I-TASSER results

I-TASSER results for job id Rv1367c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (377 residues)
MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAAMSLVDEGKLALRDPI
TRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLP
FGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIEDAPLYQIIDERVLGPAGM
TDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSFCNAGGGLWSTADDYLRFV
RMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAK
SRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSLAKL
RTAQPKFVRRTYRALGL

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIEDAPLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSFCNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL
Prediction	CEEHCCEEEEEEEEHCEHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHCCCCHCCEEEHCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCEEEEEHCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
Conf.Score	95678878999755555435799986545666665575899999999998676668998755575665786655899998767789998546765457788878888889899999996999998999999998788889986444565466665555554389999999998656889987677789889888887648899999755789998889998888887544459999999999985987487887588999998756999878655555677778866578778998444556678889998556898554568885887867876544589999768888766765545677889999999999889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIEDAPLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSFCNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL
Prediction	52124233010101021124452213410000001201100000000010203020522024102102723014427232441220620010000000000000102232201200452724450130042006002210122204111000000000000062305400320004114040000103672251004003335723132416625235313010000000000000000000014414240200002500420132103661434420331221020000000010120523334322130100010001000000132200000000000223331212233333224144124401210030177
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CEEHCCEEEEEEEEHCEHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEHCCCCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCHHHHHHHHHHHHCCCCHCCEEEHCHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCEEEEEHCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
MVWQREKLLQVNEIGYRDIDAGVPMQRDTLFRIASMTKPVTVAAAMSLVDEGKLALRDPITRWAPELCKVAVLDDAAGPLDRTHPARRAILIEDLLTHTSGLAYGFSVSGPISRAYQRLPFGQGPDVWLAALATLPLVHQPGDRVTYSHAIDVLGVIVSRIEDAPLYQIIDERVLGPAGMTDTGFYVSADAQRRAATMYRLDEQDRLRHDVMGPPHVTPPSFCNAGGGLWSTADDYLRFVRMLLGDGTVDGVRVLSPESVRLMRTDRLTDEQKRHSFLGAPFWVGRGFGLNLSVVTDPAKSRPLFGPGGLGTFSWPGAYGTWWQADPSADLILLYLIQHCPDLSVDAAAAVAGNPSLAKLRTAQPKFVRRTYRALGL

4p6bA

0.30

0.28

0.93

2.74

MUSTER

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQHA----HIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGPAPHVLVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGARGMRINDEPFA-GYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGS----------QHP-------IGSDMQAAAMSMLG-

4p6bA

0.30

0.28

0.93

6.55

dPPAS

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQHA----HIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGMGLPALKPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGA-RGMRINDEPFAGYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGSQHP-----------------IGSDMQAAAMSMLG-

4p6bA

0.30

0.28

0.93

6.92

wdPPAS

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQHA----HIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGMGLPALVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGARGMRINDEPF-AGYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGS----------QHP-------IGSDMQAAAMSMLG-

4p6bA

0.30

0.28

0.93

2.83

wMUSTER

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQHA----HIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGPAPHVLVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGARGMRINDEPFA-GYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGS----------QHP-------IGSDMQAAAMSMLG-

4p6bA

0.29

0.27

0.93

3.61

wPPAS

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQH----AHIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGMGPHVLVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGARGMR-INDEPFAGYSWNLLGRVMTDVGAAAY---ATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGS----------QHP-------IGSDMQAAAMSMLG-

4p6bA

0.30

0.28

0.93

7.14

dPPAS2

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQHA----HIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGMGLPALVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGA-RGMRINDEPFAGYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGS-QHP----------------IGSDMQAAAMSMLG-

4p6bA

0.29

0.27

0.93

3.70

PPAS

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQH----AHIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGMGPHVLVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGARGMR-INDEPFAGYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLGS-QHP----------------IGSDMQAAAMSMLG-

4p6bA

0.29

0.27

0.93

6.04

Env-PPAS

RIDQDGKPIFQGCAGVKDIETRTFIPKNAIYRIYSMTKPIVSFLAMMLIERGVFRLSSPIQNFDPRFKSMKVIDQH----AHIEPATALITIEHLLTHQAGFSYDFSLGCPISAHYRDAQLGRDLTDMMGVLAELPLVFHPGTQWKYSISTDVLAHIIECATGERVDDLLQRLIFDPLDMQDTGFSLPLDGASRLMEVYGMGPHVLVPADLGSSHPTDDPDFRRGGHGLYSTLDDYMAFANMLLSGQTPEGETLLSPAVLKLALAPRVHFGAR-GMRINDEPFAGYSWNLLGRVMTDVGAAA---YATHLGEFGWSGAAATYFWVDPTKNMTGCVMTQFLG-SQHP----------------IGSDMQAAAMSMLG-

4iviA

0.32

0.29

0.91

2.33

MUSTER

VIKRNGETAYFSSFGLRDPDTKEPT-AETIFRIYS-SKPITTVAAL--VEEGKLQLDEPVSKYIPSFANVKVGVETKGENGATGPVKRAITIQDL-RHTSGITYGFVGDGLVKKAYIASNLFDGNAEFAERIAKLPLVYQPGTTWDYGHSTDILGRVVEVVSGKSLYQFEKERLLDPLGKDTGFYVTDPAKKSLVAEAPNDRKIGGSEFDP-----RVQKKW-EPGGQGVSTIGDYARFTQVLNG-GTLDGKRYLSPKTIAYG-SNHIPQASGIVPGAYYLPGPGVGFGLGFAVRTEAGVTP---VEGSVGDLSWGGAGGTVFWIDPKENLTVVFAPV-------------------SPRARVWRTLRNIVYGAFDL

4iviA

0.30

0.27

0.91

5.32

dPPAS

VIKRNGETAYFSSFGLRDPDTKEPT-AETIFRIYS---SKPITTVAALVEEGKLQLDEPVSKYIPSFANVKVGVETKGENGATGPVKRAITIQDL-RHTSGITYGFVGDGLVKKAYIASNLDFDNAEFAERIAKLPLVYQPGTTWDYGHSTDILGRVVEVVSGKSLYQFEKERLLDPLGKDTGFYVTDPAKKSLVAEAPNDRKIGGSEFDPRVQKKWEP------GGQGVSTIGDYARFTQVLN-GGTLDGKRYLSPKTIAYG-SNHIPQASGIVPGAYYLPGPGVGFGLGFAVRTEAGVTP---VEGSVGDLSWGGAGGTVFWIDPKENLTVVFAPV-------------------SPRARVWRTLRNIVYGAFDR

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.01

Estimated TM-score = 0.85±0.08

Estimated RMSD = 4.6±3.0Å

Download Model 2

C-score=-1.75

Download Model 3

C-score=-1.37

Download Model 4

C-score=0.44

Download Model 5

C-score=-3.32

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4p6bA	0.915	0.97	0.291	0.931
2	4iviA	0.833	2.40	0.333	0.899
3	3hlgA	0.827	2.84	0.254	0.923
4	1ci8A	0.804	2.37	0.327	0.875
5	2efxA	0.734	3.08	0.212	0.836
6	2qmiA	0.732	3.05	0.221	0.825
7	3wrtA	0.725	2.76	0.238	0.809
8	3o3vA	0.724	2.90	0.182	0.814
9	4gdnA	0.724	2.66	0.197	0.801
10	4y7pA	0.721	3.06	0.214	0.817

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.54	153	3o88A	BSH	Rep, Mult	34,35,38,104,105,147,149,227,317,318,319,340
2	0.16	61	2wzzA	ZX1	Rep, Mult	35,147,227,315,316,317,318
3	0.03	12	1l2sA	STC	Rep, Mult	35,38,149,227,317,318,319,340
4	0.03	13	2zm7A	ACA	Rep, Mult	35,147,281,293,316,318,361
5	0.01	3	2hdsA	4MB	Rep, Mult	105,145,147,289,290,292
6	0.01	3	1scwA	CP5	Rep, Mult	34,35,147,293,307,308,309,314,315
7	0.01	3	2qmiH	DO3	Rep, Mult	56,57,93,290
8	0.01	4	2hdqB	C21	Rep, Mult	3,6,8,237,238,241
9	0.01	5	3s22A	3S2	Rep, Mult	35,106,147,227,289,312,313,314
10	0.01	5	2hdrB	4A3	Rep, Mult	106,217,218,227,315,316
11	0.00	1	2hdrA	4A3	Rep, Mult	122,123,219,220,221
12	0.00	1	1kvlA	KCP	Rep, Mult	63,64,123,124,125,128,157,160,221
13	0.00	1	3gv9A	GV9	Rep, Mult	112,123,124,128,221,222
14	0.00	1	2hdqA	C21	Rep, Mult	243,244,246,262,307,309,327
15	0.00	1	2hdrB	4A3	Rep, Mult	265,266,299,300,301,302,303
16	0.00	1	3gv9A	GV9	Rep, Mult	63,160,161
17	0.00	1	1pi5B	SM2	Rep, Mult	278,280,281,284,285,290,295
18	0.00	1	2hdrA	4A3	Rep, Mult	283,284,285
19	0.00	1	2hdsA	4MB	Rep, Mult	93,94,142,267,268
20	0.00	1	2hduA	F12	Rep, Mult	40,43,44,47

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.384	1ci8A	0.804	2.37	0.327	0.875	3.1.1.1	35,38,315
2	0.230	1c3bA	0.716	2.85	0.207	0.804	3.5.2.6	35,38
3	0.118	2zc7A	0.710	2.91	0.188	0.801	3.5.2.6	35,38,147
4	0.117	1zkjA	0.707	2.95	0.210	0.801	3.5.2.6	35,38
5	0.115	1fr1A	0.714	2.97	0.193	0.806	3.5.2.6	35,38
6	0.066	3bfdA	0.477	4.18	0.107	0.584	3.5.2.6	NA
7	0.066	2blmA	0.474	4.26	0.140	0.592	3.5.2.6	35,38,148
8	0.066	3c4pA	0.483	4.01	0.153	0.578	3.5.2.6	238
9	0.066	1g68A	0.488	4.09	0.124	0.592	3.5.2.6	NA
10	0.066	1yljA	0.474	4.15	0.116	0.581	3.5.2.6	NA
11	0.066	1dy6A	0.477	4.21	0.107	0.586	3.5.2.6	35,38,148
12	0.066	1iysA	0.476	4.08	0.099	0.578	3.5.2.6	NA
13	0.066	1hzoA	0.480	4.19	0.107	0.589	3.5.2.6	NA
14	0.066	1bueA	0.476	4.21	0.103	0.584	3.5.2.6	35,38,148
15	0.066	1mfoA	0.475	3.98	0.134	0.576	3.5.2.6	NA
16	0.066	2jc7A	0.453	3.36	0.094	0.533	3.5.2.6	35
17	0.066	2rl3B	0.451	3.72	0.111	0.546	3.5.2.6	35
18	0.060	2v2fF	0.482	4.24	0.077	0.607	3.4.16.4	NA
19	0.060	1iyqA	0.474	4.02	0.103	0.576	3.5.2.6	NA
20	0.060	2qz6A	0.705	2.92	0.213	0.793	3.5.2.6	NA
21	0.060	3fwmA	0.493	4.43	0.103	0.623	2.4.1.129,	35
22	0.060	1ga0A	0.714	3.11	0.201	0.814	3.5.2.6	35,38,147
23	0.060	3czdA	0.485	4.55	0.119	0.618	3.5.1.2	35
24	0.060	3fwlA	0.485	4.52	0.110	0.615	2.4.1.129	NA
25	0.060	2qmiA	0.732	3.05	0.221	0.825	3.5.2.6	35,38
26	0.060	2rcxB	0.714	2.88	0.207	0.804	3.5.2.6	238
27	0.060	2e8iA	0.685	3.34	0.201	0.790	3.5.1.46	238
28	0.060	2vgkD	0.519	4.50	0.105	0.655	3.4.16.4	NA
29	0.060	1u60C	0.490	4.27	0.109	0.615	3.5.1.2	NA
30	0.060	1ei5A	0.675	3.35	0.159	0.780	3.4.11.19	35,38,147
31	0.060	3a3iA	0.510	4.43	0.092	0.652	3.4.16.4	229
32	0.060	1e25A	0.494	3.95	0.121	0.592	3.5.2.6	35,38
33	0.060	2v1zA	0.488	4.02	0.132	0.584	3.5.2.6	NA
34	0.060	1xp4A	0.481	4.50	0.143	0.602	3.4.16.4	35
35	0.060	2wzxA	0.720	2.98	0.202	0.812	3.5.2.6	172,177,179,238
36	0.060	3bydA	0.477	4.18	0.099	0.584	3.5.2.6	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.54	0.865	2.32	0.34	0.93	4iviA	GO:0016787 GO:0052689
1	0.37	0.804	2.37	0.33	0.88	1ci8A	GO:0005737 GO:0016787
2	0.36	0.705	3.22	0.20	0.80	1cefA	GO:0004180 GO:0005576 GO:0006508 GO:0008233 GO:0008360 GO:0009002 GO:0009252 GO:0016787 GO:0071555
3	0.33	0.714	2.99	0.21	0.81	5e2hA	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677
4	0.33	0.721	3.06	0.21	0.82	4y7pA	GO:0004180 GO:0006508
5	0.32	0.659	3.47	0.19	0.76	4gb7A	GO:0016054 GO:0016787 GO:0019875
6	0.31	0.724	2.66	0.20	0.80	4gdnA	GO:0005886 GO:0016020 GO:0016021
7	0.28	0.695	3.06	0.21	0.80	5eviB	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677
8	0.26	0.705	2.92	0.21	0.79	2qz6A	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0042597 GO:0046677
9	0.25	0.724	2.90	0.18	0.81	3o3vA	GO:0008800 GO:0016020 GO:0016021 GO:0016787 GO:0017001 GO:0030288 GO:0046677
10	0.25	0.686	3.36	0.20	0.79	3a65A	GO:0016787 GO:0019875 GO:0019876
11	0.25	0.723	2.96	0.20	0.81	4gzbA	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0033252 GO:0042597 GO:0046677
12	0.25	0.717	3.03	0.19	0.81	3s4xA	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0042597 GO:0046677
13	0.25	0.723	2.79	0.23	0.81	3ws1A	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677 GO:0046872
14	0.22	0.710	2.91	0.19	0.80	2zc7A	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677
15	0.20	0.732	3.05	0.22	0.82	2qmiA
16	0.18	0.827	2.83	0.25	0.92	3hlfA	GO:0016740 GO:0016746 GO:0016787 GO:0017000 GO:0030639 GO:0050832
17	0.10	0.698	2.92	0.23	0.78	5e2gA	GO:0008800 GO:0016787 GO:0017001 GO:0030288 GO:0046677
18	0.10	0.679	2.55	0.19	0.75	4e6xA	GO:0008800 GO:0016020 GO:0016021 GO:0016787 GO:0017001 GO:0030288 GO:0046677

Consensus prediction of GO terms

Molecular Function	GO:0052689	GO:0009002	GO:0008800
GO-Score	0.54	0.36	0.33
Biological Processes	GO:0006508	GO:0009252	GO:0071555	GO:0008360	GO:0046677	GO:0017001
GO-Score	0.57	0.36	0.36	0.36	0.33	0.33
Cellular Component	GO:0005737	GO:0005576	GO:0030288
GO-Score	0.37	0.36	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.