I-TASSER results

I-TASSER results for job id Rv1366

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (273 residues)
MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQD
RIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLA
REIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQIRTILQSLWANFYELLAD
AYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMA
LGEASKNKATVLATTKFRLERAINEAESAGGGG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG
Prediction	CCCCCCCCCEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCHHHHHHHHHHHCCCCHHHHCEEEEEEEEHCCCHHHHHHHHHHHHHHCCCCCCCEHCCCCCCCCCCEEEEEEEEHCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEHCCCCCEEEHCCCCCCCCCCHCCCCCHHHHHHHHHHHCCCCCC
Conf.Score	976545654444445777558999999999998776555589999999999999999999999998669879998757899999999999799988875346899999589689999999999997899877544677899989758999999799689999855767788879999998767798865457899999999999999999999999998888887765434579976876555667665444454467999999875567889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG
Prediction	613122443324234536224520540253046225435326304501420540054035205524761341203122132420140055367340533110000100041246002200510373161435414110444422310010001146330201420330020021001021236551455345334203402520450153054036415634541551353424753333055246544322333424144115526646668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCEHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHCCCHHHHHHHHHHHCCCCHHHHCEEEEEEEEHCCCHHHHHHHHHHHHHHCCCCCCCEHCCCCCCCCCCEEEEEEEEHCCEEEEEEEHCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEHCCCCCEEEHCCCCCCCCCCHCCCCCHHHHHHHHHHHCCCCCC
MVVALVGSAIVDLHSRPPWSNNAVRRLGVALRDGVDPPVDCPSYAEVMLWHADLAAEVQDRIEGRSWSASELLVTSRAKSQDTLLAKLRRRPYLQLNTIQDIAGVRIDADLLLGEQTRLAREIADHFGADQPAIHDLRDHPHAGYRAVHVWLRLPAGRVEIQIRTILQSLWANFYELLADAYGRGIRYDERPEQLAAGVVPAQLQELVGVMQDASADLAMHEAEWQHCAEIEYPGQRAMALGEASKNKATVLATTKFRLERAINEAESAGGGG

5decA

0.24

0.15

0.63

2.00

MUSTER

----------------------------------------DDKWERFLVPYRQAVEELKVKLKGIRTLSPIEFVTGRVKPVASILEKARRKPLHEIETMQDIAGLRIMCQF-VDDIQIVKEMLFARKDFTVVDQRDYI----AGYRSYHLVVLYPHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEA-------------------------------------------------------

5decA

0.23

0.15

0.63

3.44

dPPAS

----------------------------------------DDKWERFLVPYRQAVEELKVKLKGIRTLSPIEFVTGRVKPVASILEKARRKSLHEIETMQDIAGLRIMCQF-VDDIQIVKEMLFARKDFTVVDQRDYI----AGYRSYHLVVLYPHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEA-------------------------------------------------------

1vj7A3

0.18

0.09

0.51

5.90

wdPPAS

----------------------------------------------KRREREALVDDIVTKIKSYTTEGLFGDVYGRPKHIYSIYRKMRDKK-KRFDQIFDLIAIRCVMET-QSDVYAMVGYIHELWRPMPGRFKDYIAAPKNGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAANWIKELVEL--------------------------------------------------------------------------------------

5decA

0.24

0.15

0.63

2.97

wMUSTER

----------------------------------------DDKWERFLVPYRQAVEELKVKLKGIRTLSPIEFVTGRVKPVASILEKARRKPLHEIETMQDIAGLRIMCQF-VDDIQIVKEMLFARKDFTVVDQRDYI----AGYRSYHLVVLYPHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEA-------------------------------------------------------

1vj7A3

0.18

0.09

0.51

4.19

wPPAS

----------------------------------------------KRREREALVDDIVTKIKSYTTEGLFGDVYGRPKHIYSIYRKMRDKK-KRFDQIFDLIAIRCVMET-QSDVYAMVGYIHELWRPMPGRFKDYIAAPKNGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAANWIKELVEL--------------------------------------------------------------------------------------

5decA

0.23

0.15

0.63

6.96

dPPAS2

----------------------------------------DDKWERFLVPYRQAVEELKVKLKGIRTLSPIEFVTGRVKPVASILEKARRKSLHEIETMQDIAGLRIMCQF-VDDIQIVKEMLFARKDFTVVDQRDYI----AGYRSYHLVVLYPHVLVEIQIRTLAMNFWATIEHSLNYKYSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEA-------------------------------------------------------

1vj7A3

0.18

0.09

0.51

2.97

PPAS

----------------------------------------------KRREREALVDDIVTKIKSYTTEGLFGDVYGRPKHIYSIYRKMRDKK-KRFDQIFDLIAIRCVMET-QSDVYAMVGYIHELWRPMPGRFKDYIAAPKNGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAANWIKELVEL--------------------------------------------------------------------------------------

1vj7A3

0.18

0.09

0.51

4.99

Env-PPAS

----------------------------------------------KRREREALVDDIVTKIKSYTTEGLFGDVYGRPKHIYSIYRKMRDKK-KRFDQIFDLIAIRCVMET-QSDVYAMVGYIHELWRPMPGRFKDYIAAPKNGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAANWIKELVEL--------------------------------------------------------------------------------------

1vj7A3

0.18

0.09

0.51

1.78

MUSTER

----------------------------------------------KRREREALVDDIVTKIKSYTTEGLFGDVYGRPKHIYSIYRKMRDKKK-RFDQIFDLIAIRCVMET-QSDVYAMVGYIHELWRPMPGRFKDYIAAPKNGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAANWIKELVEL--------------------------------------------------------------------------------------

1vj7A3

0.18

0.09

0.51

3.27

dPPAS

----------------------------------------------KRREREALVDDIVTKIKSYTTEGLFGDVYGRPKHIYSIYRKMRDKK-KRFDQIFDLIAIRCVMET-QSDVYAMVGYIHELWRPMPGRFKDYIAAPKNGYQSIHTTVYGPKGPIEIQIRTKEMHQVAEYGVAANWIKELVEL--------------------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.86

Estimated TM-score = 0.49±0.15

Estimated RMSD = 10.2±4.6Å

Download Model 2

C-score=-2.57

Download Model 3

C-score=-2.79

Download Model 4

C-score=-2.57

Download Model 5

C-score=-3.56

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5decA	0.621	0.91	0.237	0.634
2	2be3A	0.610	1.78	0.230	0.648
3	3ayfA	0.500	5.75	0.060	0.769
4	1vj7A	0.491	3.89	0.169	0.612
5	3o0rB	0.480	5.75	0.046	0.747
6	3mk7A	0.478	5.90	0.039	0.747
7	4xydA	0.474	5.81	0.036	0.740
8	4av3A	0.467	5.89	0.045	0.758
9	3irhC	0.457	5.30	0.030	0.692
10	4a01A	0.449	5.91	0.048	0.718

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.18	7	5deeU	APC	Rep, Mult	75,77,79,80,83,87,90,101,104,105,106,160,162,176
2	0.16	5	5dedA	0O2	Rep, Mult	77,79,87,90,91,135,137,142,145,149,160,162,172,175,176
3	0.05	2	5dedB	0O2	Rep, Mult	59,63,66,73,75,169
4	0.05	2	5f2vU	MG	Rep, Mult	101,160,162
5	0.04	2	3fyiA	DMU	Rep, Mult	143,168,172,175
6	0.03	1	5f2vY	MG	Rep, Mult	87,101,160
7	0.02	1	1vj7B	GPX	Rep, Mult	1,2
8	0.02	1	1qleA	CA	Rep, Mult	87,91,92,100
9	0.02	1	3fyeA	DMU	Rep, Mult	170,171,174,175,178
10	0.02	1	1vj7A	GDP	Rep, Mult	77,135,137,142,145,149,162,172

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	2occN	0.438	5.93	0.051	0.685	1.9.3.1	NA
2	0.060	1pn0C	0.388	5.77	0.045	0.615	1.14.13.7	NA
3	0.060	2tmdA	0.366	6.28	0.069	0.626	1.5.8.2	NA
4	0.060	1ax4A	0.385	6.56	0.040	0.689	4.1.99.1	NA
5	0.060	3hx0A	0.391	4.79	0.079	0.553	2.7.7.7,	NA
6	0.060	1eqbB	0.394	6.09	0.072	0.659	2.1.2.1	79
7	0.060	1occA	0.401	5.69	0.044	0.634	1.9.3.1	NA
8	0.060	1bxrA	0.423	6.17	0.032	0.718	6.3.5.5	NA
9	0.060	1m56A	0.449	5.97	0.029	0.714	1.9.3.1	174
10	0.060	1mhsA	0.400	5.73	0.046	0.619	3.6.3.6	108
11	0.060	3gbxA	0.374	6.27	0.061	0.630	2.1.2.1	NA
12	0.060	1vj7A	0.491	3.89	0.169	0.612	2.7.6.5,3.1.7.2	199
13	0.060	2w00B	0.389	5.97	0.039	0.637	3.1.21.3	NA
14	0.060	1jmsA	0.439	5.05	0.144	0.637	2.7.7.31	NA
15	0.060	1eulA	0.383	6.01	0.037	0.615	3.6.3.8	110
16	0.060	3b8eC	0.383	5.87	0.047	0.623	3.6.3.9	86,108,165
17	0.060	1up8A	0.376	6.06	0.063	0.641	1.11.1.18	NA
18	0.060	2ihmB	0.408	4.82	0.073	0.582	2.7.7.7	NA
19	0.060	3fvsA	0.348	6.75	0.038	0.630	2.6.1.7,2.6.1.64,4.4.1.13	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.29	0.617	2.18	0.23	0.66	3l9dA	GO:0015969 GO:0016301 GO:0016310
1	0.28	0.621	1.46	0.23	0.65	5dedA	GO:0000166 GO:0005524 GO:0005525 GO:0008728 GO:0008893 GO:0015969 GO:0015970 GO:0016301 GO:0016310 GO:0016740 GO:0042594 GO:0046872
2	0.22	0.631	1.90	0.22	0.67	2be3A	GO:0015969
3	0.21	0.480	5.75	0.05	0.75	3o0rB	GO:0004129 GO:0005506 GO:0005886 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0019333 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
4	0.14	0.480	3.71	0.15	0.59	5iqr8	GO:0000166 GO:0005524 GO:0005525 GO:0005618 GO:0005886 GO:0008152 GO:0008728 GO:0008893 GO:0015949 GO:0015969 GO:0015970 GO:0016301 GO:0016310 GO:0016597 GO:0016740 GO:0042594
5	0.13	0.491	3.89	0.17	0.61	1vj7A	GO:0000166 GO:0005524 GO:0005525 GO:0008152 GO:0008728 GO:0008893 GO:0015969 GO:0015970 GO:0016301 GO:0016310 GO:0016597 GO:0016740 GO:0016787 GO:0046872
6	0.07	0.500	5.75	0.06	0.77	3ayfA	GO:0004129 GO:0005506 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0020037 GO:0046872 GO:0055114 GO:1902600
7	0.06	0.474	5.81	0.04	0.74	4xydA	GO:0004129 GO:0005506 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0016966 GO:0020037 GO:0055114 GO:0070469 GO:1902600
8	0.06	0.479	5.88	0.04	0.75	5djqA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006119 GO:0009055 GO:0009060 GO:0015078 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016705 GO:0019411 GO:0019646 GO:0019825 GO:0020037 GO:0045154 GO:0045278 GO:0046872 GO:0055114 GO:0070069 GO:0070469 GO:0070470 GO:1902600
9	0.06	0.303	6.24	0.03	0.50	4b2qE	GO:0000166 GO:0005524 GO:0005739 GO:0005743 GO:0005754 GO:0005758 GO:0005829 GO:0006626 GO:0006754 GO:0006810 GO:0006811 GO:0015986 GO:0015991 GO:0015992 GO:0016020 GO:0016787 GO:0016820 GO:0016887 GO:0033178 GO:0045261 GO:0046034 GO:0046933 GO:0046961
10	0.06	0.316	6.13	0.07	0.55	3qe9Y	GO:0000731 GO:0000732 GO:0002376 GO:0002455 GO:0003677 GO:0003682 GO:0003824 GO:0004518 GO:0004519 GO:0004523 GO:0004527 GO:0005634 GO:0005654 GO:0005737 GO:0006260 GO:0006281 GO:0006298 GO:0006310 GO:0006974 GO:0008409 GO:0016446 GO:0016787 GO:0016788 GO:0035312 GO:0045145 GO:0045190 GO:0046872 GO:0048256 GO:0051321 GO:0051908 GO:0090305 GO:0090502 GO:1901796
11	0.06	0.268	6.26	0.03	0.45	4rpwA	GO:0000155 GO:0000160 GO:0005622 GO:0006355 GO:0007165 GO:0009584 GO:0009881 GO:0016301 GO:0016310 GO:0018298 GO:0023014
12	0.06	0.295	6.25	0.04	0.49	4lnvB	GO:0004866 GO:0005576 GO:0005615 GO:0010951
13	0.06	0.241	6.07	0.06	0.40	1imvA	GO:0001822 GO:0004867 GO:0005576 GO:0005604 GO:0005615 GO:0007275 GO:0007568 GO:0007614 GO:0008283 GO:0010447 GO:0010596 GO:0010629 GO:0010951 GO:0010976 GO:0016525 GO:0030424 GO:0031012 GO:0042470 GO:0042698 GO:0043025 GO:0043203 GO:0046685 GO:0048471 GO:0050728 GO:0050769 GO:0060041 GO:0060770 GO:0070062 GO:0071279 GO:0071300 GO:0071333 GO:0071549 GO:1901215
14	0.06	0.267	6.90	0.04	0.50	3e49A	GO:0003824 GO:0016740 GO:0019475 GO:0046872
15	0.06	0.282	5.62	0.07	0.44	4q5rA	GO:0004364 GO:0016740
16	0.06	0.245	6.67	0.01	0.45	5cuvA	GO:0000287 GO:0004427 GO:0005737 GO:0006796
17	0.06	0.246	6.23	0.04	0.42	4ekzA	GO:0000302 GO:0003756 GO:0004656 GO:0005178 GO:0005576 GO:0005783 GO:0005788 GO:0005793 GO:0005886 GO:0005925 GO:0006457 GO:0009897 GO:0016020 GO:0016222 GO:0016853 GO:0018401 GO:0019899 GO:0031012 GO:0034663 GO:0034976 GO:0042158 GO:0042470 GO:0044822 GO:0045454 GO:0046598 GO:0046982 GO:0070062 GO:0071456 GO:1902175
18	0.06	0.283	6.13	0.04	0.48	2vcvA	GO:0004364 GO:0005737 GO:0005829 GO:0006749 GO:0008152 GO:0016740 GO:0070062 GO:1901687

Consensus prediction of GO terms

Molecular Function	GO:0016301	GO:0015078	GO:0046906	GO:0015002	GO:0046914	GO:0016662	GO:0016676	GO:0005524	GO:0008893	GO:0008728	GO:0005525
GO-Score	0.56	0.42	0.42	0.42	0.42	0.42	0.42	0.38	0.38	0.38	0.38
Biological Processes	GO:0016310	GO:0045333	GO:0071941	GO:0015992	GO:0098662	GO:0015970	GO:0042594
GO-Score	0.56	0.42	0.42	0.42	0.42	0.38	0.38
Cellular Component	GO:0031224	GO:0005886
GO-Score	0.33	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.