDAQQMIIYAFAAELTEALREGLKQQVLARIGQRLPGGAR

5awfA

0.30

0.13

0.44

2.88

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAKGINERAISAKRNEPEWMLEFRLNAYRAWLEMEEPHWLKA------------------------------------------------------HEKLAEQGIIFCS--------------------FGEAIHDHPELVRKYLGTVVPGNDNFFAALNAASDGTFIYVPKGVRCPMELSTYFRIKTGQFERTILVADEDSYVSYIEGCSA---PVRDSYQLHAAVVEVIIHKNAEVKYSTVQNWTGGILNFVTKRALCGENSKMSWTQSETGSAITWKYPSCILRGDNSIGEFYSVALTSGHQQADTGTKMIHIGKNTKSTIISKGISAGHSQNSYRGLVKIMPTATNARNFTQCDSMLIGANCGAHTFPYVECRNNSAQLEHEATTSRIGEDQLFYCLQRGISEEDAISMIVNGFCKDVFSELPLEFAVEAQKLLAISLEHSVG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.07

Estimated TM-score = 0.28±0.09

Estimated RMSD = 19.4±1.9Å

Download Model 2

C-score=-4.06

Download Model 3

C-score=-4.14

Download Model 4

C-score=-4.22

Download Model 5

C-score=-4.10

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2zu0A	0.478	1.29	0.178	0.486
2	4dn7A	0.424	3.02	0.223	0.455
3	5awfA	0.401	2.91	0.387	0.430
4	5a22A	0.303	8.80	0.038	0.488
5	3eqnA	0.284	5.82	0.040	0.358
6	3vstA	0.284	6.82	0.035	0.385
7	1t3tA	0.283	9.23	0.037	0.479
8	3ecqB	0.280	8.53	0.051	0.436
9	4j5tA	0.276	8.09	0.025	0.422
10	1ogmX	0.275	6.35	0.049	0.364

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.11	6	2ckjD	FES	Rep, Mult	48,49,50,51,53,54,55,56,107
2	0.07	4	2zu0B	III	Rep, Mult	794,795,798,799,802,803,804,812,816
3	0.04	2	3eqnA	ZN	Rep, Mult	707,714
4	0.04	2	2no5A	CNR	Rep, Mult	835,838
5	0.02	1	3eubS	FES	Rep, Mult	168,169,170,204,205,206
6	0.02	1	3poyA	BGC	Rep, Mult	219,222,249
7	0.02	1	1z44A	NPO	Rep, Mult	810,811,814
8	0.02	1	2qyvA	ZN	Rep, Mult	191,243,623
9	0.02	1	3mruA	ZN	Rep, Mult	191,623
10	0.02	1	2zu0B	III	Rep, Mult	798,802
11	0.02	1	1jwlA	NUC	Rep, Mult	196,200
12	0.02	1	3tptB	MG	Rep, Mult	714,718,757
13	0.02	1	1bglB	MG	Rep, Mult	98,191,395,397,439
14	0.02	1	3fltA	CA	Rep, Mult	777,785
15	0.02	1	2eulD	ZN	Rep, Mult	832,835
16	0.02	1	2nr9A	PA6	Rep, Mult	837,841
17	0.02	1	3scxA	CA	Rep, Mult	423,427

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3cf4A	0.272	9.03	0.035	0.448	1.2.99.2	NA
2	0.060	1bxrA	0.250	9.10	0.024	0.420	6.3.5.5	NA
3	0.060	2cqsA	0.257	8.63	0.044	0.412	2.4.1.20	NA
4	0.060	3b9jJ	0.163	6.49	0.040	0.220	1.17.1.4,1.17.3.2	652
5	0.060	3ikmD	0.258	8.98	0.040	0.422	2.7.7.7	NA
6	0.060	3h09B	0.252	8.00	0.026	0.378	3.4.21.72	70
7	0.060	1t3tA	0.283	9.23	0.037	0.479	6.3.5.3	NA
8	0.060	2uveA	0.255	6.53	0.032	0.340	3.2.1.82	208,248
9	0.060	3eqoA	0.284	5.86	0.040	0.359	3.2.1.58	NA
10	0.060	2r72A	0.252	8.95	0.043	0.414	2.7.7.48	203
11	0.060	2z8yD	0.263	7.37	0.049	0.376	1.2.7.4,1.2.99.2	317,324
12	0.060	2pdaA	0.246	8.69	0.018	0.392	1.2.7.1	NA
13	0.060	2azdB	0.256	8.45	0.057	0.402	2.4.1.1	NA
14	0.060	3l4uA	0.259	8.28	0.040	0.400	3.2.1.20,3.2.1.3	61,108
15	0.060	1k32A	0.254	8.91	0.033	0.412	3.4.21.-	NA
16	0.060	3ecqB	0.280	8.53	0.051	0.436	3.2.1.97	233
17	0.060	1ogmX	0.275	6.35	0.049	0.364	3.2.1.11	NA
18	0.060	1ahpA	0.253	8.52	0.051	0.401	2.4.1.1	74,199
19	0.060	3b9jC	0.210	9.10	0.033	0.346	1.17.3.2,1.17.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.478	1.29	0.18	0.49	2zu0A	GO:0006979 GO:0016226
1	0.06	0.433	2.98	0.22	0.46	4dn7A	GO:0005524 GO:0016226
2	0.06	0.401	2.91	0.39	0.43	5awfA	GO:0016226 GO:0051539
3	0.06	0.225	8.14	0.06	0.34	3ictA	GO:0000166 GO:0003756 GO:0005623 GO:0016491 GO:0045454 GO:0050451 GO:0050660 GO:0050661 GO:0055114
4	0.06	0.209	6.74	0.04	0.29	2x6kA	GO:0000166 GO:0000421 GO:0005524 GO:0005769 GO:0006897 GO:0006914 GO:0009267 GO:0010506 GO:0016301 GO:0016303 GO:0016310 GO:0016322 GO:0016740 GO:0033227 GO:0034271 GO:0035004 GO:0035005 GO:0035032 GO:0035096 GO:0036092 GO:0045850 GO:0046854 GO:0046934 GO:0048015
5	0.06	0.161	7.66	0.02	0.24	2cb1A	GO:0003824 GO:0016829 GO:0030170
6	0.06	0.170	6.49	0.04	0.23	1c9wA	GO:0004032 GO:0005737 GO:0016491 GO:0055114
7	0.06	0.186	7.70	0.06	0.28	1sezA	GO:0004729 GO:0005739 GO:0006779 GO:0006782 GO:0006783 GO:0016491 GO:0055114
8	0.06	0.161	5.88	0.04	0.21	2yhaA	GO:0003676
9	0.06	0.135	6.13	0.03	0.18	4gq0A	GO:0001523 GO:0001758 GO:0004033 GO:0005576 GO:0005764 GO:0005829 GO:0006081 GO:0007586 GO:0008202 GO:0016488 GO:0016491 GO:0044597 GO:0044598 GO:0045550 GO:0047718 GO:0055114 GO:0070062
10	0.06	0.171	7.51	0.02	0.25	4cnjA	GO:0000166 GO:0016491 GO:0055114
11	0.06	0.151	7.14	0.04	0.22	1qzzA	GO:0008168 GO:0008171 GO:0016829 GO:0016831 GO:0017000 GO:0032259
12	0.06	0.147	7.41	0.04	0.21	5chsB	GO:0000166 GO:0001172 GO:0003824 GO:0003968 GO:0004482 GO:0005524 GO:0006139 GO:0006370 GO:0006397 GO:0008152 GO:0008168 GO:0016740 GO:0016779 GO:0019012 GO:0030430 GO:0032259 GO:0036265 GO:0039689
13	0.06	0.151	6.31	0.04	0.20	2exxA	GO:0000050 GO:0005634 GO:0005737 GO:0005829 GO:0048471
14	0.06	0.144	4.92	0.09	0.17	4q16D	GO:0000166 GO:0003952 GO:0005524 GO:0005737 GO:0008795 GO:0009435 GO:0016874
15	0.06	0.160	6.92	0.05	0.22	2ip2A	GO:0008168 GO:0008171 GO:0008757 GO:0016740 GO:0019438 GO:0032259
16	0.06	0.165	6.88	0.06	0.23	4pmxA	GO:0000272 GO:0004553 GO:0005975 GO:0008152 GO:0016787 GO:0016798 GO:0031176 GO:0045493 GO:0046872
17	0.06	0.170	6.76	0.04	0.23	4hnnF	GO:0003824 GO:0008152 GO:0008840 GO:0009089 GO:0016829
18	0.06	0.136	6.81	0.04	0.19	4dppA	GO:0003824 GO:0008152 GO:0008652 GO:0008840 GO:0009085 GO:0009089 GO:0009507 GO:0009536 GO:0016829 GO:0019877

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0051539	GO:0003756	GO:0050661	GO:0016303	GO:0050451	GO:0050660	GO:0046934	GO:0035005
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:0006790	GO:0031163	GO:0051188
GO-Score	0.36	0.36	0.36
Cellular Component	GO:0005769	GO:0034271	GO:0000421
GO-Score	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.