I-TASSER results

I-TASSER results for job id Rv1375

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (439 residues)
MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPSRVLGSADPTTIAHRH
GTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQAVRPASLTLSVSQGKAAS
YRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQLRHRPGSLYHAGVKLDW
MVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLASGNCYDEATLHALYEVME
RHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVDLARIDVWDGYYCFAAELTS
ATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGAREDLPSAIYHRFGRVHTYAKAR
KTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGTEPLAVVCDFADACVPVVKVLA
PGLVLSSASPMRTPLQEAE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPSRVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQAVRPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQLRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLASGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVDLARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGAREDLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGTEPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE
Prediction	CCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCEEEHCCCCCCHCCCCCCCCCCCCCCEEHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCEEEEEHCCCCCCEHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEHCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEHHHHHCCCCCCCCCCCCEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEHCCCCCCCEEEEEEEHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCC
Conf.Score	9876655665566555555544443345776677658886445555578888876545478777789999999999998876976898855677778868999876888754547889999999999999999999857888763334477656778899888656677789999755679988778997898636665358888888777645468888888999999999999999999999999985778888855567857999999999989989999768899967999999779998589987589999999999999999998777656556888654456665555544454555566666666677777875899999999999997995999988977678589999957987778887767765579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPSRVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQAVRPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQLRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLASGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVDLARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGAREDLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGTEPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE
Prediction	7544322404523440364333000201324300232251322214125346413121253322323053005203510571302200422514310000000001332100000010113200100000000001000213341112204306563103153034225530357231200202102564200000000002032643332201200000000110111000000000000000000024433151142406422033005104736030100001351100000000125633100000001111220011001000000022133334414443143144143124145222414443322242253620350023004200653302000000015202000000000201012213211233568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCHHHHHHHHHCCHHHHHCCCCCEEEHCCCCCCHCCCCCCCCCCCCCCEEHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCCEEEEEHCCCCCCEHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEHCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCEEEEEEEHCCCCCEEEEEHHHHHCCCCCCCCCCCCEHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEHCCCCCCCEEEEEEEHCCCCCCEEEEHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHCCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCC
MTGRRLARFPAFRAGVAQDDDVGSTLSQGSTTGVLSGPNWSYWPSRVLGSADPTTIAHRHGTHRITSPDETWLALQPFLAPAGITGVADVTWLDCLGIPTVQAVRPASLTLSVSQGKAASYRAAQVSAVMESLEGWHAENVTADLWSATARDLEADLTYDPAQLRHRPGSLYHAGVKLDWMVATTLLTGRRTWVPWTAVLVNVATRDCWEPPMFEMDTTGLASGNCYDEATLHALYEVMERHSVAAAVAGETMFEVPTDDVAGSDSAHLVEMIRDAGDDVDLARIDVWDGYYCFAAELTSATLEVTFGGFGLHHDPNVALSRAITEAAQSRITAISGAREDLPSAIYHRFGRVHTYAKARKTSLRLNRARPTPWRVPDVDSLPELVASAATAVANRSGTEPLAVVCDFADACVPVVKVLAPGLVLSSASPMRTPLQEAE

4bs9A

0.19

0.18

0.95

1.88

MUSTER

ERPTARATLPSTLQTGLQWAATEIAKWMVKRHLNAIAPGTARFPTLAGKQTTLELKAHPLSRRPQCPTCGDRETLQRRGFE--------PLKLESRPKHPEQTVQKYQHLIGPITGVVTELVRSRASGLCEAIERYSGIFQGDEPKRATLAEL-GDLAIHPEQCLHFSPQRFDASKAHDWTPVWSLTEQTHKYLPTALCYYRYPF--PPEHRFCRSDSNGNAAGNTLEEAILQGFMELVERDSVCLWWYNRVSPAVDLSSFDEPYFLQLQQFYQTQNRDLWVLDLTADLGIPAFVGVSNRKASERIILGFGAHLDPTVAILRALTEVNQIGLEL--DATDWLVNATLAASPYLVA-------DASQPLKTAKDYPRRWSDD-IYTDVMTCVEIAKQAGLETLVLDQTRPDIGLNVVKVIVPGMRFWSFGSGRLGWREQP

4q84A

0.17

0.14

0.81

2.52

dPPAS

-----------------------------------------------------------------AALEDSIARFQQKLSDLGF-QIEEASWLNPVP-NVWSVHIRDALC--FTNGKGATKKAALASALGEYFERLSTNYFFADFWLGETIANGPEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIG-------------NLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISLPEIPADVRYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLIKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4q84A

0.18

0.14

0.81

3.71

wdPPAS

-----------------------------------------------------------------AALEDSIARFQQKLSDLGF-QIEEASWLNP--VPNVWSVHIRD-ALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGPFVHYPNEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIGN-------------LYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISLPEIPADVRYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLIKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4q84A

0.18

0.15

0.81

1.72

wMUSTER

------------------------------------------------------------------ALEDSIARFQQKLSDLGF-QIEEASWLNP--VPNVWSVHIRD-ALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGPFVHYPNEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIG-------------NLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESSLPEIPADVLAYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLIKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4q84A

0.19

0.15

0.81

3.12

wPPAS

-----------------------------------------------------------------AALEDSIARFQQKLSDLGF-QIEEASWLNP--VPNVWSVHIRD-ALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGPFVHYPNEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIGNLY-------------VSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISPEIPADVLRYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTP-PTFDDEEVAEHTNLETHFIDSSGLKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4q84A

0.18

0.14

0.81

8.46

dPPAS2

-----------------------------------------------------------------AALEDSIARFQQKLSDLGF-QIEEASWLNP--VPNVWSVHIRD-ALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGETIANGPEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIG-------------NLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESISLPEIPADVRYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLIKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4q84A

0.19

0.15

0.81

2.57

PPAS

-----------------------------------------------------------------AALEDSIARFQQKLSDLGF-QIEEASWLNP--VPNVWSVHIRD-ALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGTENDDVPEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIG-------------NLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESSLPEIPADVLAYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLIKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4bs9A2

0.20

0.12

0.59

3.75

Env-PPAS

---RPQCPTC---GDRETLQRRGFE------------PLKL--------------------ESRPKHPEQTVQKYQHLIGP--------------------------------ITGVVTELVRSRASGLCEAIERYSGIFQGDERKRATLAEL-GDLAIHPEQCLHFSPQRFDASKAHDWTPVWSLTEQTHKYLPTALCYYRY--PFPPEHRFCRSDSNGNAAGNTLEEAILQGFMELVERDSVCLWWYNRSDDIYT-------DVMTCVEIAKQAGLETLVLDQTRDIGLNVVKVIVPGMRFWSRF-GSGRLYDVPVKLGWREQPLAEAQMNPTPMPF----------------------------------------------------------------------------------------------------

4q84A

0.18

0.15

0.81

1.83

MUSTER

-----------------------------------------------------------------AALEDSIARFQQKLSDLGF-QIEEASWLNP--VPNVWSVHIRD-ALCFTNGKGATKKAALASALGEYFERLSTNYFFADFWLGETIANGPEGLLDDRLRAFIDLQSGNEDRGICGLPFTRQSDNQTVYIPMNIIG-------------NLYVSNGMSAGNTRNEARVQGLSEVFERYVKNRIIAESSLPEIPADVLAYPAVVEAIETLEAEGFPIFAYDGSLGGQYPVICVVLFNPANGTCFASFGAHPDFGVALERTVTELLQGRGLKDLDVFTPPTFDDEEVAEHTNLETHFIDSSGLIKQDADYPFVDWNFSGTTEEEFATLMAIFNKEDKEVYIADYE--HLGVYACRIIVPGMSDIYPAEDLWLANNSM

4bs9A

0.17

0.95

2.39

dPPAS

ERPTARATLPSTLQTGLQWAATEIAKWMVKRHLNAIAPGTARFPTLTFNQTTLELKAHPLSRRPQCPTCGDRETLQRRGFEP--------LKLESRPKHPEQTVQKYQHLIGPITGVVTELVRSRASGLCEAIERYSGIFQGDEPRKRATLAELGDLAIHPEQCLHFSPQRFDASKAHDWTPVWSLTEQTHKYLPTALCYYRYPF--PPEHRFCRSDSNGNAAGNTLEEAILQGFMELVERDSVCLWWYNRVSPAVDLSSFDEPYFLQLQQFYQTQNRDLWVLDLTADLGIPAFVGVSNRGSSERIILGFGAHLDPTVAILRALTEVNQIGLELDATD----------WLVNATLAASPYLVADASQPLKTAKDYPRRWSDDIYTDVMTCVEIAKQAGLETLVLDQTRPDIGLNVVKVIVPGMRFWSRFGSGLGWREQP

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.77

Estimated TM-score = 0.62±0.14

Estimated RMSD = 8.8±4.6Å

Download Model 2

C-score=-1.24

Download Model 3

C-score=-2.91

Download Model 4

C-score=-3.62

Download Model 5

C-score=-3.76

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4q84A	0.783	1.49	0.177	0.809
2	4bs9A	0.683	4.31	0.172	0.827
3	3fahA	0.395	7.33	0.076	0.665
4	1dgjA	0.387	7.27	0.042	0.654
5	4r04A	0.381	7.05	0.047	0.617
6	3cu7A	0.371	6.86	0.046	0.592
7	1hn0A	0.371	7.23	0.038	0.620
8	4ff1A	0.371	7.28	0.041	0.620
9	1t3tA	0.370	7.47	0.052	0.633
10	4kmqA	0.368	7.10	0.047	0.604

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.20	12	4q85B	APC	Rep, Mult	71,117,126,127,130,131,134,222,223,225,229,233,237,241,322,326
2	0.07	4	4q85A	MG	Rep, Mult	117,240,241,322,326
3	0.04	3	4q85A	MG	Rep, Mult	134,221,237
4	0.03	2	1ofdA	F3S	Rep, Mult	394,399,400,402,403,422,424
5	0.03	2	1sijA	FES	Rep, Mult	116,119,122,124
6	0.03	2	3fahA	GOL	Rep, Mult	274,277,278,279,281
7	0.03	2	3kziX	CLA	Rep, Mult	221,224
8	0.03	2	1lm1A	F3S	Rep, Mult	244,246,247,252,254,285,294,295
9	0.02	1	4v1uA	CA	Rep, Mult	117,326
10	0.01	1	2xvaB	ZN	Rep, Mult	242,243
11	0.01	1	3phxA	ZN	Rep, Mult	313,315
12	0.01	1	3d1lB	MPR	Rep, Mult	153,219,220
13	0.01	1	3b2xA	NA	Rep, Mult	274,275,276,277,279
14	0.01	1	1zzhB	ZN	Rep, Mult	131,134
15	0.01	1	3lw52	CLA	Rep, Mult	194,326
16	0.01	1	2e69A	SO4	Rep, Mult	285,329
17	0.01	1	3gxqB	NUC	Rep, Mult	233,235

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3c46B	0.371	7.30	0.023	0.626	2.7.7.6	322
2	0.060	1i8qA	0.341	7.33	0.036	0.579	4.2.2.1	391
3	0.060	2vncB	0.331	6.86	0.034	0.533	3.2.1.-	NA
4	0.060	3ebgA	0.330	7.30	0.035	0.553	3.4.11.-	NA
5	0.060	1g5aA	0.337	7.21	0.047	0.553	2.4.1.4	NA
6	0.060	3k1dA	0.336	7.23	0.027	0.560	2.4.1.18	128
7	0.060	1dgjA	0.387	7.27	0.042	0.654	1.2.-.-	326
8	0.060	1t3tA	0.370	7.47	0.052	0.633	6.3.5.3	NA
9	0.060	1f1sA	0.338	7.31	0.034	0.567	4.2.2.1	140
10	0.060	1bglA	0.345	7.24	0.049	0.583	3.2.1.23	240
11	0.060	3fr8B	0.338	6.93	0.045	0.533	1.1.1.86	131
12	0.060	1ofdA	0.359	7.01	0.040	0.583	1.4.7.1	NA
13	0.060	2j5wA	0.338	7.63	0.027	0.585	1.16.3.1	NA
14	0.060	3btaA	0.333	7.39	0.025	0.570	3.4.24.69	NA
15	0.060	1s46A	0.335	7.11	0.047	0.547	2.4.1.4	NA
16	0.060	2rnpC	0.312	7.49	0.014	0.540	2.7.7.6	NA
17	0.060	2vdcF	0.365	7.20	0.037	0.601	1.4.1.13	NA
18	0.060	2vdcA	0.365	6.88	0.041	0.581	1.4.1.13	NA
19	0.060	1vlbA	0.393	7.22	0.074	0.658	1.2.99.7	242

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.37	0.786	1.69	0.17	0.82	4q86B	GO:0000287 GO:0005829 GO:0018339 GO:0047693
1	0.30	0.747	4.19	0.18	0.90	4v1tB	GO:0000166 GO:0046872
2	0.28	0.683	4.31	0.17	0.83	4bs9A	GO:0046872
3	0.06	0.387	7.27	0.04	0.65	1dgjA	GO:0009055 GO:0016491 GO:0046872 GO:0051536 GO:0051537 GO:0055114
4	0.06	0.374	7.42	0.04	0.64	1fo4A	GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0016903 GO:0043546 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0055114
5	0.06	0.298	7.71	0.05	0.52	4uhxA	GO:0003824 GO:0004031 GO:0004854 GO:0005506 GO:0005737 GO:0005829 GO:0006954 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0042816 GO:0043546 GO:0046872 GO:0050660 GO:0051287 GO:0051536 GO:0051537 GO:0055114 GO:0070062 GO:0072593
6	0.06	0.336	7.30	0.03	0.57	3ax7A	GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0016903 GO:0043546 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0055114
7	0.06	0.282	8.18	0.06	0.53	1t3qB	GO:0016491 GO:0055114
8	0.06	0.316	8.06	0.04	0.58	2e1qA	GO:0001933 GO:0001937 GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0006195 GO:0006919 GO:0007595 GO:0009055 GO:0009115 GO:0010629 GO:0016491 GO:0016529 GO:0016614 GO:0016903 GO:0030856 GO:0042803 GO:0043546 GO:0045602 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0051898 GO:0055114 GO:1900745 GO:1900747 GO:2000379 GO:2001213
9	0.06	0.363	7.55	0.04	0.64	3zyvB	GO:0003824 GO:0004031 GO:0004854 GO:0005506 GO:0005737 GO:0005829 GO:0009055 GO:0009115 GO:0016491 GO:0016614 GO:0030151 GO:0046872 GO:0050660 GO:0051287 GO:0051536 GO:0051537 GO:0055114
10	0.06	0.302	7.62	0.05	0.53	1jroB	GO:0016491 GO:0030151 GO:0046872 GO:0055114
11	0.06	0.300	6.98	0.05	0.49	2fj0A	GO:0016787
12	0.06	0.302	7.63	0.05	0.53	1rm6A	GO:0016491 GO:0018525 GO:0055114
13	0.06	0.287	7.43	0.03	0.49	1n63B	GO:0005507 GO:0016491 GO:0018492 GO:0030151 GO:0046872 GO:0055114
14	0.06	0.395	7.33	0.08	0.67	3fahA	GO:0009055 GO:0016491 GO:0033727 GO:0046872 GO:0051536 GO:0051537 GO:0055114
15	0.06	0.292	7.64	0.04	0.52	1ffuB	GO:0005507 GO:0016491 GO:0018492 GO:0030151 GO:0046872 GO:0055114
16	0.06	0.293	7.51	0.04	0.51	4zohA	GO:0016491 GO:0055114
17	0.06	0.259	7.08	0.05	0.42	1jroA	GO:0000166 GO:0003824 GO:0004854 GO:0004855 GO:0009055 GO:0016491 GO:0016614 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0055114
18	0.06	0.308	7.47	0.06	0.52	2ckjA	GO:0001933 GO:0001937 GO:0003824 GO:0004854 GO:0004855 GO:0005506 GO:0005576 GO:0005615 GO:0005737 GO:0005777 GO:0005829 GO:0006195 GO:0006919 GO:0007595 GO:0009055 GO:0009115 GO:0010629 GO:0016491 GO:0016529 GO:0016614 GO:0016903 GO:0030856 GO:0042803 GO:0043546 GO:0045602 GO:0046872 GO:0050660 GO:0051536 GO:0051537 GO:0051898 GO:0055114 GO:1900745 GO:1900747 GO:2000379 GO:2001213

Consensus prediction of GO terms

Molecular Function	GO:0000287	GO:0047693	GO:0000166
GO-Score	0.37	0.37	0.30
Biological Processes	GO:0018339
GO-Score	0.37
Cellular Component	GO:0005829
GO-Score	0.41

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.