I-TASSER results

I-TASSER results for job id Rv1424c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (253 residues)
MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPAEKLVFPVLLGILTLL
LSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKLAPSRPQVVACDSREAR
IRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPAVTTPGKPPSVLLYAPSA
CDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRCDSASVSLQPPEEIEGPAI
PPASSQLVCVAPK

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPAEKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKLAPSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPAVTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRCDSASVSLQPPEEIEGPAIPPASSQLVCVAPK
Prediction	CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHCHHHHHHHCCCCCCCCCCCCCEEHCCCCCEEEHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCEEEHCCC
Conf.Score	9877899888866567856888998877765554578877899864567999999999999987754567888888876446789887454555554345667788898567656664355457877789864554366655556789999999987654555678999985899867777678999743455467876554555567787777648888766555557896446789999877757987589
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 \| \| \| \| \| \| \| \| \| \| \| \| MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPAEKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKLAPSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPAVTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRCDSASVSLQPPEEIEGPAIPPASSQLVCVAPK
Prediction	7433443454335215443134024233534344241452442404300000011101100310432436425424324301020011130020023132545134533312304345241454314351320240314102552201100200030010111033454331000102421575144340020113234424440231013304521343415435141532751633413434330101148
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEHCHHHHHHHCCCCCCCCCCCCCEEHCCCCCEEEHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCCEEEHCCC
MTVVPGAPSRPASAVSRPSYRQCVQASAQTSARRYSFPSYRRPPAEKLVFPVLLGILTLLLSACQTASASGYNEPRGYDRATLKLVFSMDLGMCLNRFTYDSKLAPSRPQVVACDSREARIRNDGFHANAPSCMRIDYELITQNHRAYYCLKYLVRVGYCYPAVTTPGKPPSVLLYAPSACDESLPSPRVATALVPGTRSANREFSRFVVTEIKSLGAGGRCDSASVSLQPPEEIEGPAIPPASSQLVCVAPK

5j1sB

0.18

0.15

0.83

0.55

MUSTER

----NSYYSSPAQQVPKNPALEAFLAQFSQLEDK--FPGQS-----SFLWQRGRKFLQKHLNA---------SNPTE---ATIIFTAARETLKCLSHHVADAYTSSQ-------KVSPIQIDGAGRTWQ---------DSDTVKLLVDLELSYGFENGQKAAVVHH---PAGSTLIFYKYCDENAAFKDVALVLTLEASVGPRETEEKVRDLLWAKFTNS--DTPTSFNHMDSDKLSGLWSRISHLVLPVQPV

5j1sB

0.18

0.15

0.85

0.62

dPPAS

----NSYYSSPAQQVPKNPALEAFLAQFSQLEDKFPGQS-----------SFLWQRGRKFLQKHLNASNPT--EP-----ATIIFTAAREGRETLKCLSHHVADAYTSSQ----KVSPIQIDGAGRTWQD---------SDTVKLLVDLELSYGFENGQKAAVVHHFESPAGSTLIFYKYCDENAAFKDVALVLTLEASVGPRETEEKVRDLLWAKFTNS--DTPTSFNHMDSDKLSGLWSRISHLVLPVQPV

5j1sB

0.21

0.16

0.79

0.44

wdPPAS

----NSYYSSPAQQVPKNPALEAFLAQFSQLEDK--FPGQS---------SFLWQRGRKFLQKHLNASNP--TEP-----ATIIFTAAREGRETLKCLS--HHVA-TSSQ----KVSPIQIDGAGRTWQ---------DSDTVKLLVDLELSYGFENGQKA-AVVHH--PAGSIFYK---CDENAAFKDVALVLTLEASVGPRETEEKVRDLLWA-------NSDTPTSF--NHMDSDKLSG-SHLVLPVQPV

5ahvF

0.13

0.12

0.91

0.53

wMUSTER

KALK-KACSVEETAPKRKHVRACIVY---TWDHQSSKAVFTLPLANDQLFKMLIVLHKIIPSALAEAIRDR-DWIRSLGRV------GSSYSKLIREYVRVLKLDAHHRGFNNGTFEYEEYVSLVSVSDPDEGYETILDLMSLQDSLDEFSQIIFA---SIQSERRNTE---CKISALIPLAESYGIYKFITSMLAEGDAALQPLKERYELQHARLFE-ADCSS----VKYLTTVTIPKLPVDAPDVFLINDV

4jb9H

0.36

0.22

0.62

0.47

wPPAS

-EVVSGP--KPSS-IS------C-ATS-------YNFRDFRFNRRYGF-----IGI-----------PMWGYAR-QG--R------VSM---------SRLSQDLYYPDRGTA----ESGLTSA------------D----T----AYFC----VRRGSSCPHVVASTKGPSVFPLAPSGCD--FPEP-VTVSWNSGALTSGHTF---V------LQSSGL--SSVVTV-PSSSLGTQTY-KPSNTKVDKKPK

5j1sB

0.20

0.17

0.84

0.54

dPPAS2

----NSYYSSPAQQVPKNPALEAFLAQFSQLEDK--FPGQS---------SFLWQRGRKFLQKHLNASNPT--EP-----ATIIFTAAREGRETLKCLSHHVADAYTSSQ----KVSPIQIDGAGRTWQ---------DSDTVKLLVDLELSYGFENGQKA-AVVHHFPAGSTLFYK--YCDENAAFKDVALVLTLEASVGPRETEEKVRDLLWAKFTNS--DTPTSFNHMDSDKLSGLWSRISHLVLPVQPV

2ocwA2

0.17

0.14

0.81

0.49

PPAS

-STIPRSPT----VVKGVA--LCPYNRKESKSIKY----CLWEGAQN--------------GRCPLVDSEGWVEGR-PGNGTFTVILNQDAGFCLTNGDTLWR---TTVEIKIIEGEPNLKVPGNVTAVLGETVPCHFPCKFSSYEKYWC-----KWNGCQALPSQDEGPSKAFV-----CD---ENSRLVSLTLNLTRAVKQGHFYVAVEERKAAGSRDV-SLAKADAAPDEKVLDSGIENKAIQ----DPR

3pntA

0.16

0.15

0.90

0.64

Env-PPAS

EKKFKEIKDKWVTDKQADEFIETADKYADKAVQSASRAEYYRYVSRKYQY--KKEFVEKLKQVYKESGASSKKDLLAFDDAKRKTIGRQENGLFVTSFAEDALLFTDQGKLKSADQIEN-IKDSGKYSDG--VYQYEYD--------SELTKNIDKLGYIRTASDTPG---ANSLNIPGCSGKHIENSE-SELIFPSISVKDLK-SKAVLAEIDAKGYFEIIDPTIIAPNGDHKVTG--------RFKIKKQD

1qr0A

0.15

0.12

0.83

0.55

MUSTER

MKIIY--MDRPLSQEENERFMTFISPEKREKCRRFYHK------EDAHRTLLGDVLVRSVISRQYQLDKSDYGKPPDLPDAHFNISHSGRWVIGA---------FDSQPIGIDIKPISLEIAKRFFSKTYSDLLAKDKDEQTDYFYHLWSMKESFIKQEG----KGLSLPL-------DSFSVRLHQDGQVSIELPDSHSPCY------IKTY-EVDPGYKM--AVCAAHPPEDITMVSY----EELLRAAA-

5gaoE

0.12

1.00

0.59

dPPAS

AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAATTKEAYK

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.27

Estimated TM-score = 0.45±0.14

Estimated RMSD = 11.1±4.6Å

Download Model 2

C-score=-3.45

Download Model 3

C-score=-3.50

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5j1sB	0.770	2.19	0.167	0.846
2	4tvsA	0.731	2.37	0.170	0.814
3	1r6bX3	0.577	3.36	0.066	0.715
4	5j1sA	0.574	3.74	0.064	0.743
5	1qvrA	0.572	3.77	0.077	0.731
6	3hwsA	0.562	3.50	0.066	0.712
7	5kneA	0.554	4.01	0.066	0.743
8	1um8A	0.551	3.65	0.078	0.712
9	4ciuA2	0.548	3.41	0.080	0.692
10	4xguA	0.548	4.20	0.058	0.731

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.09	6	1ht2E	ADP	Rep, Mult	24,25,26,53,54,55,56,57,58
2	0.08	5	3cf0A	ADP	Rep, Mult	20,21,25,57,58,59,60,61,105
3	0.08	5	3eihA	AGS	Rep, Mult	34,35,36,89,90,91,94,95,96,97,197,253
4	0.03	2	3av7A	KYN	Rep, Mult	72,216
5	0.03	2	3wu2h	CLA	Rep, Mult	49,53
6	0.02	1	4xnjA	78M	Rep, Mult	40,50
7	0.02	1	4rkuL	CLA	Rep, Mult	53,57
8	0.02	1	3hvrA	MG	Rep, Mult	182,223
9	0.02	1	3oruA	ZN	Rep, Mult	133,150,181
10	0.02	1	3eq1B	SO4	Rep, Mult	17,19,129
11	0.02	1	4r7cC	GLY	Rep, Mult	61,62,65
12	0.02	1	3c5iA	MG	Rep, Mult	129,137
13	0.02	1	1ofhB	PO4	Rep, Mult	23,24,30,101,102
14	0.02	1	3i0oA	MG	Rep, Mult	123,137
15	0.02	1	2wl3A	CA	Rep, Mult	75,137
16	0.02	1	1f8iB	MG	Rep, Mult	101,137
17	0.02	1	4dgtB	MG	Rep, Mult	241,247
18	0.02	1	1sgf8	III	Rep, Mult	12,13,14,16

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3cioA	0.442	4.77	0.101	0.636	2.7.10.2	NA
2	0.060	1t64A	0.478	4.90	0.026	0.704	3.5.1.98	NA
3	0.060	1g8pA	0.441	3.72	0.054	0.573	6.6.1.1	NA
4	0.060	2pflA	0.384	6.42	0.037	0.704	2.3.1.54	NA
5	0.060	2qi9D	0.429	4.25	0.059	0.585	3.6.3.33	57,61
6	0.060	2vdcA	0.444	5.20	0.079	0.660	1.4.1.13	NA
7	0.060	2gxaE	0.456	4.10	0.071	0.609	3.6.4.12	53
8	0.060	1njgA	0.467	3.58	0.082	0.597	2.7.7.7	27,56
9	0.060	2wwyA	0.436	4.31	0.040	0.609	3.6.4.12	NA
10	0.060	2awnB	0.431	4.40	0.096	0.593	3.6.3.19	31,52,56
11	0.060	1w36D	0.383	6.10	0.038	0.668	3.1.11.5	NA
12	0.060	2c9oA	0.494	3.74	0.034	0.640	3.6.4.12	NA
13	0.060	1ea0A	0.444	5.20	0.079	0.660	1.4.1.13	NA
14	0.060	3glfG	0.472	3.39	0.071	0.589	2.7.7.7	NA
15	0.060	2awnA	0.412	4.26	0.102	0.545	3.6.3.19	31
16	0.060	2w00B	0.461	4.90	0.054	0.676	3.1.21.3	107
17	0.060	3kx2B	0.455	5.29	0.059	0.680	3.6.4.13	110
18	0.060	3maxA	0.479	4.76	0.057	0.696	3.5.1.98	23
19	0.060	1esmA	0.440	5.21	0.067	0.676	2.7.1.33	24,85

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.11	0.731	2.37	0.17	0.81	4tvsA	GO:0001671 GO:0005521 GO:0005634 GO:0005635 GO:0005637 GO:0008092 GO:0016020 GO:0016021 GO:0032781 GO:0034504 GO:0051117 GO:0071763
1	0.07	0.575	3.41	0.06	0.72	1ksfX	GO:0000166 GO:0004176 GO:0005524 GO:0005829 GO:0006508 GO:0006979 GO:0016887 GO:0019538 GO:0043335
2	0.07	0.586	4.13	0.04	0.79	3j3rA	GO:0000166 GO:0005524 GO:0006351 GO:0006355 GO:0019538 GO:0030420
3	0.07	0.562	3.50	0.07	0.71	3hwsA	GO:0000166 GO:0004176 GO:0005524 GO:0005759 GO:0005829 GO:0006457 GO:0006508 GO:0008270 GO:0016032 GO:0016887 GO:0030163 GO:0042802 GO:0043335 GO:0046872 GO:0046983 GO:0051082 GO:0051301 GO:0051704
4	0.07	0.572	3.77	0.08	0.73	1qvrA	GO:0000166 GO:0005524 GO:0005737 GO:0009408 GO:0016485 GO:0019538 GO:0042802
5	0.07	0.484	3.95	0.08	0.64	3eccA	GO:0000166 GO:0005524 GO:0006260 GO:0042802 GO:0043565
6	0.07	0.545	3.49	0.05	0.69	3hteE	GO:0000166 GO:0004176 GO:0005524 GO:0005759 GO:0005829 GO:0006457 GO:0006508 GO:0008270 GO:0016032 GO:0016887 GO:0030163 GO:0042802 GO:0043335 GO:0046872 GO:0046983 GO:0051082 GO:0051301 GO:0051704
7	0.07	0.551	3.65	0.08	0.71	1um8A	GO:0000166 GO:0005524 GO:0006457 GO:0008270 GO:0046872 GO:0046983 GO:0051082
8	0.07	0.483	3.66	0.07	0.62	5bq5B	GO:0000166 GO:0005524
9	0.07	0.411	4.82	0.04	0.61	1e94E	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0006508 GO:0009376 GO:0009408 GO:0016020 GO:0016887 GO:0042802 GO:0043335 GO:0070011
10	0.07	0.530	3.73	0.05	0.69	1g4aE	GO:0000166 GO:0005524 GO:0005737 GO:0005829 GO:0006508 GO:0009376 GO:0009408 GO:0016020 GO:0016887 GO:0042802 GO:0043335 GO:0070011
11	0.07	0.528	3.69	0.04	0.68	1ofhA	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
12	0.07	0.528	3.52	0.05	0.67	1im2A	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
13	0.07	0.511	3.58	0.05	0.65	1g3iA	GO:0000166 GO:0005524 GO:0005737 GO:0006508 GO:0009376 GO:0016887 GO:0043335 GO:0070011
14	0.07	0.493	3.93	0.04	0.65	4ww4B	GO:0000166 GO:0003678 GO:0004386 GO:0005524 GO:0005634 GO:0006281 GO:0006351 GO:0006355 GO:0006974 GO:0016568 GO:0016787 GO:0032508 GO:0043141
15	0.07	0.499	4.20	0.03	0.67	2xszC	GO:0000166 GO:0000812 GO:0003678 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005815 GO:0005856 GO:0005913 GO:0006281 GO:0006310 GO:0006351 GO:0006355 GO:0006357 GO:0006974 GO:0007049 GO:0007067 GO:0007283 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0031011 GO:0032508 GO:0034080 GO:0035267 GO:0040008 GO:0043231 GO:0043967 GO:0043968 GO:0051301 GO:0070062 GO:0071339 GO:0097255 GO:0098609 GO:0098641 GO:1903146 GO:1903955 GO:1904837 GO:1904874
16	0.07	0.494	4.30	0.03	0.67	3uk6F	GO:0000166 GO:0000812 GO:0000979 GO:0000980 GO:0001094 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005719 GO:0005737 GO:0006281 GO:0006310 GO:0006338 GO:0006351 GO:0006355 GO:0006457 GO:0006974 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0030529 GO:0031011 GO:0031490 GO:0032508 GO:0034644 GO:0035066 GO:0035267 GO:0040008 GO:0042802 GO:0042803 GO:0043141 GO:0043531 GO:0043967 GO:0043968 GO:0045944 GO:0051082 GO:0051117 GO:0070062 GO:0071169 GO:0071339 GO:0071392 GO:0071733 GO:0071899 GO:0097255 GO:1904874
17	0.07	0.496	3.91	0.05	0.65	3uk6G	GO:0000166 GO:0000812 GO:0000979 GO:0000980 GO:0001094 GO:0003678 GO:0004003 GO:0004386 GO:0005524 GO:0005622 GO:0005634 GO:0005654 GO:0005719 GO:0005737 GO:0006281 GO:0006310 GO:0006338 GO:0006351 GO:0006355 GO:0006457 GO:0006974 GO:0016020 GO:0016363 GO:0016568 GO:0016787 GO:0016887 GO:0030529 GO:0031011 GO:0031490 GO:0032508 GO:0034644 GO:0035066 GO:0035267 GO:0040008 GO:0042802 GO:0042803 GO:0043141 GO:0043531 GO:0043967 GO:0043968 GO:0045944 GO:0051082 GO:0051117 GO:0070062 GO:0071169 GO:0071339 GO:0071392 GO:0071733 GO:0071899 GO:0097255 GO:1904874
18	0.07	0.472	3.39	0.07	0.59	3glfG	GO:0000166 GO:0003677 GO:0003689 GO:0003887 GO:0005524 GO:0005663 GO:0006260 GO:0006261 GO:0009360 GO:0016740 GO:0016779 GO:0016887 GO:0017111 GO:0030337 GO:0042802 GO:0043846 GO:0071897
19	0.07	0.368	5.00	0.05	0.56	5a5bJ	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006289 GO:0006338 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0019904 GO:0030163 GO:0030433 GO:0031595 GO:0032968 GO:0034515 GO:0036402 GO:0043161 GO:0043433 GO:0045899 GO:0051091 GO:0070651 GO:0070682 GO:1901800
20	0.07	0.484	3.70	0.05	0.62	5a5bI	GO:0000166 GO:0000502 GO:0005524 GO:0005634 GO:0005737 GO:0006511 GO:0008540 GO:0016787 GO:0016887 GO:0017025 GO:0030163 GO:0030433 GO:0031503 GO:0031595 GO:0031597 GO:0036402 GO:0043171 GO:0045732 GO:0045899 GO:0070651 GO:0070682 GO:1901800

Consensus prediction of GO terms

Molecular Function	GO:0032550	GO:0032559	GO:0035639
GO-Score	0.48	0.48	0.48
Biological Processes	GO:0043170	GO:0044238
GO-Score	0.37	0.32
Cellular Component	GO:0005829	GO:0016021	GO:0005637	GO:0005759
GO-Score	0.13	0.11	0.11	0.07

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.