I-TASSER results

I-TASSER results for job id Rv1357c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (307 residues)
MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWADSDRDQVNTRHYLSTS
MRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPL
TAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQL
ELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVDVVKLGGKFIEC
LDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAARLRAFGCKAAQGWHFAKAL
PVDFFRE

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWADSDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAARLRAFGCKAAQGWHFAKALPVDFFRE
Prediction	CCEEEEEEHCEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCEEHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEHCCCCCEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCHHHHHCCCHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHC
Conf.Score	9869999844589986899999999999999999989997886859999999999999999999998996999977788799978999999864588889999545345556669846779999999999999999989999976999847888668999999999999989996675344567888757999999999999989989997589987777776658998776646776456678788876699999999999998997999756879999999999998676443579999888769
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWADSDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAARLRAFGCKAAQGWHFAKALPVDFFRE
Prediction	7614030100000000052263044303202300661432210135215303503510530250156500301320101053330000006036522530201233000001100041404310042014103412745372502000200030043650263035006627041620100000120042164015205403704010003324032000210340303402001010340452464354021003000200550705000000015411411362436202111002202273158
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEEEHCEEEEHCCCCCCCHHHHHHHHHHHHHHCCCCEEHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEHCCCCCEEEEEEEEEHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHCCHHHHHCCCHHHHHHHHHHHHCCCHHHCHHHHHHHHHHHCHHHHHHHHHHHHHHCCEEEEHCCCCCCCCHHHHHCCCCCEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEHCCCHHHHHHHHHHCCCEEEEEHCCCCCCHHHHHC
MDRCCQRATAFACALRPTKLIDYEEMFRGAMQARAMVANPDQWADSDRDQVNTRHYLSTSMRVALDRGEFFLVYQPIIRLADNRIIGAEALLRWEHPTLGTLLPGRFIDRAENNGLMVPLTAFVLEQACRHVRSWRDHSTDPQPFVSVNVSASTICDPGFLVLVEGVLGETGLPAHALQLELAEDARLSRDEKAVTRLQELSALGVGIAIDDFGIGFSSLAYLPRLPVDVVKLGGKFIECLDGDIQARLANEQITRAMIDLGDKLGITVTAKLVETPSQAARLRAFGCKAAQGWHFAKALPVDFFRE

4rnfA

0.35

0.34

0.98

4.64

MUSTER

LEREFFVTASIGVALSPQDGAELSLLMKNADTAMYH-KNNFQFYQEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKVRV-PKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

7.40

dPPAS

-------------------------------------------QAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKV-RVPKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

7.20

wdPPAS

-------------------------------------------QAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKV-RVPKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA

0.35

0.34

0.98

5.18

wMUSTER

LEREFFVTASIGVALSPQDGAELSLLMKNADTAMYH-KNNFQFYQEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKVRV-PKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

4.55

wPPAS

--------------------------------------------QEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKV-RVPKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

6.63

dPPAS2

-------------------------------------------QAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKV-RVPKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

4.43

PPAS

-------------------------------------------QAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKV-RVPKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

6.65

Env-PPAS

-------------------------------------------QAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKV-RVPKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4rnfA2

0.37

0.31

0.84

4.12

MUSTER

-------------------------------------------QAEMNARALERLELESDLRRALELGEFVLHYQPQFTGDGRRLTGAEALLRWQHPRRGLVPPSEFIPVLEEIGLVAQVGDWLLAEACKQLRSWHKAKVRV-PKVSVNLSARQFADGQLGERIAAILYETGIPPACLELELTESILMSDVAEAMQILSGLKRLGLAIAVNNFGTGYSSLNYLKQFPIDVLKIDRSFVDGLPHG----EQDAQIARAIIAMAHSLNLMVIAEGVESQAQLDFLREHGCDEVQGYLFGRPMPAEQFGM

4hu3A

0.32

0.27

0.84

6.81

dPPAS

-------------------------------------------SPAMNEMVKERLVLGAALKEAISNNQLKLVYQPQIFAETGELYGIEALARWHDPLHGHVPPSRFIPLAEEIGEIENIGRWVIAEACRQLAEWRSQNI-HIPALSVNLSALHFRSNQLPNQVSDAMHAWGIDGHQLTVEITESMMMEHDTEIFKRIQILRDMGVGLSVDDFGTGFSGLSRLVSLPVTEIKIDKSFVDRCLTE----KRILALLEAITSIGQSLNLTVVAEGVETKEQFEMLRKIHCRVIQGYFFSRPLPAEEIPG

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.64

Estimated TM-score = 0.94±0.05

Estimated RMSD = 3.0±2.1Å

Download Model 2

C-score=-4.18

Download Model 3

C-score=-3.90

Download Model 4

C-score=-4.19

Download Model 5

C-score=-4.23

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4rnfA	0.964	1.01	0.344	0.984
2	3sy8A	0.786	3.30	0.261	0.899
3	4hu3A	0.756	2.35	0.314	0.840
4	3ii8B	0.753	1.94	0.381	0.805
5	4kieA	0.734	2.54	0.266	0.818
6	3pjwA	0.734	2.99	0.203	0.844
7	4y8eA	0.731	2.26	0.314	0.798
8	4f3hA	0.725	2.33	0.211	0.805
9	3hv9A	0.722	2.34	0.230	0.795
10	3s83A	0.718	2.13	0.366	0.775

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.63	44	3pjtA	C2E	Rep, Mult	75,89,91,92,93,103,104,105,108,120,121,124,149,211,212,273,275,293,294,299
2	0.55	35	3gg0A	MN	Rep, Mult	89,149,181,211,232
3	0.06	6	3n3tA	MG	Rep, Mult	211,212,234,272
4	0.04	5	2w27A	5GP	Rep, Mult	75,89,91,93,149,239,273,275,293,294
5	0.02	3	4lj3A	HB0	Rep, Mult	77,86,87,88,145,179,181,209,230,270,290
6	0.01	1	3iivB	MG	Rep, Mult	89,181,292
7	0.01	1	4afyA	MG	Rep, Mult	75,89,292
8	0.01	1	4f48A	C2E	Rep, Mult	91,93,103,104,105,108,149,151,273,294
9	0.01	1	3gfyA	FMN	Rep, Mult	8
10	0.01	1	3gfzA	FMN	Rep, Mult	1

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.139	1j2wA	0.452	3.54	0.097	0.560	4.1.2.4	272
2	0.066	1wx0A	0.460	3.63	0.129	0.567	2.2.1.2	181
3	0.066	1xbzB	0.457	3.67	0.067	0.560	4.1.1.85	122
4	0.060	2osxA	0.525	4.40	0.034	0.691	3.2.1.123	262
5	0.060	1izjA	0.442	4.84	0.037	0.612	3.2.1.135,3.2.1.1	181
6	0.060	1cdgA	0.516	5.11	0.040	0.717	2.4.1.19	181
7	0.060	2fhbA	0.511	5.53	0.045	0.775	3.2.1.41	NA
8	0.060	3bq5A	0.564	5.22	0.064	0.814	2.1.1.14	NA
9	0.060	2qf7A	0.538	4.35	0.053	0.710	6.4.1.1	NA
10	0.060	1ciuA	0.520	4.90	0.044	0.717	2.4.1.19	271
11	0.060	2oykB	0.523	4.39	0.038	0.684	3.2.1.123	NA
12	0.060	1h1nA	0.516	4.73	0.054	0.700	3.2.1.4	89
13	0.060	1qhoA	0.523	4.94	0.054	0.720	3.2.1.133	NA
14	0.060	1q45B	0.502	4.11	0.082	0.645	1.3.1.42	NA
15	0.060	1gynA	0.512	4.72	0.071	0.687	4.1.2.13	NA
16	0.060	3bg3A	0.542	4.34	0.065	0.717	6.4.1.1	NA
17	0.060	1cygA	0.515	4.93	0.037	0.704	2.4.1.19	181
18	0.060	1r8lB	0.514	4.56	0.076	0.687	3.2.1.89	NA
19	0.060	1cgtA	0.511	5.03	0.047	0.707	2.4.1.19	211
20	0.060	1h4pA	0.514	4.92	0.073	0.700	3.2.1.58	181
21	0.060	1edqA	0.497	4.87	0.033	0.697	3.2.1.14	211
22	0.060	1vbgA	0.518	4.66	0.055	0.694	2.7.9.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.57	0.964	1.01	0.34	0.98	4rnfA	GO:0000155 GO:0000160 GO:0000166 GO:0005622 GO:0016020 GO:0016021 GO:0023014 GO:0042802 GO:0046872
1	0.51	0.666	2.76	0.16	0.75	3gfxB	GO:0000166 GO:0009785 GO:0009882 GO:0046872 GO:0071949
2	0.47	0.792	3.23	0.26	0.90	3sy8B	GO:0000160 GO:0005622 GO:0045892 GO:0046872
3	0.43	0.765	2.05	0.36	0.82	4hjfA	GO:0000166 GO:0046872
4	0.43	0.739	2.22	0.33	0.81	4y9mA	GO:0016020 GO:0016021
5	0.41	0.756	2.35	0.31	0.84	4hu3A	GO:0000155 GO:0000160 GO:0000287 GO:0005622 GO:0006351 GO:0006355 GO:0016787 GO:0019826 GO:0020037 GO:0023014 GO:0046872 GO:0050896 GO:0070482 GO:0071111
6	0.41	0.767	2.50	0.25	0.84	3sy8D	GO:0000160 GO:0005622 GO:0045892 GO:0046872
7	0.39	0.734	2.54	0.27	0.82	4kieA	GO:0003677 GO:0006355 GO:0016787 GO:0071111
8	0.33	0.722	2.34	0.23	0.79	3hv9A	GO:0000160 GO:0000166 GO:0005622 GO:0006355
9	0.30	0.734	2.99	0.20	0.84	3pjwA	GO:0000166 GO:0004871 GO:0007165 GO:0016020 GO:0016021
10	0.30	0.703	2.23	0.23	0.78	3pfmA	GO:0004871 GO:0007165 GO:0016020 GO:0016021
11	0.27	0.752	2.62	0.20	0.84	4fokA	GO:0000166 GO:0046872
12	0.27	0.614	2.57	0.14	0.68	3gfyB	GO:0000166 GO:0009785 GO:0009882 GO:0046872 GO:0071949
13	0.24	0.621	3.12	0.16	0.73	3tlqA	GO:0006351 GO:0006355 GO:0008134 GO:0043433 GO:1902201 GO:2000678
14	0.23	0.589	3.02	0.16	0.69	3kzpB	GO:0046872
15	0.14	0.768	1.94	0.37	0.82	3n3tB	GO:0000166 GO:0016020 GO:0016021 GO:0046872
16	0.06	0.320	5.50	0.05	0.48	1jalA	GO:0000166 GO:0005524 GO:0005525 GO:0016887 GO:0043022 GO:0043023 GO:0046872
17	0.06	0.288	6.66	0.06	0.50	3ezuA
18	0.06	0.282	6.10	0.05	0.46	4h54A	GO:0000166 GO:0005525 GO:0008270 GO:0016740 GO:0043709 GO:0046872 GO:0051271 GO:0052621 GO:1902209
19	0.06	0.293	5.72	0.11	0.47	4eekA	GO:0008152 GO:0016787 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0046872	GO:0000155	GO:0042802	GO:0071949	GO:0009882
GO-Score	0.94	0.57	0.57	0.51	0.51
Biological Processes	GO:0000160	GO:0023014	GO:0009785	GO:0045892
GO-Score	0.77	0.57	0.51	0.47
Cellular Component	GO:0005622	GO:0016021
GO-Score	0.77	0.75

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.