I-TASSER results

I-TASSER results for job id Rv1453

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (421 residues)
MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAADPALATVVKRSNRAH
LIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIYRIGQNVAWRRWTDIAF
GLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLTRDVPAERRKIVQLLIDG
APISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVADAFGHAGGCPHPLVVVAGA
ATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEGFRRSHRDALTTARMIIRLE
SPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASPALKTTLLTFINQQCNASRAA
RLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQQWREKPTSDPPAKKESNGTKM
R

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIYRIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLTRDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVADAFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEGFRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASPALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQQWREKPTSDPPAKKESNGTKMR
Prediction	CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
Conf.Score	9988888789999999999999889999999999999985776557568999999999999999999975788888877778999999999998899989999999999999999999997589999999999999999999999999999999999999999999999999999999899999999999989999887899999858998757889999999999857777489985885799985688875699999999866896899856568999999999999999999998688998588644548899879999999999999987876688999999999998999999999889999999999999999989999985899999999999986777788888888888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIYRIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLTRDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVADAFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEGFRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASPALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQQWREKPTSDPPAKKESNGTKMR
Prediction	7645524640250033005202641440042004202420441252341241024001300230031015343432536225201420231023414241010010000000310031034233526202300310131023002200310041034014313441342023003201525422242112124030410000000003434422110110121012102121000000122100100333443214202310241440100000001002101300500330040045245752000000000010014227203500440043037336301500200043523143006404002100210051026017230724201010000004015543463446566645547
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEHCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEHCCCCEEEEEHCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
MALRETSPRIHELIREAARIALNPTQEWLDEFDRAILAANPSIAADPALATVVKRSNRAHLIHFAAANLRNPGAPVPANLGPEPLRMARDLVRVGLDALALDIYRIGQNVAWRRWTDIAFGLTSDPDELHELLDVPFRTANEFVDTTLAGITTEMQLERDKLTRDVPAERRKIVQLLIDGAPISREHAEARLGYPLDRSHTAAVIWGDQAQGDHSHLDRVADAFGHAGGCPHPLVVVAGAATRWVWVKDAPGFDIDLIHEVLHDIPDARIAIGATAPGIEGFRRSHRDALTTARMIIRLESPHRVAFFTDVEMVALLTENAEGADDFIQRTLGNLESASPALKTTLLTFINQQCNASRAARLLFTHRNTLMNRLETAQRLLPRPLADTTIHVAVALEAQQWREKPTSDPPAKKESNGTKMR

3onqA

0.15

0.09

0.58

1.19

MUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLS--HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDF--NCFAIGGVPSASLASTSLAIRKAVRDLGGEH--VVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

3onqA

0.14

0.08

0.58

1.34

dPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT-DDRVVSLNILGWQGDFNCFAIGGV---PSASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

3onqA

0.15

0.09

0.58

2.53

wdPPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT-DDRVVSLNILGWQGDFNCFAIGGVPS--ASLASTSLAIRKAVRDLGGEH--VVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

3onqA

0.15

0.09

0.58

1.65

wMUSTER

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLS--HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPS--ASLASTSLAIRKAVRDLGGEH--VVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

3onqA

0.15

0.09

0.58

3.32

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPS--ASLASTSLAIRKAVRDLGGEH--VVIGTYGTFLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

3onqA

0.14

0.08

0.58

2.98

dPPAS2

---------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT-DDRVVSLNILGWQGDFNCFAIGGV---PSASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

3onqA

0.14

0.08

0.58

2.37

PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGV---PSASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDDAYVLTTALAIGRRDR------------------

3onqA

0.13

0.08

0.58

3.73

Env-PPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGV---PSASLASTSLAIRKAVRDLGGEHVVIGTYGT-FLLALACQGAVTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL-STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR----------------

5dlqB1

0.11

0.10

0.96

0.79

MUSTER

--AALGPPEVIAQLENAAKVLMAPPSMVSNEQRQHAEHIFLSFRKSAVCRHILETSKVDYVLFQAATAIMEA-VLLEKGSIESLRTFLLTYVLQRPNLQ--KYVREQILLAVAVIVKRGSLDKSISQLISSGNPTVQTLACSILTALLSEFSNCKRVFQEEDLRQIFMLTVGVLQEFSRRENLSAQMSSVFQRY-LALANQVLSWNFLPPTEDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFCLTHLTCSFGRSAALEEVLMVYMEAYDKLLESRHFLKLVFDMLVLQNTEMTAAGEAF---YTLVCLYQAEYSELVETLLQDPVIYQRLADAFNKLTASSTPDRK-------QKMA

5cwqA

0.11

0.06

0.55

0.68

dPPAS

-----------EELERESEEAERRLQEARKRSEEARERGDLKELAEALIEEARAVQELARVACERGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNSEEAERASEKAQRVLEEARKVSEEAREQGDDEVLALALIAIALAVLALAEVACCRGNKEEAERAYEDARRVEEEARKVKESAEEQGDSEVKRLAEEAEQLAREARRHVQECRGGWLEHHH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.28

Estimated TM-score = 0.45±0.14

Estimated RMSD = 12.4±4.3Å

Download Model 2

C-score=-2.81

Download Model 3

C-score=-1.30

Download Model 4

C-score=-1.67

Download Model 5

C-score=-2.12

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4c0oA	0.768	4.05	0.074	0.929
2	2x19B	0.695	4.51	0.075	0.891
3	3gjxA	0.677	4.76	0.069	0.886
4	3m1iC	0.658	5.06	0.075	0.881
5	3a6pA	0.658	5.38	0.067	0.924
6	5dlqB	0.647	5.19	0.070	0.884
7	3w3tA	0.631	5.04	0.068	0.850
8	2x1gF	0.630	4.90	0.073	0.841
9	5hb4B	0.628	5.57	0.092	0.900
10	4fgvA	0.617	5.54	0.069	0.862

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	5	1f59B	III	Rep, Mult	287,290,291,294,295,330,333,334
2	0.05	3	3du2L	BPH	Rep, Mult	282,286,289,290
3	0.04	2	3m9iA	3PE	Rep, Mult	289,293
4	0.04	2	3q0oB	NUC	Rep, Mult	30,33,60,62,63,66,103,106,140,222,223,226,280,281,283,284,287,321,324,325,328
5	0.04	2	1e8dA	CNH	Rep, Mult	280,364,365
6	0.04	2	3sgfH	MG	Rep, Mult	370,373
7	0.02	1	1u6g0	III	Rep, Mult	279,283,319,320,321
8	0.02	1	3ae4C	N1M	Rep, Mult	215,219
9	0.02	1	2vglA	IHP	Rep, Mult	330,331,355,359,369,373,374,377
10	0.02	1	2jdq0	III	Rep, Mult	288,291,292,322,325,326,327,369,370,376
11	0.02	1	2e75G	OPC	Rep, Mult	342,346
12	0.02	1	2xo6D	NUC	Rep, Mult	349,353
13	0.02	1	1cgpA	CMP	Rep, Mult	335,339
14	0.02	1	4fe1J	CLA	Rep, Mult	366,370
15	0.02	1	3a6pF	NUC	Rep, Mult	63,225,368,372
16	0.02	1	1r6nA	ALQ	Rep, Mult	346,347,366
17	0.02	1	5kl8A	NUC	Rep, Mult	30,33,59,60,63,99,103,106,140,222,223,226,281,283,284,287,319,321,324,325,328,366,367,368,370
18	0.02	1	3jcuS	CLA	Rep, Mult	282,286

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1trkA	0.384	7.30	0.063	0.663	2.2.1.1	269,291
2	0.060	2fhbA	0.372	7.44	0.058	0.646	3.2.1.41	NA
3	0.060	1f1sA	0.402	6.78	0.047	0.667	4.2.2.1	334,402
4	0.060	1ea0A	0.416	6.98	0.033	0.689	1.4.1.13	NA
5	0.060	1ay0A	0.383	7.31	0.057	0.670	2.2.1.1	NA
6	0.060	1ug9A	0.388	6.93	0.053	0.641	3.2.1.70	NA
7	0.060	3draA	0.396	6.46	0.071	0.622	2.5.1.58,2.5.1.59	NA
8	0.060	2eabA	0.394	6.81	0.056	0.637	3.2.1.63	NA
9	0.060	2bs9E	0.377	7.20	0.061	0.637	3.2.1.37	NA
10	0.060	2j5wA	0.401	7.36	0.050	0.689	1.16.3.1	NA
11	0.060	2bfgA	0.382	7.20	0.067	0.641	3.2.1.37	NA
12	0.060	1djnA	0.392	6.75	0.056	0.622	1.5.8.2,1.5.99.7	NA
13	0.060	3h09B	0.419	6.73	0.050	0.679	3.4.21.72	NA
14	0.060	1l2aE	0.387	6.47	0.045	0.601	3.2.1.4	288
15	0.060	2dqmA	0.403	6.64	0.077	0.641	3.4.11.2	NA
16	0.060	3dpyA	0.420	6.21	0.059	0.634	2.5.1.58,2.5.1.59	294,315,329,372
17	0.060	2vdcA	0.426	7.11	0.031	0.710	1.4.1.13	NA
18	0.060	2vtfA	0.382	7.12	0.043	0.634	3.2.1.96	333
19	0.060	1ho8A	0.412	5.87	0.060	0.611	3.6.3.14	332,374,380

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.15	0.782	3.60	0.09	0.92	4ol0B	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
1	0.12	0.630	4.90	0.07	0.84	2x1gF	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
2	0.12	0.746	3.82	0.09	0.89	4c0qA	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
3	0.12	0.721	4.36	0.08	0.91	3zjyE	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
4	0.12	0.741	3.66	0.09	0.87	4c0qB	GO:0004872 GO:0005634 GO:0005737 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0035048 GO:0042802 GO:0043231
5	0.11	0.710	4.37	0.08	0.91	2xwuB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965
6	0.10	0.683	4.90	0.08	0.90	3wyfC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
7	0.10	0.566	5.74	0.04	0.83	5difC	GO:0000055 GO:0000776 GO:0005634 GO:0005737 GO:0005816 GO:0006406 GO:0006611 GO:0006810 GO:0006886 GO:0008536 GO:0008565 GO:0015031 GO:0034501 GO:0048471
8	0.07	0.608	4.31	0.09	0.77	3zkvA	GO:0005737 GO:0006606 GO:0006886 GO:0007270 GO:0008139 GO:0008536 GO:0008565 GO:0031965 GO:0042331 GO:0050804
9	0.06	0.388	6.77	0.04	0.62	2iw3B	GO:0000166 GO:0001933 GO:0003723 GO:0003746 GO:0005524 GO:0005737 GO:0005840 GO:0006412 GO:0006414 GO:0006415 GO:0006469 GO:0010494 GO:0016887 GO:0019843 GO:0022626 GO:0042788
10	0.06	0.373	7.04	0.06	0.62	2hivA	GO:0000166 GO:0003677 GO:0003909 GO:0003910 GO:0005524 GO:0005737 GO:0006260 GO:0006273 GO:0006281 GO:0006310 GO:0006974 GO:0007049 GO:0016874 GO:0046872 GO:0051103 GO:0051301 GO:0071897
11	0.06	0.244	5.71	0.06	0.35	2htmC	GO:0003824 GO:0005737 GO:0009228 GO:0009229 GO:0016740 GO:0016783
12	0.06	0.225	5.36	0.05	0.31	4muzA	GO:0003824 GO:0004590 GO:0006207 GO:0006221 GO:0008152 GO:0016829 GO:0016831 GO:0044205
13	0.06	0.222	6.93	0.03	0.37	4rk9A	GO:0005215 GO:0006810
14	0.06	0.184	6.49	0.03	0.28	2yn3C	GO:0005509 GO:0007156 GO:0016020 GO:0016491 GO:0030151 GO:0046872 GO:0055114
15	0.06	0.163	6.26	0.04	0.24	4gqnB	GO:0016491 GO:0055114
16	0.06	0.151	4.09	0.04	0.19	4exnA	GO:0001934 GO:0002376 GO:0005125 GO:0005157 GO:0005576 GO:0005615 GO:0006954 GO:0008083 GO:0008284 GO:0045087 GO:0045651 GO:0045657
17	0.06	0.128	5.60	0.01	0.19	4izeA	GO:0002376 GO:0005125 GO:0005149 GO:0005576 GO:0005615 GO:0006954 GO:0007267 GO:0019221 GO:0045087
18	0.06	0.138	5.21	0.02	0.19	2lbmA	GO:0000166 GO:0000228 GO:0000781 GO:0000784 GO:0000792 GO:0003677 GO:0003678 GO:0003682 GO:0004386 GO:0005524 GO:0005634 GO:0005694 GO:0005720 GO:0005721 GO:0006281 GO:0006306 GO:0006310 GO:0006334 GO:0006336 GO:0006338 GO:0006351 GO:0006355 GO:0006974 GO:0007283 GO:0010571 GO:0015616 GO:0016568 GO:0016605 GO:0016787 GO:0030330 GO:0030900 GO:0031297 GO:0031933 GO:0032206 GO:0032508 GO:0035064 GO:0035128 GO:0035264 GO:0042393 GO:0045944 GO:0046872 GO:0060009 GO:0070087 GO:0070198 GO:0070603 GO:0072520 GO:0072711 GO:1900112 GO:1901581 GO:1901582 GO:1904908 GO:1990707

Consensus prediction of GO terms

Molecular Function	GO:0008139	GO:0008565	GO:0017016	GO:0004872	GO:0042802
GO-Score	0.49	0.49	0.46	0.34	0.34
Biological Processes	GO:0035048
GO-Score	0.34
Cellular Component	GO:0005737	GO:0031965
GO-Score	0.49	0.49

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.