I-TASSER results

I-TASSER results for job id Rv1268c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (232 residues)
MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAAKYWRQQTYDDCVLMS
AADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHPNSGMGTSVADIPTLLA
HYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAEMIWGQPVEETDSAGNPR
SDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWATSHDFMAVTT

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAAKYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHPNSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAEMIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWATSHDFMAVTT
Prediction	CCCCCHHHHHHHCCHCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCEEEEHCCCCCCCCCEEHCHHHHHHHHHHHCCEEEEHC
Conf.Score	9876566666544444566665667778877887568657766665444567888489999999999869999999999999986986678755655777777778888888899999999899647865666544456787999999999899699998566446777776777777788779999999889998999689999888666679999999998598799979
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAAKYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHPNSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAEMIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWATSHDFMAVTT
Prediction	6534422421432333334223314254346344030112144325204424242010100010033135450326301520473422243242224454353444431242520240055241424234344444544423053036106743200000214302444465445344521200000000137542000000125735634132620250054443201227
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHCCHCCCCCCCCCCCCCCCCCCCCEEHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCEEHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEHCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEHCCCCEEEEHCCCCCCCCCEEHCHHHHHHHHHHHCCEEEEHC
MTTSKIATAFKTATFALAAGAVALGLASPADAAAGTMYGDPAAAAKYWRQQTYDDCVLMSAADVIGQVTGREPSERAIIKVAQSTPSVVHPGSIYTKPADAEHPNSGMGTSVADIPTLLAHYGVDAVITDEDHATATGVATGMAALEQYLGSGHAVIVSINAEMIWGQPVEETDSAGNPRSDHAVVVTGVDTENGIVHLNDSGTPTGRDEQIPMETFVEAWATSHDFMAVTT

3ervA

0.16

0.12

0.79

1.47

MUSTER

-------------------------------DEKVILSNVPFIQQ---LPELDRGCEVTSLAMMLQYA--ITVDKMKLANEIKKVDFMGNPNEGFVGNI-YTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPL-KDSLDVKVPREKFEQAWVQMGSQAISYV

3ervA

0.15

0.12

0.80

1.49

dPPAS

-------------------------------DEKVILSNVPFIQQ---LPELDRGCEVTSLAMMLQYAG-ITVDKMKLANEIKKVDFMNDGPNEGFVGNIYTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPLKDS-LDVKVPREKFEQAWVQMGSQAISYV

3ervA

0.16

0.12

0.78

3.01

wdPPAS

--------------------------------DEKVIL----SNVPFIQQELDRGCEVTSLAMMLQYA--ITVDKMKLANEIKKVDFRGNPNEGFVGNI-YTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPLKDS-LDVKVPREKFEQAWVQMGSQAISYV

3ervA

0.16

0.12

0.78

2.00

wMUSTER

--------------------------------EKVIL-----SNVPFIQQELDRGCEVTSLAMMLQYA--ITVDKMKLANEIKKVDFMGNPNEGFVGNI-YTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPL-KDSLDVKVPREKFEQAWVQMGSQAISYS

3ervA

0.16

0.12

0.78

3.65

wPPAS

--------------------------------DEKVI-----SNVPFIQQELDRGCEVTSLAMMLQYA--ITVDKMKLANEIKKVDFRGNPNEGFVGNI-YTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPLKDS-LDVKVPREKFEQAWVQMGSQAISYV

3ervA

0.16

0.12

0.79

4.01

dPPAS2

--------------------------------DEKVIL----SNVPFIQQELDRGCEVTSLAMMLQYAG-ITVDKMKLANEIKKVDFRGNPNEGFV-GNIYTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPLKDS-LDVKVPREKFEQAWVQMGSQAISYV

3ervA

0.16

0.12

0.78

2.40

PPAS

--------------------------------DEKVIL----SNVPFIQQELDRGCEVTSLAMMLQYA--ITVDKMKLANEIKKVDFRGNPNEGFV-GNIYTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPLKDS-LDVKVPREKFEQAWVQMGSQAISYV

3ervA

0.16

0.12

0.79

2.89

Env-PPAS

--------------------------------DEKVIL----SNVPFIQQELDRGCEVTSLAMMLQYAG-ITVDKMKLANEIKKVDFRGNPNEGFV-GNIYTFSESGYGVYHGPLFQLAKKY--------LPNKAVDLTGKSIEELYKSVKAGQPVVIITNATFAPLDEDENNGDVSITYNEHCVVLIGYD--QESVYIRDPLKDS-LDVKVPREKFEQAWVQMGSQAISYV

3k8uA

0.19

0.11

0.58

0.95

MUSTER

-------------------------------------------HYKLVPQIDTRDCGPAVLASVAKHYG-SNYSIAYLRELSK---------------------TNKQGTTALGIVEAAKKLGFETRSIKADMTLFDYNDLTY-----------PFIVHVIKG---------------KRLQHYYVVYGSQ--NNQLIIGDPD-PSVKVTRMSKERFQSEWT----LAIFLA

3k8uA

0.19

0.11

0.58

0.82

dPPAS

-------------------------------------------HYKLVPQIDTRDCGPAVLASVAKHYG-SNYSIAYLRELSK---------------------TNKQGTTALGIVEAAKKLGFETRSIKADMTLFDYNDLT-----------YPFIVHVIKG---------------KRLQHYYVVYGSQ--NNQLIIGDP-DPSVKVTRMSKERFQSEWT---GLAIFLA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-1.54

Estimated TM-score = 0.53±0.15

Estimated RMSD = 9.1±4.6Å

Download Model 2

C-score=-1.81

Download Model 3

C-score=-2.00

Download Model 4

C-score=-3.08

Download Model 5

C-score=-1.94

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3ervA	0.754	1.28	0.164	0.789
2	3oisA	0.627	3.37	0.142	0.780
3	4ci7A	0.616	3.40	0.113	0.767
4	3hhiA	0.614	3.63	0.108	0.776
5	2pbhA	0.614	3.65	0.087	0.780
6	1deuA	0.610	3.75	0.101	0.784
7	5fpwA	0.610	3.64	0.091	0.776
8	3qj3A2	0.610	3.81	0.149	0.797
9	1pciA	0.608	3.50	0.119	0.763
10	3qt4A	0.607	3.83	0.125	0.784

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.23	24	2fraA	CRV	Rep, Mult	50,54,55,56,57,98,110,111,159,182,184,227
2	0.19	16	1ppdA	BME	Rep, Mult	50,54,56,182,183
3	0.02	2	8pchA	III	Rep, Mult	56,110,111,137,138,159,182,184,227,228
4	0.02	2	2fkwD	BCL	Rep, Mult	153,156
5	0.01	1	2wvkA	ZN	Rep, Mult	183,193
6	0.01	1	2aznB	MA5	Rep, Mult	199,200
7	0.01	1	1z2nX	MG	Rep, Mult	191,201
8	0.01	1	3mpeA	N2A	Rep, Mult	115,116,117,137,183,184,227
9	0.01	1	2x8fA	CA	Rep, Mult	41,183
10	0.01	1	2wl3A	CA	Rep, Mult	91,132
11	0.01	1	3fcsC	IMD	Rep, Mult	173,224

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.428	1iwdA	0.570	3.20	0.132	0.703	3.4.22.-	50,56,183,200
2	0.418	2pnsA	0.564	3.20	0.121	0.694	3.4.22.-	50,56,183,200
3	0.417	1cqdA	0.571	3.35	0.114	0.707	3.4.22.67	50,56,183,200
4	0.413	1o0eA	0.565	3.25	0.116	0.694	3.4.22.-	50,56,183,200
5	0.371	1bp4A	0.566	3.31	0.162	0.703	3.4.22.2	50,56,183
6	0.342	2efmA	0.575	3.09	0.145	0.703	3.4.22.51	50,56,183
7	0.341	1s4vB	0.576	3.30	0.130	0.716	3.4.22.-	50,56,183
8	0.338	2fo5A	0.580	3.26	0.124	0.716	3.4.22.-	50,56,183
9	0.320	2bdzA	0.565	3.14	0.152	0.690	3.4.22.-	50,56,183
10	0.316	1cv8A	0.549	3.24	0.070	0.668	3.4.22.48	50,56,183
11	0.244	3f75A	0.586	3.57	0.136	0.746	3.4.22.15	56,183
12	0.117	1cqdC	0.571	3.35	0.114	0.707	3.4.22.67	50,56,183,203
13	0.107	3bpmA	0.592	4.01	0.110	0.772	3.4.22.-	50,56,183,200
14	0.093	9papA	0.567	3.15	0.158	0.694	3.4.22.2	56,107
15	0.088	1jqpA	0.578	3.84	0.100	0.746	3.4.14.1	50,56,183,200
16	0.084	2ghuA	0.594	3.78	0.115	0.767	3.4.22.-	50,56,183,200
17	0.070	3d6sA	0.603	3.25	0.112	0.750	3.4.22.65	50,56,183,200
18	0.067	1m6dA	0.574	3.46	0.129	0.724	3.4.22.41	NA
19	0.067	1nb3A	0.593	3.39	0.098	0.737	3.4.22.16	189
20	0.067	2frqA	0.573	3.36	0.112	0.716	3.4.22.27	NA
21	0.060	2c0yA	0.594	3.48	0.089	0.750	3.4.22.27	50,183
22	0.060	1fh0A	0.578	3.44	0.116	0.724	3.4.22.43	56,182
23	0.060	2o6xA	0.601	3.84	0.103	0.780	3.4.22.15	50,200
24	0.060	7pckD	0.572	3.43	0.103	0.720	3.4.22.38	50,56,183
25	0.060	7pckA	0.598	3.67	0.102	0.767	3.4.22.38	220
26	0.060	1csbE	0.450	3.35	0.090	0.556	3.4.22.1	113
27	0.060	2nqdB	0.572	3.42	0.134	0.720	3.4.22.15	109,158,183,202
28	0.060	1itoA	0.589	3.31	0.087	0.724	3.4.22.1	51,56
29	0.060	1megA	0.572	3.19	0.138	0.703	3.4.22.30	56,184,203
30	0.060	1gecE	0.574	3.28	0.132	0.707	3.4.22.25	56,183,200
31	0.060	2oz2C	0.574	3.09	0.145	0.703	3.4.22.51	51,56,107,183,204
32	0.060	1aecA	0.575	3.22	0.142	0.711	3.4.22.14	50,56,183
33	0.060	1pbhA	0.614	3.62	0.097	0.780	3.4.22.1	NA
34	0.060	2djfC	0.180	3.53	0.121	0.228	3.4.14.1	184,202
35	0.060	8pchA	0.593	3.24	0.103	0.733	3.4.22.16	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.25	0.512	2.26	0.18	0.58	3k8uA	GO:0000166 GO:0005524 GO:0006508 GO:0006810 GO:0008233 GO:0008234 GO:0016020 GO:0016021 GO:0016887 GO:0022885 GO:0042626 GO:0043213 GO:0055085
1	0.22	0.586	3.57	0.14	0.75	3f75A	GO:0006508 GO:0008233 GO:0008234 GO:0016020 GO:0016021 GO:0016787
2	0.22	0.549	3.24	0.07	0.67	1cv8A	GO:0005576 GO:0006508 GO:0008233 GO:0008234 GO:0009405 GO:0016787
3	0.21	0.618	3.54	0.07	0.78	1mirA	GO:0004175 GO:0004197 GO:0005576 GO:0005615 GO:0005737 GO:0005739 GO:0005764 GO:0005901 GO:0006508 GO:0006914 GO:0007283 GO:0007519 GO:0008233 GO:0008234 GO:0009611 GO:0009612 GO:0009749 GO:0009897 GO:0009986 GO:0014070 GO:0014075 GO:0016324 GO:0016787 GO:0030984 GO:0032403 GO:0034097 GO:0042277 GO:0042383 GO:0042470 GO:0043434 GO:0043621 GO:0045471 GO:0048471 GO:0050790 GO:0051603 GO:0060548 GO:0070670 GO:0071260
4	0.21	0.754	1.28	0.16	0.79	3ervA	GO:0016020 GO:0016021
5	0.20	0.574	3.28	0.13	0.71	1gecE	GO:0006508 GO:0008233 GO:0008234 GO:0016787
6	0.15	0.462	2.31	0.13	0.53	3b79A	GO:0000166 GO:0005524 GO:0006508 GO:0006810 GO:0008233 GO:0016020 GO:0016021 GO:0016887 GO:0042626 GO:0055085
7	0.14	0.463	2.44	0.08	0.53	3zuaA	GO:0000166 GO:0005524 GO:0005886 GO:0006508 GO:0006810 GO:0008233 GO:0008565 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0030253 GO:0030256 GO:0042626 GO:0055085
8	0.14	0.614	3.63	0.09	0.78	1pbhA	GO:0002224 GO:0004175 GO:0004197 GO:0004252 GO:0005518 GO:0005576 GO:0005615 GO:0005622 GO:0005730 GO:0005737 GO:0005739 GO:0005764 GO:0005901 GO:0006508 GO:0006914 GO:0007283 GO:0007519 GO:0008233 GO:0008234 GO:0009611 GO:0009612 GO:0009749 GO:0009897 GO:0009986 GO:0014070 GO:0014075 GO:0016324 GO:0016787 GO:0030574 GO:0030855 GO:0030984 GO:0032403 GO:0034097 GO:0036021 GO:0042277 GO:0042383 GO:0042470 GO:0042981 GO:0043231 GO:0043394 GO:0043434 GO:0043621 GO:0045471 GO:0046697 GO:0046718 GO:0048471 GO:0050790 GO:0051603 GO:0060548 GO:0070062 GO:0070670 GO:0071260 GO:0097067
9	0.07	0.627	3.37	0.14	0.78	3oisA	GO:0000166 GO:0006508 GO:0008233 GO:0008234
10	0.07	0.614	3.66	0.09	0.78	4i04B	GO:0004197 GO:0005615 GO:0005764 GO:0006508 GO:0008233 GO:0008234 GO:0016787 GO:0050790 GO:0051603
11	0.07	0.610	3.81	0.15	0.80	3qj3A	GO:0006508 GO:0008233 GO:0008234 GO:0016787
12	0.07	0.582	3.40	0.12	0.73	2b1nA	GO:0006508 GO:0008234
13	0.07	0.603	3.25	0.11	0.75	3d6sA	GO:0005576 GO:0006508 GO:0008233 GO:0008234 GO:0016787
14	0.07	0.609	3.76	0.09	0.78	5egwA	GO:0006508 GO:0008233 GO:0008234 GO:0016787
15	0.07	0.591	3.84	0.12	0.78	1cs8A	GO:0001968 GO:0002224 GO:0002250 GO:0004197 GO:0004252 GO:0005518 GO:0005576 GO:0005615 GO:0005634 GO:0005764 GO:0006508 GO:0008233 GO:0008234 GO:0016787 GO:0019882 GO:0019886 GO:0022617 GO:0030574 GO:0036021 GO:0042393 GO:0043202 GO:0043394 GO:0051603 GO:0070062 GO:0071888 GO:0097067 GO:0097655
16	0.07	0.598	3.80	0.10	0.77	1a6rA	GO:0000122 GO:0000978 GO:0003677 GO:0003690 GO:0003697 GO:0003729 GO:0004197 GO:0005737 GO:0005739 GO:0006508 GO:0008233 GO:0008234 GO:0016787 GO:0043418 GO:0046677
17	0.07	0.604	3.27	0.11	0.75	1xkgA	GO:0005576 GO:0006508 GO:0008233 GO:0008234 GO:0016787
18	0.07	0.616	3.40	0.11	0.77	4ci7A	GO:0006508 GO:0008233 GO:0008234 GO:0046872
19	0.07	0.601	3.84	0.10	0.78	2o6xA	GO:0004175 GO:0004197 GO:0005576 GO:0006508 GO:0008233 GO:0008234 GO:0016787
20	0.07	0.617	3.59	0.10	0.78	4n4zA	GO:0004197 GO:0005615 GO:0005764 GO:0006508 GO:0008234 GO:0016787 GO:0051603
21	0.07	0.590	3.29	0.09	0.72	2dc6A	GO:0004197 GO:0005518 GO:0005576 GO:0005615 GO:0005730 GO:0005739 GO:0005764 GO:0006508 GO:0008233 GO:0008234 GO:0016787 GO:0030574 GO:0030855 GO:0042470 GO:0043231 GO:0043394 GO:0046697 GO:0046718 GO:0048471 GO:0050790 GO:0051603 GO:0070062 GO:0097067
22	0.07	0.579	3.40	0.10	0.72	3n4cB	GO:0001968 GO:0002224 GO:0002250 GO:0004197 GO:0004252 GO:0005518 GO:0005576 GO:0005615 GO:0005764 GO:0006508 GO:0006955 GO:0008233 GO:0008234 GO:0010447 GO:0016485 GO:0016787 GO:0019882 GO:0019886 GO:0022617 GO:0030574 GO:0034769 GO:0036021 GO:0043202 GO:0043231 GO:0043236 GO:0043394 GO:0048002 GO:0051603 GO:0097067 GO:2001259

Consensus prediction of GO terms

Molecular Function	GO:0008234	GO:0032559	GO:1904680	GO:0032550	GO:0043492	GO:0015450	GO:0035639	GO:0016820	GO:0005515	GO:0033218	GO:0044877
GO-Score	0.64	0.51	0.51	0.51	0.51	0.51	0.51	0.51	0.42	0.42	0.42
Biological Processes	GO:0006508	GO:0044765	GO:0015833	GO:0048232	GO:0009725	GO:0010941	GO:0014706	GO:0071496	GO:0065009	GO:0044257	GO:0006950	GO:0071214	GO:0060538	GO:0097305	GO:0009746	GO:0048523	GO:1901652
GO-Score	0.64	0.51	0.51	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.42
Cellular Component	GO:0016021	GO:0048770	GO:0009986	GO:0045177	GO:0044853	GO:0044421	GO:0098552	GO:0000323
GO-Score	0.54	0.42	0.42	0.42	0.42	0.42	0.42	0.42

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.