I-TASSER results

I-TASSER results for job id Rv1232c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (435 residues)
MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVLGLVVDLATRRKIFIP
ILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKVNDPALPELAGVDVVVT
DLGVEQTRSRDWMVTRVAVRTQRRLRRRCPVHVVDWHNVAGLTPSALAMPGQDVAQLLDQ
FEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPELDQAEVLSQLGTERAADV
LEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLTHSPDTAGGLMTSDPVVLTP
DTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLGCVHLQRLLRDPPAELVGGVV
DTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLGAVTVDDLLDHLLPHDWRVDMP
ELDPSGAPDRPGGPR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVLGLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKVNDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRCPVHVVDWHNVAGLTPSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPELDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLTHSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLGCVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLGAVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR
Prediction	CCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHCCCCCCCEEEEEEEEHCCCEEEEEHCCEEEEHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEHCCCCCCCCCEEEEEEEEEEHCCCCCCCCEEEEEEHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEHCCCCCHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHHCCCCEEHCCCCCHHHHHHHHHHHCCEEEEEEHCCCCEEEEEEHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
Conf.Score	998864566788788656899987767899999977888898689999997898589987544567658879997577677654446764567776557589986544454577579999977544557776444444444444467777646645765457899999987899999999987999999999997999999999998998799999997999999999997999999999997998899999997999999999986999999999999959988765557887699879999999999999969885535699997787778999689998777888789998678875699677589999999999999989858889858995999986778899986555789999985898877888999
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300 320 340 360 380 400 420 \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| \| MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVLGLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKVNDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRCPVHVVDWHNVAGLTPSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPELDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLTHSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLGCVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLGAVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR
Prediction	864222000020062201245343001010000003455520200000022465220000033034035520202044141440332221100142004230303125145145130000000023124342103300232242143424432131730540450352056521540261057130000020045233720120052045630030042035720440065045720250066042610130053035621320032245612520340051344200110230100033722043005203733543520110000224322673100000103200203462333300365123041724042004004626010000005741000000010003202545133013412313565557358
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260                 280                 300                 320                 340                 360                 380                 400                 420

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEEEEHCCCCCCCEEEEEEEEHCCCEEEEEHCCEEEEHCCCEEEEHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEHCCCCCCCCCEEEEEEEEEEHCCCCCCCCEEEEEEHCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEHCCCCCHHHHHHHHHHHCCCCCCEEEEEEHCCCCCCCCCCEEEEEEHHHHHHCCCCCCHHHHHCCCCEEHCCCCCHHHHHHHHHHHCCEEEEEEHCCCCEEEEEEHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCC
MGSVNRVYLARLSRMSVLGPLGESFGRVRDVVISISIVRQQPRVLGLVVDLATRRKIFIPILRVAAIEPHAVTLSTGNVSLHRFEQRPGEALALGQVLDTLVKVNDPALPELAGVDVVVTDLGVEQTRSRDWMVTRVAVRTQRRLRRRCPVHVVDWHNVAGLTPSALAMPGQDVAQLLDQFEGWKAVDVADAIRGLPPKRRHEVFKALHDKRLADVLQELPELDQAEVLSQLGTERAADVLEEMDPDDAADLLAVLNPTEAELLLTRMDPGDSGQVRRLLTHSPDTAGGLMTSDPVVLTPDTSIAEALARVRDPDLTPALASMVFVARPPTATPTGHYLGCVHLQRLLRDPPAELVGGVVDTDLLTLTPETPLAAVTRYFAAYNLVCGPVVDDENHLLGAVTVDDLLDHLLPHDWRVDMPELDPSGAPDRPGGPR

2yvxA

0.28

0.17

0.61

1.86

MUSTER

------------------------------------------------------------------------------------------------------------------------------------------------------------------VSLQEALQEGDTRALREVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEYLKTLPPWRLREILEELSLDDLADALQAVRPAYFQRLKDLLDPRTRAEVEALARYEEDEAGGLMTPEYVAVREGMTVEEVLRFLRRAAPDAETIYYIYVV-----DEKGRLKGVLSLRDLIVADPRTRVAEIMNPKVVYVRTDTDQEEVARLMADYDFTVLPVVDEEGRLVGIVTVDDVLDVLEA-EATEDIHKLGAVDVPDLVYSEA

2yvzA

0.29

0.16

0.55

3.03

dPPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------LAVSLQEALQEGDTRALREVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEYLKTLPPWRLREILEELSLDDLADALQAVDPAYFQRLKDLLDPRTRAEVEALARYEEDEAGGLTPEYVAVR--EGTVEEVLRFLRRAAPDAETIYYIYVV-----DEKGRLKGVLSLRDLIVADPRTRVAEIN-PKVVYVRTDTDQEEVAR-LADYDFTVLPVVDEEGRLVGIVTVDDVLDVL-------------------------

2ouxA

0.19

0.11

0.57

3.44

wdPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------EEEQFALLLETLKNQQ-NEFRELFLALHIYEQGQFYQSLDEKDRQHLYNYLSPKELADFDVIEEDNENKDYLAER----PSYAADLAEYTDNAVDLLNLDKSQKAKYLSLLSSEEAGEIKELLHYEDETAGA-ITTEFVSIVANQTVRSAYVLKNQA--DAETIYYVYVV-----DQENHLVGVISLRDLIVNDDDTLIADILNERVISVHVGDDQEDVAQTIRDYDFLAVPVTDYDDHLLGIVTVDDIIDVIDDEAAS-------------------

2yvxA

0.28

0.17

0.61

2.25

wMUSTER

-----------------------------------------------------------------------------------------------------------------------------------------------------------------VS-LQEALQEGDTRALREVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEYLKTLPPWRLREILEELSLDDLADALQAVRPAYFQRLKDLLDPRTRAEVEALARYEEDEAGGLMTPEYVAVREGMTVEEVLRFLRRAAPDAETIYYIYVV-----DEKGRLKGVLSLRDLIVADPRTRVAEIMNPKVVYVRTDTDQEEVARLMADYDFTVLPVVDEEGRLVGIVTVDDVLDVLEA-EATEDIHKLGAVDVPDLVYSEA

2ouxA

0.19

0.11

0.56

2.91

wPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------EEEQFALLLETLKNQQ-NEFRELFLALHIYEQGQFYQSLDEKDRQHLYNYLSPKELADFDVIEEDNENKDYLAER----PSYAADLAEYTDNAVDLLNLDKSQKAKYLSLLSSEEAGEIKELLHYEDETAGA-ITTEFVSIVANQTVRSAYVLKNQA--DAETIYYVYVV-----DQENHLVGVISLRDLIVNDDDTLIADILNERVISVHVGDDQEDVAQTIRDYDFLAVPVTDYDDHLLGIVTVDDIIDVIDDEAS--------------------

2yvzA

0.29

0.16

0.55

6.45

dPPAS2

----------------------------------------------------------------------------------------------------------------------------------------------------------------LAVSLQEALQEGDTRALREVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEYLKTLPPWRLREILEELSLDDLADALQAVRPAYFQRLKDLLDPRTRAEVEALARYEEDEAGGLTP-EYVAVR-EGTVEEVLRFLRRAAPDAETIYYIYVV-----DEKGRLKGVLSLRDLIVADPRTRVAEIN-PKVVYVRTDTDQEEVAR-LADYDFTVLPVVDEEGRLVGIVTVDDVLDVL-------------------------

2yvzA

0.29

0.16

0.55

2.83

PPAS

----------------------------------------------------------------------------------------------------------------------------------------------------------------LAVSLQEALQEGDTRALREVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEYLKTLPPWRLREILEELSLDDLADALQAVRPAYFQRLKDLLDPRTRAEVEALARYEEDEAGGLTP-EYVAVR-EGTVEEVLRFLRRAAPDAETIYYIYVV-----DEKGRLKGVLSLRDLIVADPRTRVAEIN-PKVVYVRTDTDQEEVAR-LADYDFTVLPVVDEEGRLVGIVTVDDVLDVL-------------------------

2ouxA

0.21

0.12

0.57

4.39

Env-PPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------EEEQFALLLETLKNQQ-NEFRELFLALHIYEQGQFYQSLDEKDRQHLYNYLSPKELADFDVIEEDNENKDYLAER-PSYAADLAEY---TDNAVDLLNLDKSQKAKYLSLLSSEEAGEIKELLHYEDETAGAITT-EFVSIVANQTVRSA--YVLKNQADAETIYYVYVV-----DQENHLVGVISLRDLIVNDDDTLIADILNERVISVHVGDDQEDVAQTIRDYDFLAVPVTDYDDHLLGIVTVDDIIDVIDDEAAS-------------------

2yvzA

0.29

0.16

0.55

1.59

MUSTER

----------------------------------------------------------------------------------------------------------------------------------------------------------------LAVSLQEALQEGDTRALREVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEYLKTLPPWRLREILEELSLDDLADALQAVRPAYFQRLKDLLDPRTRAEVEALARYEEDEAGGLTP-EYVAVR-EGTVEEVLRFLRRAAPDAETIYYIYVV-----DEKGRLKGVLSLRDLIVADPRTRVAEIN-PKVVYVRTDTDQEEVAR-LADYDFTVLPVVDEEGRLVGIVTVDDVLDVL-------------------------

2ouxA

0.19

0.11

0.57

2.96

dPPAS

-------------------------------------------------------------------------------------------------------------------------------------------------------------EEEQFALLLETLKNQQ-NEFRELFLALHIYEQGQFYQSLDEKDRQHLYNYLSPKELADFDVIEEDNENKDYLAER----PSYAADLAEYTDNAVDLLNLDKSQKAKYLSLLSSEEAGEIKELLHYEDETAGAIT-TEFVSIVANQTVRSA--YVLKNQADAETIYYVYVV-----DQENHLVGVISLRDLIVNDDDTLIADILNERVISVHVGDDQEDVAQTIRDYDFLAVPVTDYDDHLLGIVTVDDIIDVIDDEAAS-------------------

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-3.24

Estimated TM-score = 0.35±0.12

Estimated RMSD = 15.0±3.5Å

Download Model 2

C-score=-3.48

Download Model 3

C-score=-3.71

Download Model 4

C-score=-4.14

Download Model 5

C-score=-4.33

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	2yvxA	0.560	2.46	0.285	0.614
2	2ouxA	0.550	1.21	0.224	0.563
3	4kf7A	0.408	6.58	0.072	0.623
4	4kihA	0.403	6.56	0.054	0.634
5	4ui9A	0.402	7.22	0.055	0.676
6	4jjjA	0.402	6.82	0.057	0.644
7	5ijoJ	0.400	6.66	0.042	0.616
8	1lf9A	0.399	6.39	0.055	0.614
9	1ulvA	0.399	6.63	0.054	0.634
10	4el8A	0.398	6.72	0.042	0.632

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.39	13	2zy9A	MG	Rep, Mult	247,248,402,405
2	0.13	5	2zy9A	MG	Rep, Mult	251,254,289
3	0.06	4	2yvxB	MG	Rep, Mult	374,414,417,418
4	0.05	3	2zy9A	MG	Rep, Mult	381,382,384
5	0.04	2	2yvxD	MG	Rep, Mult	402,404,405
6	0.03	2	2yvxC	MG	Rep, Mult	372,374,414
7	0.03	2	2zy9B	MG	Rep, Mult	220,408
8	0.02	1	2ouxA	MG	Rep, Mult	323,325,387,388,389
9	0.02	1	2yvy0	III	Rep, Mult	190,312,315,318,321,322,343,344,345,348,382,383,384,403,404,407
10	0.02	1	2ouxB	MG	Rep, Mult	285,413
11	0.02	1	2yvxA	MG	Rep, Mult	405,409

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1dl2A	0.371	6.64	0.047	0.584	3.2.1.113	NA
2	0.060	1dgjA	0.369	7.17	0.030	0.628	1.2.-.-	NA
3	0.060	2cqsA	0.400	7.07	0.073	0.660	2.4.1.20	NA
4	0.060	2pflA	0.364	6.53	0.043	0.563	2.3.1.54	282,406
5	0.060	1z1wA	0.379	5.69	0.066	0.542	3.4.11.-	NA
6	0.060	1w6jA	0.374	6.71	0.055	0.595	5.4.99.7	NA
7	0.060	1fa9A	0.378	7.60	0.042	0.667	2.4.1.1	NA
8	0.060	3b9jJ	0.218	7.07	0.054	0.359	1.17.1.4,1.17.3.2	186
9	0.060	1g72A	0.370	7.03	0.047	0.609	1.1.99.8	NA
10	0.060	2ivfA	0.367	7.36	0.031	0.630	1.17.99.2	NA
11	0.060	1vlbA	0.364	7.63	0.051	0.637	1.2.99.7	NA
12	0.060	1kv9A	0.378	7.36	0.039	0.644	1.1.99.-	116
13	0.060	1kb0A	0.368	7.58	0.045	0.644	1.1.99.-	NA
14	0.060	1fo4A	0.400	7.40	0.050	0.683	1.17.1.4	NA
15	0.060	1lrwC	0.379	6.85	0.028	0.605	1.1.99.8	245
16	0.060	1nxcA	0.372	6.66	0.057	0.589	3.2.1.113	NA
17	0.060	1w6sC	0.377	6.19	0.044	0.568	1.1.99.8	50
18	0.060	1g87B	0.363	7.13	0.029	0.598	3.2.1.4	NA
19	0.060	2ckjA	0.384	7.73	0.045	0.678	1.17.1.4,1.17.3.2	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.32	0.560	2.46	0.28	0.61	2yvxA	GO:0000287 GO:0005886 GO:0006810 GO:0006812 GO:0008324 GO:0015095 GO:0015693 GO:0016020 GO:0016021 GO:0042803 GO:0046872 GO:0098655 GO:1903830
1	0.19	0.574	1.13	0.22	0.59	2ouxA	GO:0005886 GO:0006810 GO:0006812 GO:0008324 GO:0015095 GO:0015693 GO:0016020 GO:0016021 GO:0046872 GO:0098655 GO:1903830
2	0.11	0.259	2.49	0.16	0.28	3fv6B	GO:0003677 GO:0006351 GO:0006355 GO:0045013
3	0.08	0.336	2.84	0.21	0.37	3kxrA	GO:0006812 GO:0008324 GO:0016020 GO:0016021 GO:0098655
4	0.06	0.339	5.15	0.08	0.45	3ddjA	GO:0000166 GO:0003824
5	0.06	0.328	5.36	0.08	0.44	2v8qE	GO:0000166 GO:0004679 GO:0005524 GO:0005654 GO:0006468 GO:0006629 GO:0006631 GO:0006633 GO:0016208 GO:0019901 GO:0031588 GO:0042304 GO:0043234 GO:0043531 GO:0050790 GO:0051291
6	0.06	0.322	5.02	0.09	0.41	3lfzA
7	0.06	0.304	4.11	0.13	0.36	2yzqA	GO:0003824 GO:0046872 GO:0051536 GO:0051539
8	0.06	0.290	5.16	0.08	0.37	4qfsC	GO:0000166 GO:0004679 GO:0005524 GO:0005654 GO:0006468 GO:0006629 GO:0006631 GO:0006633 GO:0016208 GO:0019901 GO:0031588 GO:0042304 GO:0043234 GO:0043531 GO:0050790 GO:0051291
9	0.06	0.279	3.11	0.22	0.31	5aweA	GO:0003824
10	0.06	0.319	5.08	0.10	0.42	1zfjA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
11	0.06	0.325	4.09	0.17	0.39	4dqwA	GO:0000166 GO:0003824 GO:0003938 GO:0005524 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
12	0.06	0.259	6.98	0.07	0.42	4lzdA	GO:0003677 GO:0003887 GO:0005634 GO:0005654 GO:0006281 GO:0006303 GO:0006310 GO:0006974 GO:0016446 GO:0016740 GO:0016779 GO:0030183 GO:0034061 GO:0046872 GO:0071897
13	0.06	0.267	7.43	0.03	0.46	4fxsA	GO:0000166 GO:0003824 GO:0003938 GO:0006164 GO:0006177 GO:0009152 GO:0016491 GO:0046872 GO:0055114
14	0.06	0.327	5.02	0.11	0.42	4z87A	GO:0000166 GO:0003824 GO:0003938 GO:0005737 GO:0005829 GO:0006164 GO:0006177 GO:0016491 GO:0046872 GO:0055114
15	0.06	0.260	2.34	0.24	0.28	4gqyA	GO:0009507 GO:0009536 GO:0009570 GO:0045454
16	0.06	0.264	2.06	0.19	0.28	1yavB
17	0.06	0.259	2.88	0.20	0.29	2o16B
18	0.06	0.259	2.14	0.24	0.28	1vr9A	GO:0008152 GO:0016597

Consensus prediction of GO terms

Molecular Function	GO:0015095	GO:0042803	GO:0000287
GO-Score	0.45	0.32	0.32
Biological Processes	GO:0098655	GO:0015693	GO:1903830
GO-Score	0.49	0.45	0.45
Cellular Component	GO:0016021	GO:0005886
GO-Score	0.49	0.45

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.