I-TASSER results

I-TASSER results for job id Rv1192

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Input Sequence in FASTA format

>protein (275 residues)
MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRMLPAGDGHPVLVLPGLL
AGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDLLDKLHSRYHTPVSLIGWS
LGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWSFNRYAHLHTERHELPLEMES
EPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRSSHIGYGHNPPVVWAIADRLAQP
QGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA

Predicted Secondary Structure

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRMLPAGDGHPVLVLPGLLAGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDLLDKLHSRYHTPVSLIGWSLGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWSFNRYAHLHTERHELPLEMESEPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRSSHIGYGHNPPVVWAIADRLAQPQGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA
Prediction	CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHCCEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEEHCCCCCEHCCHHHHCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
Conf.Score	99988888877788985678776444445665555555655665888889859996899999668999999999989979986899888986899999999999999997998899997888999999999955745679997699988876545545567776566665545666656788998789986689976766676456888757899866654456899999999999986678887788887765567888777776677666789
	H:Helix; S:Strand; C:Coil

Predicted Solvent Accessibility

Sequence	20 40 60 80 100 120 140 160 180 200 220 240 260 \| \| \| \| \| \| \| \| \| \| \| \| \| MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRMLPAGDGHPVLVLPGLLAGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDLLDKLHSRYHTPVSLIGWSLGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWSFNRYAHLHTERHELPLEMESEPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRSSHIGYGHNPPVVWAIADRLAQPQGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA
Prediction	74234331445525323122110322202120211111231144146353200000001001320021015105724041212322333323440053025104401742643000000000000001003402530210000000132444432321321331441434335233524542220100021143011020420353445413102030102310213300210151054357525415364223211242634253554266458
	Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Normalized B-facotr

(B-factor is a value to indicate the extent of the inherent thermal mobility of residues/atoms in proteins. In I-TASSER, this value is deduced from threading template proteins from the PDB in combination with the sequence profiles derived from sequence databases. The reported B-factor profile in the figure below corresponds to the normalized B-factor of the target protein, defined by B=(B'-u)/s, where B' is the raw B-factor value, u and s are respectively the mean and standard deviation of the raw B-factors along the sequence. (Click here to read more about predicted normalized B-factor)

Top 10 threading templates used by I-TASSER

Rank

PDB
Hit

Iden1

Iden2

Cov

Norm.
Zscore

Download
Align.

                  20                  40                  60                  80                 100                 120                 140                 160                 180                 200                 220                 240                 260

                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |                   |

Sec.Str
Seq

CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCEEEEHCCCCCCCHHHHHHHHHHHHHCCEEEHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHCHHHHHHHHHHHHCCCCCCEEEEHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEEEHCCCCCEHCCHHHHCCCCCCEEEEEEHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
MLLPVLEPADRPCDAPGWFLYLTDIPRAGVEYGQLLAVLPLQRMLPAGDGHPVLVLPGLLAGDGSTWILRRILRRLGYAAYGWGLGRNIGPTAKAVSGMRDLLDKLHSRYHTPVSLIGWSLGGIFARGLARDHPSAVRQVITLGSPFGMRDTCETRSAWSFNRYAHLHTERHELPLEMESEPLPVPTTAIYSRCDGMVAWQTCMNSPSERAENIAVRSSHIGYGHNPPVVWAIADRLAQPQGAWAPFRPPKVLSPLFPRPDTPAEAVSTPQTRPA

1lbtA

0.17

0.16

0.93

1.21

MUSTER

------LPSGSDPAFSQ-------------PKSVLDAGLTCQGASPSSVSKPILLVPGTGTTGPQSFDWIPLSTQLGYTPCWISPPFMLNDTQVNTEYMVNAITALYAGSGNKLPVLTWSQGGLVAQWGLTFFPSKVDRLMAFAPDYKGTVLAGPLDALPSVWQQTTGSALTTALRNAGGLTQIVPTTNLYSATDEIVQPQVSNSPYLFNGKNVQAQIDHAGSLTSQFSYVVGRSALRSTTGQARSADYGITDCNPLPANDLTAPAAAAIVAGPK

1i6wB

0.17

0.11

0.63

1.75

dPPAS

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWSLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNLGNKVANVVTLGGANRLTTGKALPG---------------------TDPNQKILYTSIYSSADMIVMNYLS--RLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1i6wB

0.18

0.11

0.63

2.17

wdPPAS

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWSLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNLGNKVANVVTLGGANRLTTGKALPG---------------------TDPNQKILYTSIYSSADMIVMNYLSRL---DGARNVQIHVGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1lbtA

0.17

0.16

0.93

1.55

wMUSTER

-------PSGSDPAFSQ-------------PKSVLDAGLTCQGASPSSVSKPILLVPGTGTTGPQSFDWIPLSTQLGYTPCWISPPFMLNDTQVNTEYMVNAITALYAGSGNKLPVLTWSQGGLVAQWGLTFFPSKVDRLMAFAPDYKGTVLAGPLDALPSVWQQTTGSALTTALRNAGGLTQIVPTTNLYSATDEIVQPQVSNSPLDFNGKNVQAQIDHAGSLTSQFSYVVGRSALRSTTGQARSADYGITDCNPLPANDLTAPAAAAIVAGPK

1i6wB

0.17

0.11

0.63

2.67

wPPAS

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWSLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNLGNKVANVVTLGGANRLTTGKALPG---------------------TDPNQKILYTSIYSSADMIVMNYLS-RLDGA--RNVQIHVGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1i6wB

0.18

0.11

0.63

3.30

dPPAS2

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWSLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNLGNKVANVVTLGGANRLTTGKALPG---------------------TDPNQKILYTSIYSSADMIVMNYLSRL---DGARNVQIHGGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1i6wB

0.17

0.11

0.63

2.29

PPAS

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWSLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNLGNKVANVVTLGGANRLTTGKALPG---------------------TDPNQKILYTSIYSSADMIVMNYLS-RLDGA--RNVQIHGGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1i6wB

0.18

0.11

0.63

2.64

Env-PPAS

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWSLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNLGNKVANVVTLGGANRLTTGK----------ALPGTDP-----------NQKILYTSIYSSADMIVMNYLSRL---DGARNVQIHGGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1i6wB

0.18

0.11

0.63

1.16

MUSTER

------------------------------------------------EHNPVVMVHGIGGASFNFAGIKSYLVSQGWKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGKKVDIVAHSMGGANTLYYIKNGGNKVANVVTLGGANRLTTGKALPG---------------------TDPNQKILYTSIYSSADMIVMNYLSRL---DGARNVQIHVGHIGLLYSSQVNSLIKEGLNGGGQNTN------------------------------

1lbtA

0.17

0.16

0.93

1.59

dPPAS

------LPSGSDPAFSQ-------------PKSVLDAGLTCQGASPSSVSKPILLVPGTGTTGPQSFDWIPLSTQLGYTPCWISPPFMLNDTQVNTEYMVNAITALYAGSGNKLPVLTWSQGGLVAQWGLTFFPSKVDRLMAFAPDYKGTVLAGPLDALPSVWQQTTGSALTTALRNAGGLTQIVPTTNLYSATDEIVQPQVSNSPLDSNGKNVQAQIDHAGSLTSQFSYVVGRSALRSTTGQARSADYGITDCNPLPANDLTPEQKVAAAALLA

(a)	Iden1 is the number of template residues identical to query divided by number of aligned residues.
(b)	Iden2 is the number of template residues identical to query divided by query sequence length.
(c)	Cov is equal the number of aligned template residues divided by query sequence length.
(d)	Norm. Zscore is the normalized Z-score of the threading alignments. A Normalized Z-score >1 means a good alignment.
(e)	Download Align. list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.

Top 5 final models predicted by I-TASSER

(For each target, I-TASSER simulations generate a large ensemble of structural conformations, called decoys. To select the final models, I-TASSER uses the SPICKER program to cluster all the decoys based on the pair-wise structure similarity, and reports up to five models which corresponds to the five largest structure clusters. The confidence of each model is quantitatively measured by C-score that is calculated based on the significance of threading template alignments and the convergence parameters of the structure assembly simulations. C-score is typically in the range of [-5, 2], where a C-score of higher value signifies a model with a high confidence and vice-versa. TM-score and RMSD are estimated based on C-score and protein length following the correlation observed between these qualities. Since the top 5 models are ranked by the cluster size, it is possible that the lower-rank models have a higher C-score in rare cases. Although the first model has a better quality in most cases, it is also possible that the lower-rank models have a better quality than the higher-rank models as seen in our benchmark tests. If the I-TASSER simulations converge, it is possible to have less than 5 clusters generated. This is usually an indication that the models have a good quality because of the converged simulations.)

More about C-score

Local structure accuracy of first model

Download Model 1

C-score=-0.22

Estimated TM-score = 0.68±0.12

Estimated RMSD = 6.5±3.9Å

Download Model 2

C-score=-2.68

Download Model 3

C-score=-3.04

Download Model 4

C-score=-3.72

Download Model 5

C-score=-2.05

Proteins structureally close to the target in PDB (as identified by TM-align

(After the structure assembly simulation, I-TASSER uses the TM-align structural alignment program to match the first I-TASSER model to all structures in the PDB library. This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e. the highest TM-score, to the predicted I-TASSER model. Due to the structural similarity, these proteins often have similar function to the target. However, users are encouraged to use the data in the next section 'Predicted function using COACH' to infer the function of the target protein, since COACH has been extensively trained to derive biological functions from multi-source of sequence and structure features which has on average a higher accuracy than the function annotations derived only from the global structure comparison.)

Top 10 Identified stuctural analogs in PDB

Rank	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov
1	1lbtA	0.866	1.84	0.164	0.931
2	2veoA	0.681	4.43	0.095	0.916
3	2vtvA	0.662	3.23	0.115	0.793
4	1lnsA2	0.655	4.44	0.110	0.880
5	2fj0A	0.654	4.28	0.085	0.855
6	1qo9A	0.651	4.19	0.067	0.840
7	1aknA	0.648	4.17	0.086	0.840
8	1lpsA	0.648	4.31	0.071	0.844
9	3vdxA1	0.647	2.84	0.147	0.742
10	1k8qA	0.647	2.83	0.113	0.749

(a)	Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b)	Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by length of the query protein.

Predicted function using COACH

(This section reports biological annotations of the target protein by COACH based on the I-TASSER structure prediction. COACH is a meta-server approach that combines multiple function annotation results from the COFACTOR, TM-SITE and S-SITE programs.)

Ligand binding sites

Rank	C-score	Cluster size	PDB Hit	Lig Name	Download Complex	Ligand Binding Site Residues
1	0.30	7	1r50A	SIL	Rep, Mult	58,59,61,65,119,120,121,197,202,220,221
2	0.20	5	1lbtA	T80	Rep, Mult	58,120,121,146,150,152,165,196,197,220,274,275
3	0.07	2	2xmgA	UUU	Rep, Mult	126,130,133,134,186

	Download the all possible binding ligands and detailed prediction summary.
	Download the templates clustering results.
(a)	C-score is the confidence score of the prediction. C-score ranges [0-1], where a higher score indicates a more reliable prediction.
(b)	Cluster size is the total number of templates in a cluster.
(c)	Lig Name is name of possible binding ligand. Click the name to view its information in the BioLiP database.
(d)	Rep is a single complex structure with the most representative ligand in the cluster, i.e., the one listed in the Lig Name column. Mult is the complex structures with all potential binding ligands in the cluster.

Enzyme Commission (EC) numbers and active sites

Rank	Cscore^EC	PDB Hit	TM-score	RMSD^a	IDEN^a	Cov	EC Number	Active Site Residues
1	0.333	3cn7A	0.560	2.47	0.126	0.629	3.1.1.1	59,120,195,220
2	0.331	1i6wB	0.541	2.20	0.199	0.593	3.1.1.3	120,220
3	0.320	1auoA	0.565	2.68	0.156	0.640	3.1.1.1	59,120,195,220
4	0.275	2ocgA	0.608	3.41	0.167	0.742	3.1.-.-	56,116,120,122,126,195,198,220
5	0.193	3e3aB	0.638	2.69	0.149	0.735	1.11.1.-	58
6	0.162	2h1iA	0.528	3.20	0.106	0.633	3.1.1.1	64,120,146
7	0.161	3esbA	0.484	3.19	0.126	0.575	3.1.1.74	120,220
8	0.136	1vkhA	0.613	3.44	0.103	0.753	3.5.1.9	58
9	0.121	1va4A	0.627	2.65	0.167	0.713	3.1.1.2	120
10	0.067	1fj2A	0.568	3.18	0.110	0.673	3.1.4.39	59
11	0.067	1dinA	0.557	2.90	0.124	0.654	3.1.1.45	195,220
12	0.066	3dcnA	0.485	3.15	0.136	0.571	3.1.1.74	120
13	0.066	3gbsA	0.487	3.27	0.128	0.575	3.1.1.74	120,220
14	0.060	1c7jA	0.636	4.40	0.082	0.836	3.1.1.-	80
15	0.060	2ecfA	0.619	4.04	0.100	0.782	3.4.14.5	195,220
16	0.060	1hlgB	0.644	3.00	0.112	0.753	3.1.1.3	NA
17	0.060	1a88A	0.633	2.73	0.114	0.724	1.11.1.10	NA
18	0.060	1cleA	0.648	4.36	0.071	0.847	3.1.1.3	NA
19	0.060	1a88B	0.634	2.72	0.114	0.724	1.11.1.10	NA
20	0.060	1maaD	0.644	4.21	0.086	0.836	3.1.1.7	NA
21	0.060	1zoiA	0.633	2.54	0.095	0.716	3.1.1.-	120,220
22	0.060	1a7uA	0.641	2.66	0.149	0.727	1.11.1.10	120
23	0.060	1eveA	0.646	4.28	0.093	0.844	3.1.1.7	NA
24	0.060	1qo9A	0.651	4.19	0.067	0.840	3.1.1.7	NA
25	0.060	1b41A	0.640	4.33	0.086	0.840	3.1.1.7	NA
26	0.060	1a8sA	0.628	2.68	0.126	0.713	1.11.1.10	120,220
27	0.060	1e5tA	0.623	3.95	0.106	0.782	3.4.21.26	120
28	0.060	2fj0A	0.654	4.28	0.085	0.855	3.1.1.1	NA
29	0.060	1lnsA	0.655	4.44	0.110	0.880	3.4.14.11	120,195,220
30	0.060	1k8qA	0.647	2.83	0.113	0.749	3.1.1.3	56
31	0.060	1k4yA	0.637	4.32	0.087	0.836	3.1.1.1	NA
32	0.060	1tccA	0.865	1.86	0.164	0.931	3.1.1.3	120

(a)	Cscore^EC is the confidence score for the EC number prediction. Cscore^EC values range in between [0-1]; where a higher score indicates a more reliable EC number prediction.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.

Gene Ontology (GO) terms

Rank	Cscore^GO	TM-score	RMSD^a	IDEN^a	Cov	PDB Hit	Associated GO Terms
Homologous GO templates in PDB
0	0.36	0.556	3.00	0.14	0.65	3trdA	GO:0016787
1	0.30	0.810	2.05	0.16	0.88	3icwA	GO:0004806 GO:0006629 GO:0016042 GO:0016787
2	0.27	0.544	2.85	0.13	0.63	1uxoA	GO:0016787
3	0.25	0.537	3.23	0.12	0.64	2qs9A	GO:0005634 GO:0005730 GO:0005737 GO:0016787 GO:0042127 GO:0070062
4	0.24	0.863	1.97	0.16	0.93	4k6gB	GO:0004806 GO:0006629 GO:0016042 GO:0016787
5	0.23	0.521	2.69	0.15	0.60	3bdvA	GO:0016787 GO:0046872
6	0.19	0.599	2.61	0.15	0.68	1hqdA	GO:0004806 GO:0006629 GO:0016042 GO:0016787 GO:0046872
7	0.18	0.616	3.13	0.12	0.73	4x00A	GO:0016787
8	0.18	0.621	4.42	0.10	0.82	3i2gA	GO:0005737 GO:0006508 GO:0008239 GO:0016787 GO:0050784 GO:0052689
9	0.18	0.622	4.42	0.07	0.83	3iiiA	GO:0006508 GO:0008239 GO:0016787
10	0.15	0.595	3.18	0.15	0.70	1j1iA	GO:0016787
11	0.14	0.585	2.94	0.12	0.69	3p2mA	GO:0052689
12	0.13	0.540	2.20	0.20	0.59	5ct4B	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787
13	0.13	0.594	2.70	0.16	0.68	1tahA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787 GO:0046872
14	0.11	0.626	3.40	0.11	0.76	4opmA	GO:0004806 GO:0016787
15	0.09	0.655	4.44	0.11	0.88	1lnsA	GO:0004177 GO:0005737 GO:0006508 GO:0008233 GO:0008236 GO:0008239 GO:0016787
16	0.09	0.673	4.35	0.10	0.91	3guuA	GO:0004806 GO:0005576 GO:0006629 GO:0016042 GO:0016787
17	0.08	0.662	3.29	0.11	0.80	4bvkB	GO:0016787
18	0.08	0.632	3.41	0.11	0.76	2wtmA
19	0.07	0.615	3.66	0.12	0.76	4eziA	GO:0004806 GO:0016042
20	0.07	0.602	3.81	0.15	0.76	3h2kA	GO:0004177 GO:0004806 GO:0006508 GO:0016042
21	0.07	0.605	3.50	0.13	0.74	1u2eA	GO:0003824 GO:0005737 GO:0016787 GO:0018771 GO:0019380 GO:0019439 GO:0019622 GO:0042803 GO:0052823
22	0.07	0.602	2.53	0.16	0.68	1ex9A	GO:0004806 GO:0005576 GO:0005615 GO:0006629 GO:0009986 GO:0016042 GO:0016298 GO:0016787 GO:0046872
23	0.07	0.599	2.61	0.13	0.68	4hs9A	GO:0004806 GO:0016787 GO:0046872
24	0.07	0.449	5.58	0.06	0.69	3egdB	GO:0000139 GO:0002474 GO:0005737 GO:0005783 GO:0005789 GO:0005794 GO:0005829 GO:0006810 GO:0006886 GO:0006888 GO:0008270 GO:0012507 GO:0015031 GO:0016020 GO:0016192 GO:0019886 GO:0030127 GO:0045714 GO:0048208 GO:0048471 GO:0050714 GO:2000189
25	0.06	0.388	5.92	0.07	0.63	3raoB	GO:0016705 GO:0055114
26	0.06	0.368	4.70	0.14	0.51	4ptyD	GO:0006974 GO:0008752 GO:0009970 GO:0016491 GO:0046306 GO:0051289 GO:0052873 GO:0055114
27	0.06	0.399	5.61	0.06	0.63	3flmA	GO:0000287 GO:0003824 GO:0009234 GO:0016740 GO:0030145 GO:0030976 GO:0046872 GO:0070204
28	0.06	0.363	6.36	0.06	0.64	3sqzA	GO:0003824 GO:0004421 GO:0008152 GO:0008299 GO:0016740 GO:0016746
29	0.06	0.385	6.22	0.03	0.67	3eb7A	GO:0005102 GO:0006952 GO:0009405 GO:0030435
30	0.06	0.620	4.14	0.10	0.79	3azoA	GO:0004177 GO:0006508 GO:0008236

Consensus prediction of GO terms

Molecular Function	GO:0004806
GO-Score	0.47
Biological Processes	GO:0050794	GO:0008283	GO:0016042
GO-Score	0.50	0.50	0.47
Cellular Component	GO:0031981	GO:0031988	GO:0043232	GO:1903561
GO-Score	0.50	0.50	0.50	0.50

(a)	Cscore^GO is a combined measure for evaluating global and local similarity between query and template protein. It's range is [0-1] and higher values indicate more confident predictions.
(b)	TM-score is a measure of global structural similarity between query and template protein.
(c)	RMSD^a is the RMSD between residues that are structurally aligned by TM-align.
(d)	IDEN^a is the percentage sequence identity in the structurally aligned region.
(e)	Cov represents the coverage of global structural alignment and is equal to the number of structurally aligned residues divided by length of the query protein.
(f)	The second table shows a consensus GO terms amongst the top scoring templates. The GO-Score associated with each prediction is defined as the average weight of the GO term, where the weights are assigned based on Cscore^GO of the template.

[Click on result.tar.bz2 to download the tarball file including all modelling results listed on this page]

Please cite the following articles when you use the I-TASSER server:
1.	J Yang, R Yan, A Roy, D Xu, J Poisson, Y Zhang. The I-TASSER Suite: Protein structure and function prediction. Nature Methods, 12: 7-8, 2015.
2.	J Yang, Y Zhang. I-TASSER server: new development for protein structure and function predictions, Nucleic Acids Research, 43: W174-W181, 2015.
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