I-TASSER results

I-TASSER results for job id Rv1277

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (417 residues)
MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQLGMTRHFLAGDAQPRY
SAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSLEAMRVIGLPVYLLPGN
HDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAAPWRSKAPTTDPVAEVLA
GLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQAIHYVALGDKHSLTQVGS
SGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTVDARRIGRWRFVTLHHQVDT
SRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDTCLDKYARLFAWLGLWERHTD
LAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAVDAQAALALLLRLADRGAA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSLEAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAAPWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQAIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTVDARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDTCLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAVDAQAALALLLRLADRGAA
Prediction	CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCHHHHHHHHCCCCCEEHCCCCCEEEEHCCEEEEHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEHCCCCCCEEHCCCCCEHCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCEEEEEEEEHCCCEEEEEEEEHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEHCCHHHHHHHHHHHHHHHHHHCEEEEEHCCCCEEHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
Conf.Score	998888778888876677887777776655567756898745678988789987578999999999999999999998999999968877899999999999999999869989998898999886775688888867889799858985799869989998689986577889999998768888858999864678888887776556876555777657997898678767767679997885898888887667889978999998599775567999998575679999998589888999999999866778868999999866856899999999999998543677654456465566466887485569999999999998757657999999999999999986579
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSLEAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAAPWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQAIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTVDARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDTCLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAVDAQAALALLLRLADRGAA
Prediction	754543644633321312621402175233424132011102120122133245544530250024004300510473502000000101336312240033004104717010000001013244431122101324214100003444122134200000000123331242034015413562200000000101334354233121324303430234300000000002013037532000101402120404454410000000256445340504324044130340414064563054025205614565310000103130416234204501550362021022245335142334453055142641023004302631665654324204401410340155668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEHCCCCCCCCCCCCHHHHHHHHCCCCCEEHCCCCCEEEEHCCEEEEHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEHCCCCCCEEHCCCCCEHCCCCCCCCCCCCCCCCCCEEEEEEHCCCCCCEEEEEEEEHCCCEEEEEEEEHCCCCCCHHHHHHHHHHCCCCCCCEEEEEEEEHCCHHHHHHHHHHHHHHHHHHCEEEEEHCCCCEEHCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
MSPRPGPAGRGPAPCRCADLHSLCVDSHALRRDGMRFLHTADWQLGMTRHFLAGDAQPRYSAARRDAVAGLKALAADVGAEFVVVAGDVFEHNQLAPQIVGQSLEAMRVIGLPVYLLPGNHDPLDASSVYTSTLFRAERPDNVVVLDRAGVHEVRPGVQIVAAPWRSKAPTTDPVAEVLAGLPTDAAIRLLVAHGGVDALDPDHDKPSLIRLAALDDALTRQAIHYVALGDKHSLTQVGSSGRVWYSGAPEVTNFDDVEPDPGHVLVVDIDESDPRHPVTVDARRIGRWRFVTLHHQVDTSRDIADLDLNLDLMTDKDRTVVRLALTGSLTVTDRAALDTCLDKYARLFAWLGLWERHTDLAVIPVDAEFTDLGIGGFAAAAVDELVATARGGDDESAVDAQAALALLLRLADRGAA

3auzA

0.18

0.13

0.73

1.72

MUSTER

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPLRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPL---ALLKDYVKILDGKDVINVNEEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLD---YELEHFDL------PKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEKEGKGFYLVDFSGNDLDIS-DIEKIDIECRE--FVEVNIKDKKSFNEAVNKIERCKNK--PVVFGKIKREFKPWFDTLKDKIL-----INKAIIVDDEFIDMPD------------------------------------------------------

3auzA

0.17

0.13

0.73

2.27

dPPAS

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPLRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLA---LLKDYVKILDGKDVINVNGEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLDYELEHFD---------LPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEDEGKGFYLVDFSGNDLDIS---DIEKIDIECREFVEVNIKDKKSFNEAVNKIERCKNKP------VVFGKI----KREFKPWFDTLKDKILINKAIIVDDEFIDMPD---------------------------------------------------

3auzA

0.18

0.13

0.73

3.26

wdPPAS

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPLRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLA---LLKDYVKILDGKDVINVNEEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLD---------YELEHFDLPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEDEGKGFYLVDFSGNDLD-ISDIEKIDIECRE--FVEVNIKDKKSFNEAVNKIERCKNK--PVVFGKIKREFKPWFDTLKDKIL--------AIIVDDEFIDMPD------------------------------------------------------

3auzA

0.18

0.13

0.72

2.20

wMUSTER

--------------------------------SHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPLRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPL---ALLKDYVKILDGKDVINVNEEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLD---------YELEHFDLPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEKEGKGFYLVDFSGNDLDIS-DIEKIDIECRE--FVEVNIKDKKSFNEAVNKIERCKNK--PVVFGKIKREFKPWFDTLKDKI------LINKAIIVDDEPD---------------------------------------------------------

3auzA

0.17

0.13

0.73

3.55

wPPAS

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHIKVYIVAGNHEMPRRLGEESPLA---LLKDYVKILDGKDVINVNEEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLDYE---------LEHFDLPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEDEGKGFYLVDFSGNDLD-ISDIEKIDIECRE--FVEVNIKDKKSFNEAVNKIERCKNKP--VVFGKIKREFKPWFDTLKDKIL--------AIIVDDEFIDMPD------------------------------------------------------

3auzA

0.17

0.12

0.73

4.24

dPPAS2

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPLRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLA---LLKDYVKILDGKDVINVNGEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLD---YELEHFD------LPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEDEGKGFYLVDFSGNDLD-ISDIEKIDIECR--EFVEVNIKDKKSFNEAVNKIERCKNKP------VVFGKI----KREFKPWFDTLKDKILINKAIIVDDEFIDMPD---------------------------------------------------

3auzA

0.17

0.12

0.73

3.11

PPAS

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPLRIAMQAFKKLHENNIKVYIVAGNHEMPRRLGEESPLA---LLKDYVKILDGKDVINVNEEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLDYE---------LEHFDLPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEDEGKGFYLVDFSGNDLD-ISDIEKIDIECRE--FVEVNIKDKKSFNEAVNKIERCKNKP--VVFGKIKRE--FKPWFDTLKDKILINK---AIIVDDEFIDMPD------------------------------------------------------

3auzA

0.17

0.12

0.73

3.99

Env-PPAS

------------------------------RGSHMMFVHIADNHLGYRQYNL-----DDREKDIYDSFKLCIKKILEIKPDVVLHSGDLFNDLRPPVKALRIAMQAFKKLHIKVYIVAGNHEMPRRLGEESPLAL---LKDYVKILDGKDVINVNEEIFICGTYYHKKSKREEMLDKLKNFEAKNYKKKILMLHQGINPYIPLD---YELEHFD------LPKFSYYALGHIHKRILERNDGILAYSGSTEIIYRNEYEDEGKGFYLVDFSGNDLD-ISDIEKIDIECRE--FVEVNIKDKKSFNEAVNKIERCKN--KPVVFGKIKREFKPWFDTLKDKIL-----INKAIIVDDEFIDMPD------------------------------------------------------

4ltyC

0.17

0.12

0.72

1.66

MUSTER

-------------------------------IEFMRILHTSDWHLGQNFYSKS------REAEHQAFLDWLLETAQTHQVDAIIVAGDVFDTGSPPRTLYNRFVVNLQQTGCHLVVLAGNHDSVATLNESRDIMAFLNTT--VVASAGHAPQILPRRAVLCPIPFLRPDYYQQHYADACKLRGDQPLPIIATGHLTTVGASSDAVRDIYIGTLDAFPAQNFPPADYIALGHIHRAQIIGGMEHVRYCGSPIPLSFDECGK-SKYVHLVTFSNG---KLESVENLNVPVTQMAVLKG------DLASITAQLEQ--QEPPVWLDIEID-----EYLHDIQRKIQALTESLPVEVLLV-------------------------------------------------------------

4ltyC

0.17

0.12

0.73

2.22

dPPAS

-------------------------------IEFMRILHTSDWHLGQNFYSKS------REAEHQAFLDWLLETAQTHQVDAIIVAGDVFDTGSPPRTLYNRFVVNLQQTGCHLVVLAGNHDSVATLNESRDIMAFLNTTVVASAGHAPQILPRRDGAVLCPIPFLRPDYYQQHYADACKLRGDQPLPIIATGHLTTVGASSDAVRDIYIGTLDAFPAQNFPPADYIALGHIHRAQIIGGMEHVRYCGSPIPLSFDECGKS-KYVHLVTFSNGKLESVENLNVPVTQPMAVLKG--------DLASITAQL--EQQEPPVWLDIEIDEYL-HDIQRKIQALTESLPVEVLLV-----------------------------------------------------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.04

Estimated TM-score = 0.58±0.14

Estimated RMSD = 9.3±4.6Å

Download Model 2

C-score=-2.10

Download Model 3

C-score=-1.94

Download Model 4

C-score=-2.38

Download Model 5

C-score=-1.95

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3auzA	0.717	1.18	0.170	0.734
2	4ykeA	0.624	3.53	0.154	0.729
3	4fbkA	0.619	3.46	0.124	0.719
4	1s8eA	0.612	2.75	0.180	0.679
5	3t1iA	0.608	3.58	0.137	0.712
6	4ltyC	0.602	3.39	0.168	0.698
7	2q8uA	0.559	3.64	0.147	0.664
8	2xmoA	0.554	4.60	0.105	0.700
9	5ebbA	0.542	4.56	0.103	0.681
10	5karA	0.540	4.42	0.091	0.671

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.56	75	3d03E	CO	Rep, Mult	42,88,120,121,194,231
2	0.41	52	4hd0B	MN	Rep, Mult	42,44,88,231,233
3	0.01	2	3dscA	NUC	Rep, Mult	46,47,48,49,50,51,52,58,91,348
4	0.00	1	3dsdA	QNA	Rep, Mult	94,123,125,166,167,170
5	0.00	1	2qfpA	NA	Rep, Mult	120,121,207,231

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.128	2nxfA	0.456	3.65	0.138	0.537	3.6.1.16,3.6.1.53,3.6.1.13	205,231
2	0.060	1a0dA	0.404	7.00	0.051	0.664	5.3.1.5	NA
3	0.060	2x58A	0.399	6.75	0.092	0.655	5.3.3.8,4.2.1.17,1.1.1.35	NA
4	0.060	1kbpA	0.466	4.06	0.098	0.564	3.1.3.2	NA
5	0.060	4kbpA	0.467	4.15	0.097	0.568	3.1.3.2	120
6	0.060	1a0eA	0.409	6.11	0.045	0.616	5.3.1.5	NA
7	0.060	1yq2A	0.403	6.73	0.058	0.643	3.2.1.23	NA
8	0.060	1zcjA	0.400	6.78	0.096	0.657	1.1.1.35	NA
9	0.060	1warA	0.476	3.84	0.181	0.568	3.1.3.2	121,233
10	0.060	3e0jA	0.409	4.49	0.123	0.501	2.7.7.7	123
11	0.060	1jcmP	0.319	5.06	0.066	0.434	4.1.1.48,5.3.1.24	NA
12	0.060	2j62A	0.458	5.85	0.063	0.667	3.2.1.52	NA
13	0.060	3ilvA	0.421	6.06	0.059	0.624	6.3.5.1	91
14	0.060	1piiA	0.432	6.61	0.050	0.679	4.1.1.48,5.3.1.24	NA
15	0.060	2vvnA	0.462	5.94	0.037	0.681	3.2.1.52	290
16	0.060	2epoB	0.460	6.13	0.049	0.691	3.2.1.52	NA
17	0.060	1a0dD	0.404	7.00	0.051	0.664	5.3.1.5	87,253
18	0.060	1djgB	0.419	6.24	0.052	0.640	3.1.4.11	NA
19	0.060	1xzwB	0.462	4.27	0.095	0.566	3.1.3.2	NA
20	0.060	2j5wA	0.407	7.30	0.065	0.698	1.16.3.1	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.41	0.694	1.80	0.15	0.72	3av0A	GO:0004518 GO:0004519 GO:0004527 GO:0006281 GO:0006302 GO:0006974 GO:0016787 GO:0030145 GO:0042802 GO:0046872 GO:0090305
1	0.39	0.467	3.35	0.17	0.54	3d03A	GO:0000166 GO:0004115 GO:0016787 GO:0046872
2	0.25	0.596	3.71	0.13	0.71	3qg5D	GO:0003677 GO:0004518 GO:0004519 GO:0004527 GO:0006259 GO:0006260 GO:0006310 GO:0008408 GO:0016787 GO:0046872 GO:0090305
3	0.20	0.624	3.50	0.15	0.73	4ykeB	GO:0004518 GO:0004519 GO:0004527 GO:0005634 GO:0006281 GO:0006302 GO:0006974 GO:0008408 GO:0016787 GO:0030145 GO:0030870 GO:0046872 GO:0051321 GO:0090305
4	0.19	0.615	2.65	0.19	0.68	3dscA	GO:0004518 GO:0004519 GO:0004527 GO:0006281 GO:0006302 GO:0006974 GO:0016787 GO:0030145 GO:0042802 GO:0046872 GO:0090305
5	0.19	0.611	3.33	0.14	0.71	4fcxB	GO:0000014 GO:0000723 GO:0000724 GO:0000729 GO:0000784 GO:0004518 GO:0004519 GO:0004527 GO:0005634 GO:0006281 GO:0006302 GO:0006303 GO:0006974 GO:0007131 GO:0008310 GO:0008311 GO:0008408 GO:0016787 GO:0030145 GO:0030870 GO:0031573 GO:0034613 GO:0035861 GO:0042138 GO:0051321 GO:1990421 GO:1990918
6	0.18	0.608	3.61	0.17	0.72	4ltyA	GO:0004518 GO:0004519 GO:0004527 GO:0006259 GO:0006260 GO:0006310 GO:0008408 GO:0016787 GO:0046872 GO:0090305
7	0.17	0.611	3.57	0.13	0.71	3t1iD	GO:0000014 GO:0000019 GO:0000724 GO:0000729 GO:0000731 GO:0000732 GO:0000781 GO:0000784 GO:0000790 GO:0000794 GO:0003677 GO:0003690 GO:0004003 GO:0004518 GO:0004519 GO:0004520 GO:0004527 GO:0005634 GO:0005654 GO:0005694 GO:0005737 GO:0005829 GO:0005913 GO:0006260 GO:0006281 GO:0006302 GO:0006303 GO:0006310 GO:0006974 GO:0007004 GO:0007062 GO:0007095 GO:0007129 GO:0007131 GO:0007507 GO:0008022 GO:0008283 GO:0008408 GO:0016032 GO:0016605 GO:0016787 GO:0030145 GO:0030870 GO:0031573 GO:0031860 GO:0031954 GO:0032206 GO:0032481 GO:0032508 GO:0032876 GO:0033674 GO:0035861 GO:0043066 GO:0046597 GO:0048471 GO:0051276 GO:0051321 GO:0090305 GO:0098609 GO:0098641 GO:1901796
8	0.17	0.619	3.46	0.12	0.72	4fbkA	GO:0000014 GO:0000723 GO:0000724 GO:0000729 GO:0000784 GO:0004518 GO:0004519 GO:0004527 GO:0005634 GO:0006281 GO:0006302 GO:0006303 GO:0006974 GO:0007131 GO:0008310 GO:0008311 GO:0008408 GO:0016787 GO:0030145 GO:0030870 GO:0031573 GO:0034613 GO:0035861 GO:0042138 GO:0051321 GO:1990421 GO:1990918
9	0.06	0.362	7.18	0.05	0.61	3u7vA	GO:0004553 GO:0004565 GO:0005975 GO:0008152 GO:0009341 GO:0016787 GO:0016798
10	0.06	0.325	7.51	0.03	0.58	1pguB	GO:0003779 GO:0005737 GO:0005856 GO:0005884 GO:0006970 GO:0030042 GO:0030479 GO:0032466 GO:0051016
11	0.06	0.339	6.00	0.06	0.51	4as2A	GO:0046872
12	0.06	0.264	5.93	0.04	0.39	4x9xA	GO:0008289
13	0.06	0.246	5.72	0.06	0.36	2nyvA	GO:0005975 GO:0008152 GO:0008967 GO:0016311 GO:0016787 GO:0046295 GO:0046872
14	0.06	0.230	6.35	0.04	0.35	4dgqA	GO:0004601 GO:0016491 GO:0016691 GO:0055114 GO:0098869
15	0.06	0.217	6.50	0.05	0.34	1bwzA	GO:0005737 GO:0008652 GO:0008837 GO:0009085 GO:0009089 GO:0016853
16	0.06	0.256	7.29	0.05	0.44	4imhA	GO:0006826 GO:0046872
17	0.06	0.217	5.50	0.04	0.30	1pmtA	GO:0004364 GO:0005737 GO:0016740
18	0.06	0.219	5.12	0.07	0.30	4bziB	GO:0000139 GO:0000166 GO:0000266 GO:0003400 GO:0003924 GO:0005525 GO:0005622 GO:0005739 GO:0005783 GO:0005789 GO:0005794 GO:0006810 GO:0006886 GO:0007006 GO:0012507 GO:0015031 GO:0016020 GO:0016050 GO:0016192 GO:0016787 GO:0030127 GO:0031410 GO:0044233 GO:0044802 GO:0070971

Consensus prediction of GO terms

Molecular Function	GO:0004519	GO:0030145	GO:0042802	GO:0003676	GO:0008408	GO:0004115	GO:0000166
GO-Score	0.71	0.62	0.52	0.51	0.40	0.39	0.39
Biological Processes	GO:0090305	GO:0006302	GO:0034645	GO:0044702	GO:0007049
GO-Score	0.71	0.62	0.51	0.40	0.40
Cellular Component	GO:0044428	GO:0043234
GO-Score	0.40	0.40

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.