I-TASSER results

I-TASSER results for job id Rv1353c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (261 residues)
MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKK
DDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIRAALSP
KTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSA
IEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSKAAGEVAV
RRPTATADAPTPGARAKAVAR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR
Prediction	CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	999899999999999999999999999999879654889999999899855544546999999999999999965778888889998999999999999999988658999986899997888889999999999999979999999999999999999999999975766677777578999986984548799999987557899958999999999999999999975688888888888778888888877888889
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR
Prediction	865547646556546132520040013003642153000330054171431000220541420021003100441424345363431240122002000200231220020012233222311421341022001003615044610120020021101000111224444554442341232234133521220130143145363322310220240022002202544664456655654555675643655555468
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCHHCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MQTTPGKRQRRQRGSINPEDIISGAFELAQQVSIDNLSMPLLGKHLGVGVTSIYWYFRKKDDLLNAMTDRALSKYVFATPYIEAGDWRETLRNHARSMRKTFADNPVLCDLILIRAALSPKTARLGAQEMEKAIANLVTAGLSLEDAFDIYSAVSVHVRGSVVLDRLSRKSQSAGSGPSAIEHPVAIDPATTPLLAHATGRGHRIGAPDETNFEYGLECILDHAGRLIEQSSKAAGEVAVRRPTATADAPTPGARAKAVAR

2y2zA

0.19

0.16

0.87

2.12

MUSTER

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLP--DRPGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVWG---PNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.87

2.12

dPPAS

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLP--DRPGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVW---GPNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWKVDMREWMRRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.86

2.86

wdPPAS

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLP--DRPGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVW----PNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.86

2.62

wMUSTER

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLPDR--PGPDWRAALTLAANEKRALWLRHPWLATAWRGHPVWG----PNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.86

3.52

wPPAS

IWEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLPDR--PGPDWRAALTLAANEKRALWLRHPWLATAWRGHPVWG----PNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.87

3.52

dPPAS2

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLP--DRPGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVW---GPNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.86

2.99

PPAS

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLPDR--PGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVW----PNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVDMREWMRRSGDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

2y2zA

0.19

0.16

0.87

3.84

Env-PPAS

HPEPAGRRSARSHRTLSRDQIVRAAVKVADTEGVEAASMRRVAAELGAGTMSLYYYVPTKEDLVELMVDEVIGETRLP--DRPGPDWRAALTLAANEKRALWLRHPWLATAWRNGHPVWG---PNSLRQQEFVLGTLGVFDLQVDELLSLIGLYNGYVESFVRNEVGWLEEARRTKVRSGPYAQQLVDSGEYPMFARVLAETVAPHMGPDQRFRSGLERLLDSIGASLDRL------------------------------

3b6aA

0.24

0.19

0.81

1.98

MUSTER

------------MAPLTQDRIVVTALGILDAEGLDALSMRRLAQELKTGHASLYAHVGNRDELLDLVFDIVLTEVEVPEP--EPGRWAEQVKEMCRSLRRMFLAHRDLARIAIDRVPLG----PNGMVGMERTMNLLRSGGLHDELAAYGGDLLSTFVTAEALEQSSRQGREQAGVADQLHGYLKSLPATSFPNLVHLAGPI--TSLDSDRRFELGLEIIIAGLLAGAGEAA-----------------------------

3b6aA

0.24

0.19

0.81

2.01

dPPAS

------------MAPLTQDRIVVTALGILDAEGLDALSMRRLAQELKTGHASLYAHVGNRDELLDLVFDIVLTEVEVPEP--EPGRWAEQVKEMCRSLRRMFLAHRDLARIAIDRVPLG----PNGMVGMERTMNLLRSGGLHDELAAYGGDLLSTFVTAEALEQSSRQGREQAGVADQLHGYLKSLPATSFPNLVHLAGPIT--SLDSDRRFELGLEIIIAGLLAGAGEAA-----------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.52

Estimated TM-score = 0.65±0.13

Estimated RMSD = 7.0±4.1Å

Download Model 2

C-score=-1.46

Download Model 3

C-score=-0.61

Download Model 4

C-score=-1.70

Download Model 5

C-score=-4.10

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2y2zA	0.814	1.59	0.195	0.866
2	3b6aA	0.696	2.66	0.230	0.801
3	2o7oA	0.683	2.66	0.209	0.785
4	3zqiA	0.668	2.58	0.235	0.766
5	2vprA	0.665	2.41	0.214	0.751
6	1z0xA	0.654	2.57	0.182	0.759
7	3bqyA	0.646	2.80	0.209	0.747
8	2hxoA	0.628	3.49	0.198	0.762
9	2g7gA	0.625	2.85	0.209	0.732
10	2hxiB	0.622	2.98	0.222	0.743

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.15	23	2y30B	SM8	Rep, Mult	72,76,94,98,117,119,129,130,133,134,148,154,155
2	0.12	16	3b6aD	ZCT	Rep, Mult	72,76,98,112,113,115,118,125,126,129,130,152,155
3	0.07	8	3zqlC	QNA	Rep, Mult	49,51,52,55,56
4	0.05	6	2ns8A	III	Rep, Mult	37,38,39,40,50,54,57,58,59,60
5	0.04	6	2ns8C	III	Rep, Mult	164,165,168,169,172,183,202,205,208,209
6	0.04	6	2x9dA	ITC	Rep, Mult	72,94,98,112,116,118,130,151,152,155,156
7	0.03	4	3b6cB	SDN	Rep, Mult	72,94,125,126,129,133,155
8	0.03	5	2ns8B	III	Rep, Mult	164,165,168,177,178,186,195,199,202,206
9	0.02	3	1ocoO	HEA	Rep, Mult	158,220,221
10	0.02	3	1bjyB	CTC	Rep, Mult	195,199,202
11	0.01	2	3b6aC	ZCT	Rep, Mult	72,98,112,113,129,133,155,159
12	0.01	2	2ns8B	III	Rep, Mult	98,117,118,148,151,152,155,156,159
13	0.01	2	2y30B	SM8	Rep, Mult	182,183,186,187,199,206
14	0.01	2	4nhvB	2O6	Rep, Mult	19,67
15	0.01	2	3lsjA	COA	Rep, Mult	94,136,221,222,225
16	0.01	2	1qpiA	IMD	Rep, Mult	112,113,115,116
17	0.01	1	3b6aD	ZCT	Rep, Mult	163,164

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1bucB	0.410	5.37	0.029	0.621	1.3.99.2	218,221
2	0.060	2ix6A	0.394	5.43	0.027	0.598	1.3.3.6	229
3	0.060	2fhbA	0.409	5.77	0.061	0.670	3.2.1.41	NA
4	0.060	1zyzA	0.379	6.83	0.061	0.720	1.17.4.1	NA
5	0.060	1ivhA	0.406	5.43	0.028	0.625	1.3.99.10	NA
6	0.060	1bucA	0.410	5.35	0.034	0.621	1.3.99.2	160,214
7	0.060	1xc6A	0.415	5.80	0.038	0.686	3.2.1.23	19,26
8	0.060	2fhcA	0.418	6.04	0.062	0.724	3.2.1.41	36,66,110
9	0.060	2r7oA	0.410	6.17	0.035	0.701	2.7.7.48	64,66
10	0.060	2je8B	0.419	6.18	0.036	0.713	3.2.1.25	NA
11	0.060	2ix6E	0.394	5.43	0.027	0.598	1.3.3.6	159
12	0.060	1jqiA	0.406	5.28	0.019	0.605	1.3.99.2	214
13	0.060	1d8yA	0.394	6.23	0.060	0.705	2.7.7.7	NA
14	0.060	2vdcF	0.398	6.32	0.029	0.709	1.4.1.13	NA
15	0.060	2vdcA	0.398	6.30	0.037	0.709	1.4.1.13	NA
16	0.060	2j5wA	0.414	6.17	0.053	0.740	1.16.3.1	NA
17	0.060	2cvtA	0.404	5.70	0.052	0.632	1.17.4.1	NA
18	0.060	1rx0A	0.399	5.41	0.027	0.605	1.3.99.-	NA
19	0.060	1udyA	0.410	5.16	0.044	0.605	1.3.99.3	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.39	0.596	2.75	0.25	0.70	3zqfA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
1	0.39	0.769	2.62	0.19	0.87	2y31A	GO:0003677 GO:0006351 GO:0006355 GO:0045892
2	0.35	0.648	3.08	0.23	0.79	3zqgA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
3	0.33	0.674	2.77	0.21	0.78	4auxA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
4	0.29	0.696	2.66	0.23	0.80	3b6aA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677
5	0.29	0.686	2.58	0.18	0.80	1z0xA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677
6	0.28	0.506	3.78	0.13	0.65	3crjA	GO:0003677
7	0.25	0.519	4.01	0.12	0.69	2f07A	GO:0003677 GO:0006351 GO:0006355
8	0.25	0.660	2.83	0.21	0.77	3bqyA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677
9	0.24	0.632	3.50	0.20	0.77	2hxoA	GO:0003677 GO:0006351 GO:0006355 GO:0045892
10	0.24	0.511	3.94	0.17	0.66	3vibC	GO:0003677 GO:0006351 GO:0006355
11	0.24	0.629	3.03	0.22	0.75	2hxiB	GO:0003677 GO:0006351 GO:0006355 GO:0045892
12	0.23	0.500	3.87	0.14	0.66	4ichA	GO:0003677 GO:0006351 GO:0006355
13	0.23	0.475	3.77	0.16	0.62	3dcfA	GO:0003677 GO:0006351 GO:0006355
14	0.22	0.485	2.94	0.24	0.58	3fiwA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677
15	0.21	0.461	4.07	0.16	0.62	3vprA	GO:0003677 GO:0006351 GO:0006355 GO:0042802
16	0.21	0.513	4.25	0.11	0.69	3lhqA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
17	0.20	0.484	3.90	0.16	0.64	3on4A	GO:0003677 GO:0006351 GO:0006355
18	0.19	0.508	4.32	0.14	0.69	3bcgA	GO:0003677 GO:0003700 GO:0006351 GO:0006355 GO:0008144 GO:0042493 GO:0043565 GO:0045892
19	0.18	0.484	4.32	0.14	0.67	3f0cA	GO:0003677 GO:0006351 GO:0006355
20	0.18	0.522	3.47	0.13	0.64	3whcA	GO:0003677 GO:0005737 GO:0006351 GO:0006355 GO:0006629 GO:0006631 GO:0016042
21	0.17	0.483	4.20	0.09	0.66	3f1bA	GO:0003677 GO:0006351 GO:0006355
22	0.17	0.480	4.24	0.10	0.65	2of7A	GO:0003677 GO:0006351 GO:0006355
23	0.17	0.501	3.66	0.12	0.64	3he0C	GO:0003677 GO:0006351 GO:0006355
24	0.17	0.484	3.52	0.16	0.62	4hkuA	GO:0003677 GO:0006351 GO:0006355
25	0.16	0.497	3.81	0.09	0.64	3qkxA	GO:0003677 GO:0006351 GO:0006355
26	0.16	0.534	3.27	0.14	0.66	5d18A	GO:0003677 GO:0006351 GO:0006355
27	0.16	0.464	3.90	0.12	0.61	4aciB	GO:0000287 GO:0003677 GO:0006351 GO:0006355 GO:0046872
28	0.15	0.500	4.04	0.17	0.67	2oi8A	GO:0003677 GO:0006351 GO:0006355
29	0.14	0.584	3.72	0.16	0.74	2g7lA	GO:0003677 GO:0006351 GO:0006355 GO:0045892
30	0.14	0.528	3.55	0.12	0.66	3bjbB	GO:0003677 GO:0006351 GO:0006355
31	0.14	0.502	3.89	0.09	0.67	2id6A	GO:0003677 GO:0006351 GO:0006355
32	0.14	0.490	4.00	0.14	0.66	3g7rB	GO:0003677 GO:0003700 GO:0006351 GO:0006355
33	0.12	0.484	4.01	0.13	0.65	2genA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
34	0.11	0.564	2.93	0.16	0.66	1zk8A	GO:0003677 GO:0006351 GO:0006355
35	0.11	0.527	3.42	0.14	0.66	2np5A	GO:0003677 GO:0006351 GO:0006355
36	0.10	0.471	4.12	0.14	0.64	4gctC	GO:0000976 GO:0003677 GO:0003700 GO:0005737 GO:0005829 GO:0006355 GO:0007049 GO:0009295 GO:0010974 GO:0043565 GO:0043590 GO:0051301 GO:0051302
37	0.10	0.493	3.98	0.10	0.66	3kz9B	GO:0003677 GO:0006351 GO:0006355
38	0.09	0.451	4.12	0.09	0.61	3t6nA	GO:0003677 GO:0003700 GO:0006351 GO:0006355
39	0.08	0.665	2.41	0.21	0.75	2vprA	GO:0003677 GO:0006351 GO:0006355 GO:0045892 GO:0046677 GO:0046872
40	0.07	0.496	4.26	0.10	0.67	3dpjA	GO:0003677 GO:0006351 GO:0006355
41	0.07	0.517	3.50	0.14	0.64	3htaA	GO:0003677 GO:0006351 GO:0006355
42	0.07	0.492	3.91	0.12	0.65	4gclB	GO:0003677 GO:0005737 GO:0007049 GO:0009295 GO:0010974 GO:0043565 GO:0043590 GO:0051301 GO:0051302
43	0.07	0.484	3.81	0.14	0.63	1sgmA	GO:0003677 GO:0006351 GO:0006355
44	0.07	0.464	4.15	0.09	0.62	2jj7B	GO:0003677 GO:0006351 GO:0006355 GO:0042802
45	0.07	0.468	3.89	0.07	0.61	2raeA	GO:0003677 GO:0006351 GO:0006355
46	0.07	0.478	4.31	0.09	0.65	3cwrA	GO:0003677 GO:0006351 GO:0006355
47	0.07	0.549	3.79	0.14	0.71	3c07A	GO:0003677 GO:0006351 GO:0006355
48	0.07	0.490	3.83	0.14	0.64	2nx4A	GO:0003677 GO:0006351 GO:0006355
49	0.07	0.531	4.38	0.09	0.72	1t33A	GO:0003677 GO:0003700 GO:0006351 GO:0006355
50	0.07	0.484	4.41	0.16	0.66	4cgrA	GO:0003677 GO:0006351 GO:0006355

Consensus prediction of GO terms

Molecular Function	GO:0003677	GO:0046872
GO-Score	0.89	0.74
Biological Processes	GO:0045892	GO:0046677
GO-Score	0.89	0.81
Cellular Component
GO-Score

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.