I-TASSER results

I-TASSER results for job id Rv1225c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (276 residues)
MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLTNTTTRTRRQIAEA
LGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDITEDLPGIDVVLSTEIGPED
CPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTG
MEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRT
GKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLTNTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDITEDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRTGKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC
Prediction	CCCCCCCCCEEEEHCCCCEEHCCHCCCCHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCCEEEEHCCCHHHHHHHHHCCEEHCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCEHCCCHHHHHHHHHHCCCEEEHCCCCHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHCCCCCCCCCEEHCCHHHHHHHHCC
Conf.Score	985556577899958995887986588799999999999997999958999999999999999899998888534799999999985999889999695699999877988856788766678898899985799999999999999998699599975898766899765568679999999979956998599899999999998999553899879865789999998997899758999999999886577899997997999999999859
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLTNTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDITEDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRTGKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC
Prediction	753552303000010000002375104103400520374702000000003233640251046140504452111002000200352355210000014302510461411124333243243311000000012321130012002002330100000000102154222220000021023004343121202132003100531744242000012203200200350303000010232346205514656552201010410430151068
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCEEEEHCCCCEEHCCHCCCCHHHHHHHHHHHCCCEEEHCCCCCCCHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHHCCCCEEEEHCCCHHHHHHHHHCCEEHCCCCCCCCCCCCCEEEEEHCCCCCCHHHHHHHHHHHHHCCEEEEHCCCCCCCCCCCCEHCCCHHHHHHHHHHCCCEEEHCCCCHHHHHHHHHHHCCCCCEEEEHCCCCHHHHHHHHHHCCCEEEHCCCCCCHHHHHHHHCCCCCCCCCEEHCCHHHHHHHHCC
MDVAHLMAAAVLFDIDGVLVLSWRAIPGAAETVRQLTHRGIACAYLTNTTTRTRRQIAEALGAAGIPVAADDVITAGVLTAEYLHGAYPGARCFLVNNGDITEDLPGIDVVLSTEIGPEDCPEAPDVVVLGSAGPQFDHRTLSRVYGWMLDGVPVVAMHRNMTWNTTDGLRIDTGMYLTGMEQACGKTATAIGKPAAEGFLAAADRVGVDPQQMVMIGDDLHNDVLAAQAVGMTGVLVRTGKFRQQTLDRWLAGASATRPHHVIDSVAGLPPLLGC

3pdwA

0.24

0.22

0.92

2.67

MUSTER

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGG--------ENAD-FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTDDME-----------KPTHAIDSLTEWIPYIEG

3pdwA

0.23

0.21

0.92

3.05

dPPAS

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGGENAD---------FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTD-----------DMEKPTHAIDSLTEWIPYIEG

3pdwA

0.23

0.21

0.92

3.51

wdPPAS

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGGENAD---------FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTDDME-----------KPTHAIDSLTEWIPYIEG

3pdwA

0.24

0.22

0.91

3.17

wMUSTER

LK----TYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGG--------ENAD-FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTDDME-----------KPTHAIDSLTEWIPYIEG

3pdwA

0.24

0.22

0.92

4.01

wPPAS

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGG--------ENAD-FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTDDME-----------KPTHAIDSLTEWIPYIEG

3pdwA

0.24

0.22

0.92

4.28

dPPAS2

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGG--------ENAD-FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTD-----------DMEKPTHAIDSLTEWIPYIEG

3pdwA

0.24

0.22

0.92

3.93

PPAS

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGG--------ENAD-FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTDDME-----------KPTHAIDSLTEWIPYIEG

3pdwA

0.24

0.22

0.92

5.53

Env-PPAS

---SLKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTNNSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIEENGLTFGG--------ENAD-FVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPGNGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINAGMDTLLVHTGMTDDME-----------KPTHAIDSLTEWIPYIEG

3qgmA

0.25

0.23

0.92

2.64

MUSTER

-----PDKKGYIIDIDGVIGKSVTPIPEGVEGVKKLKELGKKIIFVSNNSTRSRRILLERLRSFGLEVGEDEILVATYATARFIAREKPNAKVFTTGEEGLIEELRLAGLEIVD-------YDEAE-YLVVGSNRKINF-ELTKALRACLRGIRYIATNPDRIFPAEDGPIPGTG-IIGALYWTGREPDVVVGKPSE-VIREALDILGLDAKDVAVVGDQIDVDVAAGKAIGAETVLVLTGVTTRENLDQIE--RHGLKPDYVFNSLKDVEAL---

3qgmA

0.25

0.23

0.92

2.88

dPPAS

-----PDKKGYIIDIDGVIGKSVTPIPEGVEGVKKLKELGKKIIFVSNNSTRSRRILLERLRSFGLEVGEDEILVATYATARFIAREKPNAKVFTTGEEGLIEELRLAGLEIVDYDEAE--------YLVVGSNRKINF-ELTKALRACLRGIRYIATNPDRIFPAEDGPIPGTG-IIGALYWTGREPDVVVGKPSE-VIREALDILGLDAKDVAVVGDQIDVDVAAGKAIGAETVLVLTGVTTRENLDQIE--RHGLKPDYVFNSLKDVEAL---

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=1.00

Estimated TM-score = 0.85±0.08

Estimated RMSD = 4.0±2.7Å

Download Model 2

C-score=-1.24

Download Model 3

C-score=-1.55

Download Model 4

C-score=0.88

Download Model 5

C-score=-3.21

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	3pdwA	0.895	1.05	0.229	0.917
2	4iftA	0.874	1.68	0.200	0.924
3	4i9fA	0.839	2.73	0.222	0.946
4	1zjjB	0.839	2.47	0.249	0.946
5	2c4nA	0.838	2.06	0.244	0.906
6	1yv9A	0.833	2.39	0.234	0.927
7	1ydfA	0.820	2.47	0.240	0.920
8	3hltA	0.820	2.32	0.291	0.909
9	2oycA	0.818	3.00	0.261	0.964
10	1vjrA	0.811	2.52	0.224	0.920

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.81	97	3qgmC	CA	Rep, Mult	14,16,219,220
2	0.22	28	2cftA	PLP	Rep, Mult	14,15,16,47,48,49,133,164,196
3	0.01	3	1tj3A	MG	Rep, Mult	14,219,220,223,224
4	0.01	1	2cfsA	MG	Rep, Mult	239,244,245
5	0.01	1	2oycA	WO4	Rep, Mult	52,60,63
6	0.01	2	1zjj0	III	Rep, Mult	134,135,137,138,139,143,144,146,147,150,162,163,168,170,171,172,176,179,180,183,184
7	0.00	1	1yv90	III	Rep, Mult	83,86,152,154,190,197,201,211,229,230,232,258

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.272	2x4dA	0.741	3.45	0.257	0.917	3.6.1.1	48,173,220,233
2	0.186	1l6rA	0.520	3.75	0.115	0.649	3.1.3.18	17,197,223
3	0.066	2no4B	0.484	2.62	0.273	0.543	3.8.1.2	48,194,224
4	0.060	1rltC	0.506	4.42	0.107	0.692	3.1.3.23	197
5	0.060	2hoqA	0.475	2.79	0.260	0.543	3.-.-.-	14,194,224
6	0.060	1acmA	0.465	4.75	0.067	0.663	2.1.3.2	80
7	0.060	2i6uA	0.487	4.52	0.095	0.663	2.1.3.3	NA
8	0.060	2jfqA	0.474	5.22	0.103	0.710	5.1.1.3	NA
9	0.060	3e2pA	0.475	4.48	0.069	0.652	2.1.3.2	80
10	0.060	2ef0A	0.480	4.52	0.069	0.663	2.1.3.3	NA
11	0.060	1rdfA	0.476	2.84	0.230	0.551	3.11.1.1	NA
12	0.060	2cftA	0.831	3.16	0.265	0.986	3.1.3.74	NA
13	0.060	2gmwB	0.481	3.34	0.273	0.580	3.1.3.-	47,194
14	0.060	1o0sA	0.483	5.25	0.060	0.721	1.1.1.38	NA
15	0.060	1vjrA	0.811	2.52	0.224	0.920	3.1.3.41	201
16	0.060	1wr8B	0.522	4.44	0.165	0.692	3.1.3.18	15,17,223
17	0.060	1aq6A	0.470	2.87	0.243	0.536	3.8.1.2	48,194,224
18	0.060	2be7A	0.475	4.58	0.063	0.656	2.1.3.2	80
19	0.060	2qltA	0.470	2.90	0.217	0.547	3.1.3.-	47
20	0.060	1b73A	0.488	4.81	0.092	0.703	5.1.1.3	NA
21	0.060	1ml4A	0.469	4.66	0.065	0.659	2.1.3.2	80
22	0.060	1gq2A	0.463	5.24	0.075	0.699	1.1.1.40	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.57	0.838	2.06	0.24	0.91	2c4nA	GO:0000287 GO:0005829 GO:0005975 GO:0008253 GO:0016311 GO:0016787 GO:0046050 GO:0046872
1	0.57	0.839	2.47	0.25	0.95	1zjjB	GO:0046872
2	0.54	0.820	2.47	0.24	0.92	1ydfA	GO:0016787
3	0.50	0.820	2.32	0.29	0.91	3hltA	GO:0016311 GO:0016791 GO:0019899 GO:0046872 GO:0070062
4	0.47	0.827	2.61	0.21	0.93	3eprA	GO:0016787
5	0.43	0.741	3.45	0.26	0.92	2x4dA	GO:0000287 GO:0004427 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006470 GO:0006796 GO:0008969 GO:0009168 GO:0016787 GO:0042803 GO:0046872
6	0.42	0.864	2.71	0.24	0.98	4bkmA	GO:0000121 GO:0000287 GO:0004647 GO:0004721 GO:0004725 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005975 GO:0006114 GO:0006470 GO:0006650 GO:0007088 GO:0008152 GO:0008967 GO:0015629 GO:0016020 GO:0016311 GO:0016787 GO:0016791 GO:0030027 GO:0030496 GO:0030836 GO:0031072 GO:0031247 GO:0031258 GO:0032154 GO:0032361 GO:0032465 GO:0032587 GO:0033883 GO:0035335 GO:0042803 GO:0042995 GO:0043136 GO:0045721 GO:0046872 GO:0070062 GO:0070938 GO:0071318 GO:0098519
7	0.39	0.823	2.12	0.27	0.90	2ho4B	GO:0016311 GO:0016791 GO:0019899 GO:0046872 GO:0070062
8	0.38	0.730	3.88	0.19	0.95	2hx1A	GO:0046872
9	0.38	0.895	1.05	0.23	0.92	3pdwA	GO:0016311 GO:0016787 GO:0016791 GO:0046872
10	0.36	0.808	3.00	0.22	0.94	4i9fB	GO:0046872
11	0.35	0.824	3.13	0.27	0.98	4bx2A	GO:0000287 GO:0004647 GO:0004721 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0006470 GO:0007088 GO:0008152 GO:0015629 GO:0016020 GO:0016787 GO:0016791 GO:0030027 GO:0030496 GO:0030836 GO:0031072 GO:0031247 GO:0031258 GO:0032154 GO:0032361 GO:0032465 GO:0032587 GO:0033883 GO:0042803 GO:0042995 GO:0046872 GO:0070062 GO:0070938 GO:0071318
12	0.35	0.809	2.96	0.24	0.95	4jdpB	GO:0046872
13	0.34	0.831	2.50	0.23	0.94	1vjrA	GO:0016311 GO:0016791 GO:0046872
14	0.33	0.833	2.39	0.23	0.93	1yv9A	GO:0016787
15	0.31	0.827	2.26	0.23	0.91	1wviA
16	0.30	0.601	3.35	0.26	0.74	2x4dB	GO:0000287 GO:0004427 GO:0005634 GO:0005654 GO:0005737 GO:0005829 GO:0006470 GO:0006796 GO:0008969 GO:0009168 GO:0016787 GO:0042803 GO:0046872
17	0.29	0.822	2.34	0.22	0.91	1ys9A
18	0.29	0.743	3.68	0.19	0.94	3rf6B	GO:0046474
19	0.13	0.741	3.54	0.18	0.92	3kc2B	GO:0046474
20	0.07	0.522	4.44	0.17	0.69	1wr8B	GO:0000287 GO:0005975 GO:0008967 GO:0016311 GO:0016787 GO:0046872

Consensus prediction of GO terms

Molecular Function	GO:0000287	GO:0008253	GO:0019899
GO-Score	0.57	0.57	0.50
Biological Processes	GO:0016311	GO:0046050	GO:0005975
GO-Score	0.79	0.57	0.57
Cellular Component	GO:0005829	GO:0070062
GO-Score	0.57	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.