I-TASSER results

I-TASSER results for job id Rv1455

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (287 residues)
MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWLSWDDPEIVHADLVIL
RATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMDRGVPTVPGEVYVPGEP
VRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLVQPGGSGDETVLVFLGGE
PSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGELLYARAHITGGSRDPRLL
ELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGPFSHRRP

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWLSWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMDRGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLVQPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGELLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGPFSHRRP
Prediction	CCCCCCCCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEHCCCHHHCCCCCCCEEEHCCCCCCCCCCHCHHHHHHHHHHHHCCCCEEEEEHCCCCCEEEEEHCCEEEEEEEHCCCCCCCCCCCEEEHCCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
Conf.Score	98888887777599986888888897679999999998996899978887777688899956898588999999999988865798999998679699999999899989968877874555667898899578888877755345789999987658978998756898689999899788999976777666677657775899999999999865567775688999846995899999965898887767578999999999999999999985788888899
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 \| \| \| \| \| \| \| \| \| \| \| \| \| \| MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWLSWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMDRGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLVQPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGELLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGPFSHRRP
Prediction	46364241220000000035116346325201510472415031120424304300000000013036214302400540340101140020023240033047440100002104464325155143000001101203304324245214512657310000211653310000002310100213465244453524325244500420251052345400000000023752000000000003010432471044104320030034005411424255658
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCEEEEHCCCCCCCCCCCHHHHHHHHHHHCCEEEEEHCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEHCCCHHHCCCCCCCEEEHCCCCCCCCCCHCHHHHHHHHHHHHCCCCEEEEEHCCCCCEEEEEHCCEEEEEEEHCCCCCCCCCCCEEEHCCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCEEEEEEEHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
MKLARPDVFHPRVVLAGWPQQPAGDGDDAGLVAALRHRGLHAGWLSWDDPEIVHADLVILRATRDYPARLDEFLAWTTRVANLLNSRPVVAWNVERRYLRDLMDRGVPTVPGEVYVPGEPVRLPRKGQVFVGPTIGTGTRRCSARFAAEFVAQLHAAGQAVLVQPGGSGDETVLVFLGGEPSHAFTKQADTWRQTEPDFEIWDVGAAAVAGAAAQVGVDPGELLYARAHITGGSRDPRLLELQLVDPSLGWQWLDPDIRNLAQRDFALCVQSALERLGLGPFSHRRP

3vpbB

0.15

0.13

0.89

1.88

MUSTER

MR----------VVLIVD----IVRQEEKLIAKALEENKVQYDIINVAQEPLPRYDVAIIRPVS--MYRALYSSAVLEAAVHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAALKQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIKGRDIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIV--HGEFVSIDILEPNKGYVVNELNDV-PE--FKGFMVATNINVAQKLVEYIKENYSK-----------

3vpbB

0.13

0.12

0.89

3.04

dPPAS

----------MRVVLIVD----IVRQEEKLIAKALEENKVQYDIINVAQEPLPFYDVAIIRPV-SMYRALYSSAVLEAAGVHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAALKAYGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIQYKGIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIVHGE--FVSIDILEPNKGYVVNELND---VPEFKGFMVATNINVAQKLVEYIKENYSK-----------

3vpbB

0.15

0.13

0.89

3.48

wdPPAS

MR----------VVLIVDI----VRQEEKLIAKALEENKVQYDIINVAQEPLPRYDVAIIRPV-SMYRALYSSAVLEAAGVHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAALKA-GFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIQGRDIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIVHGE--FVSIDILEPNKGYVVNELNDV-PE--FKGFMVATNINVAQKLVEYIKENYSK-----------

3vpbB

0.15

0.13

0.88

2.30

wMUSTER

-----------RVVLIVDI----VRQEEKLIAKALEENKVQYDIINVAQEPLPRYDVAIIRPVS--MYRALYSSAVLEA-VHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAALKQRGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIKGRDIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIV--HGEFVSIDILEPNKGYVVNELNDV-PE--FKGFMVATNINVAQKLVEYIKENYSK-----------

3vpbB

0.14

0.13

0.87

3.11

wPPAS

MR----------VVLIVDI----VRQEEKLIAKALEENKVQYDIINVAQEPLPRYDVAIIRPVS--MYRALYSSAVLEA-VHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAAL---GFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIQGRDIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIV--HGEFVSIDILEPNKGYVVNELNDV-P--EFKGFMVATNINVAQKLVEYIKENYSK-----------

3vpbB

0.14

0.13

0.89

6.48

dPPAS2

MR----------VVLIVD----IVRQEEKLIAKALEENKVQYDIINVAQEPLPFYDVAIIRPVS--MYRALYSSAVLEAAVHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAALKAYGFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIKGRDIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIVHGE--FVSIDILEPNKGYVVNELND---VPEFKGFMVATNINVAQKLVEYIKENYSK-----------

3vpbB

0.14

0.12

0.89

2.70

PPAS

MR----------VVLIVDI----VRQEEKLIAKALEENKVQYDIINVAQEPLPRYDVAIIRPVS--MYRALYSSAVLEAAVHTINSSDVINVCGDKLTYSKLYREGIPIPDSIIALSAEAALKA-GFPLIDKPPIGSWGRLVSLIRDVFEGKTIIEHLKAHIVQEYIKGRDIRCIAIGEELLGCYARNIPPNEWRGGTPSNIEVDEKLKETVVKAVSIV--HGEFVSIDILEPNKGYVVNELND-VP--EFKGFMVATNINVAQKLVEYIKENYSK-----------

5k2mA

0.09

0.08

0.89

3.80

Env-PPAS

M----------RIGITYT----VLRREEMAIKERAGEFGEVVMLHELLFPGNYDLDVVIIRNVS--HFKALYTARLFESEIPTVNSSRLIFEAGDKLFATLRLAGKVPVPEWKAALSEGGALRVPGYPLVSKPVFGSWGRLLAKDSLEAVLEHRKWMKNIHYFQEFVEGRDIRSYVIGGEFVGAIYRYSNHWITNTGGKAEPCSDPEVEELSVKAWEAF--GEGALAIDIFESEKGLLVNEVNPN---MEFKNAARVTGADMAGKLVEYAVEVAKT-----------

5k2mA

0.10

0.09

0.88

1.84

MUSTER

M----------RIGITYT----VLRREEMAIKERAGEFGEVVMLHELLFPGNYDLDVVIIRNVS--HFKALYTARLFESEIPTVNSSRLIFEAGDKLFATLRLAGKVPVPEWKAALSEGGAL-SLGYPLVSKPVFGSWGRLLAKDSLEAVLEHRKWMKNIHYFQEFVPGRDIRSYVIGGEFVGAIYRYSNHWITNGGKAEPCS-DPEVEELSVKAWEAF--GEGALAIDIFESEKGLLVNEVNP---NMEFKNAARVTGADMAGKLVEYAVEVAKT-----------

5k2mA

0.09

0.08

0.89

3.02

dPPAS

----------MRIGITYT----VLRREEMAIKERAGEFGEVVMLHELLFPGNYDLDVVIIRNV-SHFKALYTARLFESEGIPTVNSSRLIFEAGDKLFATLRLAGKVPVPEWKAALSEGGALRVPGYPLVSKPVFGSWGRLLAKDSLEAVLEHRKWMKNIHYFQEFVEKPGIRSYVIGGEFVGAIYRYSNHWITNRGGKAEPCSDPEVEELSVKAWEAF--GEGALAIDIFESEKGLLVNEVNP---NMEFKNAARVTGADMAGKLVEYAVEVAKT-----------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.40

Estimated TM-score = 0.77±0.10

Estimated RMSD = 5.2±3.4Å

Download Model 2

C-score=-0.69

Download Model 3

C-score=-1.98

Download Model 4

C-score=-4.46

Download Model 5

C-score=-2.08

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3vpbB	0.838	1.66	0.145	0.888
2	5k2mA	0.809	2.08	0.106	0.885
3	4iwxA	0.804	2.29	0.113	0.895
4	3i12A	0.797	3.19	0.130	0.944
5	1ehiA	0.794	3.16	0.121	0.941
6	4fu0A	0.791	2.94	0.079	0.923
7	2i8cB	0.789	3.18	0.110	0.934
8	1gsaA	0.789	2.63	0.109	0.899
9	3tqtA	0.788	3.29	0.118	0.937
10	3lwbA	0.782	3.12	0.135	0.927

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.30	40	2zdgC	ADP	Rep, Mult	96,130,132,137,138,139,142,164,165,166,167,171,194,195,231,240,241
2	0.18	20	5k2mH	MG	Rep, Mult	136,241,243
3	0.02	2	2dlnA	PHY	Rep, Mult	137,138,227,229,241,243,247,248,253,254
4	0.01	1	1gsaA	GSH	Rep, Mult	26,27,28,61,63,64,137,173,187,245,246,247,248
5	0.01	2	4fflA	MG	Rep, Mult	229,241
6	0.01	1	5k2mJ	III	Rep, Mult	23,63,64,66,67,135,137,138,140,173,243,244,245,248
7	0.01	2	2dlnA	UUU	Rep, Mult	96,130,132,136,137,138,139,142,164,165,166,167,171,227,229,231,240,241,243,247,248,253,254
8	0.01	1	1uc80	III	Rep, Mult	48,49,51,68,69,71,72,75,76,78,79,91,94,95,97,99,100,104,112,113,114,116,117,120,123

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.181	1ez1A	0.750	3.04	0.097	0.892	2.1.2.-	96,241
2	0.140	1gsaA	0.789	2.63	0.109	0.899	6.3.2.3	NA
3	0.130	2dlnA	0.772	3.02	0.134	0.913	6.3.2.4	23,59,138
4	0.122	1gshA	0.749	2.66	0.106	0.857	6.3.2.3	NA
5	0.112	2i80B	0.788	3.30	0.110	0.941	6.3.2.4	227
6	0.085	2pvpA	0.723	3.04	0.077	0.857	6.3.2.4	227
7	0.080	1eyzA	0.751	3.02	0.089	0.892	2.1.2.-	NA
8	0.067	2z04B	0.648	3.22	0.094	0.770	4.1.1.21	NA
9	0.060	3i12A	0.797	3.19	0.130	0.944	6.3.2.4	227
10	0.060	2ys6A	0.701	3.75	0.098	0.885	6.3.4.13	NA
11	0.060	2dwcB	0.761	3.15	0.085	0.895	2.1.2.-	NA
12	0.060	1ehiB	0.779	3.17	0.127	0.920	6.3.2.4	227
13	0.060	1iovA	0.770	3.03	0.137	0.913	6.3.2.4	NA
14	0.060	1z2oX	0.717	3.18	0.102	0.857	2.7.1.159	NA
15	0.060	2qb5A	0.738	3.73	0.112	0.916	2.7.1.159,2.7.1.134	NA
16	0.060	1eudB	0.444	3.56	0.104	0.547	6.2.1.4	NA
17	0.060	1vkzB	0.716	3.18	0.105	0.861	6.3.4.13	171,241
18	0.060	2vqdA	0.748	3.26	0.102	0.895	6.3.4.14,6.4.1.2	NA
19	0.060	3lwbA	0.782	3.12	0.135	0.927	6.3.2.4	91,136,241
20	0.060	3kakB	0.473	4.11	0.073	0.617	6.3.2.3	NA
21	0.060	2i8cB	0.789	3.18	0.110	0.934	6.3.2.4	NA
22	0.060	3lp8A	0.737	3.28	0.114	0.895	6.3.4.13	240
23	0.060	1uc9A	0.766	1.93	0.105	0.826	6.3.2.-	NA
24	0.060	2qf7A	0.586	3.33	0.075	0.711	6.4.1.1	NA
25	0.060	1ehiA	0.794	3.16	0.121	0.941	6.3.2.4	227
26	0.060	1w93A	0.727	3.63	0.077	0.916	6.3.4.14,6.4.1.2	NA
27	0.060	1b6sB	0.742	2.85	0.127	0.861	4.1.1.21	96,242

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.797	3.19	0.13	0.94	3i12A	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
1	0.33	0.789	2.63	0.11	0.90	1gsaA	GO:0000166 GO:0000287 GO:0003824 GO:0004363 GO:0005524 GO:0005829 GO:0006750 GO:0016874 GO:0030145 GO:0046872
2	0.32	0.757	3.08	0.10	0.90	3r5xC	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
3	0.31	0.788	3.30	0.11	0.94	2i80B	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
4	0.31	0.838	1.66	0.14	0.89	3vpbB	GO:0000166 GO:0003824 GO:0005524 GO:0006464 GO:0006526 GO:0008652 GO:0009085 GO:0016874 GO:0046872
5	0.31	0.768	3.24	0.16	0.91	2fb9A	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
6	0.28	0.780	3.19	0.14	0.92	3rfcA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
7	0.28	0.785	3.23	0.10	0.94	3r5xD	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
8	0.27	0.823	1.82	0.11	0.88	3vpdA	GO:0000166 GO:0003824 GO:0005524 GO:0006464 GO:0008652 GO:0009085 GO:0016874 GO:0019878 GO:0046872
9	0.25	0.714	1.94	0.11	0.77	1uc8A	GO:0000166 GO:0003824 GO:0005524 GO:0006464 GO:0008652 GO:0009085 GO:0016874 GO:0019878 GO:0046872
10	0.24	0.794	3.16	0.12	0.94	1ehiA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
11	0.24	0.779	3.17	0.13	0.92	1ehiB	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
12	0.24	0.782	3.12	0.14	0.93	3lwbA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0005886 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0040007 GO:0046872 GO:0071555
13	0.24	0.788	3.29	0.12	0.94	3tqtA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
14	0.23	0.791	2.94	0.08	0.92	4fu0A	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
15	0.22	0.769	3.06	0.15	0.90	3lwbB	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0005886 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0040007 GO:0046872 GO:0071555
16	0.22	0.735	2.68	0.14	0.85	5i47B	GO:0003824 GO:0005524 GO:0046872
17	0.22	0.804	2.29	0.11	0.90	4iwxA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0006412 GO:0006464 GO:0009432 GO:0016874 GO:0018169 GO:0018410 GO:0030145 GO:0042802 GO:0046872
18	0.22	0.769	3.13	0.09	0.91	3ouuA	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0016874 GO:0046872
19	0.20	0.751	2.88	0.14	0.87	4egjA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
20	0.16	0.790	2.88	0.14	0.92	5bpfC	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
21	0.15	0.730	3.58	0.08	0.91	1dv2A	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0005737 GO:0005829 GO:0006629 GO:0006631 GO:0006633 GO:0016874 GO:0045717 GO:0046872 GO:2001295
22	0.15	0.773	3.00	0.13	0.91	4c5aA	GO:0000166 GO:0000287 GO:0003824 GO:0005524 GO:0005737 GO:0005829 GO:0008360 GO:0008716 GO:0009252 GO:0016874 GO:0030145 GO:0046872 GO:0071555
23	0.14	0.767	2.85	0.10	0.89	3r5hA	GO:0000166 GO:0003824 GO:0004638 GO:0005524 GO:0006164 GO:0006189 GO:0016829 GO:0016874 GO:0034028 GO:0046872 GO:0051287 GO:0055114
24	0.13	0.748	3.26	0.10	0.90	2vqdA	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0006629 GO:0006631 GO:0006633 GO:0016874 GO:0046872 GO:2001295
25	0.08	0.728	2.56	0.08	0.83	3ax6A	GO:0000166 GO:0003824 GO:0004638 GO:0004639 GO:0005524 GO:0006164 GO:0006189 GO:0016829 GO:0016874 GO:0034028 GO:0046084 GO:0046872
26	0.07	0.706	3.65	0.09	0.88	4mv4A	GO:0000166 GO:0003824 GO:0003989 GO:0004075 GO:0005524 GO:0006629 GO:0006631 GO:0006633 GO:0016874 GO:0046872 GO:2001295

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0030145	GO:0000287	GO:0008716	GO:0004363
GO-Score	0.86	0.79	0.79	0.69	0.33
Biological Processes	GO:0071555	GO:0008360	GO:0009252	GO:0006750	GO:0009085	GO:0006464	GO:0006526
GO-Score	0.69	0.69	0.69	0.33	0.31	0.31	0.31
Cellular Component	GO:0005829
GO-Score	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.