I-TASSER results

I-TASSER results for job id Rv1288

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (456 residues)
MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVA
GDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAA
RFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQ
TSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIV
MPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGA
LKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVS
ADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHE
VPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD
Prediction	CCEEEEHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEHCCEEEHCCCCCEEEHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHCCCCCCEEHCCCCEEHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCHHHHHCHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
Conf.Score	986788758876999999989987899999998699998756578899868898577758987899999989986788999987599986657888799968988655556886444454568998568889987588998777777655566667777766555556677654555544555666554568867887788988768998679999988656666759999986996999778999888888888888887567899999999999987999888886799877568999999998877467566437888888876554567788887755676666788878856787759899999977985899967899987544455468899999999999999899979999699766775889999999999999986577666679
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD
Prediction	744404033411002005424042510430162170532120200010203454303022412012004424144522330262160432320300030304554413034422013003313244221210021120100010100212222222222222222222222222222202021112222010000221446544151232012000110001131020330045240000000010000000021123343200000052004102730413553420000000000200000002103101000000000103431333333331332134232420111222345303210023005504623000000336422000000120202510440151057370502010113344034300350044004202401223545568
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCEEEEHCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEHCCEEEHCCCCCEEEHCCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEEHCCCCCCEEHCCCCEEHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEHCCCCCCCCCCEEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCHHHHHCHHHHHHCCCCEEEHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEHCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
MVSTHAVVAGETLSALALRFYGDAELYRLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALALRFYGDAELNWLIAAASGIADPDVVNVGQRLIMPDFTRYTVVAGDTLSALAARFYGDASLYPLIAAVNGIADPGVIDVGQVLVIFIGRSDGFGLRIVDRNENDPRLWYYRFQTSAIGWNPGVNVLLPDDYRTSGRTYPVLYLFHGGGTDQDFRTFDFLGIRDLTAGKPIIIVMPDGGHAGWYSNPVSSFVGPRNWETFHIAQLLPWIEANFRTYAEYDGRAVAGFSMGGFGALKYAAKYYGHFASASSHSGPASLRRDFGLVVHWANLSSAVLDLGGGTVYGAPLWDQARVSADNPVERIDSYRNKRIFLVAGTSPDPANWFDSVNETQVLAGQREFRERLSNAGIPHESHEVPGGHVFRPDMFRLDLDGIVARLRPASIGAAAERAD

4h18A

0.19

0.13

0.67

1.78

MUSTER

----------------------------------------------------------------------------------------------------------------------------AEVTPADVAGDTALS--------TISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNT---DGQRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFELE------

4h18A

0.20

0.13

0.67

2.62

dPPAS

-----------------------------------------------------------------------------------------------------------------------------AEVTPADVAGDTA-------LSTISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNTDG---QRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFELE------

4h18A

0.20

0.13

0.67

3.70

wdPPAS

-----------------------------------------------------------------------------------------------------------------------------AEVTPADVAGDTAL-------STISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNT---DGQRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFELE------

4h18A

0.20

0.13

0.67

2.15

wMUSTER

-----------------------------------------------------------------------------------------------------------------------AEVT------PADVAGDTA-------LSTISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNT---DGQRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFEL------E

4h18A

0.20

0.13

0.67

3.61

wPPAS

----------------------------------------------------------------------------------------------------------------AEVTPADVAGDTALS----TISDSAPADEA----------------SAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNT---DGQRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFEL------E

4h18A

0.20

0.13

0.67

5.32

dPPAS2

-----------------------------------------------------------------------------------------------------------------------------AEVTPADVAGDTA-------LSTISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNTDG---QRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFELE------

4h18A

0.20

0.13

0.66

3.03

PPAS

----------------------------------------------------------------------------------------------------------------------------------------AEVTPGDTALSTISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNT---DGQRAIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPR--GGEYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFELE------

4h18A

0.19

0.13

0.67

4.29

Env-PPAS

-----------------------------------------------------------------------------------------------------------------------------AEVTPADVAGDTA-------LSTISDSAPADEASAPRWRAHVNAADERVKEMWAYSPSMDRNVPLVVITADES---AGPRPVIYLLNGGDGGEGANWVMQTDVLDFYLEKNVNVVIPMEGKFSYYTDWVEELGGKQMWETFLVKELPGPLEEKLNTDGQR---AIAGMSMSATTSLLFPQHFPGFYDAAASFSGCAATSSLLPWEYLKLTLDRG--NATPEQMWGPRGG--EYNIYNDALINSDKLRGTELYVSNASGLAGEWETGGIIEAATNKCTHDLKAKLDSAGIPADWNLRPGTHSW--GWWQDDLRGSWTTFARAFELE------

1f0nA

0.22

0.13

0.59

1.57

MUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------SRPGLPVEYLQVPSPSMGRDIKVQFQSG------GNNSPAVYLLDGLRAQDDYNWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGTYKWETFLTSELPQWLSANRAV--KPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDA-GGYKAADMWGPS--SDPAWERNDPTQQIPKLVNTRLWVYCGNGTPGANIPAEFLENFVRSSNLKFQDAYNAAGGHNAVFNFPGTHSW--EYWGAQLNAMKGDLQSSLGAG------

1f0nA

0.21

0.13

0.59

2.31

dPPAS

-----------------------------------------------------------------------------------------------------------------------------------------------------------------------SRPGLPVEYLQVPSPSMGRDIKVQFQSG------GNNSPAVYLLDGLRAQDDYNWDINTPAFEWYYQSGLSIVMPVGGQSSFYSDWYSPACGKYKWETFLTSELPQWLSANRAV--KPTGSAAIGLSMAGSSAMILAAYHPQQFIYAGSLSALLDPSQGMGPSLIGLAMGDA-GGYKAADMWGPS--SDPAWERNDPTQQIPKLVNTRLWVYCGNGTPNELGGANFLENFVRSSNLKFQDAYNAAGGHNAVFNFPGTHSW--EYWGAQLNAMKGDLQSSLGAG------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.74

Estimated TM-score = 0.40±0.13

Estimated RMSD = 13.8±3.9Å

Download Model 2

C-score=-3.08

Download Model 3

C-score=-3.44

Download Model 4

C-score=-3.46

Download Model 5

C-score=-3.96

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4h18A	0.656	1.33	0.189	0.673
2	1f0nA	0.541	2.53	0.203	0.586
3	1r88A	0.525	2.69	0.202	0.572
4	4b6gA	0.509	2.82	0.189	0.566
5	3ls2A	0.506	2.84	0.195	0.561
6	3fcxB	0.503	2.78	0.173	0.557
7	1pv1A	0.502	3.04	0.174	0.566
8	3i6yA	0.501	2.97	0.196	0.559
9	2veoA	0.501	4.15	0.088	0.614
10	4rotA	0.499	2.95	0.221	0.555

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.26	7	1dqyA	DEP	Rep, Mult	213,214,293,294,295,320,386,387,432
2	0.09	3	1va5A	SOG	Rep, Mult	213,214,215,294,320,328,332,335,425,427
3	0.07	2	3hrhB	GOL	Rep, Mult	249,250,251,264,302,303,349,362
4	0.06	2	1f0pA	MPD	Rep, Mult	294,320,331
5	0.06	2	1u8eA	UUU	Rep, Mult	292,312,314,315,316
6	0.03	1	3hrhB	GOL	Rep, Mult	249,295,298,299,320,323,349,363

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.261	3c6bA	0.501	3.02	0.175	0.564	3.1.2.12	216,219,295,425
2	0.076	3fcxB	0.503	2.78	0.173	0.557	3.1.2.12	294,425
3	0.066	3fcyA	0.483	4.38	0.106	0.599	3.1.1.41	315
4	0.060	1hlgA	0.464	3.95	0.093	0.555	3.1.1.3	NA
5	0.060	1vlqA	0.485	4.31	0.115	0.597	3.1.1.41	317
6	0.060	2gbcA	0.477	4.32	0.076	0.579	3.4.14.5,3.4.15.5	318
7	0.060	1c7jA	0.471	5.56	0.112	0.627	3.1.1.-	294
8	0.060	1crlA	0.468	5.51	0.110	0.627	3.1.1.3	NA
9	0.060	3fvrA	0.489	4.13	0.104	0.597	3.1.1.6	NA
10	0.060	2fj0A	0.473	5.63	0.101	0.629	3.1.1.1	NA
11	0.060	1cleA	0.471	5.43	0.118	0.621	3.1.1.3	NA
12	0.060	1r9mB	0.478	4.27	0.071	0.579	3.4.14.5	318
13	0.060	1ac5A	0.463	4.51	0.074	0.581	3.4.16.6	NA
14	0.060	2ecfA	0.485	3.92	0.091	0.575	3.4.14.5	NA
15	0.060	1mx9D	0.475	5.78	0.112	0.647	3.1.1.1	NA
16	0.060	1k4yA	0.468	5.91	0.117	0.640	3.1.1.1	NA
17	0.060	2qr5A	0.479	4.10	0.089	0.575	3.4.19.1	317
18	0.060	1yr2A	0.488	4.17	0.103	0.594	3.4.21.26	294
19	0.060	2veoB	0.499	4.19	0.091	0.616	3.1.1.3	245
20	0.060	2bklB	0.490	4.40	0.077	0.608	3.4.21.26	316
21	0.060	1eveA	0.485	4.78	0.101	0.614	3.1.1.7	NA
22	0.060	1l7aA	0.488	4.13	0.108	0.594	3.1.1.72,3.1.1.41	294

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.20	0.549	2.47	0.19	0.59	1dqyA	GO:0004144 GO:0005576 GO:0005618 GO:0006869 GO:0009247 GO:0016740 GO:0016746 GO:0016747 GO:0046677 GO:0050348 GO:0071769
1	0.18	0.472	3.14	0.22	0.53	2uz0A
2	0.16	0.549	2.56	0.19	0.60	1sfrA	GO:0004144 GO:0005576 GO:0005618 GO:0005737 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0044119 GO:0044121 GO:0050348
3	0.14	0.525	2.69	0.20	0.57	1r88A	GO:0005576 GO:0016740 GO:0016746
4	0.13	0.509	2.82	0.19	0.57	4b6gA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
5	0.12	0.502	3.04	0.17	0.57	1pv1A	GO:0005737 GO:0005829 GO:0016787 GO:0018738 GO:0046294 GO:0052689
6	0.10	0.511	2.92	0.20	0.57	3i6yA	GO:0016787 GO:0018738 GO:0046294 GO:0052689
7	0.09	0.541	2.53	0.20	0.59	1f0nA	GO:0004144 GO:0005576 GO:0005618 GO:0005886 GO:0016740 GO:0016746 GO:0016747 GO:0040007 GO:0044119 GO:0046677 GO:0050348 GO:0052572
8	0.09	0.506	2.84	0.20	0.56	3ls2A	GO:0016787 GO:0018738 GO:0046294 GO:0052689
9	0.08	0.503	2.78	0.17	0.56	3fcxB	GO:0005737 GO:0005788 GO:0016023 GO:0016787 GO:0016788 GO:0018738 GO:0031410 GO:0046294 GO:0047374 GO:0052689 GO:0070062 GO:1901687
10	0.07	0.454	3.77	0.14	0.54	4opmA	GO:0004806 GO:0016787
11	0.07	0.508	2.86	0.16	0.57	3e4dA	GO:0016787 GO:0018738 GO:0046294 GO:0046872 GO:0052689
12	0.06	0.405	4.10	0.14	0.49	3p2mA	GO:0052689
13	0.06	0.387	6.98	0.03	0.62	1yiqA	GO:0005509 GO:0009055 GO:0016020 GO:0016491 GO:0016614 GO:0020037 GO:0042597 GO:0046872 GO:0055114 GO:0070968
14	0.06	0.337	5.69	0.04	0.47	1pcaA	GO:0004180 GO:0004181 GO:0005576 GO:0005615 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0046872
15	0.06	0.276	6.74	0.06	0.43	2imcB	GO:0004222 GO:0005576 GO:0006508 GO:0008233 GO:0008237 GO:0008270 GO:0008320 GO:0009405 GO:0016020 GO:0016021 GO:0016787 GO:0020002 GO:0030430 GO:0033644 GO:0044156 GO:0044164 GO:0044221 GO:0044231 GO:0046872 GO:0050827 GO:0051609 GO:0071806
16	0.06	0.320	6.27	0.06	0.47	1lfwA	GO:0005737 GO:0006508 GO:0008152 GO:0008233 GO:0008237 GO:0008270 GO:0016787 GO:0016805 GO:0046872
17	0.06	0.200	6.07	0.02	0.29	4oj2X	GO:0003091 GO:0003097 GO:0005215 GO:0005372 GO:0005794 GO:0005886 GO:0005887 GO:0006810 GO:0006833 GO:0007588 GO:0009992 GO:0015168 GO:0015250 GO:0015254 GO:0015793 GO:0016020 GO:0016021 GO:0016323 GO:0016324 GO:0030658 GO:0030659 GO:0031410 GO:0034220 GO:0042631 GO:0055037 GO:0070062 GO:0071280 GO:0071288 GO:0072205
18	0.06	0.195	5.83	0.04	0.28	2qx0A	GO:0003848 GO:0009396 GO:0016301 GO:0016310 GO:0016740
19	0.06	0.195	5.25	0.04	0.26	5etlD	GO:0000166 GO:0000287 GO:0003848 GO:0005524 GO:0009396 GO:0016301 GO:0016310 GO:0016740 GO:0046654 GO:0046656
20	0.06	0.181	6.57	0.04	0.28	4jfdE	GO:0005886 GO:0006955 GO:0016020 GO:0016021 GO:0031295 GO:0050776 GO:0050852

Consensus prediction of GO terms

Molecular Function	GO:0050348	GO:0004144
GO-Score	0.33	0.33
Biological Processes	GO:0046467	GO:0042221	GO:0010876	GO:0071766	GO:1901137	GO:0006664	GO:0071702	GO:0044765	GO:0022607	GO:0044119
GO-Score	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.40	0.32
Cellular Component	GO:0005576	GO:0005618	GO:0044424
GO-Score	0.42	0.33	0.32

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.