I-TASSER results

I-TASSER results for job id Rv1251c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (1139 residues)
MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDELMARAAVLGSAHEGRR
LDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVYQAAMFDGRFVGFADFL
IRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGE
LIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLLVGGMRV
RQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKLQIRQRDTGAPQFEIVDPRP
LTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEAGRAGVFRPLWAHDRTAERQA
LTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPL
VRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEAATVL
KEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDADPIDDGDSLASVLSKFTGD
AAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFDRLNYPVDEWSDSTDVFLASEASVT
VDWHMPPRARKPQRRVRLTGELARGDLNGNVFALYEPPAPPGMTDNPDRRAAGPAAVVET
DDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQLPS
TALMDVLLRRPPRTRSGAALPRSSDPVTDIAAAALDLDSSYLAVHGPPGTGKTYTAARVI
AELVTEHAWRIGVVAQSHATVENLLEGVISAGLDPGQVAKKPHDHTAGRWQSIDGSQYTE
FIRDTAGCVIGGTAWDFANGNRVPKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDP
QQLPQVSQGTHPEPVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGR
LCSHTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPWTDEHGTR
PLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVGTVDKFQGGQAPVVFISMTASSA
DDVPRGISFLLNRNRLNVAVSRAQYAAVIVRSELLTQYLPATPDGLVDLGAFLGLTSTS

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDELMARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVYQAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKLQIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEAGRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALYEPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAAALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAGLDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWDFANGNRVPKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAAVIVRSELLTQYLPATPDGLVDLGAFLGLTSTS
Prediction	CCEHCCEEEHCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEHCCCEEEEHCEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCEEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEHHHHHHHEEEHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCEEEEEEEEEEHCCCCCCCEEEEEEHCCCCCCCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHHHHCCCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEHCCHHHHHHCCCCHHHHHHHHHHHHHHHHC
Conf.Score	97568859986999999998966889999998788888888888999999998999999999999986876897588888746789999999999998997999868748858987447886798799999874888886789999999999999888788859999869967999737899999999999999999778889988888654556775688999999979957758999999999999898549999978998887788999999999999997577888758996787644589999858999667788888888777745667899968988588777499899999999999999999998799859767668999999999998998999999998798565778776536657888765666664577555577878656789999999987688886579999999999986789999999999998776557777777787776666555468899999986567778875689999999998788776657999999987588888875556445567999865667877665557887577777788787668885788777667787655567999999778888756999986578888777786566478888876999999999999998678876578999986789876778888877789999999999858987999889999888999999999999879879999688999999999999877664443566555566655444567777887655569998744666577555667888999966654578999999998997999958888886556777678776699999986666889875766754557899999989987599765789856765578988876777774788876689999999999999998754455567889843389996659999999999999898888886898564467877558999957889988876544446887346666776534788869999875887599999999999998759
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 440 460 480 500 520 540 560 580 600 620 640 660 680 700 720 740 760 780 800 820 840 860 880 900 920 940 960 980 1000 1020 1040 1060 1080 1100 1120 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDELMARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVYQAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKLQIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEAGRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALYEPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAAALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAGLDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWDFANGNRVPKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAAVIVRSELLTQYLPATPDGLVDLGAFLGLTSTS
Prediction	24234330000000011012010000230145254425344634004203620440044005402642342041144342435304400410240045201000000000030000000002262200000011034232400000000000014122210320000003444230302100100330140034004444455241414462031020131035204644100100313450242037230410430162545245044610430241032004545433231411435203301432200000000000123443441100000000124654301000023363034003300410141064223000000031024002300431514362034003520000003101300000141100220010000140344514401300100220141245454441340042035113200300120132024213543144344442455544563642442044024524444443432001000100301210112302300320532244124433011223140324243445434232202042424524443311101325344324444433131202003044452433001023344644212100000134420344202400240044014434402321014002432143354450354244003100010215420000001210100100000000002136100000020020001002111111100000000000000000000000000000110000000000000001100221203000011004000000000031031010000011000003304445032000000032225134331100330311034105311520154462335535425304200000102222362413303400310040023004311344244450445300140413110420252046352642650303122303034230000000000463343001003121000000000010000000320042142014002301000200558
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420                 440                 460                 480                 500                 520                 540                 560                 580                 600                 620                 640                 660                 680                 700                 720                 740                 760                 780                 800                 820                 840                 860                 880                 900                 920                 940                 960                 980                1000                1020                1040                1060                1080                1100                1120

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Sec.Str
Seq

CCEHCCEEEHCHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEHCCCEEEEHCEEEHCCCEEEEEEEHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCEEHCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEHCCCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCCCEEEEEEEEHCCCCCEEEEHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEHHHHHHHEEEHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEEEEEHCCCCCCCCCCCEEEEEHCCCCCCCCCCCCEEEEHCCCCCCCCCCCCCCEEEEEEEEEEHCCCCCCCEEEEEEHCCCCCCCCCCCCEEEHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEHCCCCCCHHHHHHHHHHHHHHHCCCEEEEHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEHHHHCCCCCCCCCCCCEEEEHCCCCHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCEEHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCEEEEEEHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEHCCCCCCCCEEEEEHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCEEEEHCCHHHHHHCCCCHHHHHHHHHHHHHHHHC
MFVTGDSIVYSASDLAAAARCQYALLREFDAKLGRGPAVAVDDELMARAAVLGSAHEGRRLDQLRHEFGDAVAIIGRPAYTPAGLAAAADATRRAIANHAPVVYQAAMFDGRFVGFADFLIRDGHRYRVADTKLARSPTVTALLQLAAYADALVHSGVPVAADAELELGDGTIVRYRVGELIPVYRSQRALLQRLLDGHYTAGTAVRWDDERVQACFRCPQCTERLRASDDLLLVGGMRVRQRDKLLEAGITTIAELADHTAPVPGLTTNALGKLTAQAKLQIRQRDTGAPQFEIVDPRPLTLLPEPNPGDLFFDFEGDPLWTADGKQWGLEYLFGVLEAGRAGVFRPLWAHDRTAERQALTDFLAIVARRRRRHPNMHIYHYAPYEKTALLRLVGRYGIGEDDVDDLLRNGVLVDLYPLVRKSIRVGTDSFSLKALEPLYLGTQPRSGDVTTAADSINSYARYCELRAAGRIDEAATVLKEIEGYNHYDCRSTRALRDWLLMRAWEAGVTPIGAQPVPDADPIDDGDSLASVLSKFTGDAAAGERTPEQTAVALLAAARGYHRREDKPFWWAHFDRLNYPVDEWSDSTDVFLASEASVTVDWHMPPRARKPQRRVRLTGELARGDLNGNVFALYEPPAPPGMTDNPDRRAAGPAAVVETDDPTVPTEVVIVERTGSDGNTFQQLPFALAPGPPVPTTALRESIESTAAAVASGSPQLPSTALMDVLLRRPPRTRSGAALPRSSDPVTDIAAAALDLDSSYLAVHGPPGTGKTYTAARVIAELVTEHAWRIGVVAQSHATVENLLEGVISAGLDPGQVAKKPHDHTAGRWQSIDGSQYTEFIRDTAGCVIGGTAWDFANGNRVPKASLDLLVIDEAGQFCLANTIAVAPAATNLLLLGDPQQLPQVSQGTHPEPVDTSALSWLVDGQHTLPDERGYFLDRSYRMHPAVCAAVSALSYEGRLCSHTERTAVRRLDGYPPGVHTRGVHHKGNSIESPEEAEAILAELRQLLGSPWTDEHGTRPLAASDVLVLAPYNAQVALVRRRLASAGLGGADGVRVGTVDKFQGGQAPVVFISMTASSADDVPRGISFLLNRNRLNVAVSRAQYAAVIVRSELLTQYLPATPDGLVDLGAFLGLTSTS

5eanA

0.17

0.14

0.83

2.29

MUSTER

-----------------------------------GGHMEPLDELDLLLLEA-VPRVELLRKKADALFPET--VLSRGVDNR-------------------LVLAVETSQNE----------RGAEEKRLHVTASQDREHEVLCILNGWSSVPVEPGGDCTSEPWIIDDDFG-MMISGTSVASSIRLRRAVLSETFRGSDPATRQMLI----------LHEVFQKAISESFAPE--RLQELALQTLREV--RHLKEMYRLNLSQDEILEEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIE-SPRFGLKGK---IDVTVGVKIHRDCKMKYKVM-ESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQ--MYPVP----ANHLDKRELLKL-----LAASLLHRVSRAAP------------GEEARLSALP----------------QIIEEEKTCKYC-----SQIGNCALYSRAVEE-------------------QGDDASIPEAMLSKIQEETRHLQLA----HLKYFSLWCLMLTLESQSKDNR-KTHQSIWLTPASELEESGNCVGNLVRT--EPVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIIL-------SGEERKLFALSKGYVKKMNKA-----AVTCLLDRNLSTLPATTVFRLDREERHGDSTPLGNLSKLME------STDPSKRLRELIIFREPQFIAYLSILKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDITEEEICRSRLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLE-----RNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLANPVCFLNTDKVPAPNGGVSNVTEARLIVFLTSTFIKAG---------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNEDG--TLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAILDLPSRE

5eanA

0.15

0.13

0.84

2.41

dPPAS

------------------------------------GGHMEPLDELDLLLLEAVPRVELLRKKADALFPETVLSRGVDNRYL-------------------VLAVETSQNER-----------GAEEKRLHVTASQDREHEVLCILNGWSSVPVEPGGDCTSEPWIIDDDFGYFILYMISGTSVASSIRCLRRAVLSETFRGSDPATRQMQKAISESFAPERLQELALQ------TLREVRHLKEMYRLNLSQDEILCEV--------EEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKT-----------------------------------GQMYPVPA---NHLDKREL-----------LKLRNWLAASLLHRVSRAAPGEEARLSALPQIIE-EEKTCKYCSQIGNCALYSRAVEEQGDDASIP----------EAMLSKIQEETRHL-----QLAHLKYFSLWCLMLTLESQSKDNRKTHQSIWLTPASELEESGNCVGNLVRTE--PVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIILSGEERKLFAL-------SKGYVKKMNK----AAVTCLLDRNLSTLPATTVFRLDREERHGDISTPLGNLSKLMESTDPS------KRLRELIIDFREPQFIAYLSSVLPNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQKFTEEEICRSRSIASLAHLPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLE-----RNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPEPDNPVCFLNTDKVPAPNVTEARLIVFLTSTFIKAG---------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNEDG--TLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLP

5eanA

0.16

0.13

0.80

4.50

wdPPAS

-----------------------------------GGHMEPLDELDLLLLE--AVPRVELLRKKADALFPRLHVTASQDREHEVLRNGWSSVP--VEPGD-LE-EPWIIDDDFILYPDMM---------ISG------SVASSIRCLRRAVLSETFRGSDPATRQMLIGT-------FQKAISEPERLQELALQTLRE-----------------------------------------VRHLKEMYRLNLSQDEILCEV--------EEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIE--PRF-------GLDVTVGVKIHRDCKMKYKVM-ESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQ--MYPVP----ANHLDKRELLKLR----LAASLLHRVSRAAP------------GEEARLSALPQ----------------IIEEEKTCKY------SQIGNCALYSRAVEE-------------------QGDDASIPEAMLSKIQEETRHLQLA----HLKYFSLWCLMLTLESQSKDNR--THQSIWLTPASELEESGNCVGNLVRTE--PVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIIL-------SGEERKLFALSKGYVKKMNKA----AVTCLLDRNLSTLPATTVFRLDREERHGDISTPLGNLSKLMESTDPS------KRLRELIIFREPQFIAYLSSVLPLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQKRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLE-----RNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLANPVCFLNTDKVPAPNGGVSNVTEARLIVFLTSTFIKAG---------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNEDG--TLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLP

5eanA

0.16

0.13

0.82

2.63

wMUSTER

------------------------------------GHMEPLDELDLLLLEA-VPRVELLRKKADALFPET--VLSRGVDNR-------------------LVLAVETSQNE----------RGAEEKRLHVTASQDREHEVLCILNGWSSVPVEPGGDCTSEPWIIDDDFG-MMISGTSVASSIRLRRAVLSETFRGSDPATRQMLI----------LHEVFQKAISESF------LQELALQTLREV--RHLKEMYRLNLSQDEILEEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIE-SPRF-------GLDVTVGVKIHRDCKMKYKVM-ESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQ--MYPV----PANHLDKRELLKL----WLAASLLHRVSRAAP------------GEEARLSALPQ----------------IIEEEKTCKYC-----SQIGNCALYSRAVEE-------------------QGDDASIPEAMLSKIQEETRHLQLA----HLKYFSLWCLMLTLESQSKDNR-KTHQSIWLTPASELEESGNCVGNLVR--TEPVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIIL-------SGEERKLFALSKGYVKKMNK----AAVTCLLDRNLS-TLPATTVFRLDRERHGDISTPLGNLSKLME------STDPSKRLRELIIFREPQFIAYLSILKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDITEEEICRSRLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLERN-----ESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLANPVCFLNTDKVPAPNGGVSNVTEARLIVFLTSTFIKAG---------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNEDG--TLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLP

5eanA

0.17

0.14

0.81

3.91

wPPAS

----GGHM--PLDELDLLLEAVPRVELLRKKADALFPETVLSRGVDNR-SQNERGAEEKRL--------HVTASQDREHEVLCILRNGWSSVP--VEPG--LE-EPWIIDDDFILYPDMMISG--------TSVASSIR----LRRAVLSETF---RGSDPATRQMLIGT-------FQKAISEPERLQELALQTLRE-----------------------------------------VRHLKEMYRLNL-SQDEILC---------EEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIE--PRF-------GLDVTVGVKIHRDCKMKYKVM-ESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQ--MYPVP----ANHLDKRELLKL----WLAASLLHRVSRAAP------------GEEARLSALPQ----------------IIEEEKTCKYC-----SQIGNCALYSRAVEE-------------------QGDDASIPEAMLSKIQEETRHLQLA----HLKYFSLWCLMLTLESQSKDNR-KTHQSIWLTPASELEESGNCVGNLVRT-----EPVSRVCDGQYLHNFQRKNGPMPATNDRIILSGEERKLFAL--------SKGYVKKMNK----AAVTCLLDRNLSTLPATTV-FRLDRERHGDISTPLGNLSKLMESTDPS------KRLRELIIFREPQFIAYLSSVKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQKRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLER-----NESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLANPVCFLNTDKVPAPNGGVSNVTEARLIVFLTSTFIKA----------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNED---GTLGLLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLP

4b3fX

0.19

0.09

0.48

6.31

dPPAS2

--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SAAVESFVTKQLDLLELERDAEVEERRSWQENSLKELQSRGVCLLKLQVSSQR---TGLYGRLLVTFEPRRAALPSNSFTSGDIVGL-------YDAANEGSQLATGILTRVTQ----KSVTVAFDSLDRENS-----YRLL---KLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPASEIHFNTCLDTSQKEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVKQ-GLKVLCCAPSNIAVDNLVERLALCKQRILRLGHPARLLKNKKKSNEREEAAMLESLTSANVVLATNTGASADGKLLPESYFDVVVIDECAQALEASCWIPLLKARKCILAGDHKQLPPTTVSHKAAGLSLSLMERLAEEY---GARVVRTLTVQYRMHQAIMRWASDTMYLGQLTAHSSVARHLLAATEETGVPLLLVDTAGESKGNPGEVRLVSLHIQALVDAG---------VPARDIAVVSPYNLQVDLLRQSLVHR----HPELEIKSVDGFQGREKEAVILSFVRSNRK---GEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAFLKTLVEYFTQHGEVRTAF

5eanA

0.16

0.13

0.82

3.39

PPAS

------------------------------------GGHMEPLDELDLLLLEAVPRVELLRKKADALFPETVLSRGVDN---------------------LVLAVETSQNERGAEEKRLHVTASQ---------DREHEVLCILR-NGWSSVPVEPGGDCTSEPWIIDDDFG---ISGTSVASSIRLRRAVLSETFRGSDPATRQMLI--QKAISESFAPERLQELALQT-------REVRHLKEMYRLNLSQDEILCEV--------EEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIE--PRF-------GLDVTVGVKIHRDCKMKYKVM-ESNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMY------PVPANHLDKRELLKL----WLAASLLHRVSRAAP------------GEEARLSALP----------------QIIEEEKTCKYC-----SQIGNCALYSRAVEE-------------------QGDDASIPEAMLSKIQEETRHLQLA----HLKYFSLWCLMLTLESQSKDNR-KTHQSIWLTPASELEESGNCVGNLVR-----TEPVSRVCDGQYLHNFQRKNGPMPATNDRIILSGEERKLFAL--------SKGYVKKMNKA-----AVTCLLDRNLSTLPATTVFRLDREERHGDSTPLGNLSKLMESTDPS------KRLRELIIFREPQFIAYLSSVLPLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQKFTEEEICRSRSIASLASHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLE-----RNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPNLFLNTDKVPAPNGGVSNVTEARLIVFLTSTFIKAG---------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNEDG--TLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLP

2xzlA

0.19

0.11

0.58

5.70

Env-PPAS

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSCAYSAKCVIKCNTKNGTSSHIVNHLVLSHHNVSLHPDSDLGDTV-LECYGRKNVFLLFVSVVLRIPCAQTKWD----TDQWQPLIEDR------------------------QLLSWVAEQPTEEEKLKARLITP----------SQISKLEAKWRSNKDATIPP-----LLL-------RYQDAYEYQRSYGPLIKLEADYDKQ---LKESQEHISVSWSLALNNRHLASFTKV-------AIGDEMILWY--------SGMQHPDWEGRGYIVRLPN---DTFTLELKPSKTPPPTHLTTGFTAE---FIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDISFDVPLPKEFSNSSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSLSASDTKRFVKLVRKTEAEIVVCCTCVGAGDKRL-DTKFRTVLIDESTQASEPECLIPIVGAKQVILVGDHQQLGPVILEAADAGLKQSLFERLISLGHVP-----IRLEVQYRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWWANYEISANGTSFLNRIEAMNCERIITKLFRDG---------VKPEQIGVITPYEGQRAYILQYMQMNGSLDYIKVEVASVDAFQGREKDYIILSCVRANEQ---QAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGT

5eanA

0.16

0.14

0.85

5.58

Env-PPAS

-----------------------------------GGHMEPLDELDLLLLEAVPRVELLRKKADALFPETVLSRGVDNRYL--------------------VLAVETSQNERGAEEKRLHVTASQDREHEVLCILRNGWSSVPVEP---GDIVHLEGDCTSEPWIIDDDFGYFILISGTSVASSIRLRRAVLSETFRGSDPATRQMLIGTQKAISESFAPERLQELALQ--TLR----EVRHLKEMYRLNLSQDEILCEV--------EEYLPSFSKWAEDFMRKGPSSFPQMQLSLPSDGRSSPCNIEVVKSLDIE-ESIWSP---RFGLDVTVGVKIHRDCKMKYKVM--------------------PLELKTGKESNSIEHRSQVVLYTLLSQERRED--------PEAGWLLYLKTGQMYPVP---ANHLDKRELLK-----------LRNWLAASLLHRVSRAAPGEEARLSALPQIIE-EEKTCKYCSQIGNCALYSRAVE----------EQGDDASIPEAMLSKIQEETRHLQLA----HLKYFSLWCLMLTLESQSKDNRKT-HQSIWLTPASELEESGNCVGNLVR--TEPVSRVCDGQYLHNFQRKNGPMPATNLMAGDRIILSGEERKLFAL-------SKGYVKKMNKA-----AVTCLLDRNLSTLPATTVFRLDREERHGDSTPLGNLSKLMESTDPS------KRLRELIIFREPQFIAYLSSVLPLNKPQRQAMKRVLLSKDYTLIVGMPGTGKTTTICALVRILSAC-GFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHKVHPDIQEEEICRSRLAHLEELYNSHPIVATTCMGINHPIFSRKTFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNARALGMSESLFKRLE-----RNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVANAVLALPPDNLNTDKVPAPNGGVSNVTEARLIVFLTSTFIKAG---------CSPSDIGVIAPYRQQLRIISDLLARSSV---GMVEVNTVDKYQGRDKSLILVSFVRSNEDG--TLGELLKDWRRLNVALTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAILDLPSRE

2xzlA

0.18

0.11

0.58

1.86

MUSTER

---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NSCAYSAKCVIK-NTKNGTS-HIVNHLVLSHH---------NVVSLHPDSD---------LGLECYNCGRKNVFLSVVLLCRIPCAQTKWDTDQWQPLIED------------RQLLSWVAEQPTEEEKLKARLITP----------SQISKLEAKWRSNKDATIPP----------LLRY---QDAYEYQRSYGPLIKLEADYDKQ---LKESQEHISVSWSLALNNRHLASF--------KVAIGDEMILWY--------SGMQHPDWEGRGYIVRLPNDT---FTLELKPSKTPPPTHLTTGFTAE---FIWKGTSYDRMQDALKKFAIDKKSISGYLYYKILGHQVVDISFDVPLPKEFSISSQSNAVSHVLQRPLSLIQGPPGTGKTVTSATIVYHLSKIHKDRILVCAPSNVAVDHLAAKLRDLGLKVVRLTAKSREDVESSVSRFVKLVRKTEAEILNKADVVCCTCVGAGDKRL-DTKFRTVLIDESTQASEPECLIPIVGAKQVILVGDHQQLGPVILEAADAGLKQSLFERLISLGHVP-----IRLEVQYRMNPYLSEFPSNMFYEGSLQNGVTIEQRTVPNSKFPWMFWAEISANGTSFLNRIEAMNCERIITKLFRDG---------VKPEQIGVITPYEGQRAYILQYMQMNGSLDYIKVEVASVDAFQGREKDYIILSCVRANEQ---QAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTLWNHLLIHFREKGCLVEGT

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.49

Estimated TM-score = 0.65±0.13

Estimated RMSD = 10.4±4.6Å

Download Model 2

C-score=-2.90

Download Model 3

C-score=-2.97

Download Model 4

C-score=-2.83

Download Model 5

C-score=-2.75

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	5eanA	0.819	1.93	0.156	0.840
2	4b3fX	0.445	3.33	0.187	0.479
3	4pj3A	0.443	5.96	0.116	0.533
4	2wjvA	0.440	4.31	0.150	0.490
5	2xzlA	0.424	4.95	0.135	0.491
6	5a22A	0.343	9.21	0.039	0.528
7	3vkwA	0.316	4.93	0.111	0.366
8	3cmuA	0.313	9.61	0.034	0.500
9	3k70D	0.308	5.77	0.137	0.373
10	3gp8A	0.305	5.19	0.140	0.356

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.22	11	2xzoA	UUU	Rep, Mult	748,768,769,770,771,772,773,774,875,902,942,943,1065,1067,1102
2	0.09	4	3cmvB	MG	Rep, Mult	773,799,803,874
3	0.07	4	2gjkA	MG	Rep, Mult	773,875,1065
4	0.05	3	4b3gA	NUC	Rep, Mult	584,629,630,631,656,697,699,700,703,796,797,798,820,823,854,856,906,990,991,1033,1034,1059,1061,1088,1089
5	0.04	2	2gk6A	PO4	Rep, Mult	768,769,772,902,943,1065,1102
6	0.04	2	5eaxA	NUC	Rep, Mult	177,179,197,205,206,329,330,353,479,568,608,609,610,632,654,675,692,694,697,796,797,798,823,856,857,906,909,1032,1033,1034,1059,1061,1062,1087,1088,1089,1095
7	0.03	2	3cmvB	ANP	Rep, Mult	768,769,771,772,773,774,804,807
8	0.02	1	2ckjC	FES	Rep, Mult	876,877,880,918,919,920,921

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1k32A	0.259	8.95	0.029	0.392	3.4.21.-	NA
2	0.060	3dy5A	0.256	8.71	0.040	0.378	1.13.11.40,4.2.1.92	NA
3	0.060	1ofdA	0.265	9.10	0.047	0.403	1.4.7.1	NA
4	0.060	1ea0A	0.268	10.04	0.048	0.445	1.4.1.13	NA
5	0.060	1n1hA	0.271	9.45	0.042	0.424	2.7.7.48	NA
6	0.060	2vdcA	0.275	9.46	0.053	0.434	1.4.1.13	NA
7	0.060	2vumA	0.265	9.41	0.043	0.414	2.7.7.6	918,926
8	0.060	3iydD	0.274	9.86	0.038	0.446	2.7.7.6	NA
9	0.060	1w36D	0.304	5.57	0.137	0.363	3.1.11.5	766,770,875,920,938,1065
10	0.060	3h0gA	0.265	9.42	0.029	0.410	2.7.7.6	811
11	0.060	3b9jI	0.080	5.72	0.064	0.098	1.17.1.4,1.17.3.2	742,755
12	0.060	1l5jA	0.256	8.94	0.041	0.389	4.2.1.3	NA
13	0.060	2fhbA	0.275	9.48	0.034	0.429	3.2.1.41	NA
14	0.060	2vdcF	0.276	9.51	0.047	0.437	1.4.1.13	NA
15	0.060	1fo4A	0.293	9.57	0.053	0.462	1.17.1.4	NA
16	0.060	2e1qA	0.295	9.46	0.039	0.460	1.17.3.2,1.17.1.4	NA
17	0.060	3b9jC	0.198	8.88	0.034	0.300	1.17.3.2,1.17.1.4	NA
18	0.060	2fgeA	0.254	9.57	0.038	0.404	3.4.24.-	NA
19	0.060	2fhcA	0.276	9.62	0.045	0.442	3.2.1.41	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.34	0.441	4.34	0.15	0.49	2wjyA	GO:0000166 GO:0000184 GO:0000294 GO:0000723 GO:0000784 GO:0000785 GO:0000932 GO:0000956 GO:0003677 GO:0003682 GO:0003723 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006260 GO:0006281 GO:0006406 GO:0006449 GO:0008270 GO:0009048 GO:0016787 GO:0032201 GO:0035145 GO:0042162 GO:0044530 GO:0044822 GO:0046872 GO:0061014 GO:0061158 GO:0071044 GO:0071222 GO:0071347
1	0.23	0.424	4.95	0.14	0.49	2xzlA	GO:0000166 GO:0000184 GO:0000956 GO:0003677 GO:0004004 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0005739 GO:0005844 GO:0006310 GO:0006449 GO:0006452 GO:0008270 GO:0008298 GO:0016567 GO:0016787 GO:0016887 GO:0030466 GO:0043024 GO:0046872 GO:0070478
2	0.16	0.819	1.93	0.16	0.84	5eanA	GO:0000076 GO:0000166 GO:0000723 GO:0000729 GO:0000784 GO:0003677 GO:0003678 GO:0003824 GO:0004386 GO:0004518 GO:0004519 GO:0005524 GO:0005634 GO:0005739 GO:0005760 GO:0006260 GO:0006264 GO:0006281 GO:0006284 GO:0006974 GO:0008152 GO:0016787 GO:0016890 GO:0017108 GO:0032508 GO:0033567 GO:0042645 GO:0043137 GO:0043139 GO:0043142 GO:0043504 GO:0045740 GO:0046872 GO:0051536 GO:0051539 GO:0090305 GO:1902990
3	0.13	0.305	5.19	0.14	0.36	3gp8A	GO:0000166 GO:0003677 GO:0004003 GO:0004386 GO:0005524 GO:0008094 GO:0016787 GO:0032508 GO:0043141
4	0.07	0.445	3.33	0.19	0.48	4b3fX	GO:0000049 GO:0000166 GO:0003676 GO:0003677 GO:0003678 GO:0003697 GO:0003723 GO:0004386 GO:0005524 GO:0005634 GO:0005737 GO:0006260 GO:0006281 GO:0006310 GO:0006351 GO:0006355 GO:0006357 GO:0006412 GO:0008026 GO:0008094 GO:0008134 GO:0008186 GO:0008270 GO:0016020 GO:0016787 GO:0030424 GO:0030426 GO:0030529 GO:0032508 GO:0032575 GO:0032797 GO:0042995 GO:0043022 GO:0043141 GO:0046872 GO:0051260
5	0.06	0.452	5.94	0.12	0.54	4pj3A	GO:0000398 GO:0003723 GO:0005634 GO:0005654 GO:0005681 GO:0006283 GO:0006397 GO:0008380 GO:0016020 GO:0044822 GO:0071013
6	0.06	0.196	8.21	0.04	0.28	1ii0B	GO:0000166 GO:0005524 GO:0015446 GO:0016787 GO:0016887 GO:0046685 GO:0071722 GO:0098655 GO:0098656
7	0.06	0.308	5.77	0.14	0.37	3k70D	GO:0000166 GO:0000724 GO:0003677 GO:0004003 GO:0004386 GO:0004518 GO:0004519 GO:0004527 GO:0005524 GO:0006281 GO:0006302 GO:0006310 GO:0006974 GO:0008854 GO:0009338 GO:0016787 GO:0032508 GO:0043142 GO:0090305
8	0.06	0.159	7.46	0.03	0.22	3dm5A	GO:0000166 GO:0003723 GO:0003924 GO:0005525 GO:0005737 GO:0006612 GO:0006614 GO:0008312 GO:0030529 GO:0048500
9	0.06	0.164	7.32	0.04	0.22	4flnB	GO:0004252 GO:0006508 GO:0008233 GO:0008236 GO:0009507 GO:0009533 GO:0009535 GO:0009536 GO:0009570 GO:0009579 GO:0009658 GO:0009941 GO:0010206 GO:0016020 GO:0016787 GO:0030163
10	0.06	0.146	5.73	0.06	0.18	1sxjC	GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0005829 GO:0006260 GO:0006272 GO:0006298 GO:0007049 GO:0007062 GO:0016887 GO:0031389 GO:0031390 GO:0031391
11	0.06	0.142	6.06	0.06	0.18	4xgcA	GO:0000166 GO:0003677 GO:0003682 GO:0005524 GO:0005634 GO:0005664 GO:0006260 GO:0006261 GO:0006270 GO:0006277 GO:0006342 GO:0008283 GO:0019233 GO:0022008 GO:0042023
12	0.06	0.117	6.82	0.02	0.15	1zu5B	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005886 GO:0006612 GO:0006614 GO:0016020 GO:0031226
13	0.06	0.130	6.28	0.07	0.16	3dmdB	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005886 GO:0006612 GO:0006614 GO:0016020 GO:0031226
14	0.06	0.129	6.74	0.06	0.17	3hteE	GO:0000166 GO:0004176 GO:0005524 GO:0005759 GO:0005829 GO:0006457 GO:0006508 GO:0008270 GO:0016032 GO:0016887 GO:0030163 GO:0042802 GO:0043335 GO:0046872 GO:0046983 GO:0051082 GO:0051301 GO:0051704
15	0.06	0.150	6.06	0.08	0.19	1sxjD	GO:0000076 GO:0000166 GO:0003677 GO:0003689 GO:0005524 GO:0005634 GO:0005663 GO:0006260 GO:0006272 GO:0006298 GO:0007049 GO:0007062 GO:0017076 GO:0031389 GO:0031390 GO:0031391
16	0.06	0.122	6.84	0.04	0.16	5l3wA	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005886 GO:0006612 GO:0006614 GO:0016020 GO:0031226
17	0.06	0.130	7.54	0.04	0.18	4ja0D	GO:0004639 GO:0005524 GO:0006164 GO:0006189
18	0.06	0.114	6.20	0.06	0.14	2yhsA	GO:0000166 GO:0003924 GO:0005525 GO:0005737 GO:0005829 GO:0005886 GO:0006612 GO:0006614 GO:0016020 GO:0031226

Consensus prediction of GO terms

Molecular Function	GO:0005524	GO:0008270	GO:0004004	GO:0043021	GO:0043139	GO:0004003	GO:0044822	GO:0003682	GO:0042162	GO:0051536	GO:0016888	GO:0048256
GO-Score	0.66	0.52	0.49	0.46	0.38	0.38	0.34	0.34	0.34	0.33	0.33	0.33
Biological Processes	GO:0000184	GO:0006449	GO:0043928	GO:0070727	GO:0006414	GO:0032446	GO:0034427	GO:0006342	GO:0032201	GO:0071347	GO:0006406	GO:0009048	GO:0061014	GO:0061158	GO:0071044	GO:0000294	GO:0071222	GO:0010557	GO:0031328	GO:0006302	GO:0051054	GO:0031570	GO:0033567	GO:0032042	GO:1903047	GO:0006275	GO:0032508
GO-Score	0.49	0.49	0.46	0.46	0.46	0.46	0.46	0.46	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.34	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.33	0.32
Cellular Component	GO:0000784	GO:0000932	GO:0005654	GO:0005829	GO:0000785	GO:0035145	GO:0044530	GO:0009295	GO:0005759	GO:0098798	GO:0042575
GO-Score	0.45	0.34	0.34	0.34	0.34	0.34	0.34	0.33	0.33	0.33	0.33

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.