I-TASSER results

I-TASSER results for job id Rv1371

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (489 residues)
MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRD
ITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRF
DDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAF
VIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSE
VDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRA
ALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGA
VNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLRE
EAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVV
AGFVGIGSV

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV
Prediction	CCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEHCCEEEHCHHHHHHCCCHHHHHHHHCCHCHHHHHHHHCCCCHHHHHHHHHCCEHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEHCCCCC
Conf.Score	988888766677777755765689877579997979865678875999599999878845899999878885889988765554456788888887655554555666655444555555545567778888877777766555556678899999999999988877777899999999999999999998765444468885788999999877654579998887756556789988888877655433444445655567888999999999999999998877777666666678899999999999999999999999999999999999999999876543688988777888888779999999975678888866788887588876444579999865678999999999999989998774557999999999999876777644567875455799788764887788666556779
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV
Prediction	645625526656542454434624534000002210000050076111034002400020001002112232321320221211021223322242422222222222222221202222222120222221221221222211201000000000000011001000100000000000000000000000000000002212100000000001000000100121002200110031301423113112222023222221000001110021012000110132122232232222001000223222201012122223133322211110112210000000000022324354244310011001000010214101000000000000000000000022103300450034006626041331321023102300330233344335555232134212141043321010100111246
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEHCCEEEHCHHHHHHCCCHHHHHHHHCCHCHHHHHHHHCCCCHHHHHHHHHCCEHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCCCEHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEEEHCCCCC
MTNDLPDVRERDGGPRPAPPAGGPRLSDVWVYNGRAYDLSEWISKHPGGAFFIGRTKNRDITAIVKSYHRDPAIVERILQRRYALGRDATPRDIHPKHNAPAFLFKDDFNSWRDTPKYRFDDPNDLLHRVKARLAEPALAARIKRMDTLFNAIVAVLAVGYFAVQGVRLVEPSWMPLWAFVIAMVLLRSSLAGFGHYALHRAQRGLNRVFNNAFDLNYVALSLVTADGHTLLHHPYTQSEVDIKKNVFTMMMRLPWLYRVPVHTIHKFGHMLSGMAIRIVDVFRITRKVGVEESYGSWRAALPHFLGSAGVRLLLVSELVVFAIAGDFWPWALQFVATLWVSTFLVVASHEFEDDTQGGAVNGEDWGIDQLEHANDLTVIGNRYVDCFLSAGLSSHRVHHVLPFQRSGFANIVTEDVLREEAAKFGVEWLPAKGFITDRLPRLCRKYLLTPSRQAKERHWGFVREHCSPAALKASASYVVAGFVGIGSV

1kbiA1

0.24

0.05

0.19

1.40

wdPPAS

----EPKLDMNKQKISPAEVAKHNKPDDCWVV-GYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKKLGPLQGSMPPELVCPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4k5yA2

0.05

0.02

0.47

1.18

dPPAS2

------------------------------------------------------------------------------------------------------HYHVAAIINYLRARSIRCLRNIIHANLIAAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLWDAYDRLRA-----WMFICIGWGVPFPIIVAWAIGKLYYDNEK--------------CWAGKRPGVYTDYIYQGPMALVLLINFIFLFNIVRILMTKLRASTTSETIQARKAVKATLVLLPLLGITYMLAFVNEVSRVVFIYFNAFLESFQGFFVSVFS--------------------------------------------------------------------------------------------------------------------------------------------

2i96A

0.14

0.03

0.22

2.03

wPPAS

MA---EQSDEAVKYYTLEEIQKHNHSKSTWLIHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVG-HSTDAREMSKTFIIGELHPDDRPKLNKPPETL----------ITTIDSSSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4wisA2

0.08

0.94

1.40

PPAS

TLEQTD-----------DNIRDKFGESVAFYFALRSY--FRFLVI-PSAFGFGAWLLLGQFSYLYALLCGLWSVVFFEYWKKQEVDLAVRGVSSIQQSRPEFEWEHEAEDPITGEPVKVYPPMKRVKTQLLQIPFALACVVALGALIVTCNSLEVFINEVYSGGKQYLGFLPTIFLVIGTPTISGVLMGAAEKLNAMENYATVDFMTSYMALFFTAFVYIPFGHILHPFLNFWRATAQTLTFSEKELPTREFQINPARISNQMFYFTVTAQIVNFATEVVVPYIKQQAFQAEFLQRVREECTVSGDYREMVMQFGYVAMFSVAWPLAACCFLVNNWVELRSDALKIAISS----PIPWRTDSIGPWLTALSFLSW-LGSITSSAIVYLCSNASPLKAEHFVLSKLDSPKERFQTKKRLLQENLGQDAAAAPGIEHSEKITREALEEEARQASIEM------FWQRQRGMQETIEIGRRMIEQQLAAG--

1kbiA1

0.24

0.05

0.19

2.17

Env-PPAS

----EPKLDMNKQKISPAEVAKHNKPDDCWVVIGYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKKLGPLQGSMPPELVCPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

3vwaA

0.07

0.06

0.87

1.39

PPAS

KADSLPKRSPENESLILNAVHKDSDPQSTFIVTERVVPFPWDNLGSLSQNKFGVELGISQLLATLGFLKGLSAFEFASRARSYYNIIGSQLPCEDPNTIDSGLGLLIKSLA------PSCLPKDWIVNVNISDGKITIENFRKRLENTETWRSNPLINFYQELRELHIKDPQGKLVVSNLENLYLESREIFRNLTPGIENFIIPELCEIIKLLTQSISSNASHKLVPFLAIVLDLTSETNTFPVGFNDLITQSFKLPDRQVRFLLLIYLPKLIGPLSKSEISSRIYPHFIQGLTDSDATLRLQTLKTIPCIVSCLTERQLNNELLRFLAKTQVVEIRTWTVIIISKISTILSTSVG----NRSNILATAFTKSLKDPQVKPRLAALYGLEKSIELTIANKILT-----VIAPGLLPIVRGRAKIL--------EEYLEKLEKEAQLIQTN---------------------------------------

2i96A

0.14

0.03

0.22

1.39

wdPPAS

MA---EQSDEAVKYYTLEEIQKHNHSKSTWLIHHKVYDLTKFLEEHPGGEEVLREQAGGDATENFEDVG-HSTDAREMSKTFIIGELHPDDRPKLNKPPETL----------ITTIDSSSS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4zyoA

0.13

0.07

0.57

1.33

wdPPAS

----------------------------------------------------------------------------------------------------------------------------DIYDPTYADAAGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHH-KFSETHAD------------------PHNSRRGFFFSHVGWLLPAVKEKGSLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFLRYAVVLNATWLVNHLFGYRPYDKNISPRE-----------------NILVSLGAVGEGFHNYHHSFPYDYSA-----FTTFFIDCMAALGLAYDRKKVSKAAILARIKR--------------------------------------------

1kbiA1

0.24

0.05

0.19

2.01

wPPAS

----EPKLDMNKQKISPAEVAKHNKPDDCWVV-GYVYDLTRFLPNHPGGQDVIKFNAGKDVTAIFEPLHAPNVIDKYIAPEKKLGPLQGSMPPELVCPP------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

4zyoA

0.10

0.06

0.56

1.15

dPPAS2

----------------------------------------------------------------------------------------------------------------------------DIYDPTYADAAGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWLWGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHH-KFSETHADPHNSRRGFF---------FSHVGWLLVRKHPAVKEKGSTLDLSDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGEFQNSVFVATFLRYAVVLNATWLVNSAAHLFGYRPYDKNISP-----------------RENILVSLGAVGEGFHNYHHSFPYDYSADRKKVSKAAILARIKR-----------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.39

Estimated TM-score = 0.34±0.11

Estimated RMSD = 15.8±3.2Å

Download Model 2

C-score=-4.11

Download Model 3

C-score=-4.26

Download Model 4

C-score=-4.64

Download Model 5

C-score=-4.98

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4wisA	0.850	2.93	0.066	0.941
2	2ycuA	0.357	7.14	0.043	0.569
3	4jspB	0.357	7.01	0.039	0.556
4	4av3A	0.355	6.22	0.029	0.515
5	5fvmA	0.351	6.97	0.033	0.550
6	4a01A	0.349	6.06	0.025	0.499
7	3h7lA	0.345	6.77	0.040	0.536
8	4xqkA	0.342	7.50	0.052	0.564
9	2cqtA	0.342	6.86	0.034	0.538
10	3zyvA	0.340	7.10	0.050	0.542

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.05	3	3q02B	ZN	Rep, Mult	398,399,400
2	0.03	2	5cloN	NS8	Rep, Mult	400,401,402
3	0.03	2	2cqsA	BGC	Rep, Mult	215,216,388
4	0.03	2	3cmvG	ANP	Rep, Mult	376,377,378,381,382,383,384
5	0.03	2	4q5zG	ZN	Rep, Mult	229,233
6	0.03	2	1qb4A	ASP	Rep, Mult	315,319,373,381
7	0.03	2	2yxoA	FE	Rep, Mult	318,350,400
8	0.03	2	3cmvC	ANP	Rep, Mult	189,190,193,194,195,196
9	0.03	2	1krfA	KIF	Rep, Mult	275,279,280,344,348
10	0.02	1	4fevD	KAN	Rep, Mult	349,350
11	0.02	1	4clvA	ZN	Rep, Mult	121,200
12	0.02	1	4wisA	CA	Rep, Mult	31,278,306,309,338,342
13	0.02	1	3qbuA	ZN	Rep, Mult	365,399,400
14	0.02	1	1jqnA	ASP	Rep, Mult	308,312,365,372
15	0.02	1	1ucgA	MN	Rep, Mult	263,267
16	0.02	1	3ehbB	HEA	Rep, Mult	143,187
17	0.02	1	5d91A	8K6	Rep, Mult	62,65
18	0.02	1	3cmvA	MG	Rep, Mult	264,272,331
19	0.02	1	1jdiA	ZN	Rep, Mult	399,400,466
20	0.02	1	3l7tA	ZN	Rep, Mult	400,420

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	3b9jI	0.109	5.58	0.031	0.151	1.17.1.4,1.17.3.2	NA
2	0.060	1h54B	0.312	7.11	0.048	0.501	2.4.1.8	NA
3	0.060	1h12A	0.309	6.62	0.060	0.468	3.2.1.8	NA
4	0.060	1jqnA	0.336	7.72	0.053	0.573	4.1.1.31	383
5	0.060	2e1qA	0.303	7.03	0.053	0.474	1.17.3.2,1.17.1.4	NA
6	0.060	3hz3A	0.322	7.91	0.040	0.558	2.4.1.5	37
7	0.060	2cqsA	0.341	7.13	0.028	0.552	2.4.1.20	292
8	0.060	2ckjA	0.306	8.15	0.013	0.548	1.17.1.4,1.17.3.2	NA
9	0.060	1llwA	0.316	7.15	0.030	0.507	1.4.7.1	NA
10	0.060	1kktA	0.330	7.44	0.059	0.538	3.2.1.113	NA
11	0.060	1z0hB	0.185	7.66	0.018	0.309	3.4.24.69	NA
12	0.060	1n1zA	0.317	7.45	0.056	0.521	5.5.1.8	NA
13	0.060	2pffA	0.328	7.34	0.059	0.536	2.3.1.41,2.3.1.86	NA
14	0.060	1ofdA	0.316	7.14	0.030	0.505	1.4.7.1	218
15	0.060	1nxcA	0.324	7.05	0.037	0.507	3.2.1.113	NA
16	0.060	2eabA	0.334	6.78	0.021	0.513	3.2.1.63	NA
17	0.060	2vdcF	0.314	7.28	0.038	0.513	1.4.1.13	NA
18	0.060	3hmjA	0.319	7.50	0.063	0.532	2.3.1.86	NA
19	0.060	1fo2A	0.325	7.25	0.050	0.517	3.2.1.113	215

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.18	0.850	2.93	0.07	0.94	4wisA	GO:0016020 GO:0016021 GO:0046872
1	0.06	0.357	7.14	0.04	0.57	2ycuA	GO:0000146 GO:0000166 GO:0000331 GO:0001725 GO:0003009 GO:0003774 GO:0003779 GO:0005200 GO:0005509 GO:0005516 GO:0005524 GO:0005737 GO:0005773 GO:0005829 GO:0005884 GO:0005903 GO:0005938 GO:0006909 GO:0006972 GO:0007275 GO:0007519 GO:0007605 GO:0008360 GO:0009267 GO:0016020 GO:0016459 GO:0016460 GO:0019228 GO:0030048 GO:0030424 GO:0030426 GO:0030587 GO:0030674 GO:0030898 GO:0031032 GO:0031252 GO:0031410 GO:0042641 GO:0043209 GO:0044351 GO:0045335 GO:0046872 GO:0048870 GO:0051015 GO:0051017 GO:0051764 GO:0070062 GO:0070584 GO:0071625 GO:0097513
2	0.06	0.317	7.66	0.04	0.53	4l79A	GO:0000146 GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005546 GO:0005547 GO:0005737 GO:0005769 GO:0005856 GO:0005884 GO:0005886 GO:0005903 GO:0006892 GO:0007015 GO:0007399 GO:0010008 GO:0016459 GO:0030048 GO:0030175 GO:0030898 GO:0032588 GO:0048471 GO:0051015 GO:0051017 GO:0070062 GO:0071944
3	0.06	0.321	7.48	0.03	0.53	2mysA	GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0016459 GO:0030016 GO:0032982
4	0.06	0.311	7.37	0.07	0.51	4pa0A	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
5	0.06	0.279	7.52	0.04	0.47	4pa0B	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
6	0.06	0.315	6.86	0.04	0.49	4zg4E	GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0016459 GO:0070062
7	0.06	0.293	7.59	0.04	0.48	2bkiA	GO:0000166 GO:0001726 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0005905 GO:0005938 GO:0006810 GO:0006886 GO:0006897 GO:0007605 GO:0015031 GO:0016020 GO:0016023 GO:0016459 GO:0016591 GO:0030048 GO:0030139 GO:0030330 GO:0031941 GO:0031965 GO:0043531 GO:0045334 GO:0045944 GO:0048471 GO:0051015 GO:0051046
8	0.06	0.296	7.50	0.03	0.48	1qviA	GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0016459 GO:0030016 GO:0032982
9	0.06	0.302	7.46	0.03	0.50	4p7hB	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006091 GO:0006936 GO:0006941 GO:0007512 GO:0008218 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0018298 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0055010 GO:0060048
10	0.06	0.311	7.39	0.05	0.51	4pd3B	GO:0000146 GO:0000166 GO:0000281 GO:0000331 GO:0001701 GO:0001725 GO:0001764 GO:0001778 GO:0003279 GO:0003774 GO:0003779 GO:0005200 GO:0005509 GO:0005516 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005773 GO:0005819 GO:0005829 GO:0005884 GO:0005886 GO:0005903 GO:0005938 GO:0006887 GO:0006909 GO:0006930 GO:0006972 GO:0007097 GO:0007155 GO:0007275 GO:0007409 GO:0007411 GO:0007420 GO:0007507 GO:0007512 GO:0008283 GO:0008360 GO:0009267 GO:0015629 GO:0016459 GO:0016460 GO:0021592 GO:0021670 GO:0021678 GO:0021680 GO:0030027 GO:0030036 GO:0030048 GO:0030239 GO:0030424 GO:0030426 GO:0030496 GO:0030587 GO:0030674 GO:0030898 GO:0031032 GO:0031175 GO:0031252 GO:0031410 GO:0031594 GO:0032154 GO:0035904 GO:0042641 GO:0042995 GO:0043005 GO:0043025 GO:0043197 GO:0043531 GO:0044351 GO:0045335 GO:0046872 GO:0048870 GO:0050885 GO:0051015 GO:0051017 GO:0051764 GO:0055003 GO:0055015 GO:0060041 GO:0060976 GO:0070062 GO:0097513
11	0.06	0.306	7.47	0.06	0.50	3i5fA	GO:0000166 GO:0003774 GO:0003779 GO:0005524 GO:0016459
12	0.06	0.304	6.97	0.04	0.47	4byfA	GO:0000166 GO:0001725 GO:0001726 GO:0003774 GO:0003779 GO:0005102 GO:0005516 GO:0005524 GO:0005634 GO:0005643 GO:0005654 GO:0005730 GO:0005737 GO:0005829 GO:0005886 GO:0005902 GO:0005903 GO:0006605 GO:0006612 GO:0006810 GO:0008022 GO:0009925 GO:0015031 GO:0016020 GO:0016023 GO:0016328 GO:0016459 GO:0016461 GO:0017160 GO:0030335 GO:0030898 GO:0031410 GO:0031941 GO:0032420 GO:0038089 GO:0038096 GO:0042995 GO:0045121 GO:0045160 GO:0045815 GO:0051028 GO:0060171 GO:0070062 GO:0090314 GO:1900748 GO:2000810
13	0.06	0.297	7.14	0.06	0.47	1br2A	GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0006939 GO:0008307 GO:0016459 GO:0030016 GO:0030241 GO:0032982 GO:0048251 GO:0048739
14	0.06	0.307	7.44	0.05	0.50	3j04A	GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0006939 GO:0008307 GO:0016459 GO:0030016 GO:0030241 GO:0032982 GO:0048251 GO:0048739
15	0.06	0.269	7.70	0.04	0.45	3dtpB	GO:0000146 GO:0000166 GO:0001725 GO:0002026 GO:0002027 GO:0003009 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005859 GO:0006936 GO:0006939 GO:0006941 GO:0007512 GO:0008307 GO:0014728 GO:0014883 GO:0016459 GO:0016887 GO:0030016 GO:0030017 GO:0030018 GO:0030049 GO:0030241 GO:0030898 GO:0031449 GO:0032982 GO:0042803 GO:0046034 GO:0046982 GO:0048251 GO:0048739 GO:0055010 GO:0060048
16	0.06	0.268	7.63	0.05	0.45	1w9jA	GO:0000146 GO:0000166 GO:0000281 GO:0001931 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0005826 GO:0005829 GO:0005856 GO:0005938 GO:0006935 GO:0006971 GO:0008104 GO:0008360 GO:0009612 GO:0016459 GO:0016460 GO:0030038 GO:0030554 GO:0030837 GO:0030866 GO:0030898 GO:0031034 GO:0031143 GO:0031152 GO:0031154 GO:0031254 GO:0031270 GO:0032009 GO:0032060 GO:0032154 GO:0032982 GO:0033275 GO:0033298 GO:0034461 GO:0042542 GO:0042641 GO:0042803 GO:0044351 GO:0045179 GO:0046847 GO:0048870 GO:0051015 GO:0060328 GO:0071889 GO:0097204 GO:1990753
17	0.06	0.287	6.04	0.04	0.41	1ng9A	GO:0000018 GO:0000166 GO:0003677 GO:0003684 GO:0005524 GO:0005829 GO:0006281 GO:0006298 GO:0006974 GO:0008301 GO:0016887 GO:0030983 GO:0032136 GO:0032300 GO:0042802 GO:0043531
18	0.06	0.310	7.38	0.03	0.50	1dflB	GO:0000166 GO:0003774 GO:0003779 GO:0005516 GO:0005524 GO:0005737 GO:0016459 GO:0030016 GO:0032982

Consensus prediction of GO terms

Molecular Function	GO:0043169	GO:0008092	GO:0035639	GO:0032559	GO:0032550	GO:0042623
GO-Score	0.47	0.46	0.46	0.46	0.46	0.36
Biological Processes	GO:0051017	GO:0046034	GO:0014728	GO:0031449	GO:0031032	GO:0055010	GO:0006091	GO:0019228	GO:0051764	GO:0030587	GO:0002026	GO:0006909	GO:0018298	GO:0007512	GO:0007605	GO:0060048	GO:0002027	GO:0044351	GO:0008360	GO:0006972	GO:0071625	GO:0007519	GO:0007399	GO:0048870	GO:0014883	GO:0070584	GO:0006892	GO:0030049	GO:0008218
GO-Score	0.12	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:0043234	GO:0044430	GO:0015629
GO-Score	0.46	0.46	0.46

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.