I-TASSER results

I-TASSER results for job id Rv1289

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (210 residues)
MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGVGTRFRTALRDSLDIY
GVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHGHADESSVEFEVSPYVN
ASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQLSWYDHVFFISVWWGWQ
DHFREIVNVDRASLVALDFGDLWNGWTPVG

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGVGTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHGHADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQLSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG
Prediction	CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHCHHHHHHHHHHHHHHHHEEEHCCCCCCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCEEEEEHCCEEHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHCCEEEEEEHCCHHHHHHHHHCCCHHHEEEHCCCCCCCCCCCCC
Conf.Score	986577999999999988558999999877555655544554565599999999987654455468988765466567777778888987899898888765445667888856788987586677555786885899999999999853677788899864688757589876544668999999766745545654566677888789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 \| \| \| \| \| \| \| \| \| \| MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGVGTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHGHADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQLSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG
Prediction	613312430350054145520410002002222542544234451253034104532410012124424373241313043531464333013001301320203445337614232313342213325633141233102010100001334445414761403024430303211234510451054244200103124315514648
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHCHHHHHHHHHHHHHHHHEEEHCCCCCCCCEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEHCCCEEEEEHCCEEHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHCCEEEEEEHCCHHHHHHHHHCCCHHHEEEHCCCCCCCCCCCCC
MCVSVGESVAQSLQQWDRKLWDVAMLHACNAVDETGRKRYPTLGVGTRFRTALRDSLDIYGVMATPGVDLEKTRFPVGVRSDLLPDKRPDIADVLYGIHRWLHGHADESSVEFEVSPYVNASAALRIANDGKIQLPKSAILGLLAVAVFAPENKGEVIPPDYQLSWYDHVFFISVWWGWQDHFREIVNVDRASLVALDFGDLWNGWTPVG

5cwnA

0.13

0.12

0.93

0.59

MUSTER

ILERAKESLERAREASERGDEEEFRKAAEKALEKRLVEQAKKEGDPELVLEAAKVALRVAELAAKNGDK------------EVFKKAAESALEVAKRLVEVAS-KEGDPELVLEAAKVALRVAELAAKNGDKEVFKKAAESALEVAKRLVEVASKEGDPEEEAAKVAEEVRKLAKKQGDEEVYEKARETAREVKEELKRVREEKGGW-LE

4nx9A

0.10

1.00

0.58

dPPAS

DGISLAQTAEGALQQSTNILQRRDLSLQSANGSNSDSERTALNGEVKQLQKELDRISNTTTFRKLLDGSFGVASFQVGSAANEIDESAESLNGTYFKADGGGAVTAATASGTVDIAIDITGGSAVNVKVDKGNETAEQAAAKIAAAVNDANVGIGAFTDGAQISYVSKTSAVSGVAITDTGSTGAGTAAGTTTFTEANDTVAKIDISTAK

3wqkA3

0.18

0.13

0.75

0.54

wdPPAS

--MN----LVSEKEFLDLPLVSVAEIVRCRGPKVSGTRRWFHLEC-NYQQAALRQSIRILKMLFEHGIETVIADMFIG--GRFSTFDFPLL--------------SGKT------SLYFTVAPS---------YMTETTLRRILYDHIYLRHFRP---KPDYSAMSAD----------QLNVLRNRYRAQPDRV--FGVGCVHDGWFAEG

4mfjA1

0.18

0.14

0.77

0.55

wMUSTER

MMMD-PETVRIALG--RTAAWLTELDELGPPAEPV---RLPRG----------EEARDLLRRLEVPELDAEEI---VAAAPD--PDRDPALWWLLERTHHAIVRHMGDHRAKPRGGPPLPYE-------GG----AAARYFHVYVFLATVPAHAERGIPDE--VGW-----TLTQL-GLVAIHRRKYGQNMQWWTTYHLGIL--------

4xa9a

0.17

0.13

0.79

0.59

wPPAS

-AIA-PQQIQERLKQEQYQKFDIGNFPHCLA-------QTPGIASGQRYQKYSTNSLSR----GAPQLTPKSAQEYIKFKKSSFKDGRVS-SNFAYHSAGVLL-------DDPQIRTQYDV-AVIGSHSNGRYL----------ITLLVPKGSRLPQPPQQLTAEVFPITLIVD--WG-KEQF-----AYNRSLATVNYGQL----TPTG

5ccfA1

0.18

0.14

0.76

0.68

dPPAS2

LALSPESRLAAAWDALNRELMSSIVHQVFPAVAS------------------LEQELLFLSSASGPHSSLSSW------------DGVPDVSDILFWILKEHGRSENR-SSDLTRIHFHTLVYHILATVDGHWANQLAAVAAGARVAGTQACATETIDTNRVSLRA-PQEFTTS-------------HLESGSRIVLNPDK------PVV

4cvhA2

0.17

0.13

0.77

0.61

PPAS

--------YKRDLYAAESIIKERISQEICVVMDT----EEDNKHVGHLLEEVLKSELNHVKVTSEA-LDQCYNFVCVNVTT-------SDFQETQKLLSMLEESSLCILYPVVVVSVHFLDFKLV---------PPSQKMENLMQIREFAKEVKERNI---YGLLISYP--------QDDQKLQESLRQGAIIIASLNSG--------IG

1b3qB1

0.18

0.17

0.93

0.69

Env-PPAS

L-VIARSRILETLKKYNIKELDESLSHLSRITNVVMKIRVPISFVFNRFPRMVRDLAKKM------NKE---VNFIM-RGEDTELDRTFEIGEPLLHLLRNAIDHGIEPPPILILSARHEGNNVIEVEDDGR-GIDKEKIIRKAIEKGLIDESKAATLSDQLNF-LFVPGFKVSEVSGRMDVVKNVVESLNGSGIESEKD-KGTKVTPLT

4xj6A1

0.16

0.13

0.82

0.57

MUSTER

------------------------------SKTESDKLKALRQIVRERTRDVFQEARQVAIDVRRQALTLESVRLKLEKTNYLSPEERADLARLIFEMEDEARDDFIKFQPRFEMDIDDGTYMPMTVFESEPS-IGHTLLLLLVDTSLKSAENDGWVFEEKGRIKIYREKTHIDVP------MYAIPKEVESDKVNLALREGVRRWS-VS

4xmqA

0.07

0.97

0.54

dPPAS

NQTDLLKVTQSTVEDFRSTNQSFTRALEKDIANLPYQSLITEENIINNVGPILKYYRHSINALNVYLGLNNGKVLLSQKSNDAKMPELRDDLDIKTKDWYQEALKTNDI---FVTPAYLDTVLSKAIYKDGKII---GVLSEDLQNLVAKTPGNTFLFDQKNKIFAATNKELLNPSIDHSPVLNAYKLNGDNNFFSYKLNNEEFAYTACI

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.61

Estimated TM-score = 0.24±0.07

Estimated RMSD = 16.9±2.8Å

Download Model 2

C-score=-4.75

Download Model 3

C-score=-4.43

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwnA	0.700	3.43	0.124	0.890
2	5cwmA	0.669	4.12	0.090	0.919
3	5cwlA	0.658	2.65	0.090	0.790
4	4u1dC	0.634	3.17	0.104	0.809
5	5cwhA	0.627	2.42	0.045	0.738
6	4c0eA	0.627	3.93	0.053	0.857
7	4by6A	0.624	3.77	0.060	0.848
8	3j7jA	0.623	3.26	0.105	0.800
9	5cwjA	0.617	2.67	0.115	0.743
10	3m1iC	0.615	4.19	0.068	0.867

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.08	4	1go8P	ZN	Rep, Mult	99,103,105
2	0.06	3	1o6oA	III	Rep, Mult	13,34,84,87,90,91
3	0.04	2	1s4bP	ZN	Rep, Mult	99,103,114
4	0.04	2	1v7uA	FPP	Rep, Mult	37,40,41,91,94,95,98,101,102,105
5	0.04	2	1ocoO	HEA	Rep, Mult	57,94,95
6	0.04	2	2yevB	HAS	Rep, Mult	49,50,53,102
7	0.04	2	3hy6A	MG	Rep, Mult	135,136,137
8	0.04	2	5csdB	ACD	Rep, Mult	33,50,53,56,60,91,95,114,118,122,125,126,129,135,142
9	0.02	1	2jfrA	MG	Rep, Mult	100,130
10	0.02	1	1upkA	III	Rep, Mult	10,13,14,18,58
11	0.02	1	3obvB	SUC	Rep, Mult	55,56,59,60,63
12	0.02	1	1xzwB	UUU	Rep, Mult	153,156
13	0.02	1	2bptA	III	Rep, Mult	13,33,34,87,90
14	0.02	1	1zoyC	EPH	Rep, Mult	146,149
15	0.02	1	4rkuL	CLA	Rep, Mult	53,57

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1y791	0.479	5.47	0.072	0.771	3.4.15.5	NA
2	0.060	1fa2A	0.496	5.31	0.049	0.819	3.2.1.2	NA
3	0.060	2eabA	0.490	5.12	0.021	0.781	3.2.1.63	NA
4	0.060	1cb8A	0.486	4.38	0.042	0.705	4.2.2.5	NA
5	0.060	1dl2A	0.492	5.28	0.044	0.795	3.2.1.113	7
6	0.060	2qnoA	0.483	5.08	0.056	0.767	3.2.1.4	NA
7	0.060	1ojnA	0.482	4.55	0.107	0.700	4.2.2.1	NA
8	0.060	2gtqA	0.512	4.48	0.012	0.738	3.4.11.2	NA
9	0.060	1wdpA	0.508	5.05	0.033	0.819	3.2.1.2	NA
10	0.060	3ismC	0.491	3.35	0.030	0.629	3.6.1.3	6,34,86
11	0.060	1kktA	0.485	5.33	0.042	0.767	3.2.1.113	NA
12	0.060	3cyvA	0.490	4.99	0.034	0.752	4.1.1.37	NA
13	0.060	3ebgA	0.512	4.25	0.096	0.729	3.4.11.-	NA
14	0.060	1gaiA	0.497	4.71	0.072	0.752	3.2.1.3	NA
15	0.060	1ujkB	0.459	3.90	0.074	0.624	3.4.23.46	10,14
16	0.060	1rw9A	0.495	5.28	0.074	0.790	4.2.2.5	NA
17	0.060	2vn4A	0.497	4.80	0.060	0.752	3.2.1.3	NA
18	0.060	1j0mA	0.519	4.79	0.089	0.776	4.2.2.12	NA
19	0.060	1l2aE	0.489	5.01	0.034	0.762	3.2.1.4	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.560	4.64	0.04	0.83	4uvkA	GO:0000755 GO:0003682 GO:0005634 GO:0005829 GO:0006473 GO:0007064 GO:0009847 GO:0031505 GO:0031618 GO:0031934 GO:0034990 GO:1990707
1	0.07	0.460	4.26	0.08	0.69	1s70B	GO:0005737 GO:0007165 GO:0019208 GO:0019901 GO:0030018 GO:0030155 GO:0031672 GO:0035507 GO:0071889 GO:0072357
2	0.07	0.442	5.29	0.10	0.71	3l0oA	GO:0000166 GO:0003676 GO:0003723 GO:0004386 GO:0005524 GO:0006351 GO:0006353 GO:0006355 GO:0008186 GO:0016787
3	0.06	0.372	5.21	0.05	0.62	5et1A	GO:0003779 GO:0005737 GO:0005856 GO:0005902 GO:0005903 GO:0007605 GO:0007626 GO:0015629 GO:0017124 GO:0030046 GO:0030054 GO:0031941 GO:0032420 GO:0032421 GO:0032426 GO:0042995 GO:0043197 GO:0051015 GO:0051017 GO:0051491 GO:0051494 GO:0051639
4	0.06	0.389	4.15	0.03	0.55	4rlvA	GO:0002027 GO:0003283 GO:0005200 GO:0005622 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0006874 GO:0006888 GO:0007165 GO:0007399 GO:0008093 GO:0010628 GO:0010881 GO:0010882 GO:0014704 GO:0016020 GO:0016323 GO:0016324 GO:0019899 GO:0019901 GO:0030018 GO:0030054 GO:0030315 GO:0030507 GO:0030674 GO:0030913 GO:0031430 GO:0031647 GO:0031672 GO:0033292 GO:0033365 GO:0034394 GO:0034613 GO:0036309 GO:0036371 GO:0042383 GO:0043005 GO:0043034 GO:0043268 GO:0044325 GO:0045121 GO:0045202 GO:0045211 GO:0050821 GO:0051117 GO:0051279 GO:0051597 GO:0051924 GO:0051928 GO:0055117 GO:0060307 GO:0070296 GO:0070972 GO:0072659 GO:0072661 GO:0086004 GO:0086005 GO:0086014 GO:0086015 GO:0086046 GO:0086066 GO:0086070 GO:0086091 GO:0098907 GO:0098910 GO:1901018 GO:1901019 GO:1901021 GO:2001259
5	0.06	0.363	5.09	0.07	0.58	2y4uA	GO:0004860 GO:0005737 GO:0005783 GO:0005788 GO:0005790 GO:0005829 GO:0006417 GO:0006986 GO:0016020 GO:0019901 GO:0031205 GO:0036494 GO:0036498 GO:0043066 GO:0051087 GO:0051603 GO:0051607 GO:0051787 GO:0070062 GO:0070417 GO:1903561 GO:1903912 GO:1904030
6	0.06	0.366	4.69	0.11	0.57	1n0rA
7	0.06	0.422	5.14	0.04	0.67	3renA	GO:0003824 GO:0004553 GO:0005975 GO:0016020 GO:0016021 GO:0016787
8	0.06	0.332	5.73	0.05	0.58	3wwpA	GO:0016829 GO:0046872
9	0.06	0.331	5.72	0.05	0.59	2cuzA	GO:0000049 GO:0000166 GO:0004812 GO:0004818 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006424 GO:0016874 GO:0016876 GO:0043039
10	0.06	0.315	5.71	0.03	0.52	4p7kA	GO:0000287 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006584 GO:0007565 GO:0007612 GO:0007614 GO:0008168 GO:0008171 GO:0008210 GO:0009712 GO:0014070 GO:0016020 GO:0016021 GO:0016036 GO:0016206 GO:0016740 GO:0030424 GO:0030425 GO:0032259 GO:0032496 GO:0032502 GO:0035814 GO:0042135 GO:0042417 GO:0042420 GO:0042493 GO:0043197 GO:0044297 GO:0045211 GO:0045963 GO:0046498 GO:0046500 GO:0046872 GO:0048265 GO:0048609 GO:0048662 GO:0050668 GO:0051930 GO:0070062
11	0.06	0.295	4.76	0.03	0.44	4otkA	GO:0005618 GO:0005886 GO:0016491 GO:0040007 GO:0055114
12	0.06	0.301	3.20	0.12	0.38	2zgdA
13	0.06	0.291	3.80	0.04	0.39	1eq1A	GO:0005576 GO:0006810 GO:0006869 GO:0008289
14	0.06	0.290	6.08	0.04	0.55	2f6uA	GO:0000287 GO:0002094 GO:0005737 GO:0006629 GO:0006650 GO:0008654 GO:0016740 GO:0016765 GO:0046474 GO:0046872 GO:0047294
15	0.06	0.285	4.77	0.02	0.42	4k3vB	GO:0006810 GO:0007155 GO:0030001 GO:0046872
16	0.06	0.256	5.37	0.06	0.41	3h7mA	GO:0000155 GO:0000160 GO:0000166 GO:0005524 GO:0005622 GO:0007165 GO:0016020 GO:0016021 GO:0016301 GO:0016310 GO:0016740 GO:0016772 GO:0023014
17	0.06	0.216	4.00	0.04	0.30	2fc3A	GO:0001682 GO:0003723 GO:0003735 GO:0004526 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0008033 GO:0019843 GO:0030529 GO:0042254 GO:0090501 GO:0090502
18	0.06	0.212	4.53	0.01	0.31	1f6vA	GO:0000166 GO:0003677 GO:0005524 GO:0006260 GO:0006313 GO:0015074 GO:0016787 GO:0016887 GO:0030430 GO:0032196 GO:0039693 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0019901	GO:0003682	GO:0005200	GO:0019208	GO:0051015	GO:0071889	GO:0044325	GO:0030507	GO:0008093	GO:0004386	GO:0017124	GO:0008186	GO:0005524	GO:0051117	GO:0003723
GO-Score	0.12	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07
Biological Processes	GO:0031505	GO:0006473	GO:0000755	GO:0009847	GO:0007064	GO:0036309	GO:0034394	GO:0098907	GO:0006353	GO:0030155	GO:1901018	GO:0070972	GO:0030913	GO:0072661	GO:0050821	GO:0086091	GO:0051491	GO:0086005	GO:0051494	GO:0010881	GO:2001259	GO:0010628	GO:0003283	GO:0030046	GO:0007626	GO:1901021	GO:0006888	GO:0035507	GO:0033292	GO:0036371	GO:0060307	GO:0051597	GO:0098910	GO:0007605	GO:0086046	GO:0006355	GO:0051639
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07
Cellular Component	GO:0044424
GO-Score	0.36

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.