I-TASSER results

I-TASSER results for job id Rv1216c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (224 residues)
MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVSTTIGPTIYLARNDPAAL
QRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSSVPAAVCVIGDVLVMTG
LGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMYAGNVVMMTGIPLALGSYWAM
FILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYRLVPYVW

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVSTTIGPTIYLARNDPAALQRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSSVPAAVCVIGDVLVMTGLGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMYAGNVVMMTGIPLALGSYWAMFILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYRLVPYVW
Prediction	CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHCCCHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHCCCCC
Conf.Score	98478899999999999999999966555467899999999999999999999866788899875565445665557899999999999999987777646665449999999999999999999999978645676666789778757744553595999999999999999866999999999999999999999999999885999999978975588879
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 \| \| \| \| \| \| \| \| \| \| \| MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVSTTIGPTIYLARNDPAALQRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSSVPAAVCVIGDVLVMTGLGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMYAGNVVMMTGIPLALGSYWAMFILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYRLVPYVW
Prediction	43130213233333333322320121132223311211123333333212100222441044125533464444022110122333333322312233323133233212221222123033222202223431434051666340011110131002213032233303213331331222323223200110330041037427504601740412215324
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEHCCCHHHCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHCCCCC
MHIGLKIFIWGVLGLVVFGALLFGPAGTFDYWQAWVFLAAFVSTTIGPTIYLARNDPAALQRRMRSGPLAEGRTIQKFIVIGAFLGFFAMMVLSACDHRYGWSSVPAAVCVIGDVLVMTGLGIAMLVVIQNRYAASTVRVEAGQILASDGLYKIVRHPMYAGNVVMMTGIPLALGSYWAMFILVPGTLVLVFRILDEEKLLTQELSGYREYRQLVRYRLVPYVW

4quvA

0.19

0.18

0.97

1.47

MUSTER

GSLDLKLFCEARPGMIFWLLMNLSMA--AKQYELHVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK-----HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQKHHFAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAASPIPYFHIVYFTILLLHREKRDDAMCLAKYEDWLQYRKKVPWRIVPKIY

4a2nB

0.18

0.15

0.84

1.45

dPPAS

-------------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNINL-PDSIRLFALIVTFLNIGLFTKIHKDLNNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4a2nB

0.18

0.15

0.84

3.63

wdPPAS

-------------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFN-INLPDSIRLFALIVTFLNIGLFTKIHKD-NNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4quvA

0.19

0.18

0.97

2.00

wMUSTER

GSLDLKLFCEARPGMIFWLLMNLSMA--AKQYELHVPMLLVVGFQSFYLIDYFIHEEAVLTTWDIK-----HEKFGWMLCWGDLVWLPFTYTLQAQYLVHHTHDLPVWGIIAIVALNLAGYAIFRGANIQKHHFAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAASPIPYFHIVYFTILLLHREKRDDAMCLAKYEDWLQYRKKVPWRIVPKIY

4a2nB

0.18

0.15

0.84

4.99

wPPAS

-------------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNI-NLPDSIRLFALIVTFLNIGLFTKIHKD-NNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4a2nB

0.18

0.15

0.84

3.29

dPPAS2

-------------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNI-NLPDSIRLFALIVTFLNIGLFTKIHKDLNNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4a2nB

0.18

0.15

0.84

3.36

PPAS

-------------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNI-NLPDSIRLFALIVTFLNIGLFTKIHKD-NNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4a2nB

0.16

0.13

0.84

3.31

Env-PPAS

--------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRP------NFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNINLPDSIRLFALIVTFLNIGLFTKIHKDLNNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4a2nB

0.18

0.15

0.84

1.41

MUSTER

-------------------------------MNENLWKICFIVMFIIWVFVRKVYGTRAMKNKSKKKVRPNFEKSLVFLNFIGMVFLPLTAVFSSYLDSFNI-NLPDSIRLFALIVTFLNIGLFTKIHKDLNNWSAILEIKDGHKLVKEGIYKNIRHPMYAHLWLWVITQGIILSWVVLIFGIVAWAILYFIRVPKEEELLIEEFDEYIEYMGKTG-RLFPK--

4quvA2

0.23

0.12

0.54

1.04

dPPAS

--------------------------------------------------------------------------------------------------------LPVWGIIAIVALNLAGYAIFRGANIQKGKPAKYIKTKQGSLLLTSGWWGIARHMNYFGDLMIALSWCLPAASPIPYFHIVYFTILLLHREKRDDAMCLAKYEDWLQYRKKVPWRIVPKIY

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=0.14

Estimated TM-score = 0.73±0.11

Estimated RMSD = 5.3±3.4Å

Download Model 2

C-score=-1.09

Download Model 3

C-score=-3.83

Download Model 4

C-score=-3.85

Download Model 5

C-score=-3.58

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4a2nB	0.778	1.79	0.169	0.844
2	4quvA	0.741	3.64	0.174	0.929
3	2jswA	0.521	4.52	0.082	0.759
4	1ocrN	0.519	4.81	0.083	0.777
5	1m56A	0.518	4.59	0.072	0.768
6	1mhsA	0.511	5.33	0.062	0.808
7	3mk7A	0.502	4.64	0.099	0.750
8	3rkoN	0.501	5.01	0.053	0.795
9	4he8L	0.500	5.29	0.083	0.799
10	4djiA	0.498	4.91	0.067	0.732

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	4	1m57G	PEH	Rep, Mult	115,116,123,160,164,165
2	0.09	3	4a2nB	SAH	Rep, Mult	131,134,135,138,139,140,144,146,147,152,157,158,159,160,197,201
3	0.06	2	3dtuC	DXC	Rep, Mult	120,123,124,127,159,162
4	0.05	2	3omnC	TRD	Rep, Mult	44,166,169,174
5	0.05	2	1m57A	PEH	Rep, Mult	113,114,115,116,119,123,164,165
6	0.03	1	1e1cB	DCA	Rep, Mult	215,218
7	0.03	1	4a2nB	CDL	Rep, Mult	118,122,126,129
8	0.03	1	1lghG	LYC	Rep, Mult	153,154,155
9	0.03	1	2wscJ	CLA	Rep, Mult	221,223
10	0.03	1	2wse1	CLA	Rep, Mult	189,193
11	0.03	1	3ujkA	MG	Rep, Mult	149,150

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1mo7A	0.250	6.33	0.036	0.478	3.6.3.9	NA
2	0.060	2uw1B	0.440	5.78	0.074	0.737	1.14.99.6	NA
3	0.060	1jtnA	0.222	5.33	0.053	0.353	3.2.1.17	NA
4	0.060	1occA	0.513	4.62	0.068	0.768	1.9.3.1	157
5	0.060	1jk0A	0.455	5.19	0.025	0.728	1.17.4.1	NA
6	0.060	3b8cA	0.483	5.35	0.025	0.772	3.6.3.6	NA
7	0.060	1uzrB	0.474	5.06	0.050	0.728	1.17.4.1	NA
8	0.060	2vuxB	0.395	5.52	0.043	0.638	1.17.4.1	NA
9	0.060	3dy5A	0.465	5.79	0.050	0.790	1.13.11.40,4.2.1.92	NA
10	0.060	1fftA	0.446	5.01	0.085	0.683	1.10.3.-	NA
11	0.060	3b8cB	0.489	5.18	0.071	0.768	3.6.3.6	161,182
12	0.060	1mhyB	0.474	4.78	0.067	0.705	1.14.13.25	90
13	0.060	2occN	0.518	4.76	0.083	0.777	1.9.3.1	116
14	0.060	1syyA	0.487	5.02	0.081	0.750	1.17.4.1	NA
15	0.060	3ee4A	0.445	5.62	0.046	0.759	1.17.4.1	NA
16	0.060	2bq1I	0.460	5.13	0.050	0.714	1.17.4.1	NA
17	0.060	1biqB	0.492	5.33	0.057	0.795	1.17.4.1	NA
18	0.060	1jqnA	0.451	5.82	0.063	0.746	4.1.1.31	NA
19	0.060	3b8eA	0.457	5.72	0.075	0.781	3.6.3.9	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.33	0.778	1.79	0.17	0.84	4a2nB	GO:0004671 GO:0006481 GO:0016020 GO:0016021
1	0.28	0.518	4.59	0.07	0.77	1m56A	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
2	0.27	0.741	3.64	0.17	0.93	4quvA	GO:0000166 GO:0006696 GO:0016020 GO:0016021 GO:0016126 GO:0016491 GO:0016628 GO:0050613 GO:0050661 GO:0055114
3	0.23	0.457	5.72	0.07	0.78	3b8eA	GO:0000166 GO:0002028 GO:0005391 GO:0005524 GO:0005886 GO:0005890 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0006883 GO:0010107 GO:0010248 GO:0015991 GO:0016020 GO:0016021 GO:0016787 GO:0030007 GO:0030955 GO:0031402 GO:0036376 GO:0042383 GO:0043231 GO:0046872 GO:0051117 GO:0086009 GO:0090662 GO:1990573
4	0.19	0.513	4.62	0.07	0.77	1occA	GO:0004129 GO:0005506 GO:0005739 GO:0005743 GO:0006119 GO:0009055 GO:0009060 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0045277 GO:0046872 GO:0055114 GO:0070469 GO:1902600
5	0.07	0.511	5.33	0.06	0.81	1mhsA	GO:0000166 GO:0005524 GO:0005886 GO:0005887 GO:0006754 GO:0006810 GO:0006811 GO:0008553 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0043231 GO:0046872 GO:0051453 GO:1902600
6	0.07	0.521	4.52	0.08	0.76	2jswA	GO:0001726 GO:0003779 GO:0005178 GO:0005200 GO:0005737 GO:0005815 GO:0005856 GO:0005886 GO:0005925 GO:0007016 GO:0007044 GO:0007155 GO:0009986 GO:0016020 GO:0017166 GO:0030054 GO:0030274 GO:0030866 GO:0032403 GO:0032587 GO:0042995 GO:0051015 GO:0070062 GO:0070527
7	0.07	0.483	5.35	0.03	0.77	3b8cA	GO:0000166 GO:0000287 GO:0005524 GO:0005886 GO:0005887 GO:0006754 GO:0006810 GO:0006811 GO:0008553 GO:0015991 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0016887 GO:0046872 GO:0051453
8	0.07	0.456	4.85	0.08	0.69	2yevA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015002 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0022904 GO:0046872 GO:0055114 GO:0070469 GO:1902600
9	0.07	0.479	4.73	0.06	0.71	1r0dA	GO:0003779 GO:0005543 GO:0005737 GO:0005856 GO:0005905 GO:0006897 GO:0006898 GO:0006915 GO:0012505 GO:0016020 GO:0030136 GO:0030276 GO:0030665 GO:0031410 GO:0035091 GO:0043231 GO:0048471 GO:0072583
10	0.07	0.443	5.51	0.07	0.73	3eh3A	GO:0004129 GO:0005506 GO:0005886 GO:0006119 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0046872 GO:0055114 GO:0070469 GO:1902600
11	0.06	0.454	4.97	0.06	0.69	1qleA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0006119 GO:0006810 GO:0006811 GO:0009055 GO:0009060 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0020037 GO:0022900 GO:0046872 GO:0055114 GO:0070469 GO:1902600
12	0.06	0.459	5.59	0.06	0.77	3ixzA	GO:0000166 GO:0000287 GO:0005391 GO:0005524 GO:0005886 GO:0005887 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0006883 GO:0008900 GO:0010107 GO:0010248 GO:0015991 GO:0015992 GO:0016020 GO:0016021 GO:0016787 GO:0030007 GO:0036376 GO:0043231 GO:0046872
13	0.06	0.446	5.01	0.09	0.68	1fftA	GO:0004129 GO:0005506 GO:0005507 GO:0005886 GO:0005887 GO:0006811 GO:0009055 GO:0009060 GO:0009319 GO:0009486 GO:0015078 GO:0015453 GO:0015990 GO:0015992 GO:0016020 GO:0016021 GO:0016491 GO:0016682 GO:0019646 GO:0020037 GO:0046872 GO:0048039 GO:0055114 GO:0070469
14	0.06	0.462	5.56	0.08	0.77	3a3yA	GO:0000166 GO:0005391 GO:0005524 GO:0006810 GO:0006811 GO:0006813 GO:0006814 GO:0010248 GO:0016020 GO:0016021 GO:0016787 GO:0046872 GO:0090662
15	0.06	0.383	5.79	0.05	0.62	4bbjA	GO:0000166 GO:0005886 GO:0006812 GO:0016020 GO:0016021 GO:0016787 GO:0019829 GO:0046872 GO:0098655
16	0.06	0.407	5.24	0.07	0.65	4umvA	GO:0000166 GO:0005886 GO:0006812 GO:0016020 GO:0016021 GO:0016787 GO:0019829 GO:0030001 GO:0046872 GO:0098655
17	0.06	0.481	5.39	0.05	0.79	3w5bA	GO:0000166 GO:0005388 GO:0005509 GO:0005524 GO:0005783 GO:0005789 GO:0005793 GO:0006810 GO:0006811 GO:0006816 GO:0006942 GO:0016020 GO:0016021 GO:0016529 GO:0016787 GO:0031448 GO:0031673 GO:0031674 GO:0033017 GO:0045988 GO:0046872 GO:0048471 GO:0070588
18	0.06	0.402	5.73	0.04	0.70	3j09A	GO:0000166 GO:0005507 GO:0005524 GO:0005886 GO:0006810 GO:0006811 GO:0006812 GO:0006825 GO:0016020 GO:0016021 GO:0016787 GO:0019829 GO:0030001 GO:0046872 GO:0098655

Consensus prediction of GO terms

Molecular Function	GO:0016627	GO:0050662	GO:0031420	GO:0019899	GO:0035639	GO:0015081	GO:0032559	GO:0032550	GO:0008556	GO:0004129	GO:0020037	GO:0005506	GO:0004671
GO-Score	0.54	0.54	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.42	0.42	0.42	0.33
Biological Processes	GO:0097384	GO:0044108	GO:0016129	GO:0008204	GO:1902653	GO:0006875	GO:0098739	GO:0015988	GO:0042391	GO:0071805	GO:0030004	GO:0071436	GO:0055075	GO:0055078	GO:0010959	GO:0009060	GO:0006119	GO:0006481
GO-Score	0.54	0.54	0.54	0.54	0.54	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.42	0.42	0.33
Cellular Component	GO:0098797	GO:0005887	GO:0090533	GO:0031966	GO:0070069	GO:0019866	GO:0098803
GO-Score	0.46	0.46	0.46	0.37	0.37	0.37	0.37

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.