I-TASSER results

I-TASSER results for job id Rv1422

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (342 residues)
MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLRSELDVVPPGDLRMAL
AALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVLADPVAALDELGRILGV
KGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGKVRRVRLLPTDPPATRQA
VDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRALVLNLVAEPGETAGFSVE
RHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATMLQAEVHFADVARPGTPLHDP
GKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDAWR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLRSELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVLADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGKVRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRALVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATMLQAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDAWR
Prediction	CCCEEEEEHCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEHCCCCCEEEEEEHCCCCCCCCCEEEEEEEEHCCCCCCCEEEEEEHCCCCCCCHHHHHHHHHCCEEEHCCCCHHHHHHHHHHCHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHCCCCCCHHHHHHHHHHHCHHHCCEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
Conf.Score	998599995885799999999987998699996888997558989998999987699999998799977899999999874899987887656799999999879999999999999899858997558987999998898666667589975776566899769999867999999999999998998998799857887777765679999998999899987898898888999999999999999788989799987998988899999998654447589973545689877899999999999999865556787656788888756777777889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLRSELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVLADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGKVRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRALVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATMLQAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDAWR
Prediction	863200000012002200400372345000000001012100301531600011101300010023453340033004100545440331102201020014124213400410040060402000002240301020442443244121021103046265302201021660611450050045000000012112000000000530250047160200000101325220561304300400261076310000000375145722452155305404041224403573222101520040024004533453455552253035325545566418
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCEEEEEHCCCHHHHHHHHHHHCCCCEEEEEHCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEHCCCCCEEEEEEHCCCCCCCCCEEEEEEEEHCCCCCCCEEEEEEHCCCCCCCHHHHHHHHHCCEEEHCCCCHHHHHHHHHHCHHHHHHHHHCCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEHCCCCCCHHHHHHHHHHHCHHHCCEEEHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCC
MTDGIVALGGGHGLYATLSAARRLTPYVTAVVTVADDGGSSGRLRSELDVVPPGDLRMALAALASDSPHGRLWATILQHRFGGSGALAGHPIGNLMLAGLSEVLADPVAALDELGRILGVKGRVLPMCPVALQIEADVSGLEADPRMFRLIRGQVAIATTPGKVRRVRLLPTDPPATRQAVDAIMAADLVVLGPGSWFTSVIPHVLVPGLAAALRATSARRALVLNLVAEPGETAGFSVERHLHVLAQHAPGFTVHDIIIDAERVPSEREREQLRRTATMLQAEVHFADVARPGTPLHDPGKLAAVLDGVCARDVGASEPPVAATQEIPIDGGRPRGDDAWR

2hzbA

0.34

0.29

0.85

2.40

MUSTER

KKKNVVVFGGGTGLSVLLRGLKTFPVSITAIVTVADDGGSSGRLRKELDIPPPGDVRNVLVALSEVE---PLLEQLFQHRFENGNGLSGHSLGNLLLAGTSI-TGDFARGISESK--LNVRGKVLPASNRSIILHGE--DGT-------IVTGESSIPKAGKKIKRVFLTPKDTKPLREGLEAIRKADVIVIGPGSLYTSVLPNLLVPGICEAIKQSTARKVYICNV-TQNGETDGYTASDHLQAIDHC-GVGIVDDILVHGEPISDTVKAKYAKEKAEPVGVGTISDYFVQDDVLRHNASKVSEAILE---------------------------------

2ppvA

0.31

0.28

0.89

4.15

dPPAS

-KQNVVLIGGGTGLSVLARGLREFPIDITAIVTVADNGG-STGKIRDVDIPAPGDIRNVIAALSDSES---ILTQLFQYRF-GENQVDGHSLGNLVIAGTNI-TNDFGHAIKELSKVLNIKGQVIPSTNASVQLNAVEDG--------EIVHGETNIPKTHKKIDRVFLEPSDV-EPNEAIEALEQADLIVLGPGSLYTSVISNLCVKGISEALLRTSAPKLYVSNV-TQPGETDNYDVKEHIDALTRQVGEPFIDFVICSSESYSKDVLQRYEEKNSKDSGIRVLTASNLNEHYVRHNTKVLSKIYELALELTSTIRFTP---------------------

2ppvA

0.31

0.28

0.88

4.48

wdPPAS

-KQNVVLIGGGTGLSVLARGLREFPIDITAIVTVADNGGSTGKIRDV--IPAPGDIRNVIAALSDSES---ILTQLFQYRF-GENQVDGHSLGNLVIAGTN--TNDFGHAIKELSKVLNIKGQVIPSTNASVQLNAVE-DGEI-------VHGETNIPKTHKKIDRVFLEPS-DVEPNEAIEALEQADLIVLGPGSLYTSVISNLCVKGISEALLRTSAPKLYVSNV-TQPGETDNYDVKEHIDALTRQVGEPFIDFVICSSESYSKDVLQRYEEKNSKDSGIRVLTASNLNEHYVRHNTKVLSKIYELALELTSTIRFTP---------------------

2hzbA

0.34

0.29

0.85

2.85

wMUSTER

-KKNVVVFGGGTGLSVLLRGLKTFPVSITAIVTVADDGGSSGRLRKELDIPPPGDVRNVLVALSEVE---PLLEQLFQHRFENGNGLSGHSLGNLLLAGTSI-TGDFARGISESK--LNVRGKVLPASNRSIILHGEE-DGTI-------VTGESSIPKAGKKIKRVFLTPKDTKPLREGLEAIRKADVIVIGPGSLYTSVLPNLLVPGICEAIKQSTARKVYICNV-TQNGETDGYTASDHLQAIDHC-GVGIVDDILVHGEPISDTVKAKYAKEKAEPVGVGTISDYFVQDDVLRHNASKVSEAILE---------------------------------

2ppvA

0.31

0.28

0.88

4.17

wPPAS

-KQNVVLIGGGTGLSVLARGLREFPIDITAIVTVADNGGSTGKIRDV--IPAPGDIRNVIAALSDSES---ILTQLFQYRF-GENQVDGHSLGNLVIAGTN--TNDFGHAIKELSKVLNIKGQVIPSTNASVQLNAVE-DGE-------IVHGETNIPKTHKKIDRVFLEPS-DVEPNEAIEALEQADLIVLGPGSLYTSVISNLCVKGISEALLRTSAPKLYVSNV-TQPGETDNYDVKEHIDALTRQVGEPFIDFVICSSESYSKDVLQRYEEKNSKDSGIRVLTASNLNEHYVRHNTKVLSKIYELALELTSTIRFTP---------------------

2ppvA

0.32

0.28

0.89

9.24

dPPAS2

-KQNVVLIGGGTGLSVLARGLREFPIDITAIVTVADNGGSTGKIRDVD-IPAPGDIRNVIAALSDSES---ILTQLFQYRF-GENQVDGHSLGNLVIAGTNI-TNDFGHAIKELSKVLNIKGQVIPSTNASVQLNAVE-DGE-------IVHGETNIPKTHKKIDRVFLEPSDV-EPNEAIEALEQADLIVLGPGSLYTSVISNLCVKGISEALLRTSAPKLYVSNV-TQPGETDNYDVKEHIDALTRQVGEPFIDFVICSSESYSKDVLQRYEEKNSKDSGIRVLTASISNEHYVRHNTKVLSKIYELALELTSTIRFTP---------------------

2hzbA

0.35

0.30

0.85

3.81

PPAS

KKKNVVVFGGGTGLSVLLRGLKTFPVSITAIVTVADDGGSSGRLRKELDIPPPGDVRNVLVALSEVE---PLLEQLFQHRFENGNGLSGHSLGNLLLAGTS--TGDFARGISESK--LNVRGKVLPASNRSIILHGEE-DGT-------IVTGESSIPKAGKKIKRVFLTPKDTKPLREGLEAIRKADVIVIGPGSLYTSVLPNLLVPGICEAIKQSTARKVYICNV-TQNGETDGYTASDHLQAIDHC-GVGIVDDILVHGEPISDTVKAKYAKEKAKALGVGTISDYFVLDDVLRHNASKVSEAILE---------------------------------

2ppvA

0.32

0.28

0.89

5.80

Env-PPAS

-KQNVVLIGGGTGLSVLARGLREFPIDITAIVTVADNGGSTGKIRDVD-IPAPGDIRNVIAALSDSES---ILTQLFQYRF-GENQVDGHSLGNLVIAGTNI-TNDFGHAIKELSKVLNIKGQVIPSTNASVQLNAVE-DGE-------IVHGETNIPKTHKKIDRVFLEPSDV-EPNEAIEALEQADLIVLGPGSLYTSVISNLCVKGISEALLRTSAPKLYVSNV-TQPGETDNYDVKEHIDALTRQVGEPFIDFVICSSESYSKDVLQRYEEKNSKDSGIRVLTASNLNEHYVRHNTKVLSKIYELALELTSTIRFTP---------------------

2ppvA

0.32

0.28

0.88

2.38

MUSTER

-KQNVVLIGGGTGLSVLARGLREFPIDITAIVTVADNGGSTGKIRDV--IPAPGDIRNVIAALSDSES---ILTQLFQYRF-GENQVDGHSLGNLVIAGTN--TNDFGHAIKELSKVLNIKGQVIPSTNASVQLNAV--DGEI-------VHGETNIPKTHKKIDRVFLEPSDVEP-NEAIEALEQADLIVLGPGSLYTSVISNLCVKGISEALLRTSAPKLYVSNV-TQPGETDNYDVKEHIDALTRQVGEPFIDFVICSSESYSKDVLQRYEEKNSKPVAIRVLTASISNEHYVRHNTKVLSKIYELALELTSTIRFTP---------------------

2hzbA

0.34

0.30

0.86

4.06

dPPAS

KKKNVVVFGGGTGLSVLLRGLKTFPVSITAIVTVADDGGSSGRLRKELDIPPPGDVRNVLVALSEVE---PLLEQLFQHRFENGNGLSGHSLGNLLLAGTSI-TGDFARGISESKV-LNVRGKVLPASNRSIILHGEEDGT--------IVTGESSIPKAGKKIKRVFLTPKDTKPLREGLEAIRKADVIVIGPGSLYTSVLPNLLVPGICEAIKQSTARKVYICNV-TQNGETDGYTASDHLQAIDHC-GVGIVDDILVHGEPISDTVKAKYAEHKLKALGVGTISDYFVQDDVLRHNASKVSEAILE---------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.15

Estimated TM-score = 0.73±0.11

Estimated RMSD = 6.2±3.8Å

Download Model 2

C-score=-1.92

Download Model 3

C-score=-0.46

Download Model 4

C-score=-0.58

Download Model 5

C-score=-2.37

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2ppvA	0.837	1.79	0.313	0.889
2	2hzbA	0.831	1.36	0.347	0.860
3	2q7xA	0.685	3.44	0.276	0.801
4	3c3dA	0.623	3.58	0.153	0.746
5	2p0yA	0.608	1.89	0.314	0.649
6	4a0fA	0.514	5.35	0.057	0.737
7	1cjyA2	0.482	5.92	0.057	0.728
8	1eg7A	0.453	5.75	0.100	0.687
9	3cb2A1	0.453	4.73	0.057	0.617
10	3ez2B	0.452	5.07	0.078	0.626

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.28	8	3c3eC	GDP	Rep, Mult	10,11,12,13,16,194,195,196,200,226,229,290,291,298
2	0.22	3	2o2zA	NAD	Rep, Mult	12,13,194,195,196,226,227,228,230,272,273,276,295,297,299
3	0.07	2	3c3dA	PO4	Rep, Mult	11,12,195,196,200,231
4	0.03	1	3du7A	MG	Rep, Mult	182,185,187
5	0.03	1	3du7C	HOS	Rep, Mult	53,56,57,77,92

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2vg8A	0.434	5.18	0.083	0.599	2.4.1.218	9
2	0.060	1edqA	0.420	6.52	0.060	0.705	3.2.1.14	NA
3	0.060	1dhsA	0.421	5.21	0.112	0.597	2.5.1.46,1.5.1.-	NA
4	0.060	2ff2B	0.430	5.05	0.057	0.594	3.2.2.1	NA
5	0.060	2qcvA	0.423	4.54	0.082	0.553	2.7.1.92	NA
6	0.060	1ahpA	0.451	5.98	0.076	0.687	2.4.1.1	NA
7	0.060	9cgtA	0.428	6.37	0.033	0.708	2.4.1.19	16,61
8	0.060	1gr0A	0.418	5.30	0.083	0.582	5.5.1.4	126
9	0.060	1de0A	0.436	5.45	0.086	0.640	1.18.6.1	NA
10	0.060	1ygpA	0.443	5.90	0.031	0.670	2.4.1.1	47
11	0.060	3lxuX	0.429	6.36	0.053	0.696	3.4.14.10	126
12	0.060	3b9eA	0.419	6.60	0.051	0.711	3.2.1.14	NA
13	0.060	1d7fA	0.427	6.63	0.055	0.728	2.4.1.19	NA
14	0.060	1qhoA	0.442	6.24	0.063	0.722	3.2.1.133	189
15	0.060	1eg7A	0.453	5.75	0.100	0.687	6.3.4.3	NA
16	0.060	3kvnX	0.432	5.93	0.032	0.661	3.1.1.1	NA
17	0.060	1cjyA	0.482	5.92	0.057	0.728	3.1.1.4,3.1.1.5	NA
18	0.060	3b9xA	0.423	4.88	0.096	0.567	3.2.2.8	256
19	0.060	1wyeA	0.419	4.35	0.096	0.541	2.7.1.45	54,55

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.57	0.845	1.36	0.34	0.87	2hzbA	GO:0005737 GO:0008360
1	0.50	0.854	1.79	0.31	0.91	2ppvA	GO:0005737 GO:0008360
2	0.38	0.706	3.51	0.27	0.83	2q7xA	GO:0005737 GO:0008360
3	0.35	0.626	1.92	0.30	0.67	2p0yA	GO:0005737 GO:0008360
4	0.23	0.638	3.62	0.16	0.76	3c3dA	GO:0000287 GO:0009108 GO:0016740 GO:0016773 GO:0016780 GO:0051188
5	0.06	0.298	6.01	0.05	0.46	1u2eA	GO:0003824 GO:0005737 GO:0016787 GO:0018771 GO:0019380 GO:0019439 GO:0019622 GO:0042803 GO:0052823
6	0.06	0.277	7.21	0.04	0.50	3o8jA	GO:0005737 GO:0006099 GO:0016740 GO:0019679 GO:0036440 GO:0046912 GO:0050440
7	0.06	0.234	5.83	0.06	0.36	5aysA	GO:0004844 GO:0006281 GO:0006284 GO:0006974 GO:0008152 GO:0016787 GO:0016798 GO:0016799
8	0.06	0.199	5.15	0.03	0.29	4eb5C	GO:0005506 GO:0016226 GO:0046872 GO:0051536 GO:0051537
9	0.06	0.232	6.48	0.03	0.38	2iewA	GO:0000122 GO:0000166 GO:0000821 GO:0000823 GO:0000824 GO:0000825 GO:0000827 GO:0005524 GO:0005634 GO:0006351 GO:0006355 GO:0006525 GO:0008440 GO:0016236 GO:0016301 GO:0016310 GO:0016740 GO:0030674 GO:0032958 GO:0035004 GO:0045944 GO:0046854 GO:0046872 GO:0050821
10	0.06	0.356	6.04	0.06	0.56	2q6tA	GO:0000166 GO:0003677 GO:0003678 GO:0004386 GO:0005524 GO:0006260 GO:0006269 GO:0016787 GO:0032508 GO:1990077
11	0.06	0.195	5.25	0.06	0.28	1zwtA	GO:0009289
12	0.06	0.175	4.48	0.10	0.23	3cgiC	GO:0006580
13	0.06	0.152	5.14	0.07	0.22	1jdqA
14	0.06	0.165	5.09	0.03	0.24	1wikA	GO:0002026 GO:0005080 GO:0005634 GO:0005737 GO:0005938 GO:0009055 GO:0010614 GO:0015035 GO:0030018 GO:0030425 GO:0044822 GO:0045454 GO:0046872 GO:0051536 GO:0055114 GO:0070062
15	0.06	0.166	4.04	0.07	0.21	3zywB	GO:0002026 GO:0005080 GO:0005634 GO:0005737 GO:0005938 GO:0009055 GO:0010614 GO:0015035 GO:0030018 GO:0030425 GO:0044822 GO:0045454 GO:0046872 GO:0051536 GO:0055114 GO:0070062
16	0.06	0.144	5.60	0.04	0.22	3lygA
17	0.06	0.165	4.01	0.05	0.20	2yanA	GO:0002026 GO:0005080 GO:0005634 GO:0005737 GO:0005938 GO:0009055 GO:0010614 GO:0015035 GO:0030018 GO:0030425 GO:0044822 GO:0045454 GO:0046872 GO:0051536 GO:0055114 GO:0070062
18	0.06	0.142	4.91	0.03	0.20	5cqxB	GO:0003677 GO:0003723 GO:0004518 GO:0004519 GO:0004521 GO:0006351 GO:0006355 GO:0006402 GO:0006417 GO:0009372 GO:0016075 GO:0016787 GO:0030308 GO:0051607 GO:0090305 GO:0090502

Consensus prediction of GO terms

Molecular Function	GO:0016772	GO:0046872
GO-Score	0.46	0.46
Biological Processes	GO:0008360	GO:0006732	GO:0051188
GO-Score	0.91	0.46	0.46
Cellular Component	GO:0005737
GO-Score	0.91

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
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