I-TASSER results

I-TASSER results for job id Rv1372

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (393 residues)
MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELF
LDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDV
SKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMN
ALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQE
KLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDN
GLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMV
QQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
Prediction	CCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEHCCCCCEHCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCEEEEHCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHCEEEEHCCCCCHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCCEEEHCCCCCHCCCCCCCCCCCCCCCCEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCHHHHHHHHHHHCC
Conf.Score	998888888777776477766567889988766899876658985558899999999856776789999988556686657888888756867765478999999987554458999999999999989997788889998589998986999999998999886355356655578999999999999989998899997643356648999955655555354434899985789988655665688767764557888876678888756765885567999999999999999998999888888997898799999999998999888888899999869865569999999999989988887589999659967899989887459
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR
Prediction	644356444445344464134243372443220100000101152203062014103612544613510430144230430220053055333102443312520241155301500140034006617252520000000000322000000200430404510210100000000000001101200453421100000000001003374323100000000000000000124445324302100101113102214210313044310211024531330253315004401661704131010000021032004301741704662031014003611000000000002202651545622110000011131000000010158
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCEEEEEEEHCCCCCEHCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHCCEEEEHCCCCCCCCCHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHCEEEEHCCCCCHHHHHHHHCCCCCCEEEEEHCCCCCCCCCCCCEEEHCCCCCHCCCCCCCCCCCCCCCCEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHCCEEEHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCHHHHHHHHHHHCC
MNVSAESGAPRRAGQRHEVGLAQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELFLDPGQRERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELCSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR

4jaoD

0.29

0.26

0.89

2.93

MUSTER

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVL-----PLQQYPSLTD-FGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRW--R

4jaoD

0.28

0.25

0.89

4.40

dPPAS

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHL------VLPLQQYPSLTDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRWR--

1teeA

0.99

0.93

0.94

4.10

wdPPAS

---------------------AQLPPAPPTTVAVIEGLATGTPRRVVNQSDAADRVAELGQ----RERIPRVYQKSRITTRRMAVDPLDAKFDVFRREPATIRDRMHLFYEHAVPLAVDVSKRALAGLPYRAAEIGLLVLATSTGFIAPGVDVAIVKELGLSPSISRVVVNFMGCAAAMNALGTATNYVRAHPAMKALVVCIELFSVNAVFADDINDVVIHSLFGDGCAALVIGASQVQEKLEPGKVVVRSSFSQLLDNTEDGIVLGVNHNGITCELSENLPGYIFSGVAPVVTEMLWDNGLQISDIDLWAIHPGGPKIIEQSVRSLGISAELAAQSWDVLARFGNMLSVSLIFVLETMVQQAESAKAISTGVAFAFGPGVTVEGMLFDIIRR

4jaoD

0.29

0.26

0.89

3.48

wMUSTER

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVL-----PLQQYPSLTD-FGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRW--R

4jaoD

0.29

0.26

0.89

3.84

wPPAS

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLV-----LPLQQYPSLTD-FGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRW--R

4jaoD

0.29

0.26

0.89

4.69

dPPAS2

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLV-----LPLQQYPSLTD-FGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRW--R

4jaoD

0.29

0.26

0.89

3.90

PPAS

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLV-----LPLQQYPSL-TDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRW--R

4jaoD

0.29

0.26

0.89

5.03

Env-PPAS

--------------------------------SVIAGVFGALPPHRYSQSEITDSFVEFPGLKEHEEIIRRLHAAAKVNGRHLVL-----PLQQYPSL-TDFGDANEIFIEKAVDLGVEALLGALDDANLRPSDIDMIATATVTGVAVPSLDARIAGRLGLRPDVRRMPLFGLGCVAGAAGVARLRDYLRGAPDDVAVLVSVELCSLTYPAVKTVSSLVGTALFGDGAAAVVAVGDRRAEQVRAGGPDILDSRSSLYPDSLHIMGWDVGSHGLRLRLSPDLTNLIERYLANDVTTFLDAHRLTKDDIGAWVSHPGGPKVIDAVATSLALPPEALELTWRSLGEIGNLSSASILHILRDTIEK-RPPSG-SAGLMLAMGPGFCTELVLLRW--R

3wd7A

0.24

0.99

2.90

MUSTER

MRGSHHHHHHGSMVTMEEIRRAKRAEGL----ATILAISTATPPNCVIQADYPDYYFGITHMTELKEKFKLLCEKSMIRKRHMCEEILKANPNMCLYMGTSLDARQDISLVEVPKLGKEAATKAIKEWGQPKSNITHLIFCTSAGVDMPGADYQLTRLIGLNPDVKRMMIYQQGCYAGATILRLAKDLAENNKGSRVLVVCSENTIPTFRGYTHIDSLVGQALFADGAAALIVGADPDTSIE-RPLYHIVSASQTLLPDSDGAIEGHIREAGLTVHLKKDVPEFFSANIEKSLVDAFTPIGISDWNSIFWIAHPGGPAILDQVEAKLGLKKDKLRASRHVMSEYGNMSSACVLFILDEMRNKCTTGEGLDWGVLFGFGPGLTVETVVLHSLPI

3wd7A

0.24

0.99

4.33

dPPAS

MRGSHHHHHHGSMVTMEEIRRAKRAEGL----ATILAISTATPPNCVIQADYPDYYFGITHMTELKEKFKLLCEKSMIRKRHMCEEILKANPNMCLYMGTSLDARQDISLVEVPKLGKEAATKAIKEWGQPKSNITHLIFCTSAGVDMPGADYQLTRLIGLNPDVKRMMIYQQGCYAGATILRLAKDLAENNKGSRVLVVCSENTIPTFRGPSHIDSLVGQALFADGAAALIVGADPDTSIE-RPLYHIVSASQTLLPDSDGAIEGHIREAGLTVHLKKDVPEFFSANIEKSLVDAFTPIGISDWNSIFWIAHPGGPAILDQVEAKLGLKKDKLRASRHVMSEYGNMSSACVLFILDEMRNKCTTGEGLDWGVLFGFGPGLTVETVVLHSLPI

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.13

Estimated TM-score = 0.87±0.07

Estimated RMSD = 4.4±2.9Å

Download Model 2

C-score=-4.60

Download Model 3

C-score=-4.51

Download Model 4

C-score=-2.14

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3wd7A	0.908	2.30	0.244	0.982
2	3wd8A	0.887	2.24	0.237	0.957
3	2d51A	0.886	2.31	0.234	0.959
4	3tsyA2	0.884	2.12	0.268	0.949
5	2p0uA	0.884	2.53	0.240	0.967
6	1u0vA	0.879	2.22	0.252	0.949
7	3ov2A	0.874	2.25	0.215	0.947
8	4jaoD	0.863	1.40	0.282	0.893
9	4b0nA	0.860	2.49	0.389	0.926
10	1teeA	0.860	2.48	0.976	0.929

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.29	55	2d52A	COA	Rep, Mult	68,71,75,76,175,216,219,223,224,264,275,277,278,279,281,282,315,316,317,318,319
2	0.18	35	1xetD	3IO	Rep, Mult	143,175,208,224,264,273,275,313,346,377
3	0.13	17	4b0nA	ACD	Rep, Mult	52,73,81,83,144,175,205,208,209,211,221,224,264,266,273,274,275,277,348
4	0.12	36	1hndA	COA	Rep, Mult	76,175,218,222,223,264,276,278,279,281,282,313,315,316,318,319,346,377
5	0.10	18	1u0wA	STL	Rep, Mult	175,203,204,205,208,224,225,226,264,265,266,273,274,275,346,347,348,379
6	0.06	22	1hndA	COA	Rep, Mult	90,94,98,99,175,218,222,223,257,276,278,279,281,282,313,315,316,318,319,346,377
7	0.06	20	3v4xD	F24	Rep, Mult	76,143,174,175,219,220,264,278,281,282,313,315,316,348,377,378,379
8	0.04	13	3a5rB	HC4	Rep, Mult	143,175,208,224,266,273,274,275,379
9	0.01	2	3s23A	XE	Rep, Mult	35,36,37,127,246,360,390
10	0.01	2	2h840	III	Rep, Mult	102,103,106,110,146,149,153,154,156,157,163,164,165,166,167,168,169,170,171,172,173,183,187,188,191,254,255,256,261,266,267,268,269,270,379,380,381,382
11	0.01	3	3s1zA	ACM	Rep, Mult	175,313,314,315,346,351,377
12	0.00	2	1mzjB	ACE	Rep, Mult	174,175,378,379
13	0.00	1	3s1zA	ACM	Rep, Mult	260,274,276,379
14	0.00	1	2eftB	MEE	Rep, Mult	135,156,161,162,164
15	0.00	2	4ku3B	MYR	Rep, Mult	175,281,285,286,312,313,319,346,375,377,378,379
16	0.00	1	3s23A	XE	Rep, Mult	293,310,327,329,375,385
17	0.00	1	1u6sA	DCC	Rep, Mult	76,143,174,175,205,208,223,224,313,315,316,346,348,378
18	0.00	1	3s23A	MN	Rep, Mult	367,390
19	0.00	1	1u6sA	DCC	Rep, Mult	147,148

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.566	1u0uA	0.882	2.19	0.233	0.949	2.3.1.-	175,224,313,346
2	0.479	1mzjA	0.719	2.89	0.241	0.812	2.3.1.180	175,224,313,346
3	0.477	3il5A	0.697	2.84	0.209	0.779	2.3.1.180	175,224,313,346
4	0.473	3il7A	0.701	2.94	0.222	0.791	2.3.1.180	175,224,313,346
5	0.467	2ebdA	0.704	2.67	0.202	0.781	2.3.1.180	175,224,313,346
6	0.393	2ahbA	0.714	3.05	0.196	0.814	2.3.1.180,2.3.1.41	175,313,346
7	0.376	1hnkA	0.624	2.56	0.237	0.687	2.3.1.180,2.3.1.41	175,313,346
8	0.341	3e1hB	0.844	2.54	0.229	0.924	2.3.1.74	81,175,223,316,377
9	0.338	3ledA	0.756	3.21	0.178	0.858	2.3.1.41	141,143,171,182,184,377
10	0.235	2gqdA	0.648	3.89	0.123	0.779	2.3.1.179	175,313
11	0.231	1b3nA	0.649	3.68	0.128	0.771	2.3.1.179,2.3.1.41	175,313,377
12	0.217	2ib7D	0.628	3.08	0.157	0.713	2.3.1.9	175,378
13	0.201	1bi5A	0.887	2.10	0.249	0.952	2.3.1.74	224,313,346
14	0.192	2p0uA	0.884	2.53	0.240	0.967	2.3.1.74	225,314,347
15	0.175	1xpmC	0.697	2.86	0.159	0.786	2.3.3.10	313
16	0.133	1z1eA	0.885	2.10	0.236	0.949	2.3.1.95	175,224,313,346
17	0.068	1kasA	0.649	3.68	0.128	0.771	2.3.1.179	313,378,380,382
18	0.068	1m1tA	0.623	3.14	0.151	0.710	2.3.1.9	175,378
19	0.067	1wdkD	0.622	3.30	0.131	0.715	2.3.1.16	NA
20	0.067	1wdkC	0.622	3.30	0.131	0.715	2.3.1.16	175,378
21	0.061	3e1hA	0.845	2.52	0.229	0.924	2.3.1.74	175,224,313,346
22	0.060	2c9hA	0.662	3.63	0.113	0.786	2.3.1.41	313,377
23	0.060	2v4wD	0.702	3.05	0.161	0.804	2.3.3.10	NA
24	0.060	2pffA	0.656	4.06	0.097	0.799	2.3.1.41,2.3.1.86	NA
25	0.060	3hmjA	0.659	4.05	0.091	0.799	2.3.1.86	NA
26	0.060	1hn9A	0.704	2.72	0.217	0.786	2.3.1.180	175,319,377
27	0.060	1w0iA	0.650	4.00	0.140	0.786	2.3.1.41	175,313,377
28	0.060	3h77B	0.730	2.60	0.197	0.809	2.3.1.180	223,313,319,346,351,382
29	0.060	2vz8B	0.651	3.57	0.114	0.768	2.3.1.85	175,313,377
30	0.060	2qx1A	0.712	3.08	0.196	0.814	2.3.1.180	175,204,277
31	0.060	2x3eA	0.709	2.75	0.212	0.791	2.3.1.180	223,319,337,342
32	0.060	1j3nA	0.649	3.75	0.163	0.771	2.3.1.41	175,313,377
33	0.060	2vz8A	0.651	3.57	0.114	0.768	2.3.1.85	175,313,377
34	0.060	3il3A	0.701	2.70	0.199	0.781	2.3.1.180	225
35	0.060	1ox0A	0.662	3.79	0.109	0.789	2.3.1.41	175,313,377
36	0.060	1ub7A	0.692	2.97	0.210	0.784	2.3.1.41	225

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.64	0.860	2.47	0.98	0.93	1tedA	GO:0003824 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0009058 GO:0009715 GO:0016740 GO:0016746 GO:0016747
1	0.54	0.860	2.49	0.39	0.93	4b0nA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
2	0.50	0.893	2.14	0.26	0.96	4yjyA	GO:0003824 GO:0008152 GO:0009058 GO:0009813 GO:0016210 GO:0016740 GO:0016746 GO:0016747
3	0.50	0.889	2.09	0.27	0.95	4wumA	GO:0003824 GO:0008152 GO:0009058 GO:0016210 GO:0016740 GO:0016746 GO:0016747
4	0.49	0.882	2.19	0.23	0.95	1u0uA	GO:0003824 GO:0005737 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747 GO:0050198
5	0.49	0.850	2.15	0.27	0.91	3oitB	GO:0003824 GO:0008152 GO:0009058 GO:0009813 GO:0016740 GO:0016746 GO:0016747 GO:0042802
6	0.49	0.908	2.30	0.24	0.98	3wd7A	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747 GO:0050635
7	0.49	0.823	2.12	0.24	0.88	1u0mA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747 GO:0042438
8	0.48	0.863	1.45	0.28	0.90	4japA	GO:0003824 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0008610 GO:0009058 GO:0009715 GO:0016740 GO:0016746 GO:0016747 GO:0071770
9	0.48	0.857	2.05	0.22	0.92	3a5qA	GO:0003824 GO:0008152 GO:0009058 GO:0009813 GO:0016740 GO:0016746 GO:0016747 GO:0018298 GO:0042803
10	0.46	0.887	2.09	0.25	0.95	1chwA	GO:0003824 GO:0008152 GO:0009058 GO:0009715 GO:0009813 GO:0016210 GO:0016740 GO:0016746 GO:0016747
11	0.46	0.867	2.08	0.28	0.93	3awjA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
12	0.44	0.887	2.24	0.24	0.96	3wd8A	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
13	0.43	0.857	2.11	0.26	0.92	1qlvA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
14	0.43	0.832	2.24	0.20	0.90	3vs8H	GO:0003824 GO:0008152
15	0.43	0.889	2.21	0.24	0.96	2d3mA	GO:0003824 GO:0008152 GO:0009058 GO:0009813 GO:0016740 GO:0016746 GO:0016747 GO:0042803
16	0.41	0.834	2.15	0.20	0.90	3vs8A	GO:0003824 GO:0008152
17	0.40	0.826	2.41	0.19	0.90	3v7iA	GO:0003824 GO:0008152 GO:0009058 GO:0016747
18	0.40	0.874	2.30	0.22	0.95	3ov2C	GO:0003824 GO:0008152 GO:0009058 GO:0009813 GO:0016740 GO:0016746 GO:0016747 GO:0042803
19	0.38	0.885	2.10	0.24	0.95	1z1eA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
20	0.37	0.846	2.22	0.23	0.91	3wxzA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
21	0.34	0.848	2.06	0.29	0.91	2h84A	GO:0003824 GO:0004871 GO:0005622 GO:0007165 GO:0008152 GO:0009813 GO:0010628 GO:0010629 GO:0016210 GO:0016491 GO:0016740 GO:0016746 GO:0019505 GO:0030639 GO:0031149 GO:0031152 GO:0043327 GO:0043949 GO:0044671 GO:0048837 GO:0055114
22	0.34	0.709	2.75	0.21	0.79	2x3eA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
23	0.32	0.733	2.60	0.20	0.81	3h77B	GO:0003824 GO:0004315 GO:0005737 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0044550
24	0.32	0.692	2.97	0.21	0.78	1ub7A	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
25	0.32	0.701	2.70	0.20	0.78	3il3A	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
26	0.32	0.704	2.69	0.21	0.78	4rybA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
27	0.31	0.845	2.52	0.23	0.92	3e1hA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
28	0.31	0.716	2.72	0.22	0.80	4dfeB	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
29	0.31	0.714	3.05	0.20	0.81	2ahbA	GO:0000062 GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0008610 GO:0016740 GO:0016746 GO:0030497 GO:0033818 GO:0035336
30	0.30	0.690	3.25	0.21	0.80	4yucA	GO:0003824 GO:0004315 GO:0006633 GO:0008152 GO:0016740
31	0.30	0.701	2.88	0.20	0.79	5bqsA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
32	0.29	0.704	2.67	0.20	0.78	2ebdA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
33	0.28	0.719	2.89	0.24	0.81	1mzjA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
34	0.28	0.701	2.77	0.21	0.78	4yltA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
35	0.27	0.711	3.10	0.20	0.80	5dwzH	GO:0003824 GO:0004315 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0033818 GO:0044550
36	0.27	0.718	2.99	0.19	0.81	4ewpA	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
37	0.25	0.884	2.53	0.24	0.97	2p0uA	GO:0003824 GO:0008152 GO:0009058 GO:0016740 GO:0016746 GO:0016747
38	0.25	0.701	2.94	0.22	0.79	3il7A	GO:0003824 GO:0004315 GO:0005737 GO:0006629 GO:0006631 GO:0006633 GO:0008152 GO:0016740 GO:0016746 GO:0033818
39	0.22	0.716	3.04	0.18	0.81	4efiA	GO:0003824 GO:0004315 GO:0006633 GO:0008152 GO:0016740 GO:0016746
40	0.20	0.884	2.12	0.26	0.95	3tsyA	GO:0000166 GO:0003824 GO:0005524 GO:0005737 GO:0008152 GO:0009058 GO:0009698 GO:0016207 GO:0016740 GO:0016746 GO:0016747 GO:0016874

Consensus prediction of GO terms

Molecular Function	GO:0016210	GO:0050198
GO-Score	0.75	0.49
Biological Processes	GO:0009715	GO:0006633	GO:0009813
GO-Score	0.64	0.64	0.51
Cellular Component	GO:0005737
GO-Score	0.49

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.