I-TASSER results

I-TASSER results for job id Rv1203c

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (194 residues)
MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLATAIAQQGHIAESAKTLQ
RAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAARTAERAGQAAVALCAWHN
AVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDAAELTAVAEELAGIGMAAAAA
DATKAAARLGPQQR

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLATAIAQQGHIAESAKTLQRAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAARTAERAGQAAVALCAWHNAVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDAAELTAVAEELAGIGMAAAAADATKAAARLGPQQR
Prediction	CCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
Conf.Score	84678789869999999999999999857898765999999999999979999999999999997598745544579999999999979968999999999999999899799999999999988957899999999987885799999999999988989999999999998777899999999999865559
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 \| \| \| \| \| \| \| \| \| MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLATAIAQQGHIAESAKTLQRAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAARTAERAGQAAVALCAWHNAVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDAAELTAVAEELAGIGMAAAAADATKAAARLGPQQR
Prediction	41302021143415401520350032037343211110001001021333426404500430373342411122222200300230144434402520350053037343202001001100111246105304500640623204001310310274336203400530461223220340241025125668
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180

                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEHCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
MLLAYVLITKGEFGAAASMLEPAAATLERTGYSWGPLSLMLLATAIAQQGHIAESAKTLQRAEARHGTKSALFAPELGLARAWTRAAAQDMTGAIAAAREAARTAERAGQAAVALCAWHNAVRLGDIRAVDPVTRLAAEIDCTVGNILVKHARGLADGDAAELTAVAEELAGIGMAAAAADATKAAARLGPQQR

4ui9O

0.14

0.13

0.99

0.98

MUSTER

YRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASKAEALEAAI--ENLNEAKNYFAKVDCKERDVVYFQARLYHTLGKTQERNRCAMLFRQLHQELP

4ke2A

0.20

0.96

0.92

dPPAS

AAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETNVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------

2pl2A

0.18

0.16

0.90

0.86

wdPPAS

LRLGVQLYALGRYDAALTLFERALKENPQD-----PEALYWLARTQLKLGLVNPALENGKTLVART-PRYL--GGYMVLSEAYVALYRQAE-----------DRERGKGYLEQALSVLKDAERVRYAPLHLQRGLVYALL-GERDKAEASLKQALALETPEIRSALAELYLSMGRLDEALAQYAKALEQAPKDL

4ui9O

0.14

0.13

0.99

1.10

wMUSTER

YRKAVVLQAQNQMSEAHKLLQKLLVHCQKLKTEMVISVLLSVAELYWRSSSPTIALPMLLQALALSKYRLQYLASETVLNLAFAQLILGIPEQALSLLHMAIEPILADGAILDKGRAMFLVAKCQVASAASKAEALEAAI--ENLNEAKNYFAKVDCKERDVVYFQARLYHTLGKTQERNRCAMLFRQLHQENH

2r5sA

0.15

0.12

0.77

0.96

wPPAS

LLQVSELLQQGEHAQALNVIQTLSDELQSR-----GDVKLAKADCLLETKQFELAQELLATILEYQDNSYKSLIAKLELHQQAAESPE-ELAANFELACELAVQYNQVGRDEEALELLWNILKAQD-GEVKKTFDILSAL-GQGNAIASKYRRQLYS------------Y------------------------

4ke2A

0.20

0.96

1.37

dPPAS2

AAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETNVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------

4ke2A

0.20

0.96

1.07

PPAS

AAAAAAASKAAVTAADAAAAAATIAASAASVAAATAADDAAASIATINAASAAAKSIAAAAAMAAKDTAAAAASAAAAAVASAAKALETNVKAAYAAATTANTAAAAAAATATTAAAAAAAKATIDNAAAAKAAAVATAVSDAAATAATAAAVAAATLEAAAAKAAATAVSAAAAAAAAAIAFAAAP-------

4ui9J4

0.12

0.11

0.95

1.27

Env-PPAS

VSLAERHYYNCDFKMCYKLTSVVMEKD-----PFHASCLPVHIGTLVELNKANELFYLSHKLVDLY-PS----NPVSWFAVGCYYLMVGHNEHARRYLSKATTLEKTYGEHDQAMAAYFTAAQLGCHLPMLYIGLEYGLTNNKLAERFFSQALSIAPEDPFVMHEVGVVAFQNGEWKTAEKWFLDALEKIKAIG

1hz4A

0.12

1.00

0.88

MUSTER

ALRAQVAINDGNPDEAERLAKLALEELPPGWFYSRIVATSVLGEVLHCKGELTRSLALMQQTEQMAQHDVWHYALWSLIQQSEILFAQGFLQTAWETQEKAFQLINEQHLPMHEFLVRIRAQLLWAEASARSGIEVLSSYQQQLQCLAMLIQCSLARGDLDNARSQLNRLENLLSDWISNANKVRVIYWQMTGD

5cwnA

0.14

0.13

0.99

0.83

dPPAS

DPEEILERAKESLERAREASERGDEEEFRKAAEKALELAKRLVEQAKKEGDPELVLEAAKVALRVAELAAKNGDKEVFKKAAESALEV--AKRLVEVASKEGDPELVLEAAKVALRVAELAAKNGDKEVFKKAAESALEVAKRLVEVASKEGDPELVEEAAKVAEEVRKLAKKQGDEEVYEKARETAREVKEEL

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-2.06

Estimated TM-score = 0.47±0.15

Estimated RMSD = 9.9±4.6Å

Download Model 2

C-score=-2.06

Download Model 3

C-score=-1.97

Download Model 4

C-score=-3.76

Download Model 5

C-score=-3.41

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	4ui9O	0.769	3.52	0.110	0.979
2	4gyoA	0.750	3.43	0.113	0.949
3	1hz4A	0.739	3.46	0.099	0.938
4	4b4tQ	0.737	3.51	0.091	0.954
5	4i1aA	0.732	3.48	0.055	0.943
6	2qfcA	0.723	3.44	0.092	0.949
7	3q15A	0.722	3.65	0.109	0.943
8	3ulqA	0.716	3.77	0.071	0.949
9	5l4kQ	0.712	3.84	0.096	0.954
10	3sf4A	0.712	3.45	0.093	0.928

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.10	4	3e6yB	III	Rep, Mult	9,40,47,48,76,79,80,83,87,113,116
2	0.08	3	2qfcB	III	Rep, Mult	1,5,6,8,9,37,40,41,44,73,76,79,113
3	0.08	3	1qpiA	IMD	Rep, Mult	119,120,122,123
4	0.03	1	2vq2A	SO3	Rep, Mult	110,112,113
5	0.03	1	1fchA	III	Rep, Mult	53,54,56,57,89,93
6	0.03	1	2amxB	CO	Rep, Mult	141,148,151
7	0.03	1	3u24A	ZN	Rep, Mult	181,184
8	0.03	1	1iw7F	MG	Rep, Mult	151,159
9	0.03	1	2np5C	NDS	Rep, Mult	87,88,90,102
10	0.03	1	1dpmA	ZN	Rep, Mult	119,151
11	0.03	1	4a1sB	III	Rep, Mult	1,2,5,33,37,40,41,44,47,48,62,78,81,82,85,88,116,119,120,126,129,130,136,161,165,168,171,172,174,186
12	0.03	1	1o9fA	FSC	Rep, Mult	5,9,41,44,45,76,111,112,115

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.060	1ia7A	0.591	4.38	0.092	0.887	3.2.1.4	NA
2	0.060	1j0mA	0.571	5.20	0.090	0.949	4.2.2.12	NA
3	0.060	2cqsA	0.557	4.98	0.085	0.907	2.4.1.20	54
4	0.060	1g87B	0.562	4.39	0.074	0.851	3.2.1.4	NA
5	0.060	3ebgA	0.585	4.41	0.044	0.912	3.4.11.-	NA
6	0.060	1fp3A	0.601	4.65	0.090	0.954	5.1.3.8	113
7	0.060	1f1sA	0.568	4.85	0.022	0.923	4.2.2.1	NA
8	0.060	2vn4A	0.581	4.99	0.079	0.949	3.2.1.3	106,139
9	0.060	1fo2A	0.571	4.52	0.056	0.897	3.2.1.113	45,150
10	0.060	1w3bA	0.645	3.42	0.129	0.835	2.4.1.-	12,21
11	0.060	1n4pB	0.547	4.76	0.034	0.892	2.5.1.59,2.5.1.-	NA
12	0.060	1hcuB	0.569	5.06	0.086	0.949	3.2.1.113	NA
13	0.060	1nxcA	0.568	5.16	0.081	0.943	3.2.1.113	NA
14	0.060	1l2aE	0.595	4.73	0.098	0.928	3.2.1.4	94
15	0.060	1tnzL	0.547	4.76	0.034	0.892	2.5.1.59	5
16	0.060	1ksdA	0.611	4.47	0.146	0.907	3.2.1.4	114,117
17	0.060	1w3bB	0.634	3.60	0.120	0.851	2.4.1.-	NA
18	0.060	2ri9B	0.557	5.00	0.061	0.923	3.2.1.113	113
19	0.060	1z1wA	0.581	4.56	0.069	0.887	3.4.11.-	NA

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.24	0.478	2.68	0.09	0.57	4gcoA	GO:0000003 GO:0005737 GO:0007275 GO:0008340 GO:0009408 GO:0030544 GO:0032780 GO:0042030 GO:0051879
1	0.23	0.735	3.42	0.09	0.95	5a6cB	GO:0000132 GO:0000166 GO:0000922 GO:0001965 GO:0005092 GO:0005654 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005911 GO:0005912 GO:0005913 GO:0005938 GO:0007052 GO:0007155 GO:0007165 GO:0007186 GO:0007267 GO:0008022 GO:0017016 GO:0030054 GO:0030695 GO:0034332 GO:0042802 GO:0043547 GO:0045177 GO:0050790 GO:0051661 GO:0060487 GO:0090557 GO:0097431 GO:0098609 GO:0098641
2	0.23	0.712	3.87	0.10	0.95	3txmA	GO:0000502 GO:0005838 GO:0005875 GO:0008541 GO:0043161
3	0.22	0.722	3.65	0.11	0.94	3q15A	GO:0004721 GO:0006470 GO:0016787
4	0.21	0.777	3.44	0.11	0.98	5g05O	GO:0005634 GO:0005654 GO:0005680 GO:0005829 GO:0007049 GO:0007067 GO:0016567 GO:0019903 GO:0031145 GO:0042787 GO:0043161 GO:0051301 GO:0051436 GO:0051437 GO:0051439 GO:0070979
5	0.20	0.745	3.51	0.12	0.95	4gyoB	GO:0004721 GO:0006470 GO:0016787
6	0.20	0.653	4.22	0.06	0.95	4jhrA	GO:0000132 GO:0000166 GO:0000922 GO:0001965 GO:0005092 GO:0005737 GO:0005856 GO:0005938 GO:0007052 GO:0030695 GO:0042802 GO:0045177 GO:0050790 GO:0051661 GO:0060487 GO:0097431
7	0.19	0.505	2.25	0.12	0.57	2vyiA	GO:0005737 GO:0005829 GO:0016020 GO:0016032 GO:1903071 GO:1904288
8	0.19	0.739	3.46	0.10	0.94	1hz4A	GO:0000166 GO:0003677 GO:0003700 GO:0005524 GO:0005975 GO:0006351 GO:0006355 GO:0042802 GO:0045893 GO:0045913 GO:0048031
9	0.18	0.708	3.64	0.06	0.94	4i1aB	GO:0004721 GO:0006470 GO:0016787
10	0.18	0.717	3.76	0.08	0.95	5a5bQ	GO:0000502 GO:0005198 GO:0006511 GO:0008541 GO:0034515 GO:0043248
11	0.16	0.725	3.62	0.07	0.94	4i9eA	GO:0004721 GO:0006470 GO:0016787
12	0.15	0.498	2.38	0.13	0.58	2lniA	GO:0005634 GO:0005737 GO:0005794 GO:0006950 GO:0008022 GO:0030544 GO:0043209 GO:0043234 GO:0044822 GO:0051087
13	0.14	0.657	3.78	0.07	0.88	4d10B	GO:0000122 GO:0000715 GO:0003714 GO:0004871 GO:0005634 GO:0005654 GO:0005737 GO:0006283 GO:0006366 GO:0007165 GO:0008180 GO:0008283 GO:0010388 GO:0030182 GO:0035914 GO:0045892 GO:1903507
14	0.13	0.491	2.44	0.12	0.58	3gz1A	GO:0005737 GO:0006950 GO:0009405
15	0.11	0.535	3.23	0.16	0.68	2fo7A
16	0.11	0.499	3.07	0.07	0.60	3uq3A	GO:0003729 GO:0005737 GO:0006457 GO:0008104 GO:0030544 GO:0042030 GO:0043086 GO:0051879
17	0.11	0.639	3.56	0.12	0.86	5a31F	GO:0005634 GO:0005654 GO:0005680 GO:0005737 GO:0005813 GO:0005819 GO:0005829 GO:0005876 GO:0007091 GO:0008283 GO:0016567 GO:0019903 GO:0031145 GO:0042787 GO:0043161 GO:0051436 GO:0051437 GO:0051439 GO:0070979
18	0.11	0.505	3.47	0.10	0.64	2dbaA	GO:0005634 GO:0005737 GO:0005913 GO:0007275 GO:0007517 GO:0030154 GO:0048471 GO:0051879 GO:0061077 GO:0098609 GO:0098641
19	0.11	0.463	2.81	0.08	0.56	1elwA	GO:0005634 GO:0005737 GO:0005794 GO:0006950 GO:0008022 GO:0030544 GO:0043209 GO:0043234 GO:0044822 GO:0051087
20	0.10	0.453	1.70	0.14	0.49	4cgwA	GO:0097255
21	0.07	0.488	2.57	0.14	0.57	4cgvB	GO:0097255
22	0.06	0.394	5.95	0.08	0.73	3vylA	GO:0046872
23	0.06	0.408	2.07	0.09	0.45	3k9iA
24	0.06	0.394	5.73	0.08	0.70	2jc4A	GO:0003677 GO:0004518 GO:0004519 GO:0005622 GO:0006281 GO:0008853 GO:0016787 GO:0090305

Consensus prediction of GO terms

Molecular Function	GO:0031072	GO:0004857	GO:0060590	GO:0031267	GO:0045296	GO:1901265	GO:0036094	GO:0098632	GO:0016791	GO:0019902
GO-Score	0.47	0.47	0.47	0.46	0.46	0.46	0.46	0.46	0.43	0.42
Biological Processes	GO:0043462	GO:0010259	GO:0009266	GO:0006950	GO:0051346	GO:0044700	GO:0051642	GO:0043087	GO:0045216	GO:0051657	GO:0040001	GO:0060479	GO:0051294	GO:0007154	GO:0051345	GO:0051716	GO:0061028	GO:0022610	GO:0060428	GO:0016311	GO:1904667	GO:0000209	GO:1904668	GO:1901990	GO:0051439	GO:2000060	GO:0000280	GO:0043161
GO-Score	0.47	0.47	0.47	0.47	0.47	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.46	0.43	0.42	0.42	0.42	0.42	0.42	0.42	0.42	0.39
Cellular Component	GO:0071944	GO:0099568	GO:0072686	GO:0070161	GO:0000922	GO:0022624	GO:0031461	GO:0000152	GO:0005654	GO:0005829	GO:0016020
GO-Score	0.46	0.46	0.46	0.46	0.46	0.46	0.42	0.42	0.39	0.39	0.35

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
3.	A Roy, A Kucukural, Y Zhang. I-TASSER: a unified platform for automated protein structure and function prediction. Nature Protocols, 5: 725-738, 2010.
4.	Y Zhang. I-TASSER server for protein 3D structure prediction. BMC Bioinformatics, 9: 40, 2008.