I-TASSER results

I-TASSER results for job id Rv1429

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (422 residues)
MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAV
HYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPA
DRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPR
AERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPVANSLMVPTD
EREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGDGLRGFRASLKQAERVKALA
LAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLL
RNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRA
KQ

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ
Prediction	CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCEEEHCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHCCCCCCC
Conf.Score	98877766999999999999999999999999986776567568999999999999999999976888887777599999999999989999999999999999999999999987688567899999999999999999999999999999999999999999999999989998999999998999988779999996788887556789999999998877665445577699984677645676567654568999999998768986999858889999999999999999999997577889977986455688998799999999999998654567777858999999999989999999999899999999999999999899998989999999999999998545577889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ
Prediction	65535452023004203631440042014102520330252451252023002200210031024424345251242015102410335130520020011000000310141045244563031023004100300130032003103401431344244102300320164542224200310313031100000000144443442242033014202331222112222000000023321100113322210121022006424130000000002202101300400330130122242455310000000000100242262035004500430341475333003001000436231430054050320002100510260072317303300100000100201232314378
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEEHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHCCCCCEEEHCCCCCHHHHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHCCCCCCC
MAEAGGGPISVIARHMQLIRDDFISELFDKMKAEIRGLDYDARMADLWRASITENFVTAVHYLDRDTPQSLVEAPAAALAYARAAAQRDIPLSGLVRAHRLGHARFLEVAMQYVSLLEPADRVSTIIELVNRSARLVDLVADQLIVAYEHEHDRWLSRRSGLQQQWVSELLADTPVDVPRAERALGYRLDGVHIAAVVWVDSAVPIGDVVAQFDQVRCLLAGELGPELGPVANSLMVPTDEREARLWFSPAPTRAFAPSRIRAAFESAGIRARLACGRVGDGLRGFRASLKQAERVKALALAGGARPGGRVMFYDDVAPVALLADDLEELRRFVTDVLGDLSVDDERNSWLRETLREFLLRNRSYVATADAMILHRNTIQYRVIQAMELCGQNLDDPDAAFRVQMALEVCRWMAPAVLRAKQ

3onqA

0.18

0.10

0.59

1.16

MUSTER

-------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLS--HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDF--NCFAIGGVPSASLASTSLAIRKAVRDLG----------GEHVVIGTYGTFLLALACQGAVT---PEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLR-GENPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

5ic0A

0.06

0.95

1.03

PPAS

INDMSYFGCLDSVMENSKVLGEAMTGISQNAKNNLPEFGDAATASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGQAIQMACQSLGEPGCTVLSAATIVAKHTSALCNSCRLASARTANPTAKRQFVQSAKEVANSTANLVKTIKALDGDFTEENRAQCRAATAPLLEAVDN-----LSAFASNPEFSSVPAQI-----------SPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPRWSVLAGHSRTVSDSIKKLITSMRDKAP-GQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGI---SQEALHTQMLTAVQEISHLIEPLASAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLA-NPKQAAHTQEALEEAVQMMTEAVEDLTTTLN

3onqA

0.19

0.11

0.59

1.29

dPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTN-TDDRVVSLNILGWQGDFNCFAIGGVPSAS-----------LASTSLAIRKAVRDLGGEHVVIGTYGTFLLALACQGAVTPEVTCTAVPAF----SEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPDD-PTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

5dlqB1

0.10

0.98

1.01

PPAS

-AALGPPQLENAAKVLMAPPSMVSNEQRQHAEHIFLSFRKSKLETSKVDYVLFQAATAIMEAVVREWVLLEKGSIESLRTFLLTYVLQRPNLQ---KYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISSGNPTVQTLACSILTALLSEFSNCKRVFQEEDLRQIFM---LTVGVLQEFSRRENLSAQMSSVFQRLPPTESWREALLDSRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHGPIFPDEGSQVDYLAHFIEGLLNTINGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELTCSFGRSAALEEVLDKDMEAYDKLLESWLTLVRLFLATRHFLKLVFDMLVLQNTEMTTAAGEAF--YTLVCLYQAEYSELVETSQQDPVIYQRLADAFNKLTAS-STPDRKQK

3onqA

0.19

0.11

0.59

2.47

wdPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTNT-DDRVVSLNILGWQGDFNCFAIGGVPSAS-----LASTSLAIRKAVRDL--------GEHVVIGTYGTFLLALACQGAVT---PEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLR-GENPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

3onqA

0.18

0.11

0.59

1.57

wMUSTER

-------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLS--HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPSAS-----LASTSLAIRKAVRDLG-------GEHVVIGTYGTFLLALACQGAVT---PEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLR-GENPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

3onqA

0.19

0.11

0.59

3.44

wPPAS

-------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGH-------------TDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPSAS-----LASTSLAIRKAVRDL--------GEHVVIGTYGTFLLALACQGAVT---PEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLR-GENPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

3onqA

0.18

0.10

0.59

2.78

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSGHTDDTTIERLAFECLLTN-TDDRVVSLNILGWQGDF--NCFAIGGVPSASLASTSLAIRKAVRDLG----------GEHVVIGTYGTFLLALACQGAV---TPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPDD-PTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

3onqA

0.18

0.11

0.59

2.36

PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPSAS-----LASTSLAIRKAVRDLG-------GEHVVIGTYGTFLLALACQGAV---TPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLR-GENPDDPTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

3onqA

0.18

0.11

0.59

3.80

Env-PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------ADILDLLSG-HTDDTTIERLAFECLLTNTD-DRVVSLNILGWQGDFNCFAIGGVPSAS-----LASTSLAIRKAVRDLG-------GEHVVIGTYGTFLLALACQGA---VTPEVTCTAVPAFSEDEPLYLSPVRSGVAGASHALRETFSLQAAPAL---STPSRPLRADELLPERALLGDDYAREELYRNVYQVLRGENPDD-PTYLTVSTFLKYGSSLENTAKELNVHPNTVRYRLKRAAETTGWDATDPRDAYVLTTALAIGRRDR--------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.70

Estimated TM-score = 0.40±0.14

Estimated RMSD = 13.5±4.0Å

Download Model 2

C-score=-2.31

Download Model 3

C-score=-2.74

Download Model 4

C-score=-1.13

Download Model 5

C-score=-3.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3onqA	0.531	2.52	0.173	0.588
2	4kx7A	0.427	6.33	0.051	0.656
3	2dqmA	0.419	6.82	0.054	0.682
4	4p8qA	0.417	6.89	0.058	0.682
5	2gtqA	0.417	6.76	0.065	0.678
6	4wz9A	0.404	6.92	0.075	0.652
7	1t3tA2	0.403	7.27	0.060	0.685
8	4f5cA	0.401	7.28	0.049	0.675
9	3jcrA	0.399	7.37	0.039	0.694
10	1llwA	0.397	7.44	0.061	0.692

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	2yx4A	GLN	Rep, Mult	369,376,377
2	0.08	4	3rbmD	B73	Rep, Mult	403,407
3	0.04	2	3b2xA	NA	Rep, Mult	369,370,372,373,375
4	0.04	2	1bjeA	AZI	Rep, Mult	359,407
5	0.04	2	1a9x1	III	Rep, Mult	160,161,163,164,186,187,188
6	0.04	2	5awvB	GHP	Rep, Mult	382,385
7	0.04	2	1lm1A	F3S	Rep, Mult	297,298,299,302,317,318,322,326
8	0.02	1	2einL	ZN	Rep, Mult	375,388
9	0.02	1	1v51A	ZN	Rep, Mult	353,357
10	0.02	1	3ak1C	EDO	Rep, Mult	396,399
11	0.02	1	2e85B	CA	Rep, Mult	385,388
12	0.02	1	2e75G	OPC	Rep, Mult	351,355
13	0.02	1	5i50A	NUC	Rep, Mult	408,411

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jJ	0.215	6.91	0.025	0.353	1.17.1.4,1.17.3.2	321,342
2	0.060	1z1wA	0.395	6.88	0.067	0.637	3.4.11.-	NA
3	0.060	2vdcA	0.367	7.33	0.050	0.623	1.4.1.13	NA
4	0.060	1t3tA	0.403	7.26	0.058	0.690	6.3.5.3	NA
5	0.060	2c4mC	0.369	7.19	0.049	0.626	2.4.1.1	332
6	0.060	1yiqA	0.366	7.32	0.031	0.626	1.1.99.-	NA
7	0.060	3b9jC	0.297	7.21	0.036	0.500	1.17.3.2,1.17.1.4	328
8	0.060	3b9jI	0.153	5.24	0.081	0.216	1.17.1.4,1.17.3.2	170,286
9	0.060	1r9mB	0.363	7.82	0.026	0.666	3.4.14.5	NA
10	0.060	1fa9A	0.367	6.98	0.047	0.604	2.4.1.1	NA
11	0.060	2vdcF	0.379	7.50	0.037	0.652	1.4.1.13	NA
12	0.060	1h54B	0.368	7.21	0.039	0.628	2.4.1.8	NA
13	0.060	2ckjA	0.369	7.22	0.038	0.628	1.17.1.4,1.17.3.2	163
14	0.060	3bq5A	0.349	7.60	0.047	0.611	2.1.1.14	NA
15	0.060	1bxrA	0.389	7.05	0.045	0.644	6.3.5.5	NA
16	0.060	3gpbA	0.366	7.07	0.052	0.607	2.4.1.1	183
17	0.060	1itwB	0.365	7.31	0.064	0.630	1.1.1.42	293
18	0.060	2gtqA	0.417	6.76	0.065	0.678	3.4.11.2	NA
19	0.060	1z68A	0.368	7.44	0.024	0.637	3.4.21.-	398

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.06	0.377	6.79	0.04	0.60	2yd0A	GO:0001525 GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005138 GO:0005151 GO:0005164 GO:0005576 GO:0005615 GO:0005737 GO:0005783 GO:0005788 GO:0005789 GO:0005829 GO:0005886 GO:0006508 GO:0006509 GO:0008217 GO:0008233 GO:0008235 GO:0008237 GO:0008270 GO:0009617 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0043231 GO:0045088 GO:0045444 GO:0045766 GO:0046872 GO:0070006 GO:0070062
1	0.06	0.427	6.88	0.05	0.69	5ab0A	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
2	0.06	0.392	7.03	0.06	0.65	4xo4A	GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016787 GO:0042277 GO:0042802 GO:0043171 GO:0046872 GO:0070006
3	0.06	0.362	7.04	0.06	0.59	4qpeA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
4	0.06	0.356	7.15	0.04	0.59	3ebgA	GO:0004177 GO:0005737 GO:0005829 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
5	0.06	0.427	6.33	0.05	0.66	4kx7A	GO:0001525 GO:0002003 GO:0002005 GO:0003081 GO:0004177 GO:0005765 GO:0005886 GO:0005887 GO:0005903 GO:0006508 GO:0007267 GO:0008233 GO:0008237 GO:0008270 GO:0008283 GO:0009897 GO:0016020 GO:0016021 GO:0016324 GO:0016477 GO:0016787 GO:0031410 GO:0032835 GO:0042277 GO:0043171 GO:0045177 GO:0046872 GO:0070006 GO:0070062
6	0.06	0.419	6.48	0.05	0.65	5ab0C	GO:0002250 GO:0002376 GO:0002474 GO:0004175 GO:0004177 GO:0005783 GO:0005788 GO:0005789 GO:0005886 GO:0006508 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0019885 GO:0042277 GO:0043171 GO:0046872 GO:0070006
7	0.06	0.371	7.24	0.04	0.62	5dllA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787
8	0.06	0.422	6.85	0.06	0.68	5c97A	GO:0000209 GO:0002480 GO:0004177 GO:0005576 GO:0005622 GO:0005765 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0007165 GO:0007267 GO:0007565 GO:0008217 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016787 GO:0030163 GO:0030659 GO:0031905 GO:0042277 GO:0043171 GO:0046872 GO:0048471 GO:0060395 GO:0061024 GO:0070006
9	0.06	0.379	6.62	0.04	0.59	4fyrA	GO:0001525 GO:0001618 GO:0004177 GO:0004872 GO:0005615 GO:0005737 GO:0005765 GO:0005793 GO:0005829 GO:0005886 GO:0005887 GO:0006508 GO:0006725 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0009897 GO:0012506 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0031983 GO:0035814 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006 GO:0070062
10	0.06	0.408	6.52	0.06	0.64	4wz9B	GO:0005737 GO:0005886 GO:0006508 GO:0008237 GO:0008270 GO:0042277 GO:0043171 GO:0070006
11	0.06	0.409	7.16	0.05	0.68	4fkeA	GO:0001525 GO:0001618 GO:0004177 GO:0005737 GO:0005886 GO:0006508 GO:0007275 GO:0008233 GO:0008237 GO:0008270 GO:0016020 GO:0016021 GO:0016032 GO:0016787 GO:0030154 GO:0042277 GO:0043171 GO:0046718 GO:0046872 GO:0070006
12	0.06	0.360	7.01	0.04	0.59	5furI	GO:0000086 GO:0001075 GO:0001129 GO:0003682 GO:0005634 GO:0005654 GO:0005669 GO:0006351 GO:0006355 GO:0006366 GO:0006367 GO:0006368 GO:0006508 GO:0008237 GO:0008270 GO:0014070 GO:0033276 GO:0043565 GO:0044212 GO:0045944 GO:0051123 GO:1901796
13	0.06	0.389	7.30	0.06	0.66	3q7jA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
14	0.06	0.321	7.04	0.05	0.53	3b7rL	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0005886 GO:0006508 GO:0006691 GO:0008233 GO:0008237 GO:0008270 GO:0010043 GO:0016787 GO:0019370 GO:0042277 GO:0043171 GO:0043434 GO:0044822 GO:0046872 GO:0060509 GO:0070006 GO:0070062
15	0.06	0.324	6.91	0.04	0.53	4gaaA	GO:0004463 GO:0005737 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0019370 GO:0046872
16	0.06	0.319	7.22	0.07	0.55	3ciaA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787 GO:0046872
17	0.06	0.306	6.83	0.07	0.50	2xpyA	GO:0004177 GO:0004301 GO:0004463 GO:0005634 GO:0005737 GO:0005886 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0030163 GO:0042277 GO:0043171 GO:0044255 GO:0046872 GO:0070006
18	0.06	0.282	7.26	0.02	0.48	4fgmA	GO:0004177 GO:0006508 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046914	GO:0008235	GO:0033218
GO-Score	0.57	0.36	0.36
Biological Processes	GO:0019538	GO:0044248	GO:1901565	GO:0006518
GO-Score	0.57	0.36	0.36	0.36
Cellular Component	GO:0044424	GO:0071944
GO-Score	0.36	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.