I-TASSER results

I-TASSER results for job id Rv1358

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (1159 residues)
MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTGHMPVRRLDLI
WISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVA
AHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGT
ITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQ
LCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRGEGGVGK
TRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTFDTLSHAIGNC
HMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAI
QLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDR
FRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGG
DDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARH
RTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTWSRGNGDIAAALQLASALQPLW
SQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHH
ALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLSQIDYWQV
VGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVT
AEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRA
ALAAGDVAAIEASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGW
HLMMALIARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHG
QAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTAAWAEGAAAPLDEAI
AYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYT
KLDVTSRVQLVQEAAQHST

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST
Prediction	CCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHCCCCCCCCCCCCCCEEEEEEEHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCEEEEHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEHCHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
Conf.Score	9767875565578877665555556666677566665455555544567888755566555544566557788887777776688877665765444567645677889999999999998666555556677774788756678899999998876554566766545676434676555566546789999998765556667788998877555665566555667776654444446777777788888888888888888888888859999999999755878999858886589999999998768994999987899986789999999989988898758999999997597999996856777899999999998589859999959988888866886588888569999999999987678778877799999999998997999999999875689999999998777655688878886567899999999998999999999999856899889999999858888878779999999999998756775789874675479999999999866667899999999999999998655557668999999999999999999999875868999999999999998888999999999999986565666557788999999999998765456679999999999999865687899999999999998699999999999999999987985889999999999999989989999999999999998698589999999999999998999999999999999999889868999999999999999898789999999999998766656889999999999997866799999999998676556667788999999986858899999999998755567889999999999998999999999999999998768668999999999999987688999999999999999987776556666678899999999876788999998876576888888775567888888888888887999999999987886899998756788999999999987589989999999998679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 1140 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST
Prediction	6114011020414444232142133443432431341334422552124433413411211222342254515221222121000000000000110133244112103301200100022121012304522000000001101400310032131333312220001113122344142114112001101301331111001101310131024423143023211541441331131422412221111111111111011201100103400330241044100000011402100000000000000000000000011122210020001001012331220010012001110000000001100400120012001001000000000000101100000011011232012002300110112120122113001100110200000000000000011011001101210110111111112111000000000031014600200000000001000000000000000120101101300320012000111342110000000000000000000000000000000000000000011111110100000011001000000000011100100000000000000000000000001000100111110000000000000000000000000000000100100000011111000000000000000000000011001000100110100000000000000000000001001000100000001010000000000000000001010110110011002001101100000000000000000000000000000000001100100000000000000000010010100100011111100000000000000000000010110010000001000000000000000001101210120011000000001000000000000000011221121001001001000110100010011111110011013102331022012001101022012212422122223232221042102200100023110230032020013002200320031020420200011026258
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120                1140

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Sec.Str
Seq

CCCCCCCEEHCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHCCCCCCCCCCCCCCEEEEEEEHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEHCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEHCCCCCHHHHHHHHHHHHHCCCCCEEEEHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEEHCHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCEEEHCCCCCEEEHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
MFLSAPAFRVEPTRSRHSALRWARHRRFADGPRWQMLRSLQIADQIARTGHMPVRRLDLIWISARNAARRELDLGVAALVEAVTLLTADVEGSTRLSQTRLNELAADYPTLDQNISEAVAAHGGVTRPVDQEVGSGLVVAFLRAGDAIACALELQLSTLAPMRPRVGVHTGDVRLRGDGTITGSAINESACLRDLAHEGQTLLSAATGDLVIDQLPANTWLTDVGKYPLRGLHRQERVIQLCHRDLRNEFPPLRMSVGNRSSLPAQFTTFVGRDAQINEVQEVLTNYRLVTLRGEGGVGKTRLAIQIAAASEFRDGLCFVDLAPIADPGMVSTTAAHALGLIDRPGSSTFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLGACPELSILATSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVQPNFEIVADNFDAVSEICRRLDGMPLAIELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQRQQTLRASMDWSYALLTDTERILFRRLAVFVGGFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRLLETVRQYALEKLNESEEIDGVRARHRTHYATMAAGLNVPASTDYEQRLLQAEAEIDNLRAAFTWSRGNGDIAAALQLASALQPLWSQGRMREGLAWLESILEREGDNHLVPAGVWARALAEKVILKAWPATSPMGAPDIVAQAHHALALARDAGDCAVLARALVACGCGSGCDTEAAQPYFAEAIELARAINDEWTLSQIDYWQVVGIFISGQPIPLRAAAEQARELADSIGNRFVSRQCRLFACLAQIWEGDANGALALSRDVTAEAEVANDVVTKVLGLYVEAMALSYIGDSAARTIAGAALEAATELGGIYQDLGYGAITRAALAAGDVAAIEASEASWDLRNQHNVVTAHHELMAQAALVRGDVTTARRFADEAVLASTGWHLMMALIARARVAIAQDELGKARDDAHAAVACGVGVQTYLAMPDALELLAGLAGEAGNHGQAVRLFGAAAAQRQRTGEVRHKIWDAGYEAATAALRDAMGDEDFTAAWAEGAAAPLDEAIAYAQRGRGERKRPSNGWDALTPAEHKIVKLVTEGLVTKDIAARLFVSPRTVQTHLTHIYTKLDVTSRVQLVQEAAQHST

3w3tA

0.09

0.08

0.86

1.76

MUSTER

--------------------------LPEEVNRTLLQIVQAFA------SDNQIRSVAEKALSEEWE---------NNIEYLLTFLA-----EQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEV----------------LAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLI-TAVDINSI-------LPIFQSGFTDASDNVKIAA--VTAFVGYFKQLPKSEWSKL--GILLPSLLNSLPR-----FLDDGKDDALASVFESLIELVELAPKLFKDM-----FDQIIQFTDMVIKNKDLE-PPARTTALELLTV-----FSENAPQMCKSNQNYGQTLVMVT--LIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMITSERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPQYGCCNVLGQISTDFSPAHDRILPALISKLTSECTSRVQTHAAAANFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNSVLKGKCMEGFAVGKEKFHEHSQELISILVALQNDALRSYLEQSWSRICRILGDDFVPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMEL--LQSYATLLRGQFAVYV--KEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATLVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRDEYNEFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDEPILVIFALVVIGDLIQYEQTASMKNAFIPKVTECLISRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVSKLEENRSSTENASAAIAKI--LYAYDTYTANWFKTLPTITDKEAASFNYQFLSQLIEN--------NISAVVDSVIQALNERSLTVISSVKKLLGFLPSSDAMAIFNRYP-----------------ADIMEKVHKWFA-------------------------------------------

4ui9O

0.12

0.07

0.58

1.40

dPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDWVTPYKIAVLVLLSEMSRTG----------EGAVSLVERRRLNQQLLPLLQGPDIT----VSKLLKLIEESCPQLANSVQIRIKLMAE-GELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQSDENKKPLSQKQAEFFLSQQASLLKNDETKALT---------PASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLG-QKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMLEQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCKERIRTLGKTQERNRCAMLFRQLHQELPSVPLINHL-----------------------------------

4ui9O

0.13

0.07

0.57

1.53

wdPPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDWVT--------------PYKIAVLVLLSEMSRT---GEGAVSLVERRRLNQQL--LPLLQG-------DITVSKLLKLIEESC--------------PQLANSVQIRIKLMAEGE---LKDMEQF-----FDDLSDSFSGTEPEVHKT----SVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQSDENKKPLSQKQAEFFLSQQASLLKNDETKALT------------PASLQKELNNLLKFNPEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLG-QKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMLEQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITA--LNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCK------------ERIRDVVYFQAR-LGKTQERNRCAMLFRQLHQHL------------------------

3w3tA

0.10

0.08

0.83

1.70

wMUSTER

------------------------------PEEVNRTL-LQIVQAFASDN--QIRSVAEKALSEEWE---------NNIEYLLTFLA-----EQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEV----------------LAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLI-TAVDINSI-------LPIFQSGFTDASDNVKIAA--VTAFVGYFKQLPKSEWSKL--GILLPSLLNSLPRFL----DGKDDALASVFESLIELVELAPK------FKDM--FDQIIQFTDMVIK-NKDLEPPARTTALELLTV-----FSENAPQMCKSNQNYGQTLVMVT----LIMMTEVSIDDDDAAEWIESDDTTYDHARQALDRVALKLGGEYLA----APLFQYLQQMITSERFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPQYGCCNVLGQISTDFSPAHDRILPALISKLTSECTSRVQTHAAAANFSEFASKDILEPYLDSLLTN---------------LLVLLQS--------------KLYVQEQALTTIAFIAEA----AKNKFIKYYDTLMPLLLNVLKVNSVL--KGKCMECATLIGFAVGKEKFHEHSQELISILVALQNSDDDALRSYLEQSWSRICRILGDDF----VPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDW------------HIAIHTSVLDDKVSAMELLQSYATLL--RGQFAVYVKEVMEEIALP-HDGVRAAGATLIPILLSCL--VLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGD---------------NCLSEDQLAAFTKGVSANLTDTYERMQEYNEFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEPILVIFALVVIGDLIQYEQTASMKNAFIPKVTECLIS-PDARIRQAASYIIGVCAQYAPSADVCIPTLDTLVQIVDGSKLEENRSSTENASAAIAKILYAYDTYTANWFKTLPTITDKEAASFNYQF------------SQLNSNISAVVDSVIQALNERTVISSV---KKLLGF--SSDAMAI-FNR-ADIMEKVHKWFA

4ui9O

0.14

0.08

0.56

1.77

wPPAS

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KD---------VTPYKIAVLVGAVSLERRRLNQQLLPLLQGPD------IT--------VSKLLKLI-------EESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEV-----HKT-------------------SVVGLFLRHMILA------SKLSFSQVFKLYTAL---QQYFQSDENK--PLSQKQAEFFLSQQASLLKNDETKA----------------------------------------------------LTPASLQKELNNLLKFN-----PDFAEAHYSYLNNLRV--------------------------------------------VFSSTHSLLHYFDRLILTGA-----------------------------ESKSNGEEGYG------RSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLG-QKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMLEQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQQLWMLCDQKIQFDRAMNDGKYHLADSLVTGITA--LNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAI---LDKGRAMFLVAKCQVASAASY--------------------------------DQPKKAEALEAAIENLNE---AKNYFAKVKERIRDVVYFQARLYHTLGTQERNRCAMLFRQLHQ

4ui9O

0.13

0.07

0.56

1.92

dPPAS2

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDWVVLLSEMSRTGEGAVSLVERRRLNQQLLPLLQGPDIT----VSKLLKLIEESCPQLANSVQIRIKLMAE-GELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQSDENKKPLSQKQAEFFLSQQASLLKNDETKALT---------PASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLG-QKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMLEQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCK------------ERIRDVVYFQARLYQERNRCAMLFL---------------------------------

4ui9O

0.13

0.08

0.57

2.10

PPAS

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KDWVVLLSEMSRTGEGAVSLVERRRLNQQLLPLLQGPDIT----VSKLLKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKT--VVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQSDENKKPLSQKQAEFFLSQQASLLKNDETKALT---------PASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAESKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLG-QKRSDSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMLEQQNNTESFAVALCHLAELHAEQGCFAAASEVLKHLKERFPPNSQWMLCDQKIQFDRAMNDGKYHLADSLVTGITALNSIEGVYRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKNTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKEYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASYDQPKKAEALEAAIENLNEAKNYFAKVDCK------------ERIRDVVYFQAR-LGKTQERNRC--AMLFRQLHQELLINHL-----------------

1z6tB

0.14

0.07

0.48

2.38

Env-PPAS

----------------------------------------------------------------------------------------------------------------------------------------MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKD-LAALLHDGIPVVSSSSGKDSVSG-------ITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKWVTIHGMAGCGKSVLAAEAVRDHSFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFKDRLRILMLRKHPRSLLILDD---VWD-----SWVLKAFDSQCQILLTTRDDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLP------EQAHSIIKECKGSPLVVSLIGALLRDFPWEYYLKQLQN--KQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILW----DMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQR-YHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHIL-----------------DEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

5dlqB

0.10

0.09

0.87

1.67

MUSTER

----------------------AALGPPEVIAQLENAAKVLMAPPSMVSN--EQRQHAEHIFLSFRKSKSPFAVCRH-----------------ILETSKV---DYVLFQAATAIMEAVVREWVLLEKGSIES----------LRTFLLTYVLQRPNLQKYVREQILLAVAVIVKRGSLDKSIDCKSIFHEVSQLISPTVQTLACSILTALLSEF-SNCKRVFQEEDLRQIFMLTVGVLQE---------------FSRRENLSAQMSSV--FQRYLALANQVLSWNFL----PPTESWREALL---------------------SRVMELFFTVHRKIREDSDMAQDSLQCLAQLASLHG---IFPDEGSQVDYLAHFIEGLLNT--------------------INGIEIEDSEAVGISSIISNLITVFPRNVLTAIPSELFSSFVNCLTHLTCSFGRSAALEEVLDKMVYMEAYDKLLESWLTLVRKGFFTQHAVQVFNSYIQCHLAAPDGTRNLTANGVASREEE--------ISELQEDDRDQFSDQLASVGMLGRIAAEHCMPLLTSLLEERVTRLHGQLQRHNKMLDDLYEDIHWLILVTGYLLATPLIPPEIMEYSIKHSSEVDINTTLQILGSPGKASSIPGYSRTDSVIRLLSAVLRVSEVESRAIRADLTHLLSPQMGKDIVWFLKRWAKTYLLVDEKLYDQISLPLSTAFG--ADTEGSQWIIGYLLQKVISNLSVWSSEQDLANDTVQLLVTLVERRERANLVIQCENWWNLAKQFASRSPPLNFL--------SSPVQRTLMKALVLGGFAHMDTETKQQYWTEVLQPLQQRFLRVINQENFQQMCQQEEVKQEITATLEALCGIAEATQIDNVA-------ILFNFLMDFLNNCIGLMEVYKNTPETVNLIIEVFVEVAHKQICYLGESKAMHLYEACLTLLQVYSKNNLGRQRIDVTAEEEQYQDLLLIMELLTNLLSKVSAADVVLYGVNLILPLMSLLKFPTLCNQYYKLITFICEIFPEKIPEDLFKSLMYSLELGMTSMSSEVCQLCLEALTPLATRHFLKLVFDML-----VLQNTEMTTAAGEAFYTLVCL---YQAEYSELVQQDPVIYQRLADAFNKL--KQKMAFLKSLEEFMA

3w3tA

0.09

0.07

0.86

1.32

dPPAS

---------------------------------------------LPEEVNRTLLQIVQAFASDNQIRSVAEKALSEEWENNIEYLLTFL----AEQAAFSQDTTVAALSAVLFRKLALKAPITHIRKEV-------------LAQIRSSLLKGFLSERADSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTTVPYLITAVDINSIL----------PIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKL--GILLPSLLNSLPR---FLDDGKDDALASVFESLIELVELAPK-----LFKDMFDQIIQFTDMVIKNKDLEPPARTTALELLTVFSENAPQM----CKSNQNYGQTLVMVTLIMMTE------VSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLGGEYLAAPLFQYLQQMITSTRFAAMMALSSAAEGCADVLIGEIPKILDMVIPLINDPHPQYGCCNVLGQISTDFSPAHDRILPALISKLTSECTSRVQTHAAAANFSEFASKDILEPYLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFIKYYDTLMPLLLNVLKVNSVLKGKCMEGFAVGKEKFHEHSQELISILVALQNSDDRSYLEQSWSRICRILGDDFVPLLPIVIPPLLITAKATQDVGLIEEEEAANFQQYPDWDVVQVQGKHIAIHTSVLDDKVSAMEL--LQSYATLLRGQFAVYVKEVMEEIALPSLDFYLHDGVRAAGATLIPILLSCLLAATEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNCLSEDQLAAFTKGVSANLTDTYERMQDRDEYNEFTDEDLLDEINKSIAAVLKTTNGHYLKNLENIWPMINTFLLDNEPILVIFALVVIGDLIQYEQTASMKNAFIPKVTECLIRQAASYIIGVCAQYAPSTYADVCIPTLDTLVQIVDGSKLEENRSSTENASAAIAKILYAYDTYTANWFKTLPTITDKEAASFNYQFLSQLIENSNISAIQALNERSLTVISSVKKLLGFLPSSDAMAIFNRYPADIMEKVHKWFA------------------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.87

Estimated TM-score = 0.39±0.13

Estimated RMSD = 16.8±2.9Å

Download Model 2

C-score=-2.81

Download Model 3

C-score=-3.30

Download Model 4

C-score=-3.26

Download Model 5

C-score=-3.85

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3w3tA	0.748	4.37	0.081	0.853
2	4xriA	0.519	5.98	0.088	0.645
3	1qgkA	0.504	6.33	0.086	0.639
4	2x19B	0.479	6.25	0.068	0.599
5	1wa5C	0.477	6.35	0.053	0.598
6	3icqT	0.472	6.73	0.065	0.614
7	4c0oA	0.469	6.40	0.053	0.595
8	1qbkB	0.458	6.95	0.063	0.598
9	3gjxA	0.456	7.00	0.038	0.601
10	3ea5B	0.449	6.45	0.062	0.568

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	5	4ay2A	MG	Rep, Mult	301,367
2	0.06	3	1f59B	III	Rep, Mult	274,278,281,282,330,334
3	0.04	2	5ddlB	5AU	Rep, Mult	848,852
4	0.04	2	3ak1B	EDO	Rep, Mult	834,837
5	0.02	1	2r9rB	PGW	Rep, Mult	850,854
6	0.02	1	1f59A	III	Rep, Mult	281,284,285,334,338
7	0.02	1	3e27A	MG	Rep, Mult	367,397
8	0.02	1	3w3yA	III	Rep, Mult	413,421,425,428,464,467,499,503,534,537,539,542,574
9	0.02	1	3jzmE	MG	Rep, Mult	300,301,367,395
10	0.02	1	1o6pA	III	Rep, Mult	337,385,389
11	0.02	1	3fggB	ZN	Rep, Mult	838,842
12	0.02	1	3jzmE	MG	Rep, Mult	297,300
13	0.02	1	2i0mA	ZN	Rep, Mult	844,848
14	0.02	1	2vdcA	F3S	Rep, Mult	232,233,234,235,239,252,278,279
15	0.02	1	2nq8C	ZID	Rep, Mult	423,427
16	0.02	1	3k0aE	MG	Rep, Mult	300,301,367
17	0.02	1	2yl8A	MN	Rep, Mult	911,914
18	0.02	1	2qbyA	MG	Rep, Mult	301,367,464

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ea0A	0.310	9.56	0.047	0.487	1.4.1.13	NA
2	0.060	3b9jJ	0.125	6.81	0.038	0.164	1.17.1.4,1.17.3.2	275,304
3	0.060	2vz8A	0.263	10.40	0.049	0.448	2.3.1.85	NA
4	0.060	2np0A	0.273	9.42	0.031	0.425	3.4.24.69	NA
5	0.060	2zxqA	0.300	9.26	0.053	0.464	3.2.1.97	NA
6	0.060	2vuaA	0.136	7.49	0.032	0.186	3.4.24.69	353
7	0.060	2eabA	0.266	8.77	0.053	0.394	3.2.1.63	NA
8	0.060	1z0hB	0.139	7.39	0.044	0.190	3.4.24.69	373
9	0.060	1bxrA	0.278	9.18	0.038	0.427	6.3.5.5	293
10	0.060	3h09B	0.267	8.84	0.041	0.399	3.4.21.72	NA
11	0.060	2fhbA	0.304	9.03	0.048	0.463	3.2.1.41	315
12	0.060	3btaA	0.268	9.61	0.027	0.423	3.4.24.69	NA
13	0.060	1b0pA	0.275	9.20	0.038	0.419	1.2.7.1	NA
14	0.060	2vdcF	0.326	9.54	0.058	0.518	1.4.1.13	NA
15	0.060	1n1hA	0.268	9.50	0.036	0.419	2.7.7.48	NA
16	0.060	3b9jC	0.174	8.45	0.045	0.254	1.17.3.2,1.17.1.4	NA
17	0.060	1ofdA	0.314	9.28	0.058	0.485	1.4.7.1	NA
18	0.060	1ej6A	0.277	9.60	0.035	0.437	2.7.7.50	NA
19	0.060	1z1wA	0.265	7.61	0.046	0.359	3.4.11.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.14	0.497	6.11	0.08	0.62	2q5dB	GO:0000059 GO:0000060 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006309 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0007079 GO:0007080 GO:0008139 GO:0008270 GO:0008536 GO:0008565 GO:0015031 GO:0016020 GO:0016032 GO:0019054 GO:0019899 GO:0019904 GO:0030953 GO:0031291 GO:0031965 GO:0034399 GO:0040001 GO:0043234 GO:0044822 GO:0045184 GO:0051879 GO:0070062 GO:0071782 GO:0075733 GO:0090307
1	0.13	0.748	4.27	0.08	0.85	3w3uA	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0006406 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0007088 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0034399 GO:0060188
2	0.09	0.504	6.33	0.09	0.64	1qgkA	GO:0000059 GO:0000060 GO:0005634 GO:0005635 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006309 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0007079 GO:0007080 GO:0008139 GO:0008270 GO:0008536 GO:0008565 GO:0015031 GO:0016020 GO:0016032 GO:0019054 GO:0019899 GO:0019904 GO:0030953 GO:0031291 GO:0031965 GO:0034399 GO:0040001 GO:0043234 GO:0044822 GO:0045184 GO:0051879 GO:0070062 GO:0071782 GO:0075733 GO:0090307
3	0.07	0.536	5.76	0.09	0.66	3nd2A	GO:0000059 GO:0000060 GO:0000176 GO:0005087 GO:0005634 GO:0005643 GO:0005737 GO:0006606 GO:0006607 GO:0006610 GO:0006612 GO:0006656 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0031965 GO:0034399 GO:0043547 GO:0051028 GO:0051292 GO:0060188
4	0.07	0.519	5.98	0.09	0.65	4xriA	GO:0005622 GO:0006886 GO:0008536
5	0.07	0.501	6.01	0.06	0.60	3w3zA	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0006406 GO:0006606 GO:0006607 GO:0006610 GO:0006810 GO:0007088 GO:0008139 GO:0008565 GO:0015031 GO:0031965 GO:0034399 GO:0060188
6	0.07	0.477	6.33	0.05	0.59	1qbkB	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0005829 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0016032 GO:0031965 GO:0034399 GO:0043488 GO:0044822 GO:0070062 GO:0072372
7	0.06	0.480	6.46	0.06	0.60	4jlqA	GO:0000059 GO:0000060 GO:0005634 GO:0005737 GO:0005829 GO:0006607 GO:0006610 GO:0006810 GO:0006886 GO:0008139 GO:0008536 GO:0008565 GO:0015031 GO:0016032 GO:0031965 GO:0034399 GO:0043488 GO:0044822 GO:0070062 GO:0072372
8	0.06	0.431	6.27	0.05	0.54	5dlqA	GO:0005049 GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0006611 GO:0006810 GO:0008536 GO:0015031 GO:0046827
9	0.06	0.401	7.02	0.04	0.52	4a0cA	GO:0000151 GO:0005634 GO:0005654 GO:0005737 GO:0005794 GO:0010265 GO:0016020 GO:0016567 GO:0017025 GO:0030154 GO:0031461 GO:0043086 GO:0045893 GO:0045899 GO:0070062
10	0.06	0.301	6.47	0.05	0.39	1b3uA	GO:0000086 GO:0000159 GO:0000184 GO:0000188 GO:0000775 GO:0003823 GO:0004722 GO:0005634 GO:0005694 GO:0005737 GO:0005739 GO:0005829 GO:0006275 GO:0006355 GO:0006461 GO:0006470 GO:0006672 GO:0006915 GO:0007059 GO:0007084 GO:0007143 GO:0008380 GO:0008601 GO:0010033 GO:0015630 GO:0016020 GO:0019932 GO:0030111 GO:0030155 GO:0030308 GO:0034047 GO:0040008 GO:0042518 GO:0045595 GO:0046982 GO:0051232 GO:0051306 GO:0051754 GO:0070062 GO:0070262 GO:1903538 GO:2001241
11	0.06	0.259	5.15	0.09	0.31	1ialA	GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0016020 GO:0042826 GO:0044822
12	0.06	0.247	5.57	0.07	0.30	1wa5B	GO:0000176 GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006612 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0031144 GO:0048471
13	0.06	0.249	5.48	0.06	0.30	4rxhB	GO:0005634 GO:0005737 GO:0006606 GO:0006810 GO:0008565 GO:0015031
14	0.06	0.253	5.18	0.09	0.30	4uadA	GO:0005634 GO:0005643 GO:0005654 GO:0005737 GO:0005829 GO:0006606 GO:0006607 GO:0006810 GO:0008139 GO:0008565 GO:0015031 GO:0016020 GO:0045944 GO:0060135
15	0.06	0.198	4.31	0.07	0.22	1oyzA	GO:0006974 GO:0046677
16	0.06	0.206	8.01	0.05	0.29	1tllA	GO:0001666 GO:0001917 GO:0004517 GO:0005506 GO:0005516 GO:0005634 GO:0005737 GO:0005739 GO:0005741 GO:0005829 GO:0005886 GO:0006527 GO:0006809 GO:0007263 GO:0007565 GO:0007568 GO:0008016 GO:0008285 GO:0009408 GO:0010181 GO:0010243 GO:0010288 GO:0012506 GO:0014069 GO:0014070 GO:0014823 GO:0016020 GO:0016491 GO:0016597 GO:0017080 GO:0018119 GO:0019899 GO:0020037 GO:0030425 GO:0031284 GO:0031667 GO:0031965 GO:0032496 GO:0033137 GO:0033197 GO:0035094 GO:0042383 GO:0042582 GO:0042803 GO:0042995 GO:0043066 GO:0043197 GO:0043234 GO:0043434 GO:0043627 GO:0044325 GO:0045202 GO:0045471 GO:0045776 GO:0045822 GO:0045906 GO:0045909 GO:0046676 GO:0046870 GO:0046872 GO:0048148 GO:0048471 GO:0050660 GO:0050661 GO:0051117 GO:0051481 GO:0051930 GO:0055114 GO:0071260 GO:0071731 GO:0071872 GO:0097110 GO:1900273 GO:1901216 GO:1902307
17	0.06	0.168	7.20	0.05	0.22	3f3fH	GO:0000055 GO:0005634 GO:0005643 GO:0006406 GO:0006606 GO:0006810 GO:0015031 GO:0016020 GO:0017056 GO:0031080 GO:0031081 GO:0031965 GO:0045893 GO:0051028
18	0.06	0.144	4.10	0.09	0.16	3ltjA

Consensus prediction of GO terms

Molecular Function	GO:0031072	GO:0003723	GO:0046914	GO:0008139	GO:0008565	GO:0008536
GO-Score	0.45	0.45	0.45	0.37	0.37	0.32
Biological Processes	GO:0044068	GO:0030262	GO:0019048	GO:0007265	GO:0051310	GO:0000737	GO:0031122	GO:0000070	GO:1902850	GO:0046794	GO:0019058	GO:0051225	GO:0051305	GO:0051293	GO:1902583	GO:0016926	GO:1903320	GO:0030162	GO:0000060	GO:0006610	GO:0000059	GO:0006607
GO-Score	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.45	0.38	0.38	0.38	0.37	0.37	0.37	0.37
Cellular Component	GO:0032991	GO:1903561	GO:0098827	GO:0031988	GO:0034399	GO:0031965
GO-Score	0.45	0.45	0.45	0.45	0.37	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.