I-TASSER results

I-TASSER results for job id Rv1265

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (226 residues)
MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHGRRYGRPGGWQQAQQP
DASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPEEESAARASGRVSRFRD
ETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMTRLKQPERQVLDTLVDAG
VARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGPDLPA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHGRRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPEEESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMTRLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGPDLPA
Prediction	CCCCCCCCCCCCCCCCEEEHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCEEEEEEEEEEEEHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
Conf.Score	9878887655566775567657788885444455566664678888888898877778999889999998679974457897799967868999977899988655777788658999999999999999999999899765668888978888886555545555578999999999844566999999999999999999999999999999999998999999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHGRRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPEEESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMTRLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGPDLPA
Prediction	6423335221221453030313163342414204421244334544434444415546425274035101331254026341513133520100040353746655552445431550376037412510540364263402103415744321331102011214444240031015222241314000000310252155005403510540550376347368
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCEEEHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCEEEEHCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHCCEEEEEEEEEEEEHHHHCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
MVLARPDAVFAPARNRCHVSLPVNAMSLKMKVCNHVIMRHHHMHGRRYGRPGGWQQAQQPDASGAAEWFAGRLPEDWFDGDPTVIVDREEITVIGKLPGLESPEEESAARASGRVSRFRDETRPERMTIADEAQNRYGRKVSWGVEVGGERILFTHIAVPVMTRLKQPERQVLDTLVDAGVARSRSDALAWSVKLVGEHTEEWLAKLRTAMSAVDDLRAQGPDLPA

5cwnA

0.15

0.13

0.87

0.69

MUSTER

---MDPEEILERAK-------------ESLERAREASERGD-------------EEEFRKAAEKALELAKRLVEQAKKEGDPELVLEAAKVALVAELAAKNGDKEKAAESALEVAKRLVEVASKEDPELVLEAAKVALRVAELAAKNGDKEVF-AESALEVAKRLVEVASKEGDPELVEEAAKVAEEVRKLAKKQDEEVYEKARETAREVKEELKRVREEKGGWLE

5cwdA

0.11

0.08

0.74

0.61

dPPAS

----------------------------------------------------------TKEDARSTCEKAARKAAESNDEEVAKQAAKDCLEVAKQAGMPTKEAARSFCEAAARAAAESEEVAKIAAKACLEVAKQAGMPTKEAARSFCEAAARAAAESNDEEVAKIAAKACLEVAKQAGMTKEAARSFCEAAKRAAKESNDEEVEKIAKKACKEVAKQAGPWLE-

1rhcA

0.13

0.12

0.90

0.53

wdPPAS

AWMG---AA-LQATKKVFISTCITCPIMRAIVAQTFATLRQMYPGR--GA--GEAMGEWPSVPVRQDMTVEAV---W-ESDKPVTFKGDYFTLDKAYTKPDDEMGPKGAKLAGMYG--PSTLKNVTIPKFEEGAREAGKDPS-------EHAMLIWYSVPDYDKAVEALRFWAGCLVPSMFKYKVYDPKEVQLHANLVHCDTIKENAEEMIKEIERFKEAG--INH

1kyhA

0.16

0.15

0.89

0.58

wMUSTER

LLLAGSDALLA-ARSKLVIGTSENVIPLIVPVLPE-AT-YWRDGWKKAADAQLEETYRAPQTESVQQAVDHVLTAD----CP-VILDAG-------LAKRTYPKREGPV--PGEFFRTVNELQKKRAEYAKEWAAQLQTVIVLVIAFPDGDCWLNPTGNGALAK----TGDTLTGILGLCCHEDPKHAVLNAVYLHGACAELWTDEAHELSDILPRVWKR---FE-

2rekB

0.22

0.15

0.67

0.52

wPPAS

----RADA----RRNYDRI----------IEAAAAEVARH------------GAD-ASLEEARRA----SATL---HF---P----SRWGLLVF----------QERVAQLCDEARSLAAE--------PATALTRW-SLAVFGAV---TRGAARSLLAALDSRCEQLLTEAGADLLARAQED-RALELLSLANAVSLAAEDAAHHATRLMGIALGLGA--P----

5cwjA

0.16

0.08

0.51

0.75

dPPAS2

-----------------------------------------------------------------------------------------------------DSEEEQERIRRILKEARKSGTEESLRQAIEDVAQLA-------KKSQDSEV--LEEAIRVILRIAKALRQAIRAVAEIAKEAQDSEVLEEAIRVILRIAKESEEALRQAIRAVAEIAKEAQDPRV

2raeA

0.10

0.08

0.77

0.61

PPAS

--IGRR-----PSTTQDRI----------STVGIELFTEQ------------GFDATSVDEAEASRRTLFRYFPNAIPWGDFDAHLAE--RAQLAAQPDDIPIVDGLTAALLQFNAFPASEEINHRKRMGLILRVPALQAY-------------------SVVMYEGWRNVIAEYVASRLPTDHVPRTVGYLLLGVAMSAYEQWLDLNELLASGMQSLYDG--LSS

1ut9A2

0.16

0.15

0.91

0.60

Env-PPAS

IPIEMPYAGEQWTRPAGHIGIEPNKGDTNV-PTWPQDDEYAGIPQKNYTKTGGWYDAVVNGAVWTLMNMYERAKI-RGLDNWGPYRD-------GGMNIPEQNNG---------YPDILDEARWEIEFFKKMQVTEKEDPSIAG-MVHHKIHDFRWTALGMLPHEDPQPRYLRP--VSTAATLNFAATLAQSARLWKDYDPTFAADCLEKAEIAWQAALKHPDIYA

5cwpA

0.12

0.96

0.69

MUSTER

MSSDEEEARAKEAAERAQEAAERTGDP-RVRELARELKRLAQEAAEEVKRDPSSSDVNEALIVEAIEAAVRALEAAERTGDPEVELARELVRLAVEAAEVQRNPSSSDVNEALKLIVEAIEAAVRALEAAERTGDPEVRELA--------RELVRLAVEAAEEVQRNPSSEEVNEALKKIVKAIQEAVESLREAEEPEKREKARERVREAVERAEEVQRDPSGWLE

4a99A2

0.11

0.10

0.95

0.61

dPPAS

SVYERDNDREARIFGGTLDLHKGSGQEAMKKAGLLQTYYDLALPVKPENRFDNP----EINRNDLRAILLNSLENDWDRKLVMLEPGKKKWTLTFENKPSETADL--VILANGGMSKVRKFVTDTEVERIFPLEKPWKSKRPLPITMIGDAAHLMPPFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIYGKEAQEESTQNEIEMFK-----PDFTF

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-4.08

Estimated TM-score = 0.28±0.09

Estimated RMSD = 15.6±3.3Å

Download Model 2

C-score=-5.00

Download Model 3

C-score=-4.73

Download Model 4

C-score=-5.00

Download Model 5

C-score=-5.00

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5cwnA	0.612	4.13	0.133	0.850
2	5cwmA	0.609	4.37	0.131	0.876
3	1vsy4	0.587	4.46	0.051	0.858
4	4c0oA	0.583	4.03	0.092	0.788
5	5t8vA	0.581	4.59	0.046	0.854
6	5hb4B	0.580	4.63	0.053	0.867
7	3a6pA4	0.578	4.41	0.024	0.832
8	2x1gF	0.572	4.53	0.074	0.836
9	1vsy5	0.572	4.36	0.054	0.827
10	5dlqB3	0.571	4.55	0.073	0.827

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.04	2	3huzF	MG	Rep, Mult	174,185
2	0.04	2	1f59A	III	Rep, Mult	127,128,131,132,172,176,180
3	0.04	2	2px0B	GNP	Rep, Mult	175,218
4	0.04	2	2bptA	III	Rep, Mult	159,162,163,166,167,206,209
5	0.04	2	4id0B	ACT	Rep, Mult	78,113,117
6	0.02	1	2iubC	MG	Rep, Mult	75,76
7	0.02	1	1i12B	IMD	Rep, Mult	174,177
8	0.02	1	1u6g0	III	Rep, Mult	80,81,121,122,123
9	0.02	1	2nr9A	PA6	Rep, Mult	69,73
10	0.02	1	4qvuA	ZN	Rep, Mult	156,199,202
11	0.02	1	3obvA	SUC	Rep, Mult	135,139,183,187,190
12	0.02	1	1xvbA	BBU	Rep, Mult	185,186,187
13	0.02	1	3ic3D	BGC	Rep, Mult	119,123
14	0.02	1	1m32A	PLP	Rep, Mult	154,155
15	0.02	1	3lsmA	SO3	Rep, Mult	185,197
16	0.02	1	1o6pA	III	Rep, Mult	120,123,166,169,171,172
17	0.02	1	1y4jA	CA	Rep, Mult	174,176,180,196,198
18	0.02	1	2xecB	CA	Rep, Mult	88,132
19	0.02	1	3n12A	ZN	Rep, Mult	89,146
20	0.02	1	2a68P	MG	Rep, Mult	202,205

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1dl2A	0.488	5.05	0.062	0.765	3.2.1.113	NA
2	0.060	1fw8A	0.452	5.37	0.038	0.739	2.7.2.3	140,189
3	0.060	2eabA	0.463	5.46	0.056	0.752	3.2.1.63	NA
4	0.060	1i8qA	0.458	5.73	0.071	0.796	4.2.2.1	128
5	0.060	1pclA	0.457	4.94	0.054	0.708	4.2.2.2	NA
6	0.060	1p7cB	0.454	4.92	0.045	0.690	2.7.1.21	NA
7	0.060	3drwA	0.472	4.86	0.095	0.726	2.7.1.146	207
8	0.060	1hn0A	0.494	5.74	0.061	0.845	4.2.2.20	117
9	0.060	1ojnA	0.464	5.44	0.050	0.779	4.2.2.1	NA
10	0.060	1h54B	0.490	4.95	0.023	0.748	2.4.1.8	NA
11	0.060	1n2lA	0.457	6.08	0.066	0.823	3.1.6.8	NA
12	0.060	1ho8A	0.522	4.83	0.075	0.810	3.6.3.14	202
13	0.060	1f1sA	0.464	5.30	0.068	0.743	4.2.2.1	NA
14	0.060	3c5wA	0.500	4.51	0.089	0.730	3.1.3.16	NA
15	0.060	3dsxA	0.430	5.30	0.043	0.690	2.5.1.60	NA
16	0.060	2v1yA	0.168	4.65	0.062	0.243	2.7.1.153	176
17	0.060	1fa2A	0.448	5.79	0.094	0.757	3.2.1.2	NA
18	0.060	3evhA	0.454	5.79	0.048	0.783	4.2.2.3	NA
19	0.060	1dceA	0.454	3.80	0.053	0.606	2.5.1.60	27

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.07	0.585	4.61	0.06	0.87	4v7oA5	GO:0000502 GO:0005634 GO:0005737 GO:0005839 GO:0006281 GO:0006974 GO:0010499 GO:0010952 GO:0016504 GO:0034515 GO:0043248 GO:0043486 GO:0061136 GO:0070577 GO:0070628 GO:1990236 GO:1990237
1	0.07	0.522	4.96	0.10	0.82	4uvkA	GO:0000755 GO:0003682 GO:0005634 GO:0005829 GO:0006473 GO:0007064 GO:0009847 GO:0031505 GO:0031618 GO:0031934 GO:0034990 GO:1990707
2	0.06	0.424	5.00	0.08	0.64	3l0oA	GO:0000166 GO:0003676 GO:0003723 GO:0004386 GO:0005524 GO:0006351 GO:0006353 GO:0006355 GO:0008186 GO:0016787
3	0.06	0.386	5.78	0.05	0.67	3renA	GO:0003824 GO:0004553 GO:0005975 GO:0016020 GO:0016021 GO:0016787
4	0.06	0.405	5.01	0.04	0.61	2y4uA	GO:0004860 GO:0005737 GO:0005783 GO:0005788 GO:0005790 GO:0005829 GO:0006417 GO:0006986 GO:0016020 GO:0019901 GO:0031205 GO:0036494 GO:0036498 GO:0043066 GO:0051087 GO:0051603 GO:0051607 GO:0051787 GO:0070062 GO:0070417 GO:1903561 GO:1903912 GO:1904030
5	0.06	0.472	5.31	0.05	0.76	5dllA	GO:0004177 GO:0006508 GO:0008237 GO:0008270 GO:0016787
6	0.06	0.346	5.67	0.04	0.60	1o4sB	GO:0003824 GO:0004069 GO:0005737 GO:0008483 GO:0009058 GO:0016740 GO:0030170 GO:0080130
7	0.06	0.382	5.65	0.04	0.63	2pulA	GO:0000166 GO:0005524 GO:0008652 GO:0009086 GO:0016301 GO:0016310 GO:0016740 GO:0019284 GO:0019509 GO:0046522
8	0.06	0.350	4.85	0.01	0.53	3ftqA	GO:0000145 GO:0000166 GO:0000775 GO:0000776 GO:0000777 GO:0000910 GO:0002036 GO:0003924 GO:0005525 GO:0005634 GO:0005694 GO:0005730 GO:0005737 GO:0005819 GO:0005826 GO:0005856 GO:0005876 GO:0005886 GO:0005930 GO:0005938 GO:0007049 GO:0007067 GO:0007224 GO:0009986 GO:0015629 GO:0015630 GO:0016020 GO:0030234 GO:0030496 GO:0031105 GO:0031175 GO:0031513 GO:0032154 GO:0032391 GO:0032880 GO:0032947 GO:0035869 GO:0042384 GO:0042802 GO:0042995 GO:0043209 GO:0045202 GO:0048471 GO:0050790 GO:0051258 GO:0051301 GO:0060170 GO:0070062
9	0.06	0.327	5.90	0.06	0.57	3wwpA	GO:0016829 GO:0046872
10	0.06	0.292	6.41	0.02	0.55	4k3vB	GO:0006810 GO:0007155 GO:0030001 GO:0046872
11	0.06	0.313	6.10	0.05	0.54	2cuzA	GO:0000049 GO:0000166 GO:0004812 GO:0004818 GO:0005524 GO:0005737 GO:0006412 GO:0006418 GO:0006424 GO:0016874 GO:0016876 GO:0043039
12	0.06	0.289	4.53	0.02	0.42	2x9qA	GO:0016740 GO:0016755 GO:0016875
13	0.06	0.335	4.70	0.05	0.51	1n0rA
14	0.06	0.310	5.46	0.04	0.52	4p7kA	GO:0000287 GO:0005737 GO:0005739 GO:0005829 GO:0005886 GO:0006584 GO:0007565 GO:0007612 GO:0007614 GO:0008168 GO:0008171 GO:0008210 GO:0009712 GO:0014070 GO:0016020 GO:0016021 GO:0016036 GO:0016206 GO:0016740 GO:0030424 GO:0030425 GO:0032259 GO:0032496 GO:0032502 GO:0035814 GO:0042135 GO:0042417 GO:0042420 GO:0042493 GO:0043197 GO:0044297 GO:0045211 GO:0045963 GO:0046498 GO:0046500 GO:0046872 GO:0048265 GO:0048609 GO:0048662 GO:0050668 GO:0051930 GO:0070062
15	0.06	0.267	6.14	0.04	0.49	3ig2B	GO:0000049 GO:0000166 GO:0000287 GO:0003723 GO:0004812 GO:0004826 GO:0005524 GO:0005737 GO:0006412 GO:0006432 GO:0008033 GO:0016874 GO:0046872
16	0.06	0.289	5.80	0.04	0.51	2i3fA
17	0.06	0.290	5.94	0.05	0.50	2f6uA	GO:0000287 GO:0002094 GO:0005737 GO:0006629 GO:0006650 GO:0008654 GO:0016740 GO:0016765 GO:0046474 GO:0046872 GO:0047294
18	0.06	0.234	4.26	0.03	0.32	2fc3A	GO:0001682 GO:0003723 GO:0003735 GO:0004526 GO:0005622 GO:0005737 GO:0005840 GO:0006412 GO:0008033 GO:0019843 GO:0030529 GO:0042254 GO:0090501 GO:0090502

Consensus prediction of GO terms

Molecular Function	GO:0016504	GO:0003682	GO:0070577	GO:0070628	GO:0003723	GO:0005524	GO:0004386	GO:0008186	GO:0051787	GO:0004860	GO:0004553	GO:0051087	GO:0019901
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06	0.06	0.06
Biological Processes	GO:1990236	GO:1990237	GO:0009847	GO:0031505	GO:0007064	GO:0000755	GO:0061136	GO:0043248	GO:0043486	GO:0010499	GO:0010952	GO:0006281	GO:0006473	GO:0006353	GO:0006355	GO:1904030	GO:0043066	GO:0036494	GO:0051607	GO:0005975	GO:1903912	GO:0036498	GO:0070417
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06	0.06	0.06	0.06	0.06	0.06
Cellular Component	GO:1990707	GO:0031618	GO:0005839	GO:0034515	GO:0034990	GO:0031934	GO:0016021	GO:0031205	GO:0005790	GO:0005788	GO:0070062
GO-Score	0.07	0.07	0.07	0.07	0.07	0.07	0.06	0.06	0.06	0.06	0.06

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.