I-TASSER results

I-TASSER results for job id Rv1421

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (301 residues)
MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFG
LAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRR
SHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSV
TVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESY
HRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGR
E

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE
Prediction	CCCCCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCCCCEEEHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEHCCCC
Conf.Score	9987788888887778779999789998789999999998985754899899999999999858887669999988998758999999999999899879999986978999999875899999999999999999999999999989968858999999999999999975688877999998566679998887799847899988897886589999999999986968999999999999999999999899869999987899743599999999999986799489999657889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE
Prediction	8565555475565555030000001121112100300242300000102050044005103646651310000000033621640350053047470502000010444201410563134120367431440053036104502730420000160325402520362045335440201000001232104300000000001102116503734462640251037373035005301500320052037542320000000322421000001200520375470503031133758
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHCCEEEHCCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEHCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCCCCEEEHCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCCCEEHHHHHHHHHHHHHHHCCCEEEEEEEHCCCC
MMNHARGVENRSEGGGIDVVLVTGLSGAGRGTAAKVLEDLGWYVADNLPPQLITRMVDFGLAAGSRITQLAVVMDVRSRGFTGDLDSVRNELATRAITPRVVFMEASDDTLVRRYEQNRRSHPLQGEQTLAEGIAAERRMLAPVRATADLIIDTSTLSVGGLRDSIERAFGGDGGATTSVTVESFGFKYGLPMDADMVMDVRFLPNPHWVDELRPLTGQHPAVRDYVLHRPGAAEFLESYHRLLSLVVDGYRREGKRYMTIAIGCTGGKHRSVAIAEALMGLLRSDQQLSVRALHRDLGRE

3h0kA

0.21

0.10

0.49

1.70

dPPAS

-----------------KVILITGMPGSGKSEFAKLLKERGAKVIVGERLMDFAKRLREIYGDGTSNHDLVVFDGVRS------LAEVEEFKRLLGDSVYIVAVHSPPKIRYKRMIERLS----KEISELIRRDREELKLIGEVIAMADYIITNDS-NYEEFKRRCEEVTDRVL-------------------------------------------------------------------------------------------------------------------------------

3h0kA

0.24

0.11

0.47

1.09

wdPPAS

-----------------KVILITGMPGSGKSEFAKLLKERGAKVIVRLDGVVARLCVEELGTSNHDL----VVFDVRS------LAEVEEFKRLLGDSVYIVAVHSPPKIRYKRMIE-RLS---KEISELIRRDREELKLIGEVIAMADYIITNDS-NYEEFKRRCEEVTDRVL-------------------------------------------------------------------------------------------------------------------------------

3h0kA

0.23

0.11

0.47

3.49

dPPAS2

-----------------KVILITGMPGSGKSEFAKLLKERGAKVIVRLDGVVARLCVEELGTSNHDL----VVFDVRS------LAEVEEFKRLLGDSVYIVAVHSPPKIRYKRMIERLS----KEISELIRRDREELKLIGEVIAMADYIITNDS-NYEEFKRRCEEVTDRVL-------------------------------------------------------------------------------------------------------------------------------

3vaaA

0.15

0.08

0.51

1.42

dPPAS

---------------AMVRIFLTGYMGAGTTLGKAFARKLNVPFIDHKTAGFRELERNMLHEVAEFENVVIST-----GGGAPCFYDNMEFMNRTG---KTVFLNVHPDVLFRRLRIAKQQRPILQGKELMDFIIQALEKRAPFYTQAQYIFNADELEDRWQIESSVQRLQELLEL-----------------------------------------------------------------------------------------------------------------------------

2vliB

0.16

0.08

0.48

1.08

wdPPAS

---------------RSPIIWINGPFGVGKTHTAHTLHERGSFVFE-TP-PLLDALQYASREAAGP---LIVPVSISD----TARHRRLSGLKDRGLSVHHFTLIAPLNVVLERLRR-DGQPQVN-----VGTVEDRLNELRG--EQFQTHIDTAGLGTQQVAEQIAAQVGLTLAPP----------------------------------------------------------------------------------------------------------------------------

4eunA

0.16

0.08

0.49

2.69

dPPAS2

---------------PTRHVVVMGVSGSGKTTIAHGVADEGLEFAEGIPLRSLAEWMDARADAGVS-----TIITCSALK-----RTYRDVLREGPPSVDFLHLDGPAEVIKGRMSKR------EGHFMPASLLQSQLATLEALPDESGIVLDLRQ-PPEQLIERALTWLDIAPAVATH--------------------------------------------------------------------------------------------------------------------------

1yj5B2

0.11

0.06

0.55

1.42

dPPAS

AGPLYLPESSSLLSPNPEVVVAVGFPGAGSTFIQEHLVSAGYVHVNGSWQRCVSSCQAALRQGKR------VVIDN-TNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFRET----DPSHAPVSDVFSYRKQFEPLAEGFLEILEIPFRLQEHLDPALQRLYRQFSEG-----------------------------------------------------------------------------------------------------------------------------

1ko5A

0.15

0.07

0.50

2.61

dPPAS2

-----------TTNHDHHIYVLMGVSGSGKSAVASEVAHQLAAFLDGEPKPWLQALNDAAFAMQRTNKVSLIVC---SALK----KHYRDLLREGNPNLSFIYLKGDFDVIESRLKA-RKGHFFK-----TQMLVTQFETLEPGADETDVLVVDIDQPLEGVVASTIEVIKKG--------------------------------------------------------------------------------------------------------------------------------

1ko5A

0.14

0.07

0.50

1.39

dPPAS

-----------TTNHDHHIYVLMGVSGSGKSAVASEVAHQLAAFLDGEPKPWLQALNDAAFAMQRTNKVSLIVC---SALK----KHYRDLLREGNPNLSFIYLKGDFDVIESRLKAR------KGHFFKTQMLVTQFETLEPGADETDVLVVDIDQPLEGVVASTIEVIKKG--------------------------------------------------------------------------------------------------------------------------------

3vaaA

0.15

0.08

0.51

2.53

dPPAS2

---------------AMVRIFLTGYMGAGTTLGKAFARKLNVPFIDHKTAGFRELERNMLHEVAEFENVVIST-----GGGAPCFYDNMEFMNRTG---KTVFLNVHPDVLFRRLRIAKQQRPILQGKELMDFIIQALEKRAPFYTQAQYIFNADELEDRWQIESSVQRLQELLEL-----------------------------------------------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.80

Estimated TM-score = 0.30±0.10

Estimated RMSD = 15.6±3.3Å

Download Model 2

C-score=-4.14

Download Model 3

C-score=-4.42

Download Model 4

C-score=-4.76

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1p6xA	0.474	3.88	0.122	0.585
2	1p7cB	0.462	4.08	0.132	0.581
3	2axnA	0.460	4.74	0.088	0.628
4	4gbmA	0.459	4.49	0.064	0.615
5	1t8uB	0.457	4.30	0.060	0.608
6	4bb9A	0.454	5.90	0.087	0.734
7	1zrhA	0.452	4.22	0.063	0.595
8	2wtzB	0.450	5.46	0.086	0.654
9	1nstA	0.450	4.40	0.060	0.598
10	2ovbA	0.450	4.06	0.066	0.588

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.21	7	1ukyA	ADP	Rep, Mult	27,28,29,30,31,32,114,118,157,158,159
2	0.06	2	3r0dA	ZN	Rep, Mult	196,200
3	0.06	2	1ko8B	6PG	Rep, Mult	26,27,30
4	0.03	1	1zotA	MG	Rep, Mult	196,200,295
5	0.03	1	3qebZ	MN	Rep, Mult	46,196
6	0.03	1	1l8tA	MG	Rep, Mult	26,200
7	0.03	1	1rc8A	CA	Rep, Mult	194,196,297
8	0.03	1	3d1lB	MPR	Rep, Mult	243,266,267
9	0.03	1	2bo7J	CO	Rep, Mult	196,270,271

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1p7cB	0.462	4.08	0.132	0.581	2.7.1.21	27
2	0.060	2ad5B	0.434	5.43	0.105	0.644	6.3.4.2	32,189,191
3	0.060	2dwoA	0.458	4.82	0.079	0.631	2.7.1.105,3.1.3.46	230
4	0.060	1zrhA	0.452	4.22	0.063	0.595	2.8.2.23	31,117,138
5	0.060	1g3mA	0.430	4.64	0.043	0.588	2.8.2.4	NA
6	0.060	1brwA	0.438	6.09	0.069	0.724	2.4.2.2	114
7	0.060	3n2aA	0.430	5.48	0.080	0.654	6.3.2.12,6.3.2.17	29,31
8	0.060	2gwhB	0.430	4.58	0.065	0.588	2.8.2.-	NA
9	0.060	1djnA	0.429	5.70	0.036	0.681	1.5.8.2,1.5.99.7	NA
10	0.060	1m7hC	0.420	3.39	0.150	0.508	2.7.1.25	25,29,143
11	0.060	2tmdA	0.431	5.78	0.028	0.688	1.5.8.2	24,27
12	0.060	1osnA	0.438	4.12	0.088	0.551	2.7.1.21	NA
13	0.060	3cklB	0.434	4.69	0.056	0.595	2.8.2.-	NA
14	0.060	1z28A	0.435	4.70	0.086	0.595	2.8.2.1	NA
15	0.060	1e8cB	0.436	5.20	0.068	0.638	6.3.2.13	NA
16	0.060	1bifA	0.454	4.78	0.088	0.621	3.1.3.46,2.7.1.105	152
17	0.060	1t8uB	0.457	4.30	0.060	0.608	2.8.2.30	31,110
18	0.060	2ad1A	0.389	4.06	0.065	0.508	2.8.2.-	NA
19	0.060	2wtzB	0.450	5.46	0.086	0.654	6.3.2.13	23

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.19	0.396	2.92	0.20	0.46	2iyvA	GO:0000166 GO:0000287 GO:0004765 GO:0005524 GO:0005737 GO:0005829 GO:0008652 GO:0009073 GO:0009423 GO:0016301 GO:0016310 GO:0016740 GO:0019632 GO:0040007 GO:0046872
1	0.13	0.456	4.00	0.14	0.57	3rdpB	GO:0000166 GO:0004797 GO:0005524 GO:0006230 GO:0016301 GO:0016310 GO:0016740 GO:0071897
2	0.12	0.474	3.88	0.12	0.58	1p6xA	GO:0000166 GO:0004797 GO:0005524 GO:0006230 GO:0016301 GO:0016310 GO:0016740 GO:0071897
3	0.12	0.401	3.54	0.11	0.49	1nksA	GO:0000166 GO:0004017 GO:0005524 GO:0005737 GO:0016301 GO:0016310 GO:0016740 GO:0046939
4	0.12	0.438	4.12	0.09	0.55	1osnA	GO:0000166 GO:0004797 GO:0005524 GO:0006230 GO:0016301 GO:0016310 GO:0016740 GO:0071897
5	0.11	0.409	3.66	0.13	0.51	2a2zB	GO:0000166 GO:0004137 GO:0005524 GO:0005634 GO:0005829 GO:0006139 GO:0006220 GO:0008144 GO:0009157 GO:0009165 GO:0016301 GO:0016310 GO:0016740 GO:0019206 GO:0042803 GO:0043097 GO:0043101
6	0.09	0.454	4.78	0.09	0.62	1bifA	GO:0000166 GO:0003824 GO:0003873 GO:0004331 GO:0005524 GO:0006000 GO:0006003 GO:0008152 GO:0016301 GO:0016310 GO:0016311 GO:0016740 GO:0016787 GO:0046835
7	0.07	0.459	4.12	0.08	0.60	4eecA	GO:0008146 GO:0016740 GO:0017000
8	0.07	0.457	4.81	0.08	0.63	1k6mA	GO:0000166 GO:0003824 GO:0003873 GO:0004331 GO:0005524 GO:0005829 GO:0006000 GO:0006003 GO:0006094 GO:0006096 GO:0008152 GO:0016301 GO:0016310 GO:0016311 GO:0016740 GO:0016787 GO:0019900 GO:0031100 GO:0032868 GO:0033133 GO:0033762 GO:0042594 GO:0042802 GO:0043540 GO:0046835 GO:0051384 GO:0051591 GO:0061621 GO:0070095
9	0.07	0.460	4.74	0.09	0.63	2axnA	GO:0000166 GO:0003824 GO:0003873 GO:0004331 GO:0005524 GO:0005654 GO:0005829 GO:0006000 GO:0006003 GO:0007420 GO:0008152 GO:0016301 GO:0016310 GO:0016311 GO:0016740 GO:0016787 GO:0046835 GO:0061621
10	0.07	0.447	3.95	0.06	0.58	4goxA	GO:0003824 GO:0008152 GO:0016740 GO:0031177
11	0.07	0.444	4.00	0.06	0.57	3nibA	GO:0008146
12	0.06	0.459	4.49	0.06	0.61	4gbmA	GO:0003824 GO:0008152 GO:0016740 GO:0031177 GO:0046872
13	0.06	0.440	4.66	0.06	0.60	3ap2A	GO:0000139 GO:0005783 GO:0005794 GO:0006478 GO:0008476 GO:0016020 GO:0016021 GO:0016740 GO:0070062
14	0.06	0.439	4.35	0.07	0.58	1efhB	GO:0004062 GO:0004304 GO:0005737 GO:0005829 GO:0006629 GO:0007586 GO:0008146 GO:0008202 GO:0016042 GO:0016740 GO:0030573 GO:0047704 GO:0050294 GO:0050427 GO:0051923
15	0.06	0.430	4.69	0.05	0.59	1j99A	GO:0004062 GO:0004304 GO:0005737 GO:0005829 GO:0006629 GO:0007586 GO:0008146 GO:0008202 GO:0016042 GO:0016740 GO:0030573 GO:0047704 GO:0050294 GO:0050427 GO:0051923
16	0.06	0.430	4.58	0.07	0.59	2gwhB	GO:0004062 GO:0005737 GO:0005829 GO:0008146 GO:0016740 GO:0050427 GO:0051923
17	0.06	0.417	4.08	0.04	0.54	3rnlA	GO:0016740 GO:0046872
18	0.06	0.406	3.22	0.16	0.49	3vaaA	GO:0000166 GO:0000287 GO:0004765 GO:0005524 GO:0005737 GO:0008652 GO:0009073 GO:0009423 GO:0016301 GO:0016310 GO:0016740 GO:0019632 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0016773	GO:0046872	GO:0004797
GO-Score	0.52	0.38	0.38	0.33
Biological Processes	GO:0016310	GO:0046417	GO:0043650	GO:0009072	GO:0032787	GO:0006520	GO:0071897	GO:0006230
GO-Score	0.52	0.38	0.38	0.38	0.38	0.38	0.33	0.33
Cellular Component	GO:0044444
GO-Score	0.38

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.